Genetic Predisposition to Higher Body Mass Index or Type 2 Diabetes and Leukocyte Telomere Length in the Nurses' Health Study
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  • {"files"=>["http://files.figshare.com/484823/File_S1.docx"], "pos_in_sequence"=>0, "stats"=>{"downloads"=>0, "page_views"=>29, "likes"=>0}, "users"=>["Susan E. Hankinson", "Peter Kraft", "Immaculata De Vivo", "Edward Giovannucci", "Jennifer Prescott", "Marilyn C. Cornelis", "Mengmeng Du"], "links"=>[], "tags"=>["higher", "predisposition", "leukocyte", "study\n", "telomere"], "title"=>"Genetic Predisposition to Higher Body Mass Index or Type 2 Diabetes and Leukocyte Telomere Length in the Nurses' Health Study\n ", "figshare_url"=>"http://figshare.com/articles/Genetic_Predisposition_to_Higher_Body_Mass_Index_or_Type_2_Diabetes_and_Leukocyte_Telomere_Length_in_the_Nurses_Health_Study__/156576", "defined_type"=>3, "doi"=>["http://dx.doi.org/10.1371/journal.pone.0052240.s001"], "published_date"=>"2013-02-12 01:49:36", "article_id"=>156576, "categories"=>["Biotechnology", "Genetics", "Cell Biology", "Chemistry"], "description"=>"<div><section><h3>Background</h3><p>Although cross-sectional studies have linked higher body mass index (BMI) and type 2 diabetes (T2D) to shortened telomeres, whether these metabolic conditions play a causal role in telomere biology is unknown. We therefore examined whether genetic predisposition to higher BMI or T2D was associated with shortened leukocyte telomere length (LTL).</p> </section><section><h3>Methodology</h3><p>We conducted an analysis of 3,968 women of European ancestry aged 43&#8211;70 years from the Nurses' Health Study, who were selected as cases or controls in genome-wide association studies and studies of telomeres and disease. Pre-diagnostic relative telomere length in peripheral blood leukocytes, collected in 1989&#8211;1990, was measured by quantitative PCR. We combined information from multiple risk variants by calculating genetic risk scores based on 32 polymorphisms near 32 loci for BMI, and 36 polymorphisms near 35 loci for T2D.</p> </section><section><h3>Findings</h3><p>After adjustment for age and case-control status, there was no association between the BMI genetic risk score and LTL (β per standard deviation increase: −0.01; SE: 0.02; <em>P</em>&#8202;=&#8202;0.52). Similarly, the T2D genetic score was not associated with LTL (&#946; per standard deviation increase: &#8722;0.006; SE: 0.02; <em>P</em>&#8202;=&#8202;0.69).</p> </section><section><h3>Conclusions</h3><p>In this population of middle-aged and older women of European ancestry, those genetically predisposed to higher BMI or T2D did not possess shortened telomeres. Although we cannot exclude weak or modest effects, our findings do not support a causal relation of strong magnitude between these metabolic conditions and telomere dynamics.</p> </section></div>"}
  • {"files"=>["http://files.figshare.com/489933/Table_3.xls"], "pos_in_sequence"=>0, "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "users"=>["Susan E. Hankinson", "Peter Kraft", "Immaculata De Vivo", "Edward Giovannucci", "Jennifer Prescott", "Marilyn C. Cornelis", "Mengmeng Du"], "links"=>[], "tags"=>["squares", "variants", "scores", "ci", "higher", "telomere"], "title"=>"<p>Least squares mean telomere length (<i>z</i>-score) and 95% CI by genetic risk scores of common risk variants associated with higher body mass index or type 2 diabetes, Nurses' Health Study, 1989–1990.