Inhaled Steroids Modulate Extracellular Matrix Composition in Bronchial Biopsies of COPD Patients: A Randomized, Controlled Trial
- Publication Date
- May 07, 2013
- Journal
- PLOS ONE
- Authors
- Lisette I. Z. Kunz, Jolanda Strebus, Simona E. Budulac, Therese S. Lapperre, et al
- Volume
- 8
- Issue
- 5
- Pages
- e63430
- DOI
- https://dx.plos.org/10.1371/journal.pone.0063430
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0063430
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/23667615
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646783
- Europe PMC
- http://europepmc.org/abstract/MED/23667615
- Web of Science
- 000319654700142
- Scopus
- 84877147602
- Mendeley
- http://www.mendeley.com/research/inhaled-steroids-modulate-extracellular-matrix-composition-bronchial-biopsies-copd-patients-randomiz
Loading … 

Events
Loading … 

Mendeley | Further Information
{"title"=>"Inhaled Steroids Modulate Extracellular Matrix Composition in Bronchial Biopsies of COPD Patients: A Randomized, Controlled Trial", "type"=>"journal", "authors"=>[{"first_name"=>"Lisette I. Z.", "last_name"=>"Kunz"}, {"first_name"=>"Jolanda", "last_name"=>"Strebus"}, {"first_name"=>"Simona E.", "last_name"=>"Budulac"}, {"first_name"=>"Therese S.", "last_name"=>"Lapperre"}, {"first_name"=>"Peter J.", "last_name"=>"Sterk"}, {"first_name"=>"Dirkje S.", "last_name"=>"Postma"}, {"first_name"=>"Thais", "last_name"=>"Mauad"}, {"first_name"=>"Wim", "last_name"=>"Timens"}, {"first_name"=>"Pieter S.", "last_name"=>"Hiemstra"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0063430", "issn"=>"1932-6203", "isbn"=>"1932-6203", "pmid"=>"23667615"}, "id"=>"6b50cc4d-3554-34f2-a744-cb9eb061fde6", "abstract"=>"RATIONALE: Smoking and inflammation contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD), which involves changes in extracellular matrix. This is thought to contribute to airway remodeling and airflow obstruction. We have previously observed that long-term treatment with inhaled corticosteroids can not only reduce bronchial inflammation, but can also attenuate lung function decline in moderate-severe COPD. We hypothesized that inhaled corticosteroids and current smoking modulate bronchial extracellular matrix components in COPD.\\n\\nOBJECTIVE: To compare major extracellular matrix components (elastic fibers; proteoglycans [versican, decorin]; collagens type I and III) in bronchial biopsies 1) after 30-months inhaled steroids treatment or placebo; and 2) between current and ex-smokers with COPD.\\n\\nMETHODS: We included 64 moderate-severe, steroid-naive COPD patients (24/40 (ex)-smokers, 62±7 years, 46 (31-54) packyears, post-bronchodilator forced expiratory volume in one second (FEV1) 62±9% predicted) at baseline in this randomized, controlled trial. 19 and 13 patients received 30-months treatment with fluticasone or placebo, respectively. Bronchial biopsies collected at baseline and after 30 months were studied using (immuno)histochemistry to evaluate extracellular matrix content. Percentage and density of stained area were calculated by digital image analysis.\\n\\nRESULTS: 30-Months inhaled steroids increased the percentage stained area of versican (9.6% [CI 0.9 to 18.3%]; p = 0.03) and collagen III (20.6% [CI 3.8 to 37.4%]; p = 0.02) compared to placebo. Increased collagen I staining density correlated with increased post-bronchodilator FEV1 after inhaled steroids treatment (Rs = 0.45, p = 0.04). There were no differences between smokers and ex-smokers with COPD in percentages and densities for all extracellular matrix proteins.\\n\\nCONCLUSIONS: These data show that long-term inhaled corticosteroids treatment partially changes the composition of extracellular matrix in moderate-severe COPD. This is associated with increased lung function, suggesting that long-term inhaled steroids modulate airway remodeling thereby potentially preventing airway collapse in COPD. Smoking status is not associated with bronchial extracellular matrix proteins.\\n\\nTRIAL REGISTRATION: ClinicalTrials.gov NCT00158847.", "link"=>"http://www.mendeley.com/research/inhaled-steroids-modulate-extracellular-matrix-composition-bronchial-biopsies-copd-patients-randomiz", "reader_count"=>18, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>2, "Student > Bachelor"=>2, "Lecturer"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>2, "Student > Bachelor"=>2, "Lecturer"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>13}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Brazil"=>1, "United Kingdom"=>1}, "group_count"=>1}CrossRef
- http://doi.org/10.1002/path.4808
- http://doi.org/10.1517/14656566.2013.848856
- http://doi.org/10.1002/14651858.CD010844.pub2
- http://doi.org/10.1016/j.bbagen.2014.01.035
- http://doi.org/10.1002/14651858.CD010115.pub2
- http://doi.org/10.1093/glycob/cwu120
- http://doi.org/10.2147/COPD.S240033
- http://doi.org/10.1016/j.bcp.2014.07.026
- http://doi.org/10.1007/s00408-014-9631-4
- http://doi.org/10.2147/COPD.S233462
- http://doi.org/10.1097/ACI.0000000000000022
- http://doi.org/10.1183/16000617.0073-2017
- http://doi.org/10.1186/s12931-018-0818-8
Scopus | Further Information
{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84877147602"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84877147602?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84877147602&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84877147602&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84877147602", "dc:identifier"=>"SCOPUS_ID:84877147602", "eid"=>"2-s2.0-84877147602", "dc:title"=>"Inhaled Steroids Modulate Extracellular Matrix Composition in Bronchial Biopsies of COPD Patients: A Randomized, Controlled Trial", "dc:creator"=>"Kunz L.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"5", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-05-07", "prism:coverDisplayDate"=>"7 May 2013", "prism:doi"=>"10.1371/journal.pone.0063430", "citedby-count"=>"18", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Leiden University Medical Center - LUMC", "affiliation-city"=>"Leiden", "affiliation-country"=>"Netherlands"}], "pubmed-id"=>"23667615", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e63430", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}- {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0063430", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}
Counter
- {"month"=>"5", "year"=>"2013", "pdf_views"=>"33", "xml_views"=>"6", "html_views"=>"203"}
- {"month"=>"6", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"66"}
- {"month"=>"7", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"27"}
- {"month"=>"8", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"27"}
- {"month"=>"9", "year"=>"2013", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"42"}
- {"month"=>"10", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"145"}
