A Fully Implantable Pacemaker for the Mouse: From Battery to Wireless Power
Publication Date
October 23, 2013
Journal
PLOS ONE
Authors
Jacob I. Laughner, Scott B. Marrus, Erik R. Zellmer, Carla J. Weinheimer, et al
Volume
8
Issue
10
Pages
e76291
DOI
https://dx.plos.org/10.1371/journal.pone.0076291
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0076291
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/24194832
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806780
Europe PMC
http://europepmc.org/abstract/MED/24194832
Web of Science
000326037000011
Scopus
84885980290
Mendeley
http://www.mendeley.com/research/fully-implantable-pacemaker-mouse-battery-wireless-power
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Mendeley | Further Information

{"title"=>"A Fully Implantable Pacemaker for the Mouse: From Battery to Wireless Power", "type"=>"journal", "authors"=>[{"first_name"=>"Jacob I.", "last_name"=>"Laughner", "scopus_author_id"=>"24066873500"}, {"first_name"=>"Scott B.", "last_name"=>"Marrus", "scopus_author_id"=>"6506572466"}, {"first_name"=>"Erik R.", "last_name"=>"Zellmer", "scopus_author_id"=>"55894131300"}, {"first_name"=>"Carla J.", "last_name"=>"Weinheimer", "scopus_author_id"=>"7003292464"}, {"first_name"=>"Matthew R.", "last_name"=>"MacEwan", "scopus_author_id"=>"6506252949"}, {"first_name"=>"Sophia X.", "last_name"=>"Cui", "scopus_author_id"=>"55893927000"}, {"first_name"=>"Jeanne M.", "last_name"=>"Nerbonne", "scopus_author_id"=>"7006396641"}, {"first_name"=>"Igor R.", "last_name"=>"Efimov", "scopus_author_id"=>"7103280602"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84885980290", "pui"=>"370091172", "pmid"=>"24194832", "issn"=>"19326203", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0076291", "sgr"=>"84885980290"}, "id"=>"772f3815-e920-3749-81ca-7730673e27bf", "abstract"=>"Animal models have become a popular platform for the investigation of the molecular and systemic mechanisms of pathological cardiovascular physiology. Chronic pacing studies with implantable pacemakers in large animals have led to useful models of heart failure and atrial fibrillation. Unfortunately, molecular and genetic studies in these large animal models are often prohibitively expensive or not available. Conversely, the mouse is an excellent species for studying molecular mechanisms of cardiovascular disease through genetic engineering. However, the large size of available pacemakers does not lend itself to chronic pacing in mice. Here, we present the design for a novel, fully implantable wireless-powered pacemaker for mice capable of long-term (>30 days) pacing. This design is compared to a traditional battery-powered pacemaker to demonstrate critical advantages achieved through wireless inductive power transfer and control. Battery-powered and wireless-powered pacemakers were fabricated from standard electronic components in our laboratory. Mice (n = 24) were implanted with endocardial, battery-powered devices (n = 14) and epicardial, wireless-powered devices (n = 10). Wireless-powered devices were associated with reduced implant mortality and more reliable device function compared to battery-powered devices. Eight of 14 (57.1%) mice implanted with battery-powered pacemakers died following device implantation compared to 1 of 10 (10%) mice implanted with wireless-powered pacemakers. Moreover, device function was achieved for 30 days with the wireless-powered device compared to 6 days with the battery-powered device. The wireless-powered pacemaker system presented herein will allow electrophysiology studies in numerous genetically engineered mouse models as well as rapid pacing-induced heart failure and atrial arrhythmia in mice.", "link"=>"http://www.mendeley.com/research/fully-implantable-pacemaker-mouse-battery-wireless-power", "reader_count"=>29, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>3, "Student > Bachelor"=>6, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>3, "Student > Bachelor"=>6, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>14, "Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>2, "Neuroscience"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>14}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1255822"], "description"=>"<p>(a) Circuit layout of transmitter (top) and receiver (bottom). (b) Pulsed input into transmitter from pulse generator. (c) Output from transmitter. (d) Uncapped output from receiver. (e) Capped output from receiver. (f) Receiver output decreases minimally up to 5 cm from the transmitter coil. See text for further details.