Urokinase Plasminogen Activator Induces Pro-Fibrotic/M2 Phenotype in Murine Cardiac Macrophages
- Publication Date
- March 11, 2013
- Journal
- PLOS ONE
- Authors
- Jessica Meznarich, Laura Malchodi, Deri Helterline, Stephen A. Ramsey, et al
- Volume
- 8
- Issue
- 3
- Pages
- e57837
- DOI
- https://dx.plos.org/10.1371/journal.pone.0057837
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0057837
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/23536772
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594198
- Europe PMC
- http://europepmc.org/abstract/MED/23536772
- Web of Science
- 000316251100018
- Scopus
- 84874924453
- Mendeley
- http://www.mendeley.com/research/urokinase-plasminogen-activator-induces-profibroticm2-phenotype-murine-cardiac-macrophages
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Mendeley | Further Information
{"title"=>"Urokinase Plasminogen Activator Induces Pro-Fibrotic/M2 Phenotype in Murine Cardiac Macrophages", "type"=>"journal", "authors"=>[{"first_name"=>"Jessica", "last_name"=>"Meznarich", "scopus_author_id"=>"14009021200"}, {"first_name"=>"Laura", "last_name"=>"Malchodi", "scopus_author_id"=>"37018464000"}, {"first_name"=>"Deri", "last_name"=>"Helterline", "scopus_author_id"=>"8713093600"}, {"first_name"=>"Stephen A.", "last_name"=>"Ramsey", "scopus_author_id"=>"9735269700"}, {"first_name"=>"Kate", "last_name"=>"Bertko", "scopus_author_id"=>"35955642800"}, {"first_name"=>"Tabitha", "last_name"=>"Plummer", "scopus_author_id"=>"55619820600"}, {"first_name"=>"Abigail", "last_name"=>"Plawman", "scopus_author_id"=>"14008665500"}, {"first_name"=>"Elizabeth", "last_name"=>"Gold", "scopus_author_id"=>"7102815366"}, {"first_name"=>"April", "last_name"=>"Stempien-Otero", "scopus_author_id"=>"6603481852"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84874924453", "doi"=>"10.1371/journal.pone.0057837", "pui"=>"368506800", "issn"=>"19326203", "pmid"=>"23536772", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "scopus"=>"2-s2.0-84874924453"}, "id"=>"4936f9cd-2d67-3090-9541-54639e0a793a", "abstract"=>"OBJECTIVE: Inflammation and fibrosis are intertwined in multiple disease processes. We have previously found that over-expression of urokinase plasminogen activator in macrophages induces spontaneous macrophage accumulation and fibrosis specific to the heart in mice. Understanding the relationship between inflammation and fibrosis in the heart is critical to developing therapies for diverse myocardial diseases. Therefore, we sought to determine if uPA induces changes in macrophage function that promote cardiac collagen accumulation.\\n\\nMETHODS AND RESULTS: We analyzed the effect of the uPA transgene on expression of pro-inflammatory (M1) and pro-fibrotic (M2) genes and proteins in hearts and isolated macrophages of uPA overexpressing mice. We found that although there was elevation of the pro-inflammatory cytokine IL-6 in hearts of transgenic mice, IL-6 is not a major effector of uPA induced cardiac fibrosis. However, uPA expressing bone marrow-derived macrophages are polarized to express M2 genes in response to IL-4 stimulation, and these M2 genes are upregulated in uPA expressing macrophages following migration to the heart. In addition, while uPA expressing macrophages express a transcriptional profile that is seen in tumor-associated macrophages, these macrophages promote collagen expression in cardiac but not embryonic fibroblasts.\\n\\nCONCLUSIONS: Urokinase plasminogen activator induces an M2/profibrotic phenotype in macrophages that is fully expressed after migration of macrophages into the heart. Understanding the mechanisms by which uPA modulates macrophage function may reveal insights into diverse pathologic processes.", "link"=>"http://www.mendeley.com/research/urokinase-plasminogen-activator-induces-profibroticm2-phenotype-murine-cardiac-macrophages", "reader_count"=>15, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>5, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>5, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Canada"=>1}, "group_count"=>1}CrossRef
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Europe PMC Database Citations | Further Information
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Relative Metric
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