- {"month"=>"11", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"53"}
- {"month"=>"12", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"42"}
- {"month"=>"1", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"16"}
- {"month"=>"2", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"41"}
- {"month"=>"3", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"74"}
- {"month"=>"4", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"65"}
- {"month"=>"5", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"32"}
- {"month"=>"6", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"23"}
- {"month"=>"7", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"19"}
- {"month"=>"8", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"3", "html_views"=>"24"}
- {"month"=>"9", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"26"}
- {"month"=>"10", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"33"}
- {"month"=>"11", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"24"}
- {"month"=>"12", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"27"}
- {"month"=>"1", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"34"}
- {"month"=>"2", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"21"}
- {"month"=>"3", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
- {"month"=>"4", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"14"}
- {"month"=>"5", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"11"}
- {"month"=>"6", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"17"}
- {"month"=>"7", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"8", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"17"}
- {"month"=>"9", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"20"}
- {"month"=>"10", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"8"}
- {"month"=>"11", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"12", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"28"}
- {"month"=>"1", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"2", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"3"}
- {"month"=>"3", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"25"}
- {"month"=>"4", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"15"}
- {"month"=>"5", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"5"}
- {"month"=>"6", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"9"}
- {"month"=>"7", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"8", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"4"}
- {"month"=>"9", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"18"}
- {"month"=>"10", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"7"}
- {"month"=>"11", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
- {"month"=>"12", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"17"}
- {"month"=>"1", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"8"}
- {"month"=>"2", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
- {"month"=>"3", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
- {"month"=>"4", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"22"}
- {"month"=>"5", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"11"}
- {"month"=>"6", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"18"}
- {"month"=>"7", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"17"}
- {"month"=>"8", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"11"}
- {"month"=>"9", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"10"}
- {"month"=>"10", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"20"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"58"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"19"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
- {"month"=>"2", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"5"}
- {"month"=>"3", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"6"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"7"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"5"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"9"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"5", "html_views"=>"2"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"2"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"4"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"8"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"1"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"6"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"4"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"1"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"4"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"11"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"16"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"2"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"0"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"1"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"5"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"4"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"5"}
- {"month"=>"1", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"2"}
- {"month"=>"2", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"0"}
- {"month"=>"3", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"3"}
- {"month"=>"4", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"4", "html_views"=>"3"}
- {"month"=>"5", "year"=>"2020", "pdf_views"=>"27", "xml_views"=>"2", "html_views"=>"4"}
- {"month"=>"6", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"1"}
- {"month"=>"7", "year"=>"2020", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
- {"month"=>"8", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"3"}
- {"month"=>"9", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"2"}
- {"month"=>"10", "year"=>"2020", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"2"}
- {"month"=>"11", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"3"}
- {"month"=>"12", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"2"}
- {"month"=>"1", "year"=>"2021", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"6"}
PMC Usage Stats | Further Information
- {"unique-ip"=>"29", "full-text"=>"25", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"24", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
- {"unique-ip"=>"33", "full-text"=>"34", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"16", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
- {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
- {"unique-ip"=>"21", "full-text"=>"25", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
- {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
- {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
- {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
- {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
- {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
- {"unique-ip"=>"20", "full-text"=>"25", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
