Genetic Variation in the Interleukin-28B Gene Is Associated with Spontaneous Clearance and Progression of Hepatitis C Virus in Moroccan Patients
Publication Date
January 24, 2013
Journal
PLoS ONE
Authors
Sayeh Ezzikouri, Rhimou Alaoui, Khadija Rebbani, Ikram Brahim, et al
Volume
8
Issue
1
Pages
e54793
DOI
https://dx.plos.org/10.1371/journal.pone.0054793
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0054793
Web of Science
000314023600110
Scopus
84872844470
Mendeley
http://www.mendeley.com/research/genetic-variation-interleukin28b-gene-associated-spontaneous-clearance-progression-hepatitis-c-virus
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Mendeley | Further Information

{"title"=>"Genetic Variation in the Interleukin-28B Gene Is Associated with Spontaneous Clearance and Progression of Hepatitis C Virus in Moroccan Patients", "type"=>"journal", "authors"=>[{"first_name"=>"Sayeh", "last_name"=>"Ezzikouri", "scopus_author_id"=>"16836144700"}, {"first_name"=>"Rhimou", "last_name"=>"Alaoui", "scopus_author_id"=>"6602436585"}, {"first_name"=>"Khadija", "last_name"=>"Rebbani", "scopus_author_id"=>"38663278800"}, {"first_name"=>"Ikram", "last_name"=>"Brahim", "scopus_author_id"=>"35069050600"}, {"first_name"=>"Fatima Zohra", "last_name"=>"Fakhir", "scopus_author_id"=>"55889648500"}, {"first_name"=>"Salwa", "last_name"=>"Nadir", "scopus_author_id"=>"6701552901"}, {"first_name"=>"Helmut", "last_name"=>"Diepolder", "scopus_author_id"=>"7003321669"}, {"first_name"=>"Salim I.", "last_name"=>"Khakoo", "scopus_author_id"=>"6602868240"}, {"first_name"=>"Mark", "last_name"=>"Thursz", "scopus_author_id"=>"7003963897"}, {"first_name"=>"Soumaya", "last_name"=>"Benjelloun", "scopus_author_id"=>"16021043500"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84872844470", "sgr"=>"84872844470", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0054793", "pmid"=>"23358556", "isbn"=>"1932-6203", "pui"=>"368187537"}, "id"=>"4bb7bd41-5fc9-35d9-9a07-7f268022b182", "abstract"=>"BACKGROUND: Genetic variation in the IL28B gene has been strongly associated with treatment outcomes, spontaneous clearance and progression of the hepatitis C virus infection (HCV). The aim of the present study was to investigate the role of polymorphisms at this locus with progression and outcome of HCV infection in a Moroccan population. METHODS: We analyzed a cohort of 438 individuals among them 232 patients with persistent HCV infection, of whom 115 patients had mild chronic hepatitis and 117 had advanced liver disease (cirrhosis and hepatocellular carcinoma), 68 individuals who had naturally cleared HCV and 138 healthy subjects. The IL28B SNPs rs12979860 and rs8099917 were genotyped using a TaqMan 5' allelic discrimination assay. RESULTS: The protective rs12979860-C and rs8099917-T alleles were more common in subjects with spontaneous clearance (77.9% vs 55.2%; p = 0.00001 and 95.6% vs 83.2%; p = 0.0025, respectively). Individuals with clearance were 4.69 (95% CI, 1.99-11.07) times more likely to have the C/C genotype for rs12979860 polymorphism (p = 0.0017) and 3.55 (95% CI, 0.19-66.89) times more likely to have the T/T genotype at rs8099917. Patients with advanced liver disease carried the rs12979860-T/T genotype more frequently than patients with mild chronic hepatitis C (OR = 1.89; 95% CI, 0.99-3.61; p = 0.0532) and this risk was even more pronounced when we compared them with healthy controls (OR = 4.27; 95% CI, 2.08-8.76; p = 0.0005). The rs8099917-G allele was also associated with advanced liver disease (OR = 2.34; 95% CI, 1.40-3.93; p = 0.0100). CONCLUSIONS: In the Moroccan population, polymorphisms near the IL28B gene play a role both in spontaneous clearance and progression of HCV infection.", "link"=>"http://www.mendeley.com/research/genetic-variation-interleukin28b-gene-associated-spontaneous-clearance-progression-hepatitis-c-virus", "reader_count"=>28, "reader_count_by_academic_status"=>{"Librarian"=>1, "Researcher"=>9, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Librarian"=>1, "Researcher"=>9, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>9, "Agricultural and Biological Sciences"=>11, "Decision Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Decision Sciences"=>{"Decision Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Canada"=>1}, "group_count"=>5}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/478456"], "description"=>"<div><h3>Background</h3><p>Genetic variation in the <em>IL28B</em> gene has been strongly associated with treatment outcomes, spontaneous clearance and progression of the hepatitis C virus infection (HCV). The aim of the present study was to investigate the role of polymorphisms at this locus with progression and outcome of HCV infection in a Moroccan population.