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{"title"=>"Protective effect of curcumin on pulmonary and cardiovascular effects induced by repeated exposure to diesel exhaust particles in mice", "type"=>"journal", "authors"=>[{"first_name"=>"Abderrahim", "last_name"=>"Nemmar", "scopus_author_id"=>"6603804126"}, {"first_name"=>"Deepa", "last_name"=>"Subramaniyan", "scopus_author_id"=>"37111315900"}, {"first_name"=>"Badreldin H.", "last_name"=>"Ali", "scopus_author_id"=>"35553526000"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84862703876", "sgr"=>"84862703876", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0039554", "pmid"=>"22745783", "isbn"=>"9713713753", "pui"=>"365066368"}, "id"=>"174ee4c5-1e8c-3812-91cb-8494d59c392f", "abstract"=>"Particulate air pollution has been associated with increased risk of cardiopulmonary diseases. However, the underlying mechanisms are not fully understood. We have previously demonstrated that single dose exposure to diesel exhaust particle (DEP) causes lung inflammation and peripheral thrombotic events. Here, we exposed mice with repeated doses of DEP (15 microg/animal) every 2(nd) day for 6 days (a total of 4 exposures), and measured several cardiopulmonary endpoints 48 h after the end of the treatments. Moreover, the potential protective effect of curcumin (the yellow pigment isolated from turmeric) on DEP-induced cardiopulmonary toxicity was assessed. DEP exposure increased macrophage and neutrophil numbers, tumor necrosis factor alpha (TNF alpha) in the bronchoalveolar lavage (BAL) fluid, and enhanced airway resistance to methacoline measured invasively using Flexivent. DEP also significantly increased plasma C-reactive protein (CRP) and TNF alpha concentrations, systolic blood pressure (SBP) as well as the pial arteriolar thrombosis. It also significantly enhanced the plasma D-dimer and plasminogen activator inhibitor-1 (PAI-1). Pretreatment with curcumin by oral gavage (45 mg/kg) 1 h before exposure to DEP significantly prevented the influx of inflammatory cells and the increase of TNF alpha in BAL, and the increased airway resistance caused by DEP. Likewise, curcumin prevented the increase of SBP, CRP, TNF alpha, D-dimer and PAI-1. The thrombosis was partially but significantly mitigated. In conclusion, repeated exposure to DEP induced lung and systemic inflammation characterized by TNFalpha release, increased SBP, and accelerated coagulation. Our findings indicate that curcumin is a potent anti-inflammatory agent that prevents the release of TNFalpha and protects against the pulmonary and cardiovascular effects of DEP.", "link"=>"http://www.mendeley.com/research/protective-effect-curcumin-pulmonary-cardiovascular-effects-induced-repeated-exposure-diesel-exhaust-3", "reader_count"=>18, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>3, "Student > Master"=>3, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>3, "Student > Master"=>3, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>2, "Philosophy"=>1, "Sports and Recreations"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}, "Philosophy"=>{"Philosophy"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Italy"=>1}, "group_count"=>2}

