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{"title"=>"Sweet taste receptor deficient mice have decreased adiposity and increased bone mass", "type"=>"journal", "authors"=>[{"first_name"=>"Becky R.", "last_name"=>"Simon", "scopus_author_id"=>"55926111000"}, {"first_name"=>"Brian S.", "last_name"=>"Learman", "scopus_author_id"=>"55908656900"}, {"first_name"=>"Sebastian D.", "last_name"=>"Parlee", "scopus_author_id"=>"35082576100"}, {"first_name"=>"Erica L.", "last_name"=>"Scheller", "scopus_author_id"=>"23502151300"}, {"first_name"=>"Hiroyuki", "last_name"=>"Mori", "scopus_author_id"=>"55301150500"}, {"first_name"=>"William P.", "last_name"=>"Cawthorn", "scopus_author_id"=>"14041162900"}, {"first_name"=>"Xiaomin", "last_name"=>"Ning", "scopus_author_id"=>"36659824500"}, {"first_name"=>"Venkatesh", "last_name"=>"Krishnan", "scopus_author_id"=>"7103255625"}, {"first_name"=>"Yanfei L.", "last_name"=>"Ma", "scopus_author_id"=>"7404701174"}, {"first_name"=>"Björn", "last_name"=>"Tyrberg", "scopus_author_id"=>"6602001245"}, {"first_name"=>"Ormond A.", "last_name"=>"MacDougald", "scopus_author_id"=>"7003871202"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24466105", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0086454", "pui"=>"372981711", "isbn"=>"1932-6203", "scopus"=>"2-s2.0-84897905550", "sgr"=>"84897905550"}, "id"=>"fbd2a109-e3ff-3315-bf5a-afcd5169f7c9", "abstract"=>"Functional expression of sweet taste receptors (T1R2 and T1R3) has been reported in numerous metabolic tissues, including the gut, pancreas, and, more recently, in adipose tissue. It has been suggested that sweet taste receptors in these non-gustatory tissues may play a role in systemic energy balance and metabolism. Smaller adipose depots have been reported in T1R3 knockout mice on a high carbohydrate diet, and sweet taste receptors have been reported to regulate adipogenesis in vitro. To assess the potential contribution of sweet taste receptors to adipose tissue biology, we investigated the adipose tissue phenotypes of T1R2 and T1R3 knockout mice. Here we provide data to demonstrate that when fed an obesogenic diet, both T1R2 and T1R3 knockout mice have reduced adiposity and smaller adipocytes. Although a mild glucose intolerance was observed with T1R3 deficiency, other metabolic variables analyzed were similar between genotypes. In addition, food intake, respiratory quotient, oxygen consumption, and physical activity were unchanged in T1R2 knockout mice. Although T1R2 deficiency did not affect adipocyte number in peripheral adipose depots, the number of bone marrow adipocytes is significantly reduced in these knockout animals. Finally, we present data demonstrating that T1R2 and T1R3 knockout mice have increased cortical bone mass and trabecular remodeling. This report identifies novel functions for sweet taste receptors in the regulation of adipose and bone biology, and suggests that in these contexts, T1R2 and T1R3 are either dependent on each other for activity or have common independent effects in vivo.", "link"=>"http://www.mendeley.com/research/sweet-taste-receptor-deficient-mice-decreased-adiposity-increased-bone-mass", "reader_count"=>36, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>5, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>2, "Student > Master"=>5, "Student > Bachelor"=>7, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>5, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>2, "Student > Master"=>5, "Student > Bachelor"=>7, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>17, "Medicine and Dentistry"=>8, "Business, Management and Accounting"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Sports and Recreations"=>3, "Psychology"=>2, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Chemistry"=>{"Chemistry"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>3}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>17}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Republic of Singapore"=>1, "Sweden"=>1, "China"=>1, "Brazil"=>1}, "group_count"=>4}

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• http://doi.org/10.1371/journal.pone.0219707
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• http://doi.org/10.1007/s12576-017-0535-y
• http://doi.org/10.3390/ijms20040967
• http://doi.org/10.1371/journal.pone.0130997
• http://doi.org/10.1002/oby.22252
• http://doi.org/10.1016/j.ebiom.2016.04.031
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• http://doi.org/10.3390/molecules22030469
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• http://doi.org/10.1016/j.bbrc.2018.06.152
• http://doi.org/10.1093/chemse/bjw104

