Cholinergic Plasticity of Oscillating Neuronal Assemblies in Mouse Hippocampal Slices
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{"title"=>"Cholinergic plasticity of oscillating neuronal assemblies in mouse hippocampal slices", "type"=>"journal", "authors"=>[{"first_name"=>"Maura M.", "last_name"=>"Zylla", "scopus_author_id"=>"56483305700"}, {"first_name"=>"Xiaomin", "last_name"=>"Zhang", "scopus_author_id"=>"53165284100"}, {"first_name"=>"Susanne", "last_name"=>"Reichinnek", "scopus_author_id"=>"36457973700"}, {"first_name"=>"Andreas", "last_name"=>"Draguhn", "scopus_author_id"=>"56190195400"}, {"first_name"=>"Martin", "last_name"=>"Both", "scopus_author_id"=>"26642989000"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84894058608", "sgr"=>"84894058608", "pui"=>"372377703", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"24260462", "doi"=>"10.1371/journal.pone.0080718"}, "id"=>"504fbc7a-3442-3f19-b365-3a4e8f2ec984", "abstract"=>"The mammalian hippocampus expresses several types of network oscillations which entrain neurons into transiently stable assemblies. These groups of co-active neurons are believed to support the formation, consolidation and recall of context-dependent memories. Formation of new assemblies occurs during theta- and gamma-oscillations under conditions of high cholinergic activity. Memory consolidation is linked to sharp wave-ripple oscillations (SPW-R) during decreased cholinergic tone. We hypothesized that increased cholinergic tone supports plastic changes of assemblies while low cholinergic tone favors their stability. Coherent spatiotemporal network patterns were measured during SPW-R activity in mouse hippocampal slices. We compared neuronal activity within the oscillating assemblies before and after a transient phase of carbachol-induced gamma oscillations. Single units maintained their coupling to SPW-R throughout the experiment and could be re-identified after the transient phase of gamma oscillations. However, the frequency of SPW-R-related unit firing was enhanced after muscarinic stimulation. At the network level, these changes resulted in altered patterns of extracellularly recorded SPW-R waveforms. In contrast, recording of ongoing SPW-R activity without intermittent cholinergic stimulation revealed remarkably stable repetitive activation of assemblies. These results show that activation of cholinergic receptors induces plasticity at the level of oscillating hippocampal assemblies, in line with the different role of gamma- and SPW-R network activity for memory formation and -consolidation, respectively.", "link"=>"http://www.mendeley.com/research/cholinergic-plasticity-oscillating-neuronal-assemblies-mouse-hippocampal-slices", "reader_count"=>36, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>11, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>3, "Student > Master"=>3, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>11, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>3, "Student > Master"=>3, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Unspecified"=>2, "Agricultural and Biological Sciences"=>16, "Medicine and Dentistry"=>3, "Neuroscience"=>10, "Psychology"=>2, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>10}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Computer Science"=>{"Computer Science"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Hungary"=>1, "Chile"=>1, "Germany"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1286015"], "description"=>"<p><b>A</b>: Increase of amplitudes was significantly stronger after an intermittent carbachol induced gamma state than after ongoing SPW-R-oscillations. However, the increase in amplitude was not significantly different from values derived from the <i>atropine</i> control (p<0.05, <i>CCh</i> vs. <i>SPW-R</i>: p<0.01, <i>CCh</i> vs. <i>atropine</i>: p>0.05, ANOVA with post-hoc test between groups). <b>C</b>: Population spike amplitude in CA1 str. pyramidale (upper panel) and the slope of field-EPSPs in CA1 str. radiatum (lower panel) are potentiated after gamma oscillations. Intakes depict representative waveforms before (black) and after gamma (red).