Randomized Polypill Crossover Trial in People Aged 50 and Over
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{"title"=>"Randomized polypill crossover trial in people aged 50 and over", "type"=>"journal", "authors"=>[{"first_name"=>"David S.", "last_name"=>"Wald", "scopus_author_id"=>"7005483943"}, {"first_name"=>"Joan K.", "last_name"=>"Morris", "scopus_author_id"=>"35477488500"}, {"first_name"=>"Nicholas J.", "last_name"=>"Wald", "scopus_author_id"=>"24447332500"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"365274713", "sgr"=>"84864004299", "issn"=>"19326203", "pmid"=>"22815989", "scopus"=>"2-s2.0-84864004299", "doi"=>"10.1371/journal.pone.0041297", "isbn"=>"1932-6203"}, "id"=>"66c0726a-a684-3731-8c2f-2c3715507b7c", "abstract"=>"BACKGROUND: A Polypill is proposed for the primary prevention of cardiovascular disease in people judged to be at risk on account of their age alone. Its efficacy in reducing cholesterol and blood pressure is uncertain.\\n\\nMETHODS: We conducted a randomized double-blind placebo-controlled crossover trial of a Polypill among individuals aged 50+ without a history of cardiovascular disease and compared the reductions with those predicted from published estimates of the effects of the individual drugs. Participants took the Polypill (amlodipine 2.5 mg, losartan 25 mg, hydrochlorothiazide 12.5 mg and simvastatin 40 mg) each evening for 12 weeks and a placebo each evening for 12 weeks in random sequence. The mean within-person differences in blood pressure and low density lipoprotein (LDL) cholesterol at the end of each 12 week period were determined.\\n\\nRESULTS: 84 out of 86 participants completed both treatment periods. The mean systolic blood pressure was reduced by 17.9 mmHg (95% CI, 15.7-20.1) on the Polypill, diastolic blood pressure by 9.8 mmHg (8.1-11.5), and LDL cholesterol by 1.4 mmol/L (1.2-1.6), reductions of 12%, 11%, and 39% respectively. The results were almost identical to those predicted; 18.4 mmHg, 9.7 mmHg, and 1.4 mmol/L respectively.\\n\\nCONCLUSION: The Polypill resulted in the predicted reductions in blood pressure and LDL cholesterol. Long term reductions of this magnitude would have a substantial effect in preventing heart attacks and strokes.\\n\\nTRIAL REGISTRATION: Controlled-Trials.com ISRCTN36672232.", "link"=>"http://www.mendeley.com/research/randomized-polypill-crossover-trial-people-aged-50", "reader_count"=>66, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>5, "Librarian"=>2, "Student > Doctoral Student"=>1, "Researcher"=>8, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>4, "Student > Master"=>7, "Other"=>6, "Student > Bachelor"=>10, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>5, "Librarian"=>2, "Student > Doctoral Student"=>1, "Researcher"=>8, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>4, "Student > Master"=>7, "Other"=>6, "Student > Bachelor"=>10, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>40, "Agricultural and Biological Sciences"=>9, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1, "Psychology"=>1, "Social Sciences"=>2, "Computer Science"=>2, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>40}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"New Zealand"=>1, "United States"=>1, "United Kingdom"=>4, "Mexico"=>1, "Malaysia"=>1, "Germany"=>1, "Spain"=>1}, "group_count"=>5}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/607714"], "description"=>"<p>Observed and expected reduction in blood pressure and LDL cholesterol on the Polypill.</p>", "links"=>[], "tags"=>["ldl"], "article_id"=>278216, "categories"=>["Biochemistry", "Biotechnology", "Pharmacology"], "users"=>["David S. Wald", "Joan K. Morris", "Nicholas J. Wald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041297.g002", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Observed_and_expected_reduction_in_blood_pressure_and_LDL_cholesterol_on_the_Polypill_/278216", "title"=>"Observed and expected reduction in blood pressure and LDL cholesterol on the Polypill.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-18 02:16:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/317037", "https://ndownloader.figshare.com/files/317104"], "description"=>"<div><h3>Background</h3><p>A Polypill is proposed for the primary prevention of cardiovascular disease in people judged to be at risk on account of their age alone. Its efficacy in reducing cholesterol and blood pressure is uncertain.</p> <h3>Methods</h3><p>We conducted a randomized double-blind placebo-controlled crossover trial of a Polypill among individuals aged 50+ without a history of cardiovascular disease and compared the reductions with those predicted from published estimates of the effects of the individual drugs. Participants took the Polypill (amlodipine 2.5 mg, losartan 25 mg, hydrochlorothiazide 12.5 mg and simvastatin 40 mg) each evening for 12 weeks and a placebo each evening for 12 weeks in random sequence. The mean within-person differences in blood pressure and low density lipoprotein (LDL) cholesterol at the end of each 12 week period were determined.</p> <h3>Results</h3><p>84 out of 86 participants completed both treatment periods. The mean systolic blood pressure was reduced by 17.9 mmHg (95% CI, 15.7–20.1) on the Polypill, diastolic blood pressure by 9.8 mmHg (8.1–11.5), and LDL cholesterol by 1.4 mmol/L (1.2–1.6), reductions of 12%, 11%, and 39% respectively. The results were almost identical to those predicted; 18.4 mmHg, 9.7 mmHg, and 1.4 mmol/L respectively.</p> <h3>Conclusion</h3><p>The Polypill resulted in the predicted reductions in blood pressure and LDL cholesterol. Long term reductions of this magnitude would have a substantial effect in preventing heart attacks and strokes.