</p>", "figshare_url"=>"http://figshare.com/articles/_Least_squares_mean_telomere_length_z_score_and_95_CI_by_genetic_risk_scores_of_common_risk_variants_associated_with_higher_body_mass_index_or_type_2_diabetes_Nurses_Health_Study_1989_1990_/160443", "defined_type"=>3, "doi"=>["http://dx.doi.org/10.1371/journal.pone.0052240.t003"], "published_date"=>"2013-02-12 00:07:23", "article_id"=>160443, "categories"=>["Biotechnology", "Genetics", "Cell Biology", "Chemistry"], "description"=>"<p>Abbreviations: LS mean LTL, least squares mean leukocyte telomere length (<i>z</i>-score); CI, confidence interval; SD, standard deviation; SE, standard error.</p><span class=\"pl_xls_label\">a</span><p >Adjusted for age in years (continuous), case status (case, control).</p><span class=\"pl_xls_label\">b</span><p><i>P</i> values are 2-sided.</p>"}
  • {"files"=>["http://files.figshare.com/490012/Table_1.xls"], "pos_in_sequence"=>0, "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "users"=>["Susan E. Hankinson", "Peter Kraft", "Immaculata De Vivo", "Edward Giovannucci", "Jennifer Prescott", "Marilyn C. Cornelis", "Mengmeng Du"], "links"=>[], "tags"=>["women", "age-adjusted", "characteristics", "telomere"], "title"=>"<p>Age and age-adjusted characteristics of 3,968 women in the Nurses' Health Study by telomere length (<i>z</i>-score), 1989–1990.<sup><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052240#nt102\" target=\"_blank\">a,b</a></sup></p>", "figshare_url"=>"http://figshare.com/articles/_Age_and_age_adjusted_characteristics_of_3_968_women_in_the_Nurses_Health_Study_by_telomere_length_z_score_1989_1990_a_b_/160531", "defined_type"=>3, "doi"=>["http://dx.doi.org/10.1371/journal.pone.0052240.t001"], "published_date"=>"2013-02-12 00:08:51", "article_id"=>160531, "categories"=>["Biotechnology", "Genetics", "Cell Biology", "Chemistry"], "description"=>"<p >Abbreviations: LTL, leukocyte telomere length; MET-hrs/wk, metabolic equivalent hours of activity per week; HT, postmenopausal hormone therapy.</p><span class=\"pl_xls_label\">a</span><p >Values are means(SD) or percentages, and standardized to the age distribution of the study population at blood collection.</p><span class=\"pl_xls_label\">b</span><p >Values may not add to 100% because of missing data.</p><span class=\"pl_xls_label\">c</span><p >Value not age-adjusted.</p>"}
  • {"files"=>["http://files.figshare.com/489975/Table_2.xls"], "pos_in_sequence"=>0, "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "users"=>["Susan E. Hankinson", "Peter Kraft", "Immaculata De Vivo", "Edward Giovannucci", "Jennifer Prescott", "Marilyn C. Cornelis", "Mengmeng Du"], "links"=>[], "tags"=>["respective"], "title"=>"<p>Associations among body mass index, type 2 diabetes, and their respective genetic risk scores, Nurses' Health Study, 1989&#8211;1990.</p>", "figshare_url"=>"http://figshare.com/articles/_Associations_among_body_mass_index_type_2_diabetes_and_their_respective_genetic_risk_scores_Nurses_Health_Study_1989_8211_1990_/160494", "defined_type"=>3, "doi"=>["http://dx.doi.org/10.1371/journal.pone.0052240.t002"], "published_date"=>"2013-02-12 00:08:14", "article_id"=>160494, "categories"=>["Biotechnology", "Genetics", "Cell Biology", "Chemistry"], "description"=>"<p >Abbreviations: LS mean, least squares mean; CI, confidence interval; SD, standard deviation; SE, standard error.</p><span class=\"pl_xls_label\">a</span><p >Adjusted for age in years (continuous), case status (case, control).</p><span class=\"pl_xls_label\">b</span><p><i>P</i> values are 2-sided.</p>"}

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Relative Metric

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