</p>", "links"=>[], "tags"=>["wireless-powered"], "article_id"=>830823, "categories"=>["Biological Sciences"], "users"=>["Jacob I. Laughner", "Scott B. Marrus", "Erik R. Zellmer", "Carla J. Weinheimer", "Matthew R. MacEwan", "Sophia X. Cui", "Jeanne M. Nerbonne", "Igor R. Efimov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0076291.g003", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Layout_of_the_wireless_powered_pacemaker_/830823", "title"=>"Layout of the wireless-powered pacemaker.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-23 03:03:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1255818"], "description"=>"<p>(a) Current (blue) and voltage (gray) traces from the pacing catheter. (b) Frequency Response Analysis of distal and proximal pacing catheter electrodes (c) Lead II ECG recording in a mouse heart during sinus rhythm and right ventricular pacing by the battery-powered pacemaker over 5 days.</p>", "links"=>[], "tags"=>["powered"], "article_id"=>830819, "categories"=>["Biological Sciences"], "users"=>["Jacob I. Laughner", "Scott B. Marrus", "Erik R. Zellmer", "Carla J. Weinheimer", "Matthew R. MacEwan", "Sophia X. Cui", "Jeanne M. Nerbonne", "Igor R. Efimov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0076291.g002", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bench_top_and_in_vivo_testing_of_battery_powered_pacemaker_/830819", "title"=>"Bench top and <i>in vivo</i> testing of battery powered pacemaker.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-23 03:03:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1255832"], "description"=>"<p>Parts list for wireless transmitter and receiver circuits.</p>", "links"=>[], "tags"=>["wireless", "transmitter"], "article_id"=>830833, "categories"=>["Biological Sciences"], "users"=>["Jacob I. Laughner", "Scott B. Marrus", "Erik R. Zellmer", "Carla J. Weinheimer", "Matthew R. MacEwan", "Sophia X. Cui", "Jeanne M. Nerbonne", "Igor R. Efimov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0076291.t001", "stats"=>{"downloads"=>5, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Parts_list_for_wireless_transmitter_and_receiver_circuits_/830833", "title"=>"Parts list for wireless transmitter and receiver circuits.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-23 03:03:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1255830"], "description"=>"<p>(a) Lead II ECG during normal sinus rhythm (top) and during LV apical pacing (bottom). (b) Pacing pulse width threshold of wireless device over 30 days for all mice with stable capture. Solid red line shows linear regression on mean pulse width thresholds. Dashed black lines show 95% confidence interval bounds for the regression.</p>", "links"=>[], "tags"=>["wireless"], "article_id"=>830831, "categories"=>["Biological Sciences"], "users"=>["Jacob I. Laughner", "Scott B. Marrus", "Erik R. Zellmer", "Carla J. Weinheimer", "Matthew R. MacEwan", "Sophia X. Cui", "Jeanne M. Nerbonne", "Igor R. Efimov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0076291.g005", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_vivo_testing_of_wireless_pacemaker_/830831", "title"=>"<i>In vivo</i> testing of wireless pacemaker.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-23 03:03:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1255831"], "description"=>"<p>Comparison of battery-powered and wireless-powered pacemakers.</p>", "links"=>[], "tags"=>["battery-powered", "wireless-powered"], "article_id"=>830832, "categories"=>["Biological Sciences"], "users"=>["Jacob I. Laughner", "Scott B. Marrus", "Erik R. Zellmer", "Carla J. Weinheimer", "Matthew R. MacEwan", "Sophia X. Cui", "Jeanne M. Nerbonne", "Igor R. Efimov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0076291.t002", "stats"=>{"downloads"=>3, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_battery_powered_and_wireless_powered_pacemakers_/830832", "title"=>"Comparison of battery-powered and wireless-powered pacemakers.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-23 03:03:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1255829"], "description"=>"<p>(a) Platinum wire is attached to the circuit board, wound together, and coiled with a 0.5 cc syringe. (b) A bead of Silastic is placed on a piece of parafilm(1). The device is placed on the bead(2), coated with an additional layer of Silastic(3), and topped with a piece of gas permeable film(4). (c) Final product. (d) Artistic rendering of external transmitter interacting with abdominally implanted receiver in mouse.