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/1355756"], "description"=>"<p>A) Body weight in WT (n = 9) and T1R2 KO (n = 9) mice on Western Diet for 14 weeks. B) Fat as percent of body weight or C) as mass. D) Lean mass as percent of body weight or E) as mass in WT and T1R2 KO animals. F) Adipose depot and liver weights following Western diet feeding. Data are expressed as mean and S.D. Significance was determined using an unpaired Student’s t-test. <i>P</i> <0.05 indicated with #.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "bone", "Biochemistry", "metabolism", "Model organisms", "Animal models", "mouse", "Physiological processes", "Energy metabolism", "nutrition", "obesity", "ko", "mice", "reduced", "adiposity"], "article_id"=>908231, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Becky R. Simon", "Brian S. Learman", "Sebastian D. Parlee", "Erica L. Scheller", "Hiroyuki Mori", "William P. Cawthorn", "Xiaomin Ning", "Venkatesh Krishnan", "Yanfei L. Ma", "Björn Tyrberg", "Ormond A. MacDougald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086454.g004", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_T1R2_KO_mice_have_reduced_adiposity_on_Western_Diet_/908231", "title"=>"T1R2 KO mice have reduced adiposity on Western Diet.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 03:25:23"}
• {"files"=>["https://ndownloader.figshare.com/files/1355757"], "description"=>"<p>A) Adipocyte size frequency distribution in WT (n = 9) and T1R2 KO (n = 9) mice on Western Diet for 14 weeks shows a greater prevalence of smaller adipocytes in T1R2 KO animals. B) T1R2 KO animals show a decreased frequency of large adipocytes, defined as having a surface area greater than 7000 µm², and increased frequency of small adipocytes, defined as having a surface area smaller than 7000 µm². Significance was determined using Student’s t-test. <i>P</i> <0.05 indicated with #. Data are expressed as mean plus S.D. C) Linear relationship between eWAT (epididymal white adipose tissue) weight and average adipocyte volume for WT (r² = 0.16) and T1R2 KO (r² = 0.60) mice. Slope (<i>P</i> = 0.98) and intercept (<i>P</i> = 0.43)</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "bone", "Biochemistry", "metabolism", "Model organisms", "Animal models", "mouse", "Physiological processes", "Energy metabolism", "nutrition", "obesity", "ko", "mice", "smaller", "adipocytes", "adipocyte"], "article_id"=>908232, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Becky R. Simon", "Brian S. Learman", "Sebastian D. Parlee", "Erica L. Scheller", "Hiroyuki Mori", "William P. Cawthorn", "Xiaomin Ning", "Venkatesh Krishnan", "Yanfei L. Ma", "Björn Tyrberg", "Ormond A. MacDougald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086454.g005", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_T1R2_KO_mice_have_smaller_adipocytes_but_equal_adipocyte_numbers_/908232", "title"=>"T1R2 KO mice have smaller adipocytes but equal adipocyte numbers.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 03:25:23"}
• {"files"=>["https://ndownloader.figshare.com/files/1355753"], "description"=>"<p>A) The frequency distribution reveals that adipocyte sizes in epididymal adipose tissue from WT (n = 7) and T1R3 KO (n = 8) mice on a Western diet are shifted towards smaller cells. B) T1R3 KO animals have decreased frequency of large adipocytes, defined as having a surface area greater than 7500 µm², relative to WT animals. Significance was determined using Student’s t-test. <i>P</i> <0.05 indicated with #. Data are expressed as mean plus S.D. C) Linear relationship between eWAT (epididymal white adipose tissue) weight and average adipocyte volume for WT (r²  =  0.71) and T1R3 KO (r²  =  0.94) mice. Slope (<i>P</i>  =  0.14) and intercept (<i>P</i> < 0.05).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "bone", "Biochemistry", "metabolism", "Model organisms", "Animal models", "mouse", "Physiological processes", "Energy metabolism", "nutrition", "obesity", "ko", "mice", "adipocytes", "adipocyte"], "article_id"=>908227, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Becky R. Simon", "Brian S. Learman", "Sebastian D. Parlee", "Erica L. Scheller", "Hiroyuki Mori", "William P. Cawthorn", "Xiaomin Ning", "Venkatesh Krishnan", "Yanfei L. Ma", "Björn Tyrberg", "Ormond A. MacDougald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086454.g002", "stats"=>{"downloads"=>3, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_T1R3_KO_mice_on_a_Western_diet_have_fewer_large_adipocytes_but_increased_adipocyte_number_/908227", "title"=>"T1R3 KO mice on a Western diet have fewer large adipocytes but increased adipocyte number.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 03:25:23"}
