StreptInCor: A Candidate Vaccine Epitope against S. pyogenes Infections Induces Protection in Outbred Mice
- Publication Date
- April 08, 2013
- Journal
- PLOS ONE
- Authors
- Edilberto Postol, Raquel Alencar, Fabio T. Higa, Samar Freschi De Barros, et al
- Volume
- 8
- Issue
- 4
- Pages
- e60969
- DOI
- https://dx.plos.org/10.1371/journal.pone.0060969
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0060969
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/23593359
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620221
- Europe PMC
- http://europepmc.org/abstract/MED/23593359
- Web of Science
- 000317898000087
- Scopus
- 84876009986
- Mendeley
- http://www.mendeley.com/research/streptincor-candidate-vaccine-epitope-against-s-pyogenes-infections-induces-protection-outbred-mice
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Mendeley | Further Information
{"title"=>"StreptInCor: A Candidate Vaccine Epitope against S. pyogenes Infections Induces Protection in Outbred Mice", "type"=>"journal", "authors"=>[{"first_name"=>"Edilberto", "last_name"=>"Postol", "scopus_author_id"=>"6506068284"}, {"first_name"=>"Raquel", "last_name"=>"Alencar", "scopus_author_id"=>"13003924100"}, {"first_name"=>"Fabio T.", "last_name"=>"Higa", "scopus_author_id"=>"15724897600"}, {"first_name"=>"Samar", "last_name"=>"Freschi de Barros", "scopus_author_id"=>"13005001400"}, {"first_name"=>"Lea M.F.", "last_name"=>"Demarchi", "scopus_author_id"=>"6602244426"}, {"first_name"=>"Jorge", "last_name"=>"Kalil", "scopus_author_id"=>"55164354400"}, {"first_name"=>"Luiza", "last_name"=>"Guilherme", "scopus_author_id"=>"6603662546"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368695823", "sgr"=>"84876009986", "pmid"=>"23593359", "scopus"=>"2-s2.0-84876009986", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0060969", "issn"=>"19326203"}, "id"=>"93a85eb3-035b-3e71-af33-2174461fc400", "abstract"=>"Infection with Streptococcus pyogenes (S. pyogenes) can result in several diseases, particularly in children. S. pyogenes M protein is the major virulence factor, and certain regions of its N-terminus can trigger autoimmune sequelae such as rheumatic fever in susceptible individuals with untreated group A streptococcal pharyngitis. In a previous study, we utilized a large panel of human peripheral blood cells to define the C-terminal protective epitope StreptInCor (medical identity), which does not induce autoimmune reactions. We recently confirmed the results in HLA-transgenic mice. In the present study, we extended the experimental assays to outbred animals (Swiss mice). Herein, we demonstrate high titers of StreptInCor-specific antibodies, as well as appropriate T-cell immune responses. No cross-reaction to cardiac myosin was detected. Additionally, immunized Swiss mice exhibited 87% survival one month after challenge with S. pyogenes. In conclusion, the data presented herein reinforce previous results in humans and animals and further emphasize that StreptInCor could be an effective and safe vaccine for the prevention of S. pyogenes infections.", "link"=>"http://www.mendeley.com/research/streptincor-candidate-vaccine-epitope-against-s-pyogenes-infections-induces-protection-outbred-mice", "reader_count"=>18, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Student > Doctoral Student"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>4, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Student > Doctoral Student"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>4, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>8, "Arts and Humanities"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Tanzania"=>1, "Brazil"=>1, "Jamaica"=>1}, "group_count"=>0}CrossRef
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- http://doi.org/10.1016/j.vaccine.2013.08.043
- http://doi.org/10.1128/CMR.00101-13
- http://doi.org/10.1016/j.jinf.2016.02.002
Scopus | Further Information
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