An Evaluation of HIV Elite Controller Definitions within a Large Seroconverter Cohort Collaboration
- Publication Date
- January 28, 2014
- Journal
- PLOS ONE
- Authors
- Ashley D. Olson, Laurence Meyer, Maria Prins, Rodolphe Thiebaut, et al
- Volume
- 9
- Issue
- 1
- Pages
- e86719
- DOI
- https://dx.plos.org/10.1371/journal.pone.0086719
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0086719
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/24489776
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904947
- Europe PMC
- http://europepmc.org/abstract/MED/24489776
- Web of Science
- 000330510000076
- Scopus
- 84900338995
- Mendeley
- http://www.mendeley.com/research/evaluation-hiv-elite-controller-definitions-within-large-seroconverter-cohort-collaboration
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CiteULike | Further Information
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Mendeley | Further Information
{"title"=>"An evaluation of HIV elite controller definitions within a large seroconverter cohort collaboration", "type"=>"journal", "authors"=>[{"first_name"=>"Ashley D.", "last_name"=>"Olson", "scopus_author_id"=>"55886472300"}, {"first_name"=>"Laurence", "last_name"=>"Meyer", "scopus_author_id"=>"7203050208"}, {"first_name"=>"Maria", "last_name"=>"Prins", "scopus_author_id"=>"7102085623"}, {"first_name"=>"Rodolphe", "last_name"=>"Thiebaut", "scopus_author_id"=>"7004041016"}, {"first_name"=>"Deepti", "last_name"=>"Gurdasani", "scopus_author_id"=>"24401522500"}, {"first_name"=>"Marguerite", "last_name"=>"Guiguet", "scopus_author_id"=>"19434602300"}, {"first_name"=>"Marie Laure", "last_name"=>"Chaix", "scopus_author_id"=>"34568404900"}, {"first_name"=>"Pauli", "last_name"=>"Amornkul", "scopus_author_id"=>"6602494817"}, {"first_name"=>"Abdel", "last_name"=>"Babiker", "scopus_author_id"=>"7004544555"}, {"first_name"=>"Manjinder S.", "last_name"=>"Sandhu", "scopus_author_id"=>"7004012378"}, {"first_name"=>"Kholoud", "last_name"=>"Porter", "scopus_author_id"=>"7202104963"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"373059349", "sgr"=>"84900338995", "doi"=>"10.1371/journal.pone.0086719", "scopus"=>"2-s2.0-84900338995", "pmid"=>"24489776"}, "id"=>"57e1ef8e-96f1-341a-8ea3-0c63c686a228", "abstract"=>"BACKGROUND Understanding the mechanisms underlying viral control is highly relevant to vaccine studies and elite control (EC) of HIV infection. Although numerous definitions of EC exist, it is not clear which, if any, best identify this rare phenotype. METHODS We assessed a number of EC definitions used in the literature using CASCADE data of 25,692 HIV seroconverters. We estimated proportions maintaining EC of total ART-naïve follow-up time, and disease progression, comparing to non-EC. We also examined HIV-RNA and CD4 values and CD4 slope during EC and beyond (while ART naïve). RESULTS Most definitions classify ∼ 1% as ECs with median HIV-RNA 43-903 copies/ml and median CD4>500 cells/mm(3). Beyond EC status, median HIV-RNA levels remained low, although often detectable, and CD4 values high but with strong evidence of decline for all definitions. Median % ART-naïve time as EC was ≥ 92% although overlap between definitions was low. EC definitions with consecutive HIV-RNA measurements <75 copies/ml with follow-up ≥ six months, or with 90% of measurements <400 copies/ml over ≥ 10 year follow-up preformed best overall. Individuals thus defined were less likely to progress to endpoint (hazard ratios ranged from 12.5-19.0 for non-ECs compared to ECs). CONCLUSIONS ECs are rare, less likely to progress to clinical disease, but may eventually lose control. We suggest definitions requiring individuals to have consecutive undetectable HIV-RNA measurements for ≥ six months or otherwise with >90% of measurements <400 copies/ml over ≥ 10 years be used to define this phenotype.", "link"=>"http://www.mendeley.com/research/evaluation-hiv-elite-controller-definitions-within-large-seroconverter-cohort-collaboration", "reader_count"=>51, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>12, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>3, "Student > Master"=>9, "Other"=>4, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>12, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>3, "Student > Master"=>9, "Other"=>4, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>5, "Nursing and Health Professions"=>1, "Mathematics"=>2, "Medicine and Dentistry"=>19, "Agricultural and Biological Sciences"=>9, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Social Sciences"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>8}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>19}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>8}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Sweden"=>1, "South Africa"=>1}, "group_count"=>4}CrossRef
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Scopus | Further Information
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- {"id"=>"430715088387862528", "text"=>"An Evaluation of #HIV Elite Controller Definitions within a Large Seroconverter Cohort Collaboration http://t.co/YKMeNu6If1 @PLOSONE", "created_at"=>"2014-02-04T14:50:54Z", "user"=>"TAGHIVscience", "user_name"=>"TAGHIVscience", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000408365735/6faf498418bf2dc907cbb5eb08461603_normal.png"}
- {"id"=>"533712390588624896", "text"=>"@HackHIV see: http://t.co/friIf0BkrS, http://t.co/Cq2w6nTBV7, http://t.co/YKMeNuXvDd", "created_at"=>"2014-11-15T20:05:24Z", "user"=>"TAGHIVscience", "user_name"=>"TAGHIVscience", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000408365735/6faf498418bf2dc907cbb5eb08461603_normal.png"}
- {"id"=>"609177063803723776", "text"=>"@PLOSPathogens @ragoninstitute misleading press release unfortunately, #HIV not \"harmless\" in many elite controllers http://t.co/IDl7cr2DAT", "created_at"=>"2015-06-12T01:55:04Z", "user"=>"TAGHIVscience", "user_name"=>"TAGHIVscience", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000408365735/6faf498418bf2dc907cbb5eb08461603_normal.png"}
- {"id"=>"609308790312300544", "text"=>"@newscientist http://t.co/IDl7cr2DAT, http://t.co/DS8TsRl4AJ, http://t.co/Cq2w6nkpVv, http://t.co/Sk1op8Ww5a", "created_at"=>"2015-06-12T10:38:30Z", "user"=>"TAGHIVscience", "user_name"=>"TAGHIVscience", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000408365735/6faf498418bf2dc907cbb5eb08461603_normal.png"}
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Relative Metric
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