Is a Persistent Global Bias Necessary for the Establishment of Planar Cell Polarity?
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Is a Persistent Global Bias Necessary for the Establishment of Planar Cell Polarity?", "type"=>"journal", "authors"=>[{"first_name"=>"Sabine", "last_name"=>"Fischer", "scopus_author_id"=>"57199662673"}, {"first_name"=>"Paul", "last_name"=>"Houston", "scopus_author_id"=>"7007087102"}, {"first_name"=>"Nicholas A.M.", "last_name"=>"Monk", "scopus_author_id"=>"6603830146"}, {"first_name"=>"Markus R.", "last_name"=>"Owen", "scopus_author_id"=>"7402497349"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"23593163", "sgr"=>"84875969957", "doi"=>"10.1371/journal.pone.0060064", "scopus"=>"2-s2.0-84875969957", "pui"=>"368695890", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203"}, "id"=>"e161859a-1815-3864-a6c1-deaa65dbddee", "abstract"=>"Planar cell polarity (PCP)--the coordinated polarisation of a whole field of cells within the plane of a tissue-relies on the interaction of three modules: a global module that couples individual cellular polarity to the tissue axis, a local module that aligns the axis of polarisation of neighbouring cells, and a readout module that directs the correct outgrowth of PCP-regulated structures such as hairs and bristles. While much is known about the molecular components that are required for PCP, the functional details of--and interactions between--the modules remain unclear. In this work, we perform a mathematical and computational analysis of two previously proposed computational models of the local module (Amonlirdviman et al., Science, 307, 2005; Le Garrec et al., Dev. Dyn., 235, 2006). Both models can reproduce wild-type and mutant phenotypes of PCP observed in the Drosophila wing under the assumption that a tissue-wide polarity cue from the global module persists throughout the development of PCP. We demonstrate that both models can also generate tissue-level PCP when provided with only a transient initial polarity cue. However, in these models such transient cues are not sufficient to ensure robustness of the resulting cellular polarisation.", "link"=>"http://www.mendeley.com/research/persistent-global-bias-necessary-establishment-planar-cell-polarity", "reader_count"=>11, "reader_count_by_academic_status"=>{"Researcher"=>6, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2}, "reader_count_by_user_role"=>{"Researcher"=>6, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>9, "Physics and Astronomy"=>1}, "reader_count_by_subdiscipline"=>{"Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Germany"=>1, "Spain"=>1}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84875969957"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84875969957?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84875969957&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84875969957&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84875969957", "dc:identifier"=>"SCOPUS_ID:84875969957", "eid"=>"2-s2.0-84875969957", "dc:title"=>"Is a Persistent Global Bias Necessary for the Establishment of Planar Cell Polarity?", "dc:creator"=>"Fischer S.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"4", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-04-08", "prism:coverDisplayDate"=>"8 April 2013", "prism:doi"=>"10.1371/journal.pone.0060064", "citedby-count"=>"8", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of Nottingham", "affiliation-city"=>"Nottingham", "affiliation-country"=>"United Kingdom"}, {"@_fa"=>"true", "affilname"=>"Goethe-Universität Frankfurt am Main", "affiliation-city"=>"Frankfurt am Main", "affiliation-country"=>"Germany"}], "pubmed-id"=>"23593163", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e60064", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0060064", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"34", "xml_views"=>"4", "html_views"=>"166"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"5", "html_views"=>"35"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"36"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"4", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"33"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"6"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"0"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1017806"], "description"=>"<p>The amounts of proteins in black are higher than the amounts of proteins in grey. Arrows represent recruitment of proteins, T-signs inhibition. The grey regions at the distal sides of the cell indicate where the persistent global bias affects the dissociation rate of Dsh. This figure was reproduced from <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060064#pone-0060064-g002\" target=\"_blank\">Fig 2B</a> in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060064#pone.0060064-Amonlirdviman1\" target=\"_blank\">[7]</a>.