- {"unique-ip"=>"17", "full-text"=>"13", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
- {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
- {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
- {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
- {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
- {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
- {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
- {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
- {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"2"}
- {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
- {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"9"}
- {"unique-ip"=>"12", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
- {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
- {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
- {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
- {"unique-ip"=>"24", "full-text"=>"32", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
- {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
- {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
- {"unique-ip"=>"10", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
- {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
- {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
- {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
- {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
- {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
- {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
- {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
- {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
- {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
- {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
- {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
- {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
- {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
- {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
- {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
- {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
- {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
- {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
- {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
- {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
- {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
- {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
- {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
- {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
- {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
- {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
- {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
- {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
- {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
- {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2018", "month"=>"11"}
- {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
- {"unique-ip"=>"6", "full-text"=>"35", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2018", "month"=>"9"}
- {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
- {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
- {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
- {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
- {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
- {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
- {"unique-ip"=>"5", "full-text"=>"20", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
- {"unique-ip"=>"5", "full-text"=>"1", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
- {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
- {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
- {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
- {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
- {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
- {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
- {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
- {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
- {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
- {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
- {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
Relative Metric
{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Behavior", "average_usage"=>[306, 490, 611, 718, 817, 916, 999, 1091, 1185, 1258, 1341, 1412, 1476]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[266, 468, 593, 703, 804, 903, 993, 1084, 1171, 1256, 1339, 1422, 1492]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Pulmonology", "average_usage"=>[241, 428, 552, 659, 752, 848, 934, 1028, 1106, 1183, 1267, 1350, 1401]}, {"subject_area"=>"/Medicine and health sciences/Surgical and invasive medical procedures", "average_usage"=>[223, 396, 511, 599, 690, 775, 859, 936, 1012, 1090, 1168, 1237, 1299]}, {"subject_area"=>"/Physical sciences/Chemistry", "average_usage"=>[247, 429, 544, 647, 747, 842, 929, 1012, 1099, 1179, 1263, 1339, 1409]}]}F1000Prime | Further Information
- {"year"=>2014, "month"=>5, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2014-05-26T08:35:13Z"}
- {"year"=>2014, "month"=>6, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2014-06-30T08:35:06Z"}
- {"year"=>2014, "month"=>7, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2014-07-28T08:35:15Z"}
- {"year"=>2014, "month"=>8, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2014-08-25T08:35:13Z"}
- {"year"=>2014, "month"=>9, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2014-09-29T08:35:15Z"}
- {"year"=>2014, "month"=>10, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2014-10-27T08:34:59Z"}
- {"year"=>2014, "month"=>11, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2014-11-24T09:33:14Z"}
- {"year"=>2014, "month"=>12, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2014-12-29T09:43:02Z"}
- {"year"=>2015, "month"=>1, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2015-01-26T09:41:02Z"}
- {"year"=>2015, "month"=>2, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2015-02-23T09:41:02Z"}
- {"year"=>2015, "month"=>3, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2015-03-23T08:41:21Z"}
- {"year"=>2015, "month"=>4, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2015-04-27T08:41:10Z"}
- {"year"=>2015, "month"=>5, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2015-05-25T08:41:02Z"}
- {"year"=>2015, "month"=>6, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2015-06-29T08:41:06Z"}
- {"year"=>2015, "month"=>7, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2015-07-27T08:40:57Z"}
- {"year"=>2015, "month"=>8, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2015-08-31T08:41:09Z"}
- {"year"=>2015, "month"=>9, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2015-09-28T08:40:58Z"}
