Qualichem In Vivo: A Tool for Assessing the Quality of In Vivo Studies and Its Application for Bisphenol A
- Publication Date
- January 29, 2014
- Journal
- PLOS ONE
- Authors
- Laura Maxim & Jeroen P. Van Der Sluijs
- Volume
- 9
- Issue
- 1
- Pages
- e87738
- DOI
- https://dx.plos.org/10.1371/journal.pone.0087738
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0087738
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/24489958
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906223
- Europe PMC
- http://europepmc.org/abstract/MED/24489958
- Web of Science
- 000330570000175
- Scopus
- 84897408686
- Mendeley
- http://www.mendeley.com/research/qualichem-vivo-tool-assessing-quality-vivo-studies-application-bisphenol
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Mendeley | Further Information
{"title"=>"Qualichem in vivo: A tool for assessing the quality of in vivo studies and its application for bisphenol a", "type"=>"journal", "authors"=>[{"first_name"=>"Laura", "last_name"=>"Maxim", "scopus_author_id"=>"55673974700"}, {"first_name"=>"Jeroen P.", "last_name"=>"Van Der Sluijs", "scopus_author_id"=>"7003576366"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24489958", "sgr"=>"84897408686", "doi"=>"10.1371/journal.pone.0087738", "scopus"=>"2-s2.0-84897408686", "pui"=>"373070272", "issn"=>"19326203"}, "id"=>"c5f696fc-3d32-3a28-a719-68257ac25c55", "abstract"=>"In regulatory toxicology, quality assessment of in vivo studies is a critical step for assessing chemical risks. It is crucial for preserving public health studies that are considered suitable for regulating chemicals are robust. Current procedures for conducting quality assessments in safety agencies are not structured, clear or consistent. This leaves room for criticism about lack of transparency, subjective influence and the potential for insufficient protection provided by resulting safety standards. We propose a tool called \"Qualichem in vivo\" that is designed to systematically and transparently assess the quality of in vivo studies used in chemical health risk assessment. We demonstrate its use here with 12 experts, using two controversial studies on Bisphenol A (BPA) that played an important role in BPA regulation in Europe. The results obtained with Qualichem contradict the quality assessments conducted by expert committees in safety agencies for both of these studies. Furthermore, they show that reliance on standardized guidelines to ensure scientific quality is only partially justified. Qualichem allows experts with different disciplinary backgrounds and professional experiences to express their individual and sometimes divergent views-an improvement over the current way of dealing with minority opinions. It provides a transparent framework for expressing an aggregated, multi-expert level of confidence in a study, and allows a simple graphical representation of how well the study integrates the best available scientific knowledge. Qualichem can be used to compare assessments of the same study by different health agencies, increasing transparency and trust in the work of expert committees. In addition, it may be used in systematic evaluation of in vivo studies submitted by industry in the dossiers that are required for compliance with the REACH Regulation. Qualichem provides a balanced, common framework for assessing the quality of studies that may or may not be following standardized guidelines.", "link"=>"http://www.mendeley.com/research/qualichem-vivo-tool-assessing-quality-vivo-studies-application-bisphenol", "reader_count"=>20, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>4, "Student > Bachelor"=>4, "Professor"=>2}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>4, "Student > Bachelor"=>4, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Environmental Science"=>7, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Business, Management and Accounting"=>1, "Social Sciences"=>2, "Computer Science"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Social Sciences"=>{"Social Sciences"=>2}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Environmental Science"=>{"Environmental Science"=>7}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Norway"=>1, "Brazil"=>1, "United Kingdom"=>1}, "group_count"=>2}CrossRef
- http://doi.org/10.1016/j.coph.2014.08.005
- http://doi.org/10.1002/etc.2955
- http://doi.org/10.1016/j.envint.2016.07.011
- http://doi.org/10.1016/j.envint.2016.03.010
- http://doi.org/10.1051/nss/2017037
- http://doi.org/10.1016/j.scitotenv.2014.03.046
- http://doi.org/10.1016/j.envsci.2018.03.010
- http://doi.org/10.1080/10807039.2014.928104
- http://doi.org/10.1080/09640568.2017.1407299
Scopus | Further Information
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Relative Metric
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