</p>", "links"=>[], "tags"=>["Computational biology", "Biophysic al simulations", "developmental biology", "morphogenesis", "Numerical analysis", "Applied mathematics", "Finite element analysis", "Mathematical computing", "Nonlinear dynamics"], "article_id"=>677197, "categories"=>["Information And Computing Sciences", "Mathematics", "Biological Sciences"], "users"=>["Sabine Fischer", "Paul Houston", "Nicholas A. M. Monk", "Markus R. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060064.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Feedback_loop_and_global_bias_of_Model_A_/677197", "title"=>"Feedback loop and global bias of Model A.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-08 01:59:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017826", "https://ndownloader.figshare.com/files/1017827", "https://ndownloader.figshare.com/files/1017828", "https://ndownloader.figshare.com/files/1017829", "https://ndownloader.figshare.com/files/1017831", "https://ndownloader.figshare.com/files/1017833", "https://ndownloader.figshare.com/files/1017835", "https://ndownloader.figshare.com/files/1017836", "https://ndownloader.figshare.com/files/1017838", "https://ndownloader.figshare.com/files/1017840", "https://ndownloader.figshare.com/files/1017841", "https://ndownloader.figshare.com/files/1017843", "https://ndownloader.figshare.com/files/1017844", "https://ndownloader.figshare.com/files/1017849"], "description"=>"<div><p>Planar cell polarity (PCP)–the coordinated polarisation of a whole field of cells within the plane of a tissue–relies on the interaction of three modules: a global module that couples individual cellular polarity to the tissue axis, a local module that aligns the axis of polarisation of neighbouring cells, and a readout module that directs the correct outgrowth of PCP-regulated structures such as hairs and bristles. While much is known about the molecular components that are required for PCP, the functional details of–and interactions between–the modules remain unclear. In this work, we perform a mathematical and computational analysis of two previously proposed computational models of the local module (Amonlirdviman et al., Science, 307, 2005; Le Garrec et al., Dev. Dyn., 235, 2006). Both models can reproduce wild-type and mutant phenotypes of PCP observed in the <i>Drosophila</i> wing under the assumption that a tissue-wide polarity cue from the global module persists throughout the development of PCP. We demonstrate that both models can also generate tissue-level PCP when provided with only a transient initial polarity cue. However, in these models such transient cues are not sufficient to ensure robustness of the resulting cellular polarisation.</p></div>", "links"=>[], "tags"=>["Computational biology", "Biophysic al simulations", "developmental biology", "morphogenesis", "Numerical analysis", "Applied mathematics", "Finite element analysis", "Mathematical computing", "Nonlinear dynamics", "persistent", "planar"], "article_id"=>677214, "categories"=>["Information And Computing Sciences", "Mathematics", "Biological Sciences"], "users"=>["Sabine Fischer", "Paul Houston", "Nicholas A. M. Monk", "Markus R. Owen"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0060064.s001", "https://dx.doi.org/10.1371/journal.pone.0060064.s002", "https://dx.doi.org/10.1371/journal.pone.0060064.s003", "https://dx.doi.org/10.1371/journal.pone.0060064.s004", "https://dx.doi.org/10.1371/journal.pone.0060064.s005", "https://dx.doi.org/10.1371/journal.pone.0060064.s006", "https://dx.doi.org/10.1371/journal.pone.0060064.s007", "https://dx.doi.org/10.1371/journal.pone.0060064.s008", "https://dx.doi.org/10.1371/journal.pone.0060064.s009", "https://dx.doi.org/10.1371/journal.pone.0060064.s010", "https://dx.doi.org/10.1371/journal.pone.0060064.s011", "https://dx.doi.org/10.1371/journal.pone.0060064.s012", "https://dx.doi.org/10.1371/journal.pone.0060064.s013", "https://dx.doi.org/10.1371/journal.pone.0060064.s014"], "stats"=>{"downloads"=>5, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Is_a_Persistent_Global_Bias_Necessary_for_the_Establishment_of_Planar_Cell_Polarity_/677214", "title"=>"Is a Persistent Global Bias Necessary for the Establishment of Planar Cell Polarity?", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-04-08 02:00:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017820"], "description"=>"<p>(A) a side polarised configuration, (B) a vertex polarised configuration; (C) a triangular state: (A) and (B) are possible with six directions and (C) with two distinct orientations. (D) unpolarised configuration.</p>", "links"=>[], "tags"=>["Computational biology", "Biophysic al simulations", "developmental biology", "morphogenesis", "Numerical analysis", "Applied mathematics", "Finite element analysis", "Mathematical computing", "Nonlinear dynamics", "spatial", "dimensions", "types", "states"], "article_id"=>677211, "categories"=>["Information And Computing Sciences", "Mathematics", "Biological Sciences"], "users"=>["Sabine Fischer", "Paul Houston", "Nicholas A. M. Monk", "Markus R. