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{"title"=>"Co-Operative Additive Effects between HLA Alleles in Control of HIV-1", "type"=>"journal", "authors"=>[{"first_name"=>"Philippa C.", "last_name"=>"Matthews", "scopus_author_id"=>"16070550700"}, {"first_name"=>"Jennifer", "last_name"=>"Listgarten", "scopus_author_id"=>"14034344700"}, {"first_name"=>"Jonathan M.", "last_name"=>"Carlson", "scopus_author_id"=>"13807311800"}, {"first_name"=>"Rebecca", "last_name"=>"Payne", "scopus_author_id"=>"15760722000"}, {"first_name"=>"Kuan Hsiang Gary", "last_name"=>"Huang", "scopus_author_id"=>"35224663000"}, {"first_name"=>"John", "last_name"=>"Frater", "scopus_author_id"=>"35573097200"}, {"first_name"=>"Dominique", "last_name"=>"Goedhals", "scopus_author_id"=>"24460691700"}, {"first_name"=>"Dewald", "last_name"=>"Steyn", "scopus_author_id"=>"23467571300"}, {"first_name"=>"Cloete", "last_name"=>"van Vuuren", "scopus_author_id"=>"56378871000"}, {"first_name"=>"Paolo", "last_name"=>"Paioni", "scopus_author_id"=>"35088558000"}, {"first_name"=>"Pieter", "last_name"=>"Jooste", "scopus_author_id"=>"57198088957"}, {"first_name"=>"Anthony", "last_name"=>"Ogwu", "scopus_author_id"=>"26647836800"}, {"first_name"=>"Roger", "last_name"=>"Shapiro", "scopus_author_id"=>"7403082754"}, {"first_name"=>"Zenele", "last_name"=>"Mncube", "scopus_author_id"=>"14627623400"}, {"first_name"=>"Thumbi", "last_name"=>"Ndung'u", "scopus_author_id"=>"6507164421"}, {"first_name"=>"Bruce D.", "last_name"=>"Walker", "scopus_author_id"=>"7402209193"}, {"first_name"=>"David", "last_name"=>"Heckerman", "scopus_author_id"=>"7004273387"}, {"first_name"=>"Philip J.R.", "last_name"=>"Goulder", "scopus_author_id"=>"7003741802"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0047799", "sgr"=>"84867673440", "issn"=>"19326203", "pui"=>"365883712", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"23094091", "scopus"=>"2-s2.0-84867673440"}, "id"=>"141294f6-c0a5-3cdd-baea-641e6284d005", "abstract"=>"HLA class I genotype is a major determinant of the outcome of HIV infection, and the impact of certain alleles on HIV disease outcome is well studied. Recent studies have demonstrated that certain HLA class I alleles that are in linkage disequilibrium, such as HLA-A*74 and HLA-B*57, appear to function co-operatively to result in greater immune control of HIV than mediated by either single allele alone. We here investigate the extent to which HLA alleles--irrespective of linkage disequilibrium--function co-operatively.", "link"=>"http://www.mendeley.com/research/cooperative-additive-effects-between-hla-alleles-control-hiv1", "reader_count"=>30, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>9, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>2, "Student > Master"=>1, "Other"=>1, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>9, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>2, "Student > Master"=>1, "Other"=>1, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>2, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>13, "Medicine and Dentistry"=>2, "Philosophy"=>1, "Business, Management and Accounting"=>1, "Social Sciences"=>3, "Immunology and Microbiology"=>5}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Social Sciences"=>{"Social Sciences"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Philosophy"=>{"Philosophy"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Portugal"=>1, "India"=>1}, "group_count"=>1}

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• http://doi.org/10.1371/journal.pone.0073117
• http://doi.org/10.1038/srep11253
• http://doi.org/10.1080/21645515.2017.1340138
• http://doi.org/10.1038/s41598-018-23849-7
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• http://doi.org/10.4049/jimmunol.1300962
• http://doi.org/10.1007/s00251-013-0686-9
• http://doi.org/10.1074/jbc.M113.478412
• http://doi.org/10.1371/journal.pone.0127867
• http://doi.org/10.12688/wellcomeopenres.11135.1
• http://doi.org/10.1128/JVI.03302-12
• http://doi.org/10.1038/gene.2014.14
• http://doi.org/10.1016/j.gene.2013.07.104
• http://doi.org/10.1016/j.humimm.2013.08.287

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• {"id"=>"259414064588021760", "text"=>"RT @tcellbiology: Co-Operative Additive Effects between HLA Alleles in Control of HIV-1 http://t.co/HMxvXUF9 #plosoneTCB", "created_at"=>"2012-10-19T22:01:47Z", "user"=>"TAGHIVscience", "user_name"=>"TAGHIVscience", "user_profile_image"=>"http://a0.twimg.com/profile_images/1815060952/Screen_Shot_2012-02-09_at_7.26.54_AM_normal.png"}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/555745"], "description"=>"a<p>Pairs in bold and underlined are those that remain significant with a more stringent q<0.05.</p>b<p>Linkage is reported if relevant; otherwise designated as N/S = not significant (corrected for multiple comparisons; only values p<1.9E-05 are reported), or N/A = not applicable (two alleles at same locus).</p>", "links"=>[], "tags"=>["pairs", "hla", "hazardous", "hiv-1", "viral"], "article_id"=>226214, "categories"=>["Cancer", "Infectious Diseases", "Immunology"], "users"=>["Philippa C. Matthews", "Jennifer Listgarten", "Jonathan M. Carlson", "Rebecca Payne", "Kuan-Hsiang Gary Huang", "John Frater", "Dominique Goedhals", "Dewald Steyn", "Cloete van Vuuren", "Paolo Paioni", "Pieter Jooste", "Anthony Ogwu", "Roger Shapiro", "Zenele Mncube", "Thumbi Ndung'u", "Bruce D. Walker", "David Heckerman", "Philip J. R. Goulder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047799.t005", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multivariate_analysis_of_pairs_of_HLA_Class_I_alleles_showing_pairs_associated_with_hazardous_detrimental_impact_on_HIV_1_disease_control_with_respect_to_decline_in_CD4_T_cell_count_and_or_increased_viral_load_q_lt_0_2_/226214", "title"=>"Multivariate analysis of pairs of HLA Class I alleles, showing pairs associated with hazardous (detrimental) impact on HIV-1 disease control with respect to decline in CD4+ T cell count and/or increased viral load (q<0.2).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 21:27:41"}
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Relative Metric

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F1000Prime