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• {"files"=>["https://ndownloader.figshare.com/files/619245"], "description"=>"<p>SBP: systolic blood pressure; BAL: bronchoalveolar lavage.</p>", "links"=>[], "tags"=>["endpoints", "repeated", "intratracheal", "instillation", "saline", "diesel", "particles", "curcumin", "pretreatment"], "article_id"=>289729, "categories"=>["Physiology", "Medicine", "Biochemistry"], "users"=>["Abderrahim Nemmar", "Deepa Subramaniyan", "Badreldin H. Ali"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0039554.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Treatments_and_endpoints_following_the_repeated_intratracheal_instillation_i_t_of_saline_or_diesel_exhaust_particles_DEP_with_or_without_curcumin_pretreatment_given_by_oral_gavage_in_mice_/289729", "title"=>"Treatments and endpoints following the repeated intratracheal instillation (i.t.) of saline or diesel exhaust particles (DEP) with or without curcumin pretreatment (given by oral gavage) in mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 03:27:58"}
• {"files"=>["https://ndownloader.figshare.com/files/619316"], "description"=>"<p>Data are mean ± SEM (n = 8 in each group). Statistical analysis by one-way analysis of variance (ANOVA), followed by Bonferroni multiple-range tests.</p>", "links"=>[], "tags"=>["macrophages", "polymorphonuclear", "neutrophils", "necrosis", "interleukin-6", "concentrations", "bronchoalveolar", "repeated", "intratracheal", "instillation", "saline", "diesel", "particles", "15", "curcumin"], "article_id"=>289794, "categories"=>["Physiology", "Medicine", "Biochemistry"], "users"=>["Abderrahim Nemmar", "Deepa Subramaniyan", "Badreldin H. Ali"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0039554.g002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_macrophages_A_and_polymorphonuclear_neutrophils_PMN_B_and_tumor_necrosis_factor_945_TNF_945_C_and_interleukin_6_IL_6_D_concentrations_in_bronchoalveolar_lavage_after_repeated_intratracheal_instillation_of_saline_or_diesel_exhaust_particles_DEP_/289794", "title"=>"Number of macrophages (A) and polymorphonuclear neutrophils (PMN) (B), and tumor necrosis factor α (TNF α, C) and interleukin-6 (IL-6, D ) concentrations in bronchoalveolar lavage, after repeated intratracheal instillation of saline or diesel exhaust particles (DEP, 15 µg/animal) with or without curcumin pretreatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 03:28:25"}
• {"files"=>["https://ndownloader.figshare.com/files/619534"], "description"=>"<p> Data are mean±SEM (n = 8 in each group). Statistical analysis by one-way analysis of variance (ANOVA), followed by Bonferroni multiple-range tests.</p>", "links"=>[], "tags"=>["repeated", "intratracheal", "instillation", "saline", "diesel", "particles", "15", "curcumin"], "article_id"=>290019, "categories"=>["Physiology", "Medicine", "Biochemistry"], "users"=>["Abderrahim Nemmar", "Deepa Subramaniyan", "Badreldin H. Ali"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0039554.g005", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Systolic_blood_pressure_after_repeated_intratracheal_instillation_of_saline_or_diesel_exhaust_particles_DEP_15_181_g_animal_with_or_without_curcumin_pretreatment_/290019", "title"=>"Systolic blood pressure, after repeated intratracheal instillation of saline or diesel exhaust particles (DEP, 15 µg/animal) with or without curcumin pretreatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 03:29:46"}
• {"files"=>["https://ndownloader.figshare.com/files/619694"], "description"=>"<p> <b>µg/animal) with or without curcumin pretreatment.</b> Data are mean0±SEM (n = 8 in each group). Statistical analysis by one-way analysis of variance (ANOVA), followed by Bonferroni multiple-range tests.</p>", "links"=>[], "tags"=>["concentrations", "d-dimer", "plasminogen", "activator", "inhibitor", "von", "willebrand", "repeated", "intratracheal", "instillation", "saline", "diesel", "particles"], "article_id"=>290177, "categories"=>["Physiology", "Medicine", "Biochemistry"], "users"=>["Abderrahim Nemmar", "Deepa Subramaniyan", "Badreldin H. Ali"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0039554.g007", "stats"=>{"downloads"=>1, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Plasma_concentrations_of_D_dimer_A_plasminogen_activator_inhibitor_1_PAI_1_B_and_von_Willebrand_factor_vWF_C_after_repeated_intratracheal_instillation_of_saline_or_diesel_exhaust_particles_DEP_15_/290177", "title"=>"Plasma concentrations of D-dimer (A), plasminogen activator inhibitor 1 (PAI-1, B) and von Willebrand factor (vWF, C), after repeated intratracheal instillation of saline or diesel exhaust particles (DEP, 15", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 03:30:36"}
• {"files"=>["https://ndownloader.figshare.com/files/619607"], "description"=>"<p> Data are mean±SEM (n = 8 in each group). Statistical analysis by one-way analysis of variance (ANOVA), followed by Bonferroni multiple-range tests.</p>", "links"=>[], "tags"=>["platelets", "numbers", "occlusion", "pial", "arterioles", "repeated", "intratracheal", "instillation", "saline", "diesel", "particles", "15", "curcumin"], "article_id"=>290090, "categories"=>["Physiology", "Medicine", "Biochemistry"], "users"=>["Abderrahim Nemmar", "Deepa Subramaniyan", "Badreldin H. Ali"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0039554.g006", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Circulating_platelets_numbers_A_and_occlusion_time_in_pial_arterioles_B_after_repeated_intratracheal_instillation_of_saline_or_diesel_exhaust_particles_DEP_15_181_g_animal_with_or_without_curcumin_pretreatment_/290090", "title"=>"Circulating platelets numbers (A) and occlusion time in pial arterioles (B), after repeated intratracheal instillation of saline or diesel exhaust particles (DEP, 15 µg/animal) with or without curcumin pretreatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 03:30:07"}
• {"files"=>["https://ndownloader.figshare.com/files/619402"], "description"=>"<p>The airway resistance (<i>R</i>), after increasing concentrations of methacholine (0–10 mg/ml), was measured via the forced oscillation technique (FlexiVent) after repeated intratracheal instillation of saline or diesel exhaust particles (DEP, 15 µg/animal) with or without curcumin pretreatment. Data are mean ±SEM (n = 8 in each group). Statistical analysis by one-way analysis of variance (ANOVA), followed by Bonferroni multiple-range tests. <$>\\scale 80%\\raster=\"rg1\"<$> indicates P<0.001 between DEP and saline groups for the same methacholine concentration. Δ: indicates P<0.01 between DEP and curcumin+DEP groups for the same methacholine concentration. ΔΔ: indicates P<0.001 between DEP and curcumin+DEP groups for the same methacholine concentration.</p>", "links"=>[], "tags"=>["physiology", "respiratory medicine", "Biochemistry"], "article_id"=>289901, "categories"=>["Physiology", "Medicine", "Biochemistry"], "users"=>["Abderrahim Nemmar", "Deepa Subramaniyan", "Badreldin H. Ali"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0039554.g003", "stats"=>{"downloads"=>0, "page_views"=>31, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Airway_hyper_responsiveness_/289901", "title"=>"Airway hyper-responsiveness.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 03:29:02"}

PMC Usage Stats | Further Information

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Relative Metric

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F1000Prime