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{"title"=>"Oral administration of Lactobacillus plantarum strain AYA enhances IgA secretion and provides survival protection against influenza virus infection in mice", "type"=>"journal", "authors"=>[{"first_name"=>"Yosuke", "last_name"=>"Kikuchi", "scopus_author_id"=>"55488486300"}, {"first_name"=>"Ayami", "last_name"=>"Kunitoh-Asari", "scopus_author_id"=>"56140636200"}, {"first_name"=>"Katsuyuki", "last_name"=>"Hayakawa", "scopus_author_id"=>"56142032300"}, {"first_name"=>"Shinjiro", "last_name"=>"Imai", "scopus_author_id"=>"7401491888"}, {"first_name"=>"Kenji", "last_name"=>"Kasuya", "scopus_author_id"=>"56140835600"}, {"first_name"=>"Kimio", "last_name"=>"Abe", "scopus_author_id"=>"56140633800"}, {"first_name"=>"Yu", "last_name"=>"Adachi", "scopus_author_id"=>"56142145900"}, {"first_name"=>"Shin Ichi", "last_name"=>"Fukudome", "scopus_author_id"=>"8975805000"}, {"first_name"=>"Yoshimasa", "last_name"=>"Takahashi", "scopus_author_id"=>"35867565900"}, {"first_name"=>"Satoshi", "last_name"=>"Hachimura", "scopus_author_id"=>"7003574060"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84899633814", "sgr"=>"84899633814", "pui"=>"372981701", "isbn"=>"10.1371/journal.pone.0086416", "pmid"=>"24466081", "doi"=>"10.1371/journal.pone.0086416"}, "id"=>"4b38a7e7-6dbb-3d8c-aece-578adabe7bd3", "abstract"=>"The mucosal immune system provides the first line of defense against inhaled and ingested pathogenic microbacteria and viruses. This defense system, to a large extent, is mediated by the actions of secretory IgA. In this study, we screened 140 strains of lactic acid bacteria for induction of IgA production by murine Peyer's patch cells. We selected one strain and named it Lactobacillus plantarum AYA. We found that L. plantarum AYA-induced production of IL-6 in Peyer's patch dendritic cells, with this production promoting IgA(+) B cells to differentiate into IgA-secreting plasma cells. We also observed that oral administration of L. plantarum AYA in mice caused an increase in IgA production in the small intestine and lung. This production of IgA correlated strongly with protective ability, with the treated mice surviving longer than the control mice after lethal influenza virus infection. Our data therefore reveals a novel immunoregulatory role of the L. plantarum AYA strain which enhances mucosal IgA production and provides protection against respiratory influenza virus infection.", "link"=>"http://www.mendeley.com/research/oral-administration-lactobacillus-plantarum-strain-aya-enhances-iga-secretion-provides-survival-prot", "reader_count"=>27, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>10, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Master"=>5, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>10, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Master"=>5, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Materials Science"=>1, "Agricultural and Biological Sciences"=>16, "Medicine and Dentistry"=>4, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Japan"=>1}, "group_count"=>1}

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• http://doi.org/10.1016/j.vetmic.2020.108906
• http://doi.org/10.1016/j.virusres.2017.12.011
• http://doi.org/10.3382/ps/pex061
• http://doi.org/10.22424/jmsb.2016.34.4.203
• http://doi.org/10.12938/bmfh.2014-016
• http://doi.org/10.1016/j.biopha.2020.110625
• http://doi.org/10.3389/fimmu.2018.02223
• http://doi.org/10.1371/journal.pone.0188985
• http://doi.org/10.1139/cjm-2020-0020
• http://doi.org/10.1038/s41598-017-17487-8
• http://doi.org/10.1186/s12917-020-2264-3
• http://doi.org/10.1080/09168451.2014.940829
• http://doi.org/10.3390/nu10060681
• http://doi.org/10.1007/s00253-017-8230-8
• http://doi.org/10.1111/wrr.12607
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• http://doi.org/10.1016/j.virol.2014.07.011
• http://doi.org/10.1080/09168451.2017.1282804
• http://doi.org/10.3389/fimmu.2018.02840
• http://doi.org/10.1038/srep25835
• http://doi.org/10.3390/nu12102925
• http://doi.org/10.1038/s41598-017-18677-0
