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{"title"=>"T1-Weighted Sodium MRI of the Articulator Cartilage in Osteoarthritis: A Cross Sectional and Longitudinal Study", "type"=>"journal", "authors"=>[{"first_name"=>"Rexford D.", "last_name"=>"Newbould", "scopus_author_id"=>"8301920900"}, {"first_name"=>"Sam R.", "last_name"=>"Miller", "scopus_author_id"=>"26649543600"}, {"first_name"=>"Neil", "last_name"=>"Upadhyay", "scopus_author_id"=>"55382516400"}, {"first_name"=>"Anil W.", "last_name"=>"Rao", "scopus_author_id"=>"36091715500"}, {"first_name"=>"Peter", "last_name"=>"Swann", "scopus_author_id"=>"55247749300"}, {"first_name"=>"Garry E.", "last_name"=>"Gold", "scopus_author_id"=>"7101655810"}, {"first_name"=>"Robin K.", "last_name"=>"Strachan", "scopus_author_id"=>"7004976321"}, {"first_name"=>"Paul M.", "last_name"=>"Matthews", "scopus_author_id"=>"7202324607"}, {"first_name"=>"Peter C.", "last_name"=>"Taylor", "scopus_author_id"=>"35459177700"}, {"first_name"=>"Andrew P.", "last_name"=>"Brown", "scopus_author_id"=>"7408338729"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84881106204", "pui"=>"369492123", "pmid"=>"23940822", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0073067", "sgr"=>"84881106204"}, "id"=>"e0c6fa6a-2b3a-394e-bc9c-87cde8b13f4d", "abstract"=>"Structural magnetic resonance imaging (MRI) has shown great utility in diagnosing soft tissue burden in osteoarthritis (OA), though MRI measures of cartilage integrity have proven more elusive. Sodium MRI can reflect the proteoglycan content of cartilage; however, it requires specialized hardware, acquisition sequences, and long imaging times. This study was designed to assess the potential of a clinically feasible sodium MRI acquisition to detect differences in the knee cartilage of subjects with OA versus healthy controls (HC), and to determine whether longitudinal changes in sodium content are observed at 3 and 6 months. 28 subjects with primary knee OA and 19 HC subjects age and gender matched were enrolled in this ethically-approved study. At baseline, 3 and 6 months subjects underwent structural MRI and a 0.4ms echo time 3D T1-weighted sodium scan as well as the knee injury and osteoarthritis outcome score (KOOS) and knee pain by visual analogue score (VAS). A standing radiograph of the knee was taken for Kellgren-Lawrence (K-L) scoring. A blinded reader outlined the cartilage on the structural images which was used to determine median T1-weighted sodium concentrations in each region of interest on the co-registered sodium scans. VAS, K-L, and KOOS all significantly separated the OA and HC groups. OA subjects had higher T1-weighted sodium concentrations, most strongly observed in the lateral tibial, lateral femoral and medial patella ROIs. There were no significant changes in cartilage volume or sodium concentration over 6 months. This study has shown that a clinically-feasible sodium MRI at a moderate 3T field strength and imaging time with fluid attenuation by T1 weighting significantly separated HCs from OA subjects.", "link"=>"http://www.mendeley.com/research/t1weighted-sodium-mri-articulator-cartilage-osteoarthritis-cross-sectional-longitudinal-study", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>2, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>2, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>5, "Unspecified"=>2, "Medicine and Dentistry"=>8, "Agricultural and Biological Sciences"=>1, "Physics and Astronomy"=>3, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>5}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Physics and Astronomy"=>{"Physics and Astronomy"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>1}

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• http://doi.org/10.1148/radiol.2015141146
• http://doi.org/10.1097/RLI.0000000000000652
• http://doi.org/10.1016/j.joca.2014.07.012
• http://doi.org/10.1002/jor.23345
• http://doi.org/10.1016/j.bbagen.2017.02.008
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• http://doi.org/10.1016/j.joca.2017.11.018
• http://doi.org/10.1007/s00330-014-3497-y
• http://doi.org/10.1016/j.zemedi.2015.11.004
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• http://doi.org/10.1016/j.joca.2014.06.023
• http://doi.org/10.1177/0284185120930642
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• http://doi.org/10.1177/1941738116661975

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• {"files"=>["https://ndownloader.figshare.com/files/1143283"], "description"=>"<p>High values of sodium concentration can be found co-localized with the articular cartilage.</p>", "links"=>[], "tags"=>["3d", "dataset", "overlaid", "dess"], "article_id"=>764768, "categories"=>["Biological Sciences"], "users"=>["Rexford D. Newbould", "Sam R. Miller", "Neil Upadhyay", "Anil W. Rao", "Peter Swann", "Garry E. Gold", "Robin K. Strachan", "Paul M. Matthews", "Peter C. Taylor", "Andrew P. Brown"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073067.g002", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Example_3D_sodium_concentration_dataset_overlaid_on_the_3D_DESS_image_/764768", "title"=>"Example 3D sodium concentration dataset overlaid on the 3D DESS image.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-05 04:49:08"}
• {"files"=>["https://ndownloader.figshare.com/files/1143284"], "description"=>"<p>Whiskers denote the standard error of the mean.</p>", "links"=>[], "tags"=>["means", "oa", "hc", "subjects", "median", "months", "femoral", "patellar", "cartilage"], "article_id"=>764769, "categories"=>["Biological Sciences"], "users"=>["Rexford D. Newbould", "Sam R. Miller", "Neil Upadhyay", "Anil W. Rao", "Peter Swann", "Garry E. Gold", "Robin K. Strachan", "Paul M. Matthews", "Peter C. Taylor", "Andrew P. Brown"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073067.g003", "stats"=>{"downloads"=>2, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Group_means_in_OA_and_HC_subjects_of_median_sodium_concentration_at_baseline_3_months_and_6_months_for_whole_tibial_femoral_and_patellar_cartilage_ROIs_/764769", "title"=>"Group means in OA and HC subjects of median sodium concentration at baseline, 3 months and 6 months for whole, tibial, femoral and patellar cartilage ROIs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-05 04:49:08"}
• {"files"=>["https://ndownloader.figshare.com/files/1143282"], "description"=>"<p>The lightest plot symbols correspond to a 100ms TR, darkening with as drops to 50ms, 30ms, and finally 15ms for the darkest plot symbols. All data has been corrected for the incomplete T1 relaxation of cartilage sodium using the 250mM cartilage-mimicking 10% agar phantom. A strong linear relationship between image intensity and mean sodium concentration is found in the 10% agar cartilage like phantoms. Saline ROIs show an underestimation of the sodium concentration, which reduces as TR increases. Lower concentrations of agar underestimate the sodium concentrations more like saline, as could be expected.</p>", "links"=>[], "tags"=>["concentrations", "3d", "ute", "imaging", "phantoms", "varying"], "article_id"=>764767, "categories"=>["Biological Sciences"], "users"=>["Rexford D. Newbould", "Sam R. Miller", "Neil Upadhyay", "Anil W. Rao", "Peter Swann", "Garry E. Gold", "Robin K. Strachan", "Paul M. Matthews", "Peter C. Taylor", "Andrew P. Brown"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073067.g001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sodium_concentrations_measured_with_3D_UTE_imaging_of_sodium_phantoms_across_varying_TRs_/764767", "title"=>"Sodium concentrations measured with 3D UTE imaging of sodium phantoms across varying TRs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-05 04:49:08"}

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Relative Metric

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F1000Prime