Prophylactic Valproic Acid Treatment Prevents Schizophrenia-Related Behaviour in Disc1-L100P Mutant Mice
- Publication Date
- December 18, 2012
- Journal
- PLOS ONE
- Authors
- Tatiana V. Lipina, Fahmida Nipa Haque, Alexander Mc Girr, Paul C. Boutros, et al
- Volume
- 7
- Issue
- 12
- Pages
- e51562
- DOI
- https://dx.plos.org/10.1371/journal.pone.0051562
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0051562
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/23272119
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525594
- Europe PMC
- http://europepmc.org/abstract/MED/23272119
- Web of Science
- 000312483300018
- Scopus
- 84871295441
- Mendeley
- http://www.mendeley.com/research/prophylactic-valproic-acid-treatment-prevents-schizophreniarelated-behaviour-disc1l100p-mutant-mice
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Mendeley | Further Information
{"title"=>"Prophylactic Valproic Acid Treatment Prevents Schizophrenia-Related Behaviour in Disc1-L100P Mutant Mice", "type"=>"journal", "authors"=>[{"first_name"=>"Tatiana V.", "last_name"=>"Lipina", "scopus_author_id"=>"7003524462"}, {"first_name"=>"Fahmida Nipa", "last_name"=>"Haque", "scopus_author_id"=>"23027277500"}, {"first_name"=>"Alexander", "last_name"=>"McGirr", "scopus_author_id"=>"14626745800"}, {"first_name"=>"Paul C.", "last_name"=>"Boutros", "scopus_author_id"=>"6602545313"}, {"first_name"=>"Thorsten", "last_name"=>"Berger", "scopus_author_id"=>"12242304800"}, {"first_name"=>"Tak W.", "last_name"=>"Mak", "scopus_author_id"=>"7401931099"}, {"first_name"=>"John C.", "last_name"=>"Roder", "scopus_author_id"=>"7103002687"}, {"first_name"=>"Albert H.C.", "last_name"=>"Wong", "scopus_author_id"=>"7403147330"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"366299121", "doi"=>"10.1371/journal.pone.0051562", "sgr"=>"84871295441", "scopus"=>"2-s2.0-84871295441", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"23272119"}, "id"=>"621fa5fd-1338-3e29-a885-c47e266c78ce", "abstract"=>"BACKGROUND: Schizophrenia is a neurodevelopmental disorder with onset early in adulthood. Disrupted-In-Schizophrenia-1 (DISC1) is a susceptibility gene for schizophrenia and other psychiatric disorders. Disc1-L100P mutant mice show behaviors relevant to schizophrenia at 12 weeks, but not at 8 weeks of age, and may be useful for investigating the onset of schizophrenia in early adulthood.\\n\\nMETHODS: We investigated whether early valproic acid treatment would prevent behavioral, cellular and gene expression abnormalities in Disc1-L100P mutants.\\n\\nRESULTS: Valproic acid prevented hyperactivity and deficits in prepulse inhibition and latent inhibition in Disc1-L100P mice. Genome-wide transcription profiling identified Lcn2 (lipocalin2) transcripts as being elevated by the Disc1 mutation and corrected by valproate. Disc1-L100P mice also had increased glial cell numbers in the subventricular zone, which was normalized by valproate. Genetic deletion of Lcn2 normalized glial cell numbers and behavior in Disc1-L100P mutants.\\n\\nCONCLUSIONS: Pharmacological treatments are a feasible way of preventing abnormal behaviour in a genetic model of schizophrenia. Lcn2 is a potential novel drug target for early intervention in schizophrenia.", "link"=>"http://www.mendeley.com/research/prophylactic-valproic-acid-treatment-prevents-schizophreniarelated-behaviour-disc1l100p-mutant-mice", "reader_count"=>20, "reader_count_by_academic_status"=>{"Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Other"=>3, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>2, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Other"=>3, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>2, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>10, "Medicine and Dentistry"=>5, "Neuroscience"=>2, "Psychology"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>2}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Japan"=>1}, "group_count"=>0}CrossRef
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- http://doi.org/10.1016/j.neubiorev.2014.12.006
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- http://doi.org/10.1038/nrd4580
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- http://doi.org/10.1111/acps.12604
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- http://doi.org/10.1371/journal.pone.0156082
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- http://doi.org/10.1186/s12888-019-2271-8
- http://doi.org/10.1016/j.neuroscience.2015.12.061
Europe PMC Database Citations | Further Information
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