Co-Regulation of Cell Polarization and Migration by Caveolar Proteins PTRF/Cavin-1 and Caveolin-1
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{"title"=>"Co-regulation of cell polarization and migration by caveolar proteins PTRF/cavin-1 and caveolin-1", "type"=>"journal", "authors"=>[{"first_name"=>"Michelle M.", "last_name"=>"Hill", "scopus_author_id"=>"7404447084"}, {"first_name"=>"Noor Huda", "last_name"=>"Daud", "scopus_author_id"=>"37047021500"}, {"first_name"=>"Cho Sanda", "last_name"=>"Aung", "scopus_author_id"=>"10539346700"}, {"first_name"=>"Dorothy", "last_name"=>"Loo", "scopus_author_id"=>"35220324300"}, {"first_name"=>"Sally", "last_name"=>"Martin", "scopus_author_id"=>"7404840734"}, {"first_name"=>"Samantha", "last_name"=>"Murphy", "scopus_author_id"=>"55438854500"}, {"first_name"=>"Debra M.", "last_name"=>"Black", "scopus_author_id"=>"7402568382"}, {"first_name"=>"Rachael", "last_name"=>"Barry", "scopus_author_id"=>"55163736100"}, {"first_name"=>"Fiona", "last_name"=>"Simpson", "scopus_author_id"=>"36860600800"}, {"first_name"=>"Libin", "last_name"=>"Liu", "scopus_author_id"=>"55715239700"}, {"first_name"=>"Paul F.", "last_name"=>"Pilch", "scopus_author_id"=>"7005155822"}, {"first_name"=>"John F.", "last_name"=>"Hancock", "scopus_author_id"=>"7202389307"}, {"first_name"=>"Marie Odile", "last_name"=>"Parat", "scopus_author_id"=>"6603548758"}, {"first_name"=>"Robert G.", "last_name"=>"Parton", "scopus_author_id"=>"7101912368"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84865055662", "doi"=>"10.1371/journal.pone.0043041", "scopus"=>"2-s2.0-84865055662", "pui"=>"365445254", "pmid"=>"22912783"}, "id"=>"e8a34cfd-2139-33dc-b71a-0242e98d842d", "abstract"=>"Caveolin-1 and caveolae are differentially polarized in migrating cells in various models, and caveolin-1 expression has been shown to quantitatively modulate cell migration. PTRF/cavin-1 is a cytoplasmic protein now established to be also necessary for caveola formation. Here we tested the effect of PTRF expression on cell migration. Using fluorescence imaging, quantitative proteomics, and cell migration assays we show that PTRF/cavin-1 modulates cellular polarization, and the subcellular localization of Rac1 and caveolin-1 in migrating cells as well as PKCalpha caveola recruitment. PTRF/cavin-1 quantitatively reduced cell migration, and induced mesenchymal epithelial reversion. Similar to caveolin-1, the polarization of PTRF/cavin-1 was dependent on the migration mode. By selectively manipulating PTRF/cavin-1 and caveolin-1 expression (and therefore caveola formation) in multiple cell systems, we unveil caveola-independent functions for both proteins in cell migration.", "link"=>"http://www.mendeley.com/research/coregulation-cell-polarization-migration-caveolar-proteins-ptrfcavin1-caveolin1", "reader_count"=>24, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>16, "Medicine and Dentistry"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Sweden"=>1, "Japan"=>1, "United Kingdom"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/592760"], "description"=>"<p>(A) Relative migration in a wound-healing assay was assessed by time-lapse video microscopy as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0043041#s4\" target=\"_blank\">materials and methods</a>. P<0.01 (B) Representative still images showing cell morphology. (C) Number of projections was quantitated by three individual researchers in random single cells from three independent videos (N>30 cells assessed per researcher, shown as mean ± SEM, p<0.05). (D) Total cell lysates (20 µg) from GFP or PTRF/cavin-1-GFP PC3 cells were separated by SDS-PAGE and immunoblotted using anti-E-cadherin or anti-vimentin antibodies as indicated. Data representative of 3 independent experiments.</p>", "links"=>[], "tags"=>["pc3", "cells", "2d", "concomitant", "reduced", "protrusions", "mesenchymal", "epithelial"], "article_id"=>263230, "categories"=>["Cancer", "Biochemistry", "Cell Biology"], "users"=>["Michelle M. Hill", "Noor Huda Daud", "Cho Sanda Aung", "Dorothy Loo", "Sally Martin", "Samantha Murphy", "Debra M. Black", "Rachael Barry", "Fiona Simpson", "Libin Liu", "Paul F. Pilch", "John F. Hancock", "Marie-Odile Parat", "Robert G. Parton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043041.g002", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PTRF_cavin_1_expression_in_PC3_cells_reduces_2D_migration_concomitant_with_reduced_protrusions_and_mesenchymal_epithelial_transition_/263230", "title"=>"PTRF/cavin-1 expression in PC3 cells reduces 2D migration concomitant with reduced protrusions and mesenchymal epithelial transition.