• {"files"=>["https://ndownloader.figshare.com/files/1355766"], "description"=>"<p>WT (n = 7) and T1R3 KO (n = 8) mice were placed on Western Diet for 24 weeks. Trabecular (A) and cortical (B,C) parameters were evaluated in the femur by µCT. Significance was determined using an unpaired Student’s t-test. <i>P</i> <0.05 indicated with #, <i>P</i> <0.01 indicated with ##, and <i>P</i> <0.005 indicated with ###. Data are expressed as mean plus S.D.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "bone", "Biochemistry", "metabolism", "Model organisms", "Animal models", "mouse", "Physiological processes", "Energy metabolism", "nutrition", "obesity", "ko", "animals", "trabecular", "remodeling", "cortical"], "article_id"=>908241, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Becky R. Simon", "Brian S. Learman", "Sebastian D. Parlee", "Erica L. Scheller", "Hiroyuki Mori", "William P. Cawthorn", "Xiaomin Ning", "Venkatesh Krishnan", "Yanfei L. Ma", "Björn Tyrberg", "Ormond A. MacDougald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086454.g009", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_T1R3_KO_animals_demonstrate_trabecular_remodeling_and_increased_cortical_bone_/908241", "title"=>"T1R3 KO animals demonstrate trabecular remodeling and increased cortical bone.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 03:25:23"}
• {"files"=>["https://ndownloader.figshare.com/files/1355765"], "description"=>"<p>WT (n = 9) and T1R2 KO (n = 9) mice were placed on Western Diet for 14 weeks, as in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086454#pone-0086454-g005\" target=\"_blank\">Fig 5</a>. Trabecular (A,B,C) and cortical (D,E,F) parameters in tibia were evaluated by µCT. Significance was determined using an unpaired Student’s t-test. <i>P</i> <0.05 indicated with #, <i>P-</i><0.01 indicated with ##, and <i>P</i> <0.005 indicated with ###. Data are expressed as mean plus S.D.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "bone", "Biochemistry", "metabolism", "Model organisms", "Animal models", "mouse", "Physiological processes", "Energy metabolism", "nutrition", "obesity", "ko", "animals", "trabecular", "cortical"], "article_id"=>908240, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Becky R. Simon", "Brian S. Learman", "Sebastian D. Parlee", "Erica L. Scheller", "Hiroyuki Mori", "William P. Cawthorn", "Xiaomin Ning", "Venkatesh Krishnan", "Yanfei L. Ma", "Björn Tyrberg", "Ormond A. MacDougald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086454.g008", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_T1R2_KO_animals_have_increased_trabecular_bone_mineral_content_and_cortical_area_/908240", "title"=>"T1R2 KO animals have increased trabecular bone mineral content and cortical area.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 03:25:23"}
• {"files"=>["https://ndownloader.figshare.com/files/1355763"], "description"=>"<p>A) Adult WT (left panel) and T1R2 KO (right panel) mice were placed on Western Diet for 14 wks, and bone marrow adipocytes were stained with osmium tetroxide before µCT scanning. Representative µCT shown, WT n = 9, T1R2 KO n = 9. B) Quantification of osmium tetroxide staining in tibia marrow adipose tissue from WT and T1R2 KO mice on Western Diet for 14 weeks. Data are expressed as mean plus S.D. C) Representative osmium tetroxide histology of bone marrow adipocytes in the proximal tibia. WT left panel, T1R2 KO right panel. Significance was determined using an unpaired Student’s t-test. <i>P</i> <0.01 indicated with ##.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "bone", "Biochemistry", "metabolism", "Model organisms", "Animal models", "mouse", "Physiological processes", "Energy metabolism", "nutrition", "obesity", "ko", "mice", "marrow"], "article_id"=>908238, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Becky R. Simon", "Brian S. Learman", "Sebastian D. Parlee", "Erica L. Scheller", "Hiroyuki Mori", "William P. Cawthorn", "Xiaomin Ning", "Venkatesh Krishnan", "Yanfei L. Ma", "Björn Tyrberg", "Ormond A. MacDougald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086454.g007", "stats"=>{"downloads"=>0, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_T1R2_KO_mice_have_fewer_bone_marrow_adipocytes_/908238", "title"=>"T1R2 KO mice have fewer bone marrow adipocytes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 03:25:23"}