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060064.g009", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_two_spatial_dimensions_four_different_types_of_steady_states_can_occur_/677211", "title"=>"In two spatial dimensions four different types of steady states can occur.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-08 02:00:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017805"], "description"=>"<p>Localisation of the core planar cell polarity proteins at the cell edges.</p>", "links"=>[], "tags"=>["Computational biology", "Biophysic al simulations", "developmental biology", "morphogenesis", "Numerical analysis", "Applied mathematics", "Finite element analysis", "Mathematical computing", "Nonlinear dynamics", "planar", "polarity", "proteins"], "article_id"=>677196, "categories"=>["Information And Computing Sciences", "Mathematics", "Biological Sciences"], "users"=>["Sabine Fischer", "Paul Houston", "Nicholas A. M. Monk", "Markus R. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060064.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Localisation_of_the_core_planar_cell_polarity_proteins_at_the_cell_edges_/677196", "title"=>"Localisation of the core planar cell polarity proteins at the cell edges.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-08 01:59:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017813"], "description"=>"<p>(A) Initial condition: an imbalance in Fz with a difference of between right and left side; initially, the other proteins are distributed homogeneously; (B) final distribution of total Dsh and total Vang for a weak feedback with the corresponding parameter values and , (C) final distribution of total Dsh and total Vang for a stronger feedback with and , D final distribution of total Dsh and total Vang for an even stronger feedback with and . All other parameter values as listed in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060064#pone.0060064.s006\" target=\"_blank\">Table S1</a>.</p>", "links"=>[], "tags"=>["Computational biology", "Biophysic al simulations", "developmental biology", "morphogenesis", "Numerical analysis", "Applied mathematics", "Finite element analysis", "Mathematical computing", "Nonlinear dynamics", "states", "strengths", "imposed"], "article_id"=>677204, "categories"=>["Information And Computing Sciences", "Mathematics", "Biological Sciences"], "users"=>["Sabine Fischer", "Paul Houston", "Nicholas A. M. Monk", "Markus R. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060064.g006", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Final_states_of_Model_A_for_different_strengths_of_feedback_with_no_imposed_global_bias_/677204", "title"=>"Final states of Model A for different strengths of feedback with no imposed global bias.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-08 02:00:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017810"], "description"=>"<p>Column 1: The weaker polarity in the first and the last cell of the row is due to the boundary conditions. The polarity in the left half of the row is weaker because in cells 1–3 there is more ligand than Dsh, Vang and Pk; column 2: a shallow gradient with high levels of Ld gives weak polarity; column 3: for a shallow gradient with lower levels of Ld we get stronger polarity; column 4: the same initial gradient as in A1 and no feedback () yields weaker polarity than in B1. The parameter values are shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060064#pone.0060064.s009\" target=\"_blank\">Table S4</a>.</p>", "links"=>[], "tags"=>["Computational biology", "Biophysic al simulations", "developmental biology", "morphogenesis", "Numerical analysis", "Applied mathematics", "Finite element analysis", "Mathematical computing", "Nonlinear dynamics", "ligand", "gradient", "distributions"], "article_id"=>677201, "categories"=>["Information And Computing Sciences", "Mathematics", "Biological Sciences"], "users"=>["Sabine Fischer", "Paul Houston", "Nicholas A. M. Monk", "Markus R. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060064.g005", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_the_initial_ligand_gradient_on_the_final_Dsh_distributions_of_Model_L_with_and_without_feedback_/677201", "title"=>"Effect of the initial ligand gradient on the final Dsh* distributions of Model L with and without feedback.