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-08-13 00:53:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/592685"], "description"=>"<p>Transmigration toward the indicated serum concentration in the lower chamber was measured for (A, n = 4, p<0.0001) individual clones of DU145 prostate cancer cells or (B, n = 3, p<0.05) pooled NIH3T3 fibroblasts, stably transfected with scrambled shRNA (s) or PTRF/cavin-1 shRNA (p). Data are shown as mean ± SEM. Two-way ANOVA was used to assess the significance of PTRF/cavin-1 knockdown on migration.</p>", "links"=>[], "tags"=>["increases"], "article_id"=>263163, "categories"=>["Cancer", "Biochemistry", "Cell Biology"], "users"=>["Michelle M. Hill", "Noor Huda Daud", "Cho Sanda Aung", "Dorothy Loo", "Sally Martin", "Samantha Murphy", "Debra M. Black", "Rachael Barry", "Fiona Simpson", "Libin Liu", "Paul F. Pilch", "John F. Hancock", "Marie-Odile Parat", "Robert G. Parton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043041.g001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Loss_of_PTRF_cavin_1_increases_transmigration_/263163", "title"=>"Loss of PTRF/cavin-1 increases transmigration.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-08-13 00:52:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/311931"], "description"=>"<div><p>Caveolin-1 and caveolae are differentially polarized in migrating cells in various models, and caveolin-1 expression has been shown to quantitatively modulate cell migration. PTRF/cavin-1 is a cytoplasmic protein now established to be also necessary for caveola formation. Here we tested the effect of PTRF expression on cell migration. Using fluorescence imaging, quantitative proteomics, and cell migration assays we show that PTRF/cavin-1 modulates cellular polarization, and the subcellular localization of Rac1 and caveolin-1 in migrating cells as well as PKCα caveola recruitment. PTRF/cavin-1 quantitatively reduced cell migration, and induced mesenchymal epithelial reversion. Similar to caveolin-1, the polarization of PTRF/cavin-1 was dependent on the migration mode. By selectively manipulating PTRF/cavin-1 and caveolin-1 expression (and therefore caveola formation) in multiple cell systems, we unveil caveola-independent functions for both proteins in cell migration.</p> </div>", "links"=>[], "tags"=>["co-regulation", "polarization", "caveolar", "proteins", "caveolin-1"], "article_id"=>121530, "categories"=>["Cancer", "Biochemistry", "Cell Biology"], "users"=>["Michelle M. Hill", "Noor Huda Daud", "Cho Sanda Aung", "Dorothy Loo", "Sally Martin", "Samantha Murphy", "Debra M. Black", "Rachael Barry", "Fiona Simpson", "Libin Liu", "Paul F. Pilch", "John F. Hancock", "Marie-Odile Parat", "Robert G. Parton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043041", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Co_Regulation_of_Cell_Polarization_and_Migration_by_Caveolar_Proteins_PTRF_Cavin_1_and_Caveolin_1/121530", "title"=>"Co-Regulation of Cell Polarization and Migration by Caveolar Proteins PTRF/Cavin-1 and Caveolin-1", "pos_in_sequence"=>0, "defined_type"=>2, "published_date"=>"2012-08-13 00:25:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/592972"], "description"=>"<p>Wild type (WT), caveolin-1<sup>−/−</sup> and PTRF/cavin-1<sup>−/−</sup> mouse embryo fibroblasts (MEF) were plated on coverslips at low density. Immunostaining was performed with (A) mouse anti-caveolin-1 and rabbit anti-PTRF, (B) rabbit anti-PTRF/cavin-1, or (C) rabbit-anti-caveolin antibody respectively. Randomly migrating cells are imaged. Bar, 20 µM.</p>", "links"=>[], "tags"=>["polarization", "caveolin-1"], "article_id"=>263450, "categories"=>["Cancer", "Biochemistry", "Cell Biology"], "users"=>["Michelle M. Hill", "Noor Huda Daud", "Cho Sanda Aung", "Dorothy Loo", "Sally Martin", "Samantha Murphy", "Debra M. Black", "Rachael Barry", "Fiona Simpson", "Libin Liu", "Paul F. Pilch", "John F. Hancock", "Marie-Odile Parat", "Robert G. Parton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043041.g004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Inter_dependent_Polarization_of_caveolin_1_and_PTRF_cavin_1_/263450", "title"=>"Inter-dependent Polarization of caveolin-1 and PTRF/cavin-1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-08-13 00:57:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/593215"], "description"=>"<p>(A) Rac1 polarization was examined by confocal immunofluorescence microscopy. Polarization was measured by fluorescence intensity along the length of the cell as indicated by red lines shown. For quantitation, 20 cells over 3 independent experiments were analysed, and Rac1 was deemed polarized when staining was confined to terminal one third of the cell body. P<0.0001. (B) PTRF/cavin-1-GFP expression in PC-3 cells caused recruitment of PKCα to the lipid raft (DRM) fraction, without altering total cellular level or total membrane (P100) level. (C) Loss of PKCα from lipid raft (DRM) fraction in NIH3T3 fibroblasts with PTRF/cavin-1 knockdown.