</p>", "links"=>[], "tags"=>["assemblies", "reflected"], "article_id"=>854848, "categories"=>["Biological Sciences"], "users"=>["Maura M. Zylla", "Xiaomin Zhang", "Susanne Reichinnek", "Andreas Draguhn", "Martin Both"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0080718.g004", "stats"=>{"downloads"=>0, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Potentiation_of_unit_assemblies_is_reflected_by_plastic_changes_on_the_network_level_/854848", "title"=>"Potentiation of unit assemblies is reflected by plastic changes on the network level.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-18 03:51:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/1286012"], "description"=>"<p><b>A</b>: Schematics of recording conditions. Tetrode recordings are performed in the pyramidal cell layers of CA3 and CA1. During sharp wave-ripple oscillations (SPW-R), field potentials are generated by the recurrent network of CA3 (green) and transmitted via the Schaffer collaterals to selectively activate cell assemblies in CA1 (red). Examples of field potential waveforms are shown in the respective colors. <b>B</b>: Example traces of field potentials recorded in CA1 during SPW-R (left panel) and gamma oscillations (right panel). Raw field potential (upper trace) and the high pass filtered (0.5–10 kHz) potential in the four tetrode channels (lower traces). Filtering reveals high-frequency multiunit activity on SPW-R and gamma cycles. Firing of two individual units extracted by waveform analysis is highlighted in orange and blue. Time points of firing relative to the field potential are visualized by vertical ‘ticks’. The middle panel illustrates the detection criterion for unit events: horizontal histograms of all data points show largely normal distribution around zero. Events are detected if they exceed 4.5 times the standard deviation as indicated by the dashed red line. <b>C</b>: Wavelet spectrograms of the example traces from B. Sharp waves are superimposed by high-frequency ripple oscillations (∼200 Hz, left panel). The carbachol-induced gamma state consists of a continuous oscillation at ∼30 Hz.</p>", "links"=>[], "tags"=>["states", "corresponding", "vitro"], "article_id"=>854845, "categories"=>["Biological Sciences"], "users"=>["Maura M. Zylla", "Xiaomin Zhang", "Susanne Reichinnek", "Andreas Draguhn", "Martin Both"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0080718.g001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Different_network_states_and_corresponding_unit_activity_can_be_analyzed_in_the_in_vitro_model_/854845", "title"=>"Different network states and corresponding unit activity can be analyzed in the in vitro model.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-18 03:51:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/1286013"], "description"=>"<p><b>A</b>: Local field potential recordings and single unit activity (symbolized by vertical ticks) in CA1 and CA3 during the three experimental steps of the <i>CCh</i> experiments: baseline recording (SPW 1, left panel) followed by carbachol-induced gamma oscillations (Gamma, middle panel) and re-established SPW by wash-in of atropine (SPW 2, right panel). Two representative units are indicated by colored ticks in each region. Note that the individual units could be observed in all three phases of the experiment. <b>B</b>: Event cross-correlograms of field-potentials and firing time points of the units depicted in A. During SPW 1 and SPW 2, unit firing is correlated to the ripple-oscillation troughs in CA1 (peak intervals at ∼5 ms, corresponding to ripple cycle length); during the gamma episode they are correlated to the local gamma oscillation troughs (peak intervals at ∼30 ms). <b>C</b>: Mean firing rates of units remain constant during gamma oscillations. <b>D</b>: Firing phases of units to ripple troughs remain stable after an intermittent episode of gamma oscillations. The ripple cycle is described by a circular scale of 360° and the ripple trough is set to 0°. Each unit's preferred firing phase angle to the ripple contributes as one data point. Mean angle of the sum of all units is represented by the red arrow. The length of the red arrow is proportional to the length of the vector corresponding to the mean angle.</p>", "links"=>[], "tags"=>["units", "coupling", "precision", "alternating"], "article_id"=>854846, "categories"=>["Biological Sciences"], "users"=>["Maura M. Zylla", "Xiaomin Zhang", "Susanne Reichinnek", "Andreas Draguhn", "Martin Both"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0080718.g002", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hippocampal_units_maintain_coupling_precision_to_the_local_field_potential_during_alternating_network_states_/854846", "title"=>"Hippocampal units maintain coupling precision to the local field potential during alternating network states.