• http://doi.org/10.1177/2156587216641831

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• {"files"=>["https://ndownloader.figshare.com/files/1355333"], "description"=>"<p>(A) PP cells (1×10⁶/well) from BALB/c mice fed a normal diet (AIN93G), and each LABs were co-cultured. Supernatants were harvested after 7 days, and IgA concentrations were measured by ELISA. Data are shown as mean ± SE. n = 5. Data represent one of two similar experiments. (B) PP cells (1×10⁶ per well) from BALB/c mice fed the diet containing LAB were incubated. Supernatants were harvested, and IgA concentrations were measured by ELISA after 7 days. Data are shown as mean ± SE. n = 5. Asterisk indicate unpaired Student’s t test; P value is <0.05. Data represent one of two similar experiments.</p>", "links"=>[], "tags"=>["immunology", "immunity", "Immunity to infections", "Innate immunity", "immunoglobulins", "microbiology", "Model organisms", "Animal models", "mouse", "Clinical immunology", "Gastroenterology and hepatology", "Gastrointestinal infections", "induced", "pp"], "article_id"=>907813, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yosuke Kikuchi", "Ayami Kunitoh-Asari", "Katsuyuki Hayakawa", "Shinjiro Imai", "Kenji Kasuya", "Kimio Abe", "Yu Adachi", "Shin-ichi Fukudome", "Yoshimasa Takahashi", "Satoshi Hachimura"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086416.g001", "stats"=>{"downloads"=>4, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_IgA_production_induced_by_PP_cells_/907813", "title"=>"IgA production induced by PP cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 03:01:15"}
• {"files"=>["https://ndownloader.figshare.com/files/1355340"], "description"=>"<p>IgA⁺ B220⁺ cells were from BALB/c mice fed the normal diet with or without LAB for 28 days. We used flow cytometry to measure surface IgA and B220 expression. (A) FACS profiles of PP cells. The position of IgA⁺ B220⁺ cells in Fig. 2A is located in the upper right zone. Data represent one of two similar experiments. (B) The proportion of IgA⁺ B220⁺ cells present among PP cells. Data are shown as mean ± SE. n = 5. Asterisk indicate unpaired Mann–Whitney’s U test; P value is <0.05. Data represent one of two similar experiments. (C) IgA concentration in the washings from the upper small intestine. Data are shown as mean ± SE. n = 5. Asterisk indicate unpaired Mann–Whitney’s U test; P value is <0.05. Data represent one of two similar experiments. (D) IgA concentration in the washings from the lower small intestine. Data are shown as mean ± SE. n = 5. Asterisk indicate unpaired Mann–Whitney’s U test; P value is <0.05. Data represent one of two similar experiments.</p>", "links"=>[], "tags"=>["immunology", "immunity", "Immunity to infections", "Innate immunity", "immunoglobulins", "microbiology", "Model organisms", "Animal models", "mouse", "Clinical immunology", "Gastroenterology and hepatology", "Gastrointestinal infections", "cells", "pp"], "article_id"=>907814, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yosuke Kikuchi", "Ayami Kunitoh-Asari", "Katsuyuki Hayakawa", "Shinjiro Imai", "Kenji Kasuya", "Kimio Abe", "Yu Adachi", "Shin-ichi Fukudome", "Yoshimasa Takahashi", "Satoshi Hachimura"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086416.g002", "stats"=>{"downloads"=>2, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_proportion_of_IgA_B220_cells_present_among_PP_cells_was_measured_/907814", "title"=>"The proportion of IgA⁺B220⁺ cells present among PP cells was measured.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 03:01:15"}