</p>", "links"=>[], "tags"=>["pc3", "cells", "impairs", "rac1", "leads", "recruitment", "detergent-resistant", "membrane"], "article_id"=>263687, "categories"=>["Cancer", "Biochemistry", "Cell Biology"], "users"=>["Michelle M. Hill", "Noor Huda Daud", "Cho Sanda Aung", "Dorothy Loo", "Sally Martin", "Samantha Murphy", "Debra M. Black", "Rachael Barry", "Fiona Simpson", "Libin Liu", "Paul F. Pilch", "John F. Hancock", "Marie-Odile Parat", "Robert G. Parton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043041.g006", "stats"=>{"downloads"=>3, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PTRF_cavin_1_expression_in_PC3_cells_impairs_Rac1_polarization_but_leads_to_recruitment_of_PKC_945_to_detergent_resistant_membrane_DRM_fraction_/263687", "title"=>"PTRF/cavin-1 expression in PC3 cells impairs Rac1 polarization, but leads to recruitment of PKCα to detergent-resistant membrane (DRM) fraction.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-08-13 01:01:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/592854"], "description"=>"<p>(A) Transmigrating NIH 3T3 cells were fixed and immuno-labeled using anti-caveolin-1 or anti-PTRF/cavin-1 antibodies and imaged by confocal microscopy. Shown are xy planes of cell rear, protrusion through the pore or xz planes through the center of the pore. Bar represents 10 µM. (B) Transmigrating PTRF/cavin-1-GFP expressing PC3 cells were fixed and immuno-labeled using anti-caveolin-1 antibody followed by biotinylated anti-rabbit antibody and texas red avidin. Cells were then imaged by confocal microscopy. Bar represents 10 µM. (C) Schematic representation of the differential caveolin-1 and PTRF/cavin-1 polarization during transmigration.</p>", "links"=>[], "tags"=>["polarization", "caveolin-1", "3d"], "article_id"=>263336, "categories"=>["Cancer", "Biochemistry", "Cell Biology"], "users"=>["Michelle M. Hill", "Noor Huda Daud", "Cho Sanda Aung", "Dorothy Loo", "Sally Martin", "Samantha Murphy", "Debra M. Black", "Rachael Barry", "Fiona Simpson", "Libin Liu", "Paul F. Pilch", "John F. Hancock", "Marie-Odile Parat", "Robert G. Parton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043041.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differential_polarization_of_caveolin_1_and_PTRF_cavin_1_during_3D_migration_/263336", "title"=>"Differential polarization of caveolin-1 and PTRF/cavin-1 during 3D migration.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-08-13 00:55:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/593070"], "description"=>"<p>(A) Knockdown of caveolin-1 in GFP PC3 cells increases transmigration. (B) Knockdown of caveolin-1 in PTRF/cavin-1-GFP cells reduces rate of transmigration. N = 3, shown as mean ± SEM. p<0.00001. (C) Diagrammatic summary of the results.</p>", "links"=>[], "tags"=>["caveolar", "non-caveolar", "caveolin-1"], "article_id"=>263543, "categories"=>["Cancer", "Biochemistry", "Cell Biology"], "users"=>["Michelle M. Hill", "Noor Huda Daud", "Cho Sanda Aung", "Dorothy Loo", "Sally Martin", "Samantha Murphy", "Debra M. Black", "Rachael Barry", "Fiona Simpson", "Libin Liu", "Paul F. Pilch", "John F. Hancock", "Marie-Odile Parat", "Robert G. Parton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043041.g005", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distinct_roles_for_caveolar_and_non_caveolar_caveolin_1_in_cell_migration_/263543", "title"=>"Distinct roles for caveolar and non-caveolar caveolin-1 in cell migration.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-08-13 00:59:03"}

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Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[313, 562, 690, 796, 893, 986, 1079, 1173, 1257, 1349, 1429, 1506, 1586, 1661, 1730, 1803, 1876, 1945, 2017, 2091, 2163, 2225, 2294, 2362, 2430]}]}
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