- {"year"=>2015, "month"=>10, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2015-10-26T08:41:14Z"}
- {"year"=>2015, "month"=>11, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2015-11-30T09:41:15Z"}
- {"year"=>2015, "month"=>12, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2015-12-28T09:41:18Z"}
- {"year"=>2016, "month"=>1, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2016-01-25T09:41:19Z"}
- {"year"=>2016, "month"=>2, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2016-02-29T09:40:54Z"}
- {"year"=>2016, "month"=>3, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2016-03-28T08:40:51Z"}
- {"year"=>2016, "month"=>4, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2016-04-25T08:41:00Z"}
- {"year"=>2016, "month"=>5, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2016-05-16T08:40:58Z"}
- {"year"=>2016, "month"=>6, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2016-06-27T08:40:56Z"}
- {"year"=>2016, "month"=>7, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2016-07-25T08:40:55Z"}
- {"year"=>2016, "month"=>8, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2016-08-29T08:40:47Z"}
- {"year"=>2016, "month"=>9, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2016-09-26T08:40:53Z"}
- {"year"=>2016, "month"=>10, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2016-10-31T08:40:52Z"}
- {"year"=>2016, "month"=>11, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2016-11-28T09:40:55Z"}
- {"year"=>2016, "month"=>12, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2016-12-26T09:41:07Z"}
- {"year"=>2017, "month"=>1, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2017-01-30T09:41:01Z"}
- {"year"=>2017, "month"=>2, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2017-02-27T09:41:08Z"}
- {"year"=>2017, "month"=>3, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2017-03-27T08:40:44Z"}
- {"year"=>2017, "month"=>4, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2017-04-24T08:41:01Z"}
- {"year"=>2017, "month"=>5, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2017-05-29T08:41:00Z"}
- {"year"=>2017, "month"=>6, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"http://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2017-06-26T08:41:06Z"}
- {"year"=>2017, "month"=>7, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2017-07-31T08:41:00Z"}
- {"year"=>2017, "month"=>8, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2017-08-28T08:41:04Z"}
- {"year"=>2017, "month"=>9, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2017-09-25T08:41:03Z"}
- {"year"=>2017, "month"=>10, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2017-10-30T08:41:29Z"}
- {"year"=>2017, "month"=>11, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2017-11-27T09:41:10Z"}
- {"year"=>2017, "month"=>12, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2017-12-25T09:40:58Z"}
- {"year"=>2018, "month"=>1, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2018-01-29T09:40:45Z"}
- {"year"=>2018, "month"=>2, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2018-02-26T09:40:48Z"}
- {"year"=>2018, "month"=>3, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2018-03-26T08:40:49Z"}
- {"year"=>2018, "month"=>4, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2018-04-30T08:40:46Z"}
- {"year"=>2018, "month"=>5, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2018-05-28T08:40:48Z"}
- {"year"=>2018, "month"=>6, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2018-06-25T08:40:48Z"}
- {"year"=>2018, "month"=>7, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2018-07-30T08:40:55Z"}
- {"year"=>2018, "month"=>8, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2018-08-27T08:41:00Z"}
- {"year"=>2018, "month"=>9, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2018-09-24T08:40:56Z"}
- {"year"=>2018, "month"=>10, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2018-10-29T08:40:58Z"}
- {"year"=>2018, "month"=>11, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2018-11-26T09:40:51Z"}
- {"year"=>2018, "month"=>12, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2018-12-31T09:41:06Z"}
- {"year"=>2019, "month"=>1, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2019-01-28T09:40:52Z"}
- {"year"=>2019, "month"=>2, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2019-02-25T09:40:54Z"}
- {"year"=>2019, "month"=>3, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2019-03-25T08:40:50Z"}
- {"year"=>2019, "month"=>4, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2019-04-29T08:40:58Z"}
- {"year"=>2019, "month"=>5, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2019-05-27T08:41:04Z"}
- {"year"=>2019, "month"=>6, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2019-06-24T08:40:57Z"}
- {"year"=>2019, "month"=>7, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2019-07-29T08:41:12Z"}
- {"year"=>2019, "month"=>8, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2019-08-26T08:41:04Z"}
- {"year"=>2019, "month"=>9, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2019-09-30T08:41:02Z"}
- {"year"=>2019, "month"=>10, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2019-10-28T08:41:03Z"}
- {"year"=>2019, "month"=>11, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2019-11-25T09:41:07Z"}
- {"year"=>2019, "month"=>12, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2019-12-30T09:41:21Z"}
- {"year"=>2020, "month"=>1, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2020-01-27T09:40:58Z"}
- {"year"=>2020, "month"=>2, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2020-02-24T09:41:04Z"}
- {"year"=>2020, "month"=>3, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2020-03-30T08:41:06Z"}
- {"year"=>2020, "month"=>4, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2020-04-27T08:41:01Z"}
- {"year"=>2020, "month"=>5, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2020-05-25T08:41:01Z"}
- {"year"=>2020, "month"=>6, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2020-06-29T08:41:03Z"}
- {"year"=>2020, "month"=>7, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2020-07-27T08:41:03Z"}
- {"year"=>2020, "month"=>8, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2020-08-31T08:41:06Z"}
- {"year"=>2020, "month"=>9, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2020-09-28T08:41:06Z"}
- {"year"=>2020, "month"=>10, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2020-10-26T08:41:03Z"}
- {"year"=>2020, "month"=>11, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2020-11-30T09:41:08Z"}
- {"year"=>2020, "month"=>12, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2020-12-28T09:41:06Z"}
- {"year"=>2021, "month"=>1, "doi"=>"10.1371/journal.pone.0063430", "f1000_id"=>"718016147", "url"=>"https://f1000.com/prime/718016147", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2021-01-18T09:41:13Z"}
Loading … 

There are currently no alerts