Identification of DVA Interneuron Regulatory Sequences in Caenorhabditis elegans
- Publication Date
- January 28, 2013
- Journal
- PLOS ONE
- Authors
- Carmie Puckett Robinson, Erich M. Schwarz & Paul W. Sternberg
- Volume
- 8
- Issue
- 1
- Pages
- e54971
- DOI
- https://dx.plos.org/10.1371/journal.pone.0054971
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0054971
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/23383017
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557239
- Europe PMC
- http://europepmc.org/abstract/MED/23383017
- Web of Science
- 000315211500042
- Scopus
- 84873857993
- Mendeley
- http://www.mendeley.com/research/identification-dva-interneuron-regulatory-sequences-caenorhabditis-elegans
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Mendeley | Further Information
{"title"=>"Identification of DVA Interneuron Regulatory Sequences in Caenorhabditis elegans", "type"=>"journal", "authors"=>[{"first_name"=>"Carmie", "last_name"=>"Puckett Robinson", "scopus_author_id"=>"6506375110"}, {"first_name"=>"Erich M.", "last_name"=>"Schwarz", "scopus_author_id"=>"35412807400"}, {"first_name"=>"Paul W.", "last_name"=>"Sternberg", "scopus_author_id"=>"35230767000"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368226769", "sgr"=>"84873857993", "issn"=>"19326203", "pmid"=>"23383017", "scopus"=>"2-s2.0-84873857993", "doi"=>"10.1371/journal.pone.0054971", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"dfd2f6be-1da5-32ff-ae1e-f5ae22af3e4b", "abstract"=>"BACKGROUND: The identity of each neuron is determined by the expression of a distinct group of genes comprising its terminal gene battery. The regulatory sequences that control the expression of such terminal gene batteries in individual neurons is largely unknown. The existence of a complete genome sequence for C. elegans and draft genomes of other nematodes let us use comparative genomics to identify regulatory sequences directing expression in the DVA interneuron.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: Using phylogenetic comparisons of multiple Caenorhabditis species, we identified conserved non-coding sequences in 3 of 10 genes (fax-1, nmr-1, and twk-16) that direct expression of reporter transgenes in DVA and other neurons. The conserved region and flanking sequences in an 85-bp intronic region of the twk-16 gene directs highly restricted expression in DVA. Mutagenesis of this 85 bp region shows that it has at least four regions. The central 53 bp region contains a 29 bp region that represses expression and a 24 bp region that drives broad neuronal expression. Two short flanking regions restrict expression of the twk-16 gene to DVA. A shared GA-rich motif was identified in three of these genes but had opposite effects on expression when mutated in the nmr-1 and twk-16 DVA regulatory elements.\\n\\nCONCLUSIONS/SIGNIFICANCE: We identified by multi-species conservation regulatory regions within three genes that direct expression in the DVA neuron. We identified four contiguous regions of sequence of the twk-16 gene enhancer with positive and negative effects on expression, which combined to restrict expression to the DVA neuron. For this neuron a single binding site may thus not achieve sufficient specificity for cell specific expression. One of the positive elements, an 8-bp sequence required for expression was identified in silico by sequence comparisons of seven nematode species, demonstrating the potential resolution of expanded multi-species phylogenetic comparisons.", "link"=>"http://www.mendeley.com/research/identification-dva-interneuron-regulatory-sequences-caenorhabditis-elegans", "reader_count"=>18, "reader_count_by_academic_status"=>{"Researcher"=>5, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>2, "Student > Master"=>2, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>5, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>2, "Student > Master"=>2, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Mathematics"=>1, "Agricultural and Biological Sciences"=>14, "Neuroscience"=>1}, "reader_count_by_subdiscipline"=>{"Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>14}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Mathematics"=>{"Mathematics"=>1}}, "reader_count_by_country"=>{"United States"=>3}, "group_count"=>1}Scopus | Further Information
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Relative Metric
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