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-18 03:51:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/1286019"], "description"=>"<p><b>A</b>: Example of 2456 (left panel, baseline episode of 1000 s) and 7237 (right panel, post gamma episode of 2000 s) individual SPW-R events from one experiment sorted onto the respective reference SOM. Traces left and right to the SOM depict an enlarged view of the waveforms at the corner positions. Grey lines indicate individual events, yellow lines show mean waveforms which are also shown in the respective map unit. Note the shift in SPW-R-waveforms after intermittent gamma oscillations. <b>B</b>: Differences of reference maps and partial data maps after <i>CCh</i> (red), ongoing <i>SPW-R</i> oscillations (blue), and <i>atropine</i> application (green) are quantified by their mean distance to the reference episode. The shift to more different waveforms was significantly more pronounced after gamma oscillations than in the other two experimental groups (p<0.05; ANOVA with post-hoc test between groups). <b>C</b>: similar to B but baseline SPWs are normalized to the median SPW-amplitude during baseline recording and SPWs from the second recording episode are normalized to the median amplitude during that recording period. Again, gamma-induced modulation in SPW-R waveforms significantly exceeds changes in ongoing SPW-R recordings and <i>atropine</i> control (p<0.05; ANOVA with post-hoc test between groups).</p>", "links"=>[], "tags"=>["carbachol", "induced", "gamma", "oscillations", "spw-r-waveforms", "reflecting", "modulation", "neuronal"], "article_id"=>854850, "categories"=>["Biological Sciences"], "users"=>["Maura M. Zylla", "Xiaomin Zhang", "Susanne Reichinnek", "Andreas Draguhn", "Martin Both"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0080718.g005", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Intermittent_carbachol_induced_gamma_oscillations_lead_to_changes_in_SPW_R_waveforms_reflecting_modulation_of_local_neuronal_assembly_structure_/854850", "title"=>"Intermittent carbachol induced gamma oscillations lead to changes in SPW-R-waveforms reflecting modulation of local neuronal assembly structure.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-18 03:51:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/1286014"], "description"=>"<p><b>A</b>: Each line represents one unit and the modulation of its SPW-R-related firing rate after carbachol induced gamma oscillations. Red lines illustrate potentiated units, black lines depict suppressed units. Note the dominance of enhanced units in the <i>CCh</i> experiments in contrast to ongoing SPW-R recordings. <b>B</b>: Increase of SPW-R-coupled firing (see Methods section for plasticity coefficient) was significantly stronger in the <i>CCh</i> experiments compared to ongoing SPW-R-recordings and the <i>atropine</i> control, p<0.0001 for CA1, p<0.001 for CA3; ANOVA with post-hoc test between groups). <b>C</b>: Modulation in firing outside SPW-R was calculated as a coefficient (see <i>c2</i> in Methods Section) and compared between groups. In CA1 of <i>CCh</i> experiments firing outside SPW decreased in contrast to ongoing SPW-recordings and <i>atropine</i> control (p<0.001, ANOVA and post-hoc tests). In CA3 firing outside SPWs was slightly increased in all groups. However, groups did not differ statistically (p>0.05, ANOVA).</p>", "links"=>[], "tags"=>["firing", "enhanced", "carbachol", "induced", "gamma", "oscillations", "ca1"], "article_id"=>854847, "categories"=>["Biological Sciences"], "users"=>["Maura M. Zylla", "Xiaomin Zhang", "Susanne Reichinnek", "Andreas Draguhn", "Martin Both"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0080718.g003", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SPW_coupled_firing_is_specifically_enhanced_after_carbachol_induced_gamma_oscillations_in_both_CA1_and_CA3_/854847", "title"=>"SPW-coupled firing is specifically enhanced after carbachol induced gamma oscillations in both CA1 and CA3.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-18 03:51:30"}

PMC Usage Stats | Further Information

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Relative Metric

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