</p> <h3>Methods</h3><p>We analyzed a cohort of 438 individuals among them 232 patients with persistent HCV infection, of whom 115 patients had mild chronic hepatitis and 117 had advanced liver disease (cirrhosis and hepatocellular carcinoma), 68 individuals who had naturally cleared HCV and 138 healthy subjects. The <em>IL28B</em> SNPs rs12979860 and rs8099917 were genotyped using a TaqMan 5′ allelic discrimination assay.</p> <h3>Results</h3><p>The protective rs12979860-C and rs8099917-T alleles were more common in subjects with spontaneous clearance (77.9% vs 55.2%; p = 0.00001 and 95.6% vs 83.2%; p = 0.0025, respectively). Individuals with clearance were 4.69 (95% CI, 1.99–11.07) times more likely to have the C/C genotype for rs12979860 polymorphism (p = 0.0017) and 3.55 (95% CI, 0.19–66.89) times more likely to have the T/T genotype at rs8099917. Patients with advanced liver disease carried the rs12979860-T/T genotype more frequently than patients with mild chronic hepatitis C (OR = 1.89; 95% CI, 0.99–3.61; p = 0.0532) and this risk was even more pronounced when we compared them with healthy controls (OR = 4.27; 95% CI, 2.08–8.76; p = 0.0005). The rs8099917-G allele was also associated with advanced liver disease (OR = 2.34; 95% CI, 1.40–3.93; p = 0.0100).</p> <h3>Conclusions</h3><p>In the Moroccan population, polymorphisms near the <em>IL28B</em> gene play a role both in spontaneous clearance and progression of HCV infection.</p> </div>", "links"=>[], "tags"=>["interleukin-28b", "spontaneous", "clearance", "progression", "hepatitis", "moroccan", "patients"], "article_id"=>154286, "categories"=>["Genetics", "Immunology"], "users"=>["Sayeh Ezzikouri", "Rhimou Alaoui", "Khadija Rebbani", "Ikram Brahim", "Fatima-Zohra Fakhir", "Salwa Nadir", "Helmut Diepolder", "Salim I. Khakoo", "Mark Thursz", "Soumaya Benjelloun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054793", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Genetic_Variation_in_the_Interleukin_28B_Gene_Is_Associated_with_Spontaneous_Clearance_and_Progression_of_Hepatitis_C_Virus_in_Moroccan_Patients__/154286", "title"=>"Genetic Variation in the Interleukin-28B Gene Is Associated with Spontaneous Clearance and Progression of Hepatitis C Virus in Moroccan Patients", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-24 01:11:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/501462"], "description"=>"‡<p>Patients with mild chronic hepatitis C.</p>*<p>including patient with liver cirrhosis and hepatocellular carcinoma.</p>", "links"=>[], "tags"=>["characteristics"], "article_id"=>171972, "categories"=>["Genetics", "Immunology"], "users"=>["Sayeh Ezzikouri", "Rhimou Alaoui", "Khadija Rebbani", "Ikram Brahim", "Fatima-Zohra Fakhir", "Salwa Nadir", "Helmut Diepolder", "Salim I. Khakoo", "Mark Thursz", "Soumaya Benjelloun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054793.t001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_and_clinical_characteristics_of_the_study_subjects_/171972", "title"=>"Demographic and clinical characteristics of the study subjects.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-24 00:32:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/501372"], "description"=>"¥<p>Bonferroni correction was applied.</p>", "links"=>[], "tags"=>["polymorphisms", "outcomes", "hcv"], "article_id"=>171881, "categories"=>["Genetics", "Immunology"], "users"=>["Sayeh Ezzikouri", "Rhimou Alaoui", "Khadija Rebbani", "Ikram Brahim", "Fatima-Zohra Fakhir", "Salwa Nadir", "Helmut Diepolder", "Salim I. Khakoo", "Mark Thursz", "Soumaya Benjelloun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054793.t002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_IL28B_polymorphisms_on_the_outcomes_of_HCV_infection_/171881", "title"=>"Effect of <i>IL28B</i> polymorphisms on the outcomes of HCV infection.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-24 00:31:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/501418"], "description"=>"*<p>Adjusted for age, gender and viral genotype.</p>¥<p>Bonferroni correction was applied.</p>", "links"=>[], "tags"=>["polymorphisms", "progression", "hcv"], "article_id"=>171929, "categories"=>["Genetics", "Immunology"], "users"=>["Sayeh Ezzikouri", "Rhimou Alaoui", "Khadija Rebbani", "Ikram Brahim", "Fatima-Zohra Fakhir", "Salwa Nadir", "Helmut Diepolder", "Salim I. Khakoo", "Mark Thursz", "Soumaya Benjelloun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054793.t003", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_IL28B_polymorphisms_on_the_progression_of_HCV_infection_/171929", "title"=>"Effect of <i>IL28B</i> polymorphisms on the progression of HCV infection.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-24 00:32:09"}

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Relative Metric

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