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-08 02:00:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017808"], "description"=>"<p>(A) Initial condition with a strong polarity of Dsh and Vang in the direction opposite to the direction of the final state observed in experiments. Pk and Fz are initially distributed homogeneously; (B) final state for a global bias of and the parameter values in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060064#pone.0060064.s006\" target=\"_blank\">Table S1</a>; (C) final state for a global bias of , the parameter values in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060064#pone.0060064.s006\" target=\"_blank\">Table S1</a> but with no feedback (i.e. ). Even without feedback the cells polarise correctly, albeit more weakly than with feedback.</p>", "links"=>[], "tags"=>["Computational biology", "Biophysic al simulations", "developmental biology", "morphogenesis", "Numerical analysis", "Applied mathematics", "Finite element analysis", "Mathematical computing", "Nonlinear dynamics", "persistent", "states"], "article_id"=>677199, "categories"=>["Information And Computing Sciences", "Mathematics", "Biological Sciences"], "users"=>["Sabine Fischer", "Paul Houston", "Nicholas A. M. Monk", "Markus R. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060064.g004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_persistent_global_bias_has_a_strong_impact_on_the_final_states_of_Model_A_/677199", "title"=>"The persistent global bias has a strong impact on the final states of Model A.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-08 01:59:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017823"], "description"=>"<p>The letters indicate the steady states which are stable for a certain parameter combination, U - unpolarised, S - side polarised, T - triangular, S/T-bistable. The values for the feedback strength were chosen to cover all possible behaviour. The parameter values for Model A are shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060064#pone.0060064.s007\" target=\"_blank\">Table S2</a>; the parameter values for Model L in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060064#pone.0060064.s012\" target=\"_blank\">Table S7</a>. A vertex polarised steady state is never stable.</p>", "links"=>[], "tags"=>["Computational biology", "Biophysic al simulations", "developmental biology", "morphogenesis", "Numerical analysis", "Applied mathematics", "Finite element analysis", "Mathematical computing", "Nonlinear dynamics", "states", "parameter"], "article_id"=>677213, "categories"=>["Information And Computing Sciences", "Mathematics", "Biological Sciences"], "users"=>["Sabine Fischer", "Paul Houston", "Nicholas A. M. Monk", "Markus R. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060064.g011", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Stable_steady_states_for_different_parameter_combinations_/677213", "title"=>"Stable steady states for different parameter combinations.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-08 02:00:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017807"], "description"=>"<p>Light grey represents a lower protein concentration than black. Binding over the cell membrane is indicated by = and T-signs represent inhibition. (A) First feedback loop: Fz* and its complexes inhibit the binding of Vang to Fmi; (B) second feedback loop: the Dsh* complexes inhibit the binding of Pk to Vang complexes (Dsh is phosphorylated when binding to the Fz*-ends of the cell bridging complexes, becoming Dsh*). The triangles at the bottom represent the tissue-scale ligand (and hence Fz*) gradient.</p>", "links"=>[], "tags"=>["Computational biology", "Biophysic al simulations", "developmental biology", "morphogenesis", "Numerical analysis", "Applied mathematics", "Finite element analysis", "Mathematical computing", "Nonlinear dynamics"], "article_id"=>677198, "categories"=>["Information And Computing Sciences", "Mathematics", "Biological Sciences"], "users"=>["Sabine Fischer", "Paul Houston", "Nicholas A. M. Monk", "Markus R. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060064.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Feedback_mechanism_and_global_bias_of_Model_L_/677198", "title"=>"Feedback mechanism and global bias of Model L.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-08 01:59:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017822"], "description"=>"<p>Top: Initial Fz distribution with a slight vertex polarity and final total Dsh distribution for a fixed feedback () and different values of the diffusion strength (). Bottom: Inhomogeneous initial Fz distribution (B1, note the different scale compared to A1 to highlight the slight inhomogeneity) and final total Dsh distributions for a fixed feedback strength () and different values of the diffusion coefficients (). The remaining parameter values can be found in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060064#pone.0060064.s007\" target=\"_blank\">Table S2</a>. Columns 2 and 3: For these parameter values vertex polarity is not robust to noise in the initial Fz distribution. Column 4: For sufficiently strong diffusion both initial conditions yield the unpolarised steady state.