</p>", "links"=>[], "tags"=>["wireless", "powered"], "article_id"=>830830, "categories"=>["Biological Sciences"], "users"=>["Jacob I. Laughner", "Scott B. Marrus", "Erik R. Zellmer", "Carla J. Weinheimer", "Matthew R. MacEwan", "Sophia X. Cui", "Jeanne M. Nerbonne", "Igor R. Efimov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0076291.g004", "stats"=>{"downloads"=>2, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Assembly_process_of_wireless_powered_pacemaker_/830830", "title"=>"Assembly process of wireless powered pacemaker.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-23 03:03:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1255816"], "description"=>"<p>(a) Circuit design. (b) Printed circuit board. (c) Battery-powered pacemaker coated in biocompatible epoxy with endocardial pacing catheter attached. Inset image features the tip of the bipolar pacing catheter.</p>", "links"=>[], "tags"=>["battery-powered"], "article_id"=>830817, "categories"=>["Biological Sciences"], "users"=>["Jacob I. Laughner", "Scott B. Marrus", "Erik R. Zellmer", "Carla J. Weinheimer", "Matthew R. MacEwan", "Sophia X. Cui", "Jeanne M. Nerbonne", "Igor R. Efimov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0076291.g001", "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Layout_of_the_battery_powered_mouse_pacemaker_/830817", "title"=>"Layout of the battery-powered mouse pacemaker.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-23 03:03:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1255833"], "description"=>"<div><p>Animal models have become a popular platform for the investigation of the molecular and systemic mechanisms of pathological cardiovascular physiology. Chronic pacing studies with implantable pacemakers in large animals have led to useful models of heart failure and atrial fibrillation. Unfortunately, molecular and genetic studies in these large animal models are often prohibitively expensive or not available. Conversely, the mouse is an excellent species for studying molecular mechanisms of cardiovascular disease through genetic engineering. However, the large size of available pacemakers does not lend itself to chronic pacing in mice. Here, we present the design for a novel, fully implantable wireless-powered pacemaker for mice capable of long-term (>30 days) pacing. This design is compared to a traditional battery-powered pacemaker to demonstrate critical advantages achieved through wireless inductive power transfer and control. Battery-powered and wireless-powered pacemakers were fabricated from standard electronic components in our laboratory. Mice (n = 24) were implanted with endocardial, battery-powered devices (n = 14) and epicardial, wireless-powered devices (n = 10). Wireless-powered devices were associated with reduced implant mortality and more reliable device function compared to battery-powered devices. Eight of 14 (57.1%) mice implanted with battery-powered pacemakers died following device implantation compared to 1 of 10 (10%) mice implanted with wireless-powered pacemakers. Moreover, device function was achieved for 30 days with the wireless-powered device compared to 6 days with the battery-powered device. The wireless-powered pacemaker system presented herein will allow electrophysiology studies in numerous genetically engineered mouse models as well as rapid pacing-induced heart failure and atrial arrhythmia in mice.</p></div>", "links"=>[], "tags"=>["implantable", "pacemaker", "wireless"], "article_id"=>830834, "categories"=>["Biological Sciences"], "users"=>["Jacob I. Laughner", "Scott B. Marrus", "Erik R. Zellmer", "Carla J. Weinheimer", "Matthew R. MacEwan", "Sophia X. Cui", "Jeanne M. Nerbonne", "Igor R. Efimov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0076291", "stats"=>{"downloads"=>10, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_Fully_Implantable_Pacemaker_for_the_Mouse_From_Battery_to_Wireless_Power_/830834", "title"=>"A Fully Implantable Pacemaker for the Mouse: From Battery to Wireless Power", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-23 03:03:41"}

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Relative Metric

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