• {"files"=>["https://ndownloader.figshare.com/files/1355759"], "description"=>"<p>A) Blood glucose from WT (n = 9) and T1R2 KO (n = 9) animals on Western Diet for 10 weeks following a 16 h fast. B) IP GTT in WT (n = 9) and T1R2 KO (n = 9) mice following 10 weeks on Western Diet C) Serum insulin in WT (n = 9) and T1R2 KO (n = 9) animals 30 min following glucose injections of IP GTT. D) Random fed glucose from WT (n = 9) and T1R2 KO (n = 9) animals following 14 weeks on Western Diet. E) Non-esterified fatty acids measured from serum of WT (n = 9) and T1R2 KO (n = 9) mice following 14 weeks on Western Diet. F) Non-esterified fatty acids measured from serum of WT (n = 9) and T1R2 KO (n = 9) mice on Western Diet for 10 weeks following a 16 h fast. G) Respiratory Quotient (RQ) and H) total activity were measured on WT (n = 9) and T1R2 KO (n = 9) mice in Comprehensive Laboratory Animal Monitoring System (CLAMS) cages after 3 weeks on Western Diet. I) Food intake in WT (n = 9) and T1R2 KO (n = 9) animals on Western Diet measured over 5 weeks. Data are expressed as mean plus S.D</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "bone", "Biochemistry", "metabolism", "Model organisms", "Animal models", "mouse", "Physiological processes", "Energy metabolism", "nutrition", "obesity", "ko", "mice", "detectable", "glucose"], "article_id"=>908234, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Becky R. Simon", "Brian S. Learman", "Sebastian D. Parlee", "Erica L. Scheller", "Hiroyuki Mori", "William P. Cawthorn", "Xiaomin Ning", "Venkatesh Krishnan", "Yanfei L. Ma", "Björn Tyrberg", "Ormond A. MacDougald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086454.g006", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_T1R2_KO_mice_do_not_have_detectable_changes_in_energy_balance_or_glucose_homeostasis_/908234", "title"=>"T1R2 KO mice do not have detectable changes in energy balance or glucose homeostasis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 03:25:23"}
• {"files"=>["https://ndownloader.figshare.com/files/1355754"], "description"=>"<p>A) Fasted glucose of WT (n = 6) and T1R3 KO (n = 9) mice. B) IP GTT in WT (n = 6) and T1R3 KO (n = 9) mice on Western Diet for 23 weeks. Time course following glucose injection (left panel) and AUC (right panel). C) Serum insulin 30 min following glucose injection during IP GTT. D) Intraperitoneal insulin tolerance test (left panel) in WT (n = 6) and T1R3 KO (n = 8) mice on Western diet for 23.5 weeks. Quantification of AUC (right panel). E) Random fed glucose from WT (n = 6) and T1R3 KO (n = 9) mice on Western Diet for 24 weeks. F. Random fed NEFA from WT (n = 6) and T1R3 KO (n = 9) mice on Western Diet for 24 weeks. G. Serum NEFA from WT (n = 6) and T1R3 KO (n = 9) mice on Western Diet for 23 weeks, fasted for 16 h. For each panel, data are expressed as mean plus S.D. Significance was determined using an unpaired Student’s t-test. P <0.01 indicated with ##.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "bone", "Biochemistry", "metabolism", "Model organisms", "Animal models", "mouse", "Physiological processes", "Energy metabolism", "nutrition", "obesity", "mildly", "impaired", "insulin", "wt", "t1r3", "ko"], "article_id"=>908229, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Becky R. Simon", "Brian S. Learman", "Sebastian D. Parlee", "Erica L. Scheller", "Hiroyuki Mori", "William P. Cawthorn", "Xiaomin Ning", "Venkatesh Krishnan", "Yanfei L. Ma", "Björn Tyrberg", "Ormond A. MacDougald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086454.g003", "stats"=>{"downloads"=>3, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Glucose_tolerance_is_mildly_impaired_and_insulin_sensitivity_is_similar_between_WT_and_T1R3_KO_mice_/908229", "title"=>"Glucose tolerance is mildly impaired and insulin sensitivity is similar between WT and T1R3 KO mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 03:25:23"}
• {"files"=>["https://ndownloader.figshare.com/files/1355752"], "description"=>"<p><b>A) Body weight in WT and T1R3 KO animals after 24 weeks of Western Diet.</b> Fat mass and lean mass as percent of body weight B) or in absolute mass C) measured by NMR in WT (n = 7) and T1R3 KO (n = 8) animals after 24 weeks Western Diet. D) Weight of inguinal, epididymal, or perirenal fat pads, liver, and brown adipose tissue (BAT) following 24 weeks of Western Diet feeding. In each panel, data are expressed as mean plus S.D. Significance was determined using an unpaired Student’s t-test. <i>P</i> <0.05 indicated with #.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "bone", "Biochemistry", "metabolism", "Model organisms", "Animal models", "mouse", "Physiological processes", "Energy metabolism", "nutrition", "obesity", "ko", "mice", "reduced", "adiposity"], "article_id"=>908225, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Becky R. Simon", "Brian S. Learman", "Sebastian D. Parlee", "Erica L. Scheller", "Hiroyuki Mori", "William P. Cawthorn", "Xiaomin Ning", "Venkatesh Krishnan", "Yanfei L. Ma", "Björn Tyrberg", "Ormond A. MacDougald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086454.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_T1R3_KO_mice_have_reduced_adiposity_on_Western_Diet_/908225", "title"=>"T1R3 KO mice have reduced adiposity on Western Diet.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 03:25:23"}

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Relative Metric

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F1000Prime