</p>", "links"=>[], "tags"=>["Computational biology", "Biophysic al simulations", "developmental biology", "morphogenesis", "Numerical analysis", "Applied mathematics", "Finite element analysis", "Mathematical computing", "Nonlinear dynamics", "states", "periodic", "hexagonal"], "article_id"=>677212, "categories"=>["Information And Computing Sciences", "Mathematics", "Biological Sciences"], "users"=>["Sabine Fischer", "Paul Houston", "Nicholas A. M. Monk", "Markus R. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060064.g010", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Examples_of_the_steady_states_of_Model_A_in_a_periodic_array_of_hexagonal_cells_/677212", "title"=>"Examples of the steady states of Model A in a periodic array of hexagonal cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-08 02:00:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017818"], "description"=>"<p>We consider a row of ten cells with identical initial conditions. The strength of the initial imbalance is determined by the difference between the right and left sides of a cell in Fz for Model A and Ld for Model L, respectively; in each case the other proteins in the model are initially distributed homogeneously and there are no complexes. (A) The strength of the final polarity of Model A as the difference in total Dsh between the right and left sides of a cell. The parameter values are shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060064#pone.0060064.s006\" target=\"_blank\">Table S1</a>. (B) The strength of the final polarity of Model L as the difference in total Dsh* between right and left side of a cell. We used the parameter values in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060064#pone.0060064.s010\" target=\"_blank\">Table S5</a>. For both models even the smallest non-zero perturbations are amplified, due to the instability of the unpolarised state to polarised perturbations.</p>", "links"=>[], "tags"=>["Computational biology", "Biophysic al simulations", "developmental biology", "morphogenesis", "Numerical analysis", "Applied mathematics", "Finite element analysis", "Mathematical computing", "Nonlinear dynamics", "imbalance", "polarity", "persistent"], "article_id"=>677209, "categories"=>["Information And Computing Sciences", "Mathematics", "Biological Sciences"], "users"=>["Sabine Fischer", "Paul Houston", "Nicholas A. M. Monk", "Markus R. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060064.g008", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_the_initial_imbalance_on_the_final_polarity_of_Models_A_and_L_without_a_persistent_global_bias_/677209", "title"=>"Effect of the initial imbalance on the final polarity of Models A and L - without a persistent global bias.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-08 02:00:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017817"], "description"=>"<p>(A) Initial ligand distribution with a small imbalance in every cell, the difference between left and right in each cell is . Initially, the other proteins are distributed homogeneously and there are no protein complexes. (B) Final state of total Dsh* for the parameter set in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060064#pone.0060064.s010\" target=\"_blank\">Table S5</a>.</p>", "links"=>[], "tags"=>["Computational biology", "Biophysic al simulations", "developmental biology", "morphogenesis", "Numerical analysis", "Applied mathematics", "Finite element analysis", "Mathematical computing", "Nonlinear dynamics", "ld", "imbalance"], "article_id"=>677208, "categories"=>["Information And Computing Sciences", "Mathematics", "Biological Sciences"], "users"=>["Sabine Fischer", "Paul Houston", "Nicholas A. M. Monk", "Markus R. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060064.g007", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_For_a_small_initial_Ld_imbalance_in_each_cell_Model_L_can_yield_polarity_/677208", "title"=>"For a small initial Ld imbalance in each cell Model L can yield polarity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-08 02:00:08"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"14", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"20", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"20", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"13", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"20", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"0", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"18", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"1", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[275, 472, 605, 720, 822, 921, 1013, 1106, 1200, 1289, 1378, 1459, 1531]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Infectious diseases", "average_usage"=>[297, 523, 655, 765, 866, 971, 1070, 1159, 1256, 1337, 1424, 1496, 1568]}]}
Loading … Spinner
There are currently no alerts