Non-Random mtDNA Segregation Patterns Indicate a Metastable Heteroplasmic Segregation Unit in m.3243A>G Cybrid Cells
- Publication Date
- December 18, 2012
- Journal
- PLOS ONE
- Authors
- Anton K. Raap, Roshan S. Jahangir Tafrechi, Frans M. Van De Rijke, Angela Pyle, et al
- Volume
- 7
- Issue
- 12
- Pages
- e52080
- DOI
- https://dx.plos.org/10.1371/journal.pone.0052080
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0052080
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/23272214
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525564
- Europe PMC
- http://europepmc.org/abstract/MED/23272214
- Web of Science
- 000312483300060
- Scopus
- 84871260095
- Mendeley
- http://www.mendeley.com/research/nonrandom-mtdna-segregation-patterns-indicate-metastable-heteroplasmic-segregation-unit-m3243ag-cybr
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Mendeley | Further Information
{"title"=>"Non-Random mtDNA Segregation Patterns Indicate a Metastable Heteroplasmic Segregation Unit in m.3243A>G Cybrid Cells", "type"=>"journal", "authors"=>[{"first_name"=>"Anton K.", "last_name"=>"Raap", "scopus_author_id"=>"7006419420"}, {"first_name"=>"Roshan S.", "last_name"=>"Jahangir Tafrechi", "scopus_author_id"=>"8921572700"}, {"first_name"=>"Frans M.", "last_name"=>"van de Rijke", "scopus_author_id"=>"35498624800"}, {"first_name"=>"Angela", "last_name"=>"Pyle", "scopus_author_id"=>"15740165200"}, {"first_name"=>"Carolina", "last_name"=>"Wählby", "scopus_author_id"=>"6603157675"}, {"first_name"=>"Karoly", "last_name"=>"Szuhai", "scopus_author_id"=>"25123357900"}, {"first_name"=>"Raimond B.G.", "last_name"=>"Ravelli", "scopus_author_id"=>"6701390379"}, {"first_name"=>"René F.M.", "last_name"=>"de Coo", "scopus_author_id"=>"6602742319"}, {"first_name"=>"Harsha K.", "last_name"=>"Rajasimha", "scopus_author_id"=>"8333708000"}, {"first_name"=>"Mats", "last_name"=>"Nilsson", "scopus_author_id"=>"56192654600"}, {"first_name"=>"Patrick F.", "last_name"=>"Chinnery", "scopus_author_id"=>"9533655500"}, {"first_name"=>"David C.", "last_name"=>"Samuels", "scopus_author_id"=>"7005039547"}, {"first_name"=>"George M.C.", "last_name"=>"Janssen", "scopus_author_id"=>"7103080629"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84871260095", "sgr"=>"84871260095", "pui"=>"366299080", "isbn"=>"1932-6203", "pmid"=>"23272214", "doi"=>"10.1371/journal.pone.0052080"}, "id"=>"2456baa7-fdad-3987-a8eb-b3a776b5e676", "abstract"=>"Many pathogenic mitochondrial DNA mutations are heteroplasmic, with a mixture of mutated and wild-type mtDNA present within individual cells. The severity and extent of the clinical phenotype is largely due to the distribution of mutated molecules between cells in different tissues, but mechanisms underpinning segregation are not fully understood. To facilitate mtDNA segregation studies we developed assays that measure m.3243A>G point mutation loads directly in hundreds of individual cells to determine the mechanisms of segregation over time. In the first study of this size, we observed a number of discrete shifts in cellular heteroplasmy between periods of stable heteroplasmy. The observed patterns could not be parsimoniously explained by random mitotic drift of individual mtDNAs. Instead, a genetically metastable, heteroplasmic mtDNA segregation unit provides the likely explanation, where stable heteroplasmy is maintained through the faithful replication of segregating units with a fixed wild-type/m.3243A>G mutant ratio, and shifts occur through the temporary disruption and re-organization of the segregation units. While the nature of the physical equivalent of the segregation unit remains uncertain, the factors regulating its organization are of major importance for the pathogenesis of mtDNA diseases.", "link"=>"http://www.mendeley.com/research/nonrandom-mtdna-segregation-patterns-indicate-metastable-heteroplasmic-segregation-unit-m3243ag-cybr", "reader_count"=>21, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>5, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>5, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>11, "Medicine and Dentistry"=>3, "Neuroscience"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}}, "reader_count_by_country"=>{"Sweden"=>1, "Russia"=>1}, "group_count"=>1}CrossRef
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- http://doi.org/10.1042/EBC20170096
- http://doi.org/10.1534/genetics.117.300273
- http://doi.org/10.1093/hmg/ddz153
- http://doi.org/10.1038/s41598-019-47570-1
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- http://doi.org/10.25557/0031-2991.2017.02.92-97
- http://doi.org/10.1002/smtd.201700297
- http://doi.org/10.1146/annurev-genom-091416-035426
- http://doi.org/10.1093/nar/gkv052
- http://doi.org/10.1091/mbc.E15-10-0690
Scopus | Further Information
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Relative Metric
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