• {"files"=>["https://ndownloader.figshare.com/files/1355341"], "description"=>"<p>(a) IgA⁺ B cells from PP cells were cultured in the absence or presence of <i>L. plantarum</i> AYA. IgA concentrations in the supernatants were determined by ELISA after 4 days. Data are shown as mean ± SE. n = 3. There were no statistically significant differences as determined by Student’s t test. Data represent one of two similar experiments. (b) DCs and IgA⁺ B cells from PP cells were cultured in the absence of presence of <i>L. plantarum</i> AYA. IgA concentrations in the supernatants were determined by ELISA after four days. Data are shown as mean ± SE. n = 3. Asterisk indicate unpaired Student’s t test; P value is <0.01. Data represent one of two similar experiments.</p>", "links"=>[], "tags"=>["immunology", "immunity", "Immunity to infections", "Innate immunity", "immunoglobulins", "microbiology", "Model organisms", "Animal models", "mouse", "Clinical immunology", "Gastroenterology and hepatology", "Gastrointestinal infections", "induced", "aya"], "article_id"=>907815, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yosuke Kikuchi", "Ayami Kunitoh-Asari", "Katsuyuki Hayakawa", "Shinjiro Imai", "Kenji Kasuya", "Kimio Abe", "Yu Adachi", "Shin-ichi Fukudome", "Yoshimasa Takahashi", "Satoshi Hachimura"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086416.g003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_IgA_production_induced_by_IgA_B_cell_with_or_without_L_plantarum_AYA_and_DC_/907815", "title"=>"IgA production induced by IgA⁺ B cell with or without <i>L. plantarum</i> AYA and DC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 03:01:15"}
• {"files"=>["https://ndownloader.figshare.com/files/1355344"], "description"=>"<p>DCs from PP cells were cultured in the absence or presence of <i>L. plantarum</i> AYA for 6, 12, 18, 24, and 48 h. The level of gene expression was normalized to that of GAPDH mRNA expression in DCs from PP cells. A: IL-6, B: TGF-β, C:, BAFF, D: APRIL, E: ALDH1a1, F: ALDH1a2 and G: iNOS. Data represent one of two similar experiments.</p>", "links"=>[], "tags"=>["immunology", "immunity", "Immunity to infections", "Innate immunity", "immunoglobulins", "microbiology", "Model organisms", "Animal models", "mouse", "Clinical immunology", "Gastroenterology and hepatology", "Gastrointestinal infections", "genes", "Real-time"], "article_id"=>907818, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yosuke Kikuchi", "Ayami Kunitoh-Asari", "Katsuyuki Hayakawa", "Shinjiro Imai", "Kenji Kasuya", "Kimio Abe", "Yu Adachi", "Shin-ichi Fukudome", "Yoshimasa Takahashi", "Satoshi Hachimura"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086416.g004", "stats"=>{"downloads"=>2, "page_views"=>29, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_7_genes_was_measured_by_real_time_PCR_/907818", "title"=>"Expression of 7 genes was measured by real-time PCR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 03:01:15"}
• {"files"=>["https://ndownloader.figshare.com/files/1355346"], "description"=>"<p>(A–C) DCs from PP cells were cultured in the absence or presence of <i>L. plantarum</i> AYA for 3 days. (A) IL-6 concentration was measured. Data are shown as mean ± SE. n = 3. (B) TGF-β concentration was measured. Data are shown as mean ± SE. n = 3. There were no statistically significant differences as determined by unpaired Student’s t test. (C) BAFF concentration was measured. Data are shown as mean ± SE. n = 3. There were no statistically significant differences as determined by unpaired Student’s t test. Data represent one of two similar experiments. (D) DCs and IgA⁺ B cells from PP cells were incubated with anti-IL-6 mAb or a control mAb with or without <i>L. plantarum</i> AYA. IgA concentrations from culture supernatants were measured by ELISA. Data are shown as mean ± SE. n = 3. One asterisk indicate unpaired Student’s t test; P value is <0.05, Two asterisks indicate unpaired Student’s t test; P value is <0.01. Data represent one of two similar experiments.</p>", "links"=>[], "tags"=>["immunology", "immunity", "Immunity to infections", "Innate immunity", "immunoglobulins", "microbiology", "Model organisms", "Animal models", "mouse", "Clinical immunology", "Gastroenterology and hepatology", "Gastrointestinal infections", "iga", "induced", "pp", "cells"], "article_id"=>907820, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yosuke Kikuchi", "Ayami Kunitoh-Asari", "Katsuyuki Hayakawa", "Shinjiro Imai", "Kenji Kasuya", "Kimio Abe", "Yu Adachi", "Shin-ichi Fukudome", "Yoshimasa Takahashi", "Satoshi Hachimura"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086416.g005", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cytokine_and_IgA_production_induced_from_PP_cells_with_or_without_L_plantarum_AYA_/907820", "title"=>"Cytokine and IgA production induced from PP cells with or without <i>L. plantarum</i> AYA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 03:01:15"}
