DNA Methylation Signature of Childhood Chronic Physical Aggression in T Cells of Both Men and Women
Publication Date
January 24, 2014
Journal
PLOS ONE
Authors
Claire Guillemin, Nadine Provençal, Matthew Suderman, Sylvana M. Côté, et al
Volume
9
Issue
1
Pages
e86822
DOI
https://dx.plos.org/10.1371/journal.pone.0086822
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0086822
Scopus
84899832958
Mendeley
http://www.mendeley.com/research/dna-methylation-signature-childhood-chronic-physical-aggression-t-cells-both-men-women-2
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Mendeley | Further Information

{"title"=>"DNA methylation signature of childhood chronic physical aggression in T cells of both men and women", "type"=>"journal", "authors"=>[{"first_name"=>"Claire", "last_name"=>"Guillemin", "scopus_author_id"=>"55441268300"}, {"first_name"=>"Nadine", "last_name"=>"Provençal", "scopus_author_id"=>"6503905253"}, {"first_name"=>"Matthew", "last_name"=>"Suderman", "scopus_author_id"=>"8675316400"}, {"first_name"=>"Sylvana M.", "last_name"=>"Côté", "scopus_author_id"=>"7006183959"}, {"first_name"=>"Frank", "last_name"=>"Vitaro", "scopus_author_id"=>"56803476500"}, {"first_name"=>"Michael", "last_name"=>"Hallett", "scopus_author_id"=>"7202164876"}, {"first_name"=>"Richard E.", "last_name"=>"Tremblay", "scopus_author_id"=>"7201663558"}, {"first_name"=>"Moshe", "last_name"=>"Szyf", "scopus_author_id"=>"7005418666"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"373030813", "doi"=>"10.1371/journal.pone.0086822", "sgr"=>"84899832958", "scopus"=>"2-s2.0-84899832958", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)", "pmid"=>"24475181"}, "id"=>"77cbf166-e401-3ccb-a318-635d1d539901", "abstract"=>"BACKGROUND: High frequency of physical aggression is the central feature of severe conduct disorder and is associated with a wide range of social, mental and physical health problems. We have previously tested the hypothesis that differential DNA methylation signatures in peripheral T cells are associated with a chronic aggression trajectory in males. Despite the fact that sex differences appear to play a pivotal role in determining the development, magnitude and frequency of aggression, most of previous studies focused on males, so little is known about female chronic physical aggression. We therefore tested here whether or not there is a signature of physical aggression in female DNA methylation and, if there is, how it relates to the signature observed in males.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: Methylation profiles were created using the method of methylated DNA immunoprecipitation (MeDIP) followed by microarray hybridization and statistical and bioinformatic analyses on T cell DNA obtained from adult women who were found to be on a chronic physical aggression trajectory (CPA) between 6 and 12 years of age compared to women who followed a normal physical aggression trajectory. We confirmed the existence of a well-defined, genome-wide signature of DNA methylation associated with chronic physical aggression in the peripheral T cells of adult females that includes many of the genes similarly associated with physical aggression in the same cell types of adult males.\\n\\nCONCLUSIONS: This study in a small number of women presents preliminary evidence for a genome-wide variation in promoter DNA methylation that associates with CPA in women that warrant larger studies for further verification. A significant proportion of these associations were previously observed in men with CPA supporting the hypothesis that the epigenetic signature of early life aggression in females is composed of a component specific to females and another common to both males and females.", "link"=>"http://www.mendeley.com/research/dna-methylation-signature-childhood-chronic-physical-aggression-t-cells-both-men-women-2", "reader_count"=>31, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>13, "Medicine and Dentistry"=>5, "Neuroscience"=>2, "Psychology"=>5, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>2}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>4}}, "reader_count_by_country"=>{"Hong Kong"=>1, "United States"=>1, "United Kingdom"=>1, "Portugal"=>1}, "group_count"=>0}

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Scopus | Further Information

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