</p> <h3>Trial Registration</h3><p>Controlled-Trials.com <a href=\"http://www.controlled-trials.com/ISRCTN36672232\">ISRCTN36672232 </a></p> </div>", "links"=>[], "tags"=>["randomized", "polypill", "crossover", "aged", "50"], "article_id"=>122587, "categories"=>["Biochemistry", "Biotechnology", "Pharmacology"], "users"=>["David S. Wald", "Joan K. Morris", "Nicholas J. Wald"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0041297.s001", "https://dx.doi.org/10.1371/journal.pone.0041297.s002"], "stats"=>{"downloads"=>3, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Randomized_Polypill_Crossover_Trial_in_People_Aged_50_and_Over/122587", "title"=>"Randomized Polypill Crossover Trial in People Aged 50 and Over", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-07-18 00:43:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/607521"], "description"=>"<p>Flow chart of crossover trial.</p>", "links"=>[], "tags"=>["crossover"], "article_id"=>278012, "categories"=>["Biochemistry", "Biotechnology", "Pharmacology"], "users"=>["David S. Wald", "Joan K. Morris", "Nicholas J. Wald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041297.g001", "stats"=>{"downloads"=>2, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_chart_of_crossover_trial_/278012", "title"=>"Flow chart of crossover trial.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-18 02:13:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/607849"], "description"=>"*<p>Conversion to mg/dL: multiply by 38.67 for cholesterol and by 88.57 for triglyceride.</p>", "links"=>[], "tags"=>["medications", "discontinued", "randomisation", "lipid", "placebo"], "article_id"=>278338, "categories"=>["Biochemistry", "Biotechnology", "Pharmacology"], "users"=>["David S. Wald", "Joan K. Morris", "Nicholas J. Wald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041297.t001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_trial_participants_including_medications_discontinued_at_randomisation_and_blood_pressure_and_lipid_measurements_at_the_end_of_the_placebo_period_/278338", "title"=>"Characteristics of the trial participants including medications discontinued at randomisation and blood pressure and lipid measurements at the end of the placebo period.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-18 02:18:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/607811"], "description"=>"*<p>Polypill minus placebo.</p>**<p>(Placebo minus Polypill)/placebo for each participant. Mean percentage differences are not precisely derivable from the absolute differences because of rounding and averaging within-person differences.</p>", "links"=>[], "tags"=>["lipid", "84", "taking", "compared"], "article_id"=>278303, "categories"=>["Biochemistry", "Biotechnology", "Pharmacology"], "users"=>["David S. Wald", "Joan K. Morris", "Nicholas J. Wald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041297.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Absolute_and_relative_difference_in_blood_pressure_BP_and_lipid_measurements_in_84_participants_while_taking_the_Polypill_compared_with_the_placebo_/278303", "title"=>"Absolute and relative difference in blood pressure (BP) and lipid measurements in 84 participants while taking the Polypill, compared with the placebo.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-18 02:18:23"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
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  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"28", "full-text"=>"47", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"21", "full-text"=>"31", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"21", "full-text"=>"30", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"19", "full-text"=>"24", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"30", "full-text"=>"38", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"43", "full-text"=>"45", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"26", "full-text"=>"19", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"25", "full-text"=>"28", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"26", "full-text"=>"29", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"25", "full-text"=>"30", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"25", "full-text"=>"28", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"22", "full-text"=>"36", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"1", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"21", "full-text"=>"30", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"13", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}

Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Nutrition", "average_usage"=>[292, 539, 673, 776, 876, 986, 1099, 1210, 1305, 1390, 1476, 1560, 1633, 1726, 1813, 1903, 1969, 2024, 2082, 2153, 2235, 2301, 2366, 2432, 2495]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[312, 547, 668, 769, 861, 953, 1046, 1135, 1224, 1307, 1388, 1464, 1536, 1606, 1676, 1744, 1812, 1882, 1954, 2020, 2089, 2155, 2218, 2282, 2344]}, {"subject_area"=>"/Medicine and health sciences/Cardiology", "average_usage"=>[262, 473, 578, 664, 746, 826, 913, 992, 1078, 1143, 1201, 1272, 1338, 1385, 1442, 1507, 1565, 1618, 1680, 1741, 1816, 1871, 1903, 1952, 2009]}, {"subject_area"=>"/Medicine and health sciences/Nutrition", "average_usage"=>[307, 546, 676, 780, 888, 986, 1099, 1202, 1282, 1376, 1468, 1552, 1627, 1713, 1774, 1875, 1944, 2011, 2079, 2133, 2210, 2282, 2358, 2422, 2480]}, {"subject_area"=>"/Physical sciences/Mathematics", "average_usage"=>[325, 522, 627, 718, 804, 884, 969, 1052, 1131, 1207, 1277, 1346, 1415, 1478, 1542, 1605, 1663, 1723, 1776, 1839, 1895, 1955, 2008, 2066, 2123]}]}
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