• {"files"=>["https://ndownloader.figshare.com/files/1355347"], "description"=>"<p>Forty BALB/c mice were fed a common diet for 7 days. Then, 20 BALB/c mice per group were fed a control diet or a diet containing <i>L. plantarum</i> AYA for 28 days. After 35 days, 5 mice in each group were sacrificed, and the washings from the small intestine and BALF were collected. Fifteen mice in each group were subsequently infected with X-31 virus. After 38 days, 5 mice in each group were dissected, and BALF was collected. The remaining 10 mice per group were monitored for the survival rate for 10 days after infection. (A) The experimental procedure. (B) IgA concentration in the washings from the upper small intestine at 35 days. Data are shown as mean ± SE. n = 5. Two asterisks indicate unpaired Student’s t test; P value is <0.01. (C) IgA concentration in the washings from the lower small intestine at 35 days. Data are shown as mean ± SE. n = 5. Asterisk indicate unpaired Student’s t test; P value is <0.05. (D) IgA concentration in BALF at 35 days. Data are shown as mean ± SE. n = 5. Asterisk indicate unpaired Student’s t test; P value is <0.05. (E) IgG1 concentration in BALF at 35 days. Data are shown as mean ± SE. n = 5. (F) IgG2a concentration in BALF at 35 days. Data are shown as mean ± SE. n = 5. (G) Titer of X-31 virus in BALF of mice at 38 days. Data are shown as mean ± SE. n = 5. (H) Change of body weight. The humane endpoint is 20% body weight loss. Data are shown as mean ± SE. n = 5. One asterisk indicate unpaired Mann–Whitney’s U test; P value is <0.05, Two asterisks indicate unpaired Mann–Whitney’s U test; P value is <0.01. (I) Survival rate of mice in each group. Data are shown as mean ± SE. n = 10. Two asterisks indicate unpaired the Kaplan–Meier test; P value is <0.01. Data represent one of two similar experiments.</p>", "links"=>[], "tags"=>["immunology", "immunity", "Immunity to infections", "Innate immunity", "immunoglobulins", "microbiology", "Model organisms", "Animal models", "mouse", "Clinical immunology", "Gastroenterology and hepatology", "Gastrointestinal infections"], "article_id"=>907821, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yosuke Kikuchi", "Ayami Kunitoh-Asari", "Katsuyuki Hayakawa", "Shinjiro Imai", "Kenji Kasuya", "Kimio Abe", "Yu Adachi", "Shin-ichi Fukudome", "Yoshimasa Takahashi", "Satoshi Hachimura"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086416.g006", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effect_of_oral_administration_of_L_plantarum_AYA_/907821", "title"=>"The effect of oral administration of <i>L. plantarum</i> AYA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 03:01:15"}
• {"files"=>["https://ndownloader.figshare.com/files/1355348"], "description"=>"<p>Species of LAB.</p>", "links"=>[], "tags"=>["immunology", "immunity", "Immunity to infections", "Innate immunity", "immunoglobulins", "microbiology", "Model organisms", "Animal models", "mouse", "Clinical immunology", "Gastroenterology and hepatology", "Gastrointestinal infections"], "article_id"=>907822, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yosuke Kikuchi", "Ayami Kunitoh-Asari", "Katsuyuki Hayakawa", "Shinjiro Imai", "Kenji Kasuya", "Kimio Abe", "Yu Adachi", "Shin-ichi Fukudome", "Yoshimasa Takahashi", "Satoshi Hachimura"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086416.t001", "stats"=>{"downloads"=>1, "page_views"=>30, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Species_of_LAB_/907822", "title"=>"Species of LAB.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-22 03:01:15"}

PMC Usage Stats | Further Information

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Relative Metric

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F1000Prime