Alterations of Mass Density and 3D Osteocyte Lacunar Properties in Bisphosphonate-Related Osteonecrotic Human Jaw Bone, a Synchrotron µCT Study
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{"title"=>"Alterations of mass density and 3D osteocyte lacunar properties in bisphosphonate-related osteonecrotic human jaw bone, a synchrotron μCT study", "type"=>"journal", "authors"=>[{"first_name"=>"Bernhard", "last_name"=>"Hesse", "scopus_author_id"=>"36870776400"}, {"first_name"=>"Max", "last_name"=>"Langer", "scopus_author_id"=>"57199405694"}, {"first_name"=>"Peter", "last_name"=>"Varga", "scopus_author_id"=>"56874828400"}, {"first_name"=>"Alexandra", "last_name"=>"Pacureanu", "scopus_author_id"=>"35148268000"}, {"first_name"=>"Pei", "last_name"=>"Dong", "scopus_author_id"=>"55331986600"}, {"first_name"=>"Susanne", "last_name"=>"Schrof", "scopus_author_id"=>"37361512800"}, {"first_name"=>"Nils", "last_name"=>"Man̈nicke", "scopus_author_id"=>"36476637600"}, {"first_name"=>"Heikki", "last_name"=>"Suhonen", "scopus_author_id"=>"9045403300"}, {"first_name"=>"Cecile", "last_name"=>"Olivier", "scopus_author_id"=>"54794306000"}, {"first_name"=>"Peter", "last_name"=>"Maurer", "scopus_author_id"=>"7103209322"}, {"first_name"=>"Galateia J.", "last_name"=>"Kazakia", "scopus_author_id"=>"15757498300"}, {"first_name"=>"Kay", "last_name"=>"Raum", "scopus_author_id"=>"6602632667"}, {"first_name"=>"Francoise", "last_name"=>"Peyrin", "scopus_author_id"=>"7006057998"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84896770208", "pmid"=>"24586331", "pui"=>"372581416", "scopus"=>"2-s2.0-84896770208", "doi"=>"10.1371/journal.pone.0088481", "issn"=>"19326203"}, "id"=>"32673c8c-f4b8-3572-b1fa-003fc7a936b7", "abstract"=>"Osteonecrosis of the jaw, in association with bisphosphonates (BRONJ) used for treating osteoporosis or cancer, is a severe and most often irreversible side effect whose underlying pathophysiological mechanisms remain largely unknown. Osteocytes are involved in bone remodeling and mineralization where they orchestrate the delicate equilibrium between osteoclast and osteoblast activity and through the active process called osteocytic osteolysis. Here, we hypothesized that (i) changes of the mineralized tissue matrix play a substantial role in the pathogenesis of BRONJ, and (ii) the osteocyte lacunar morphology is altered in BRONJ. Synchrotron µCT with phase contrast is an appropriate tool for assessing both the 3D morphology of the osteocyte lacunae and the bone matrix mass density. Here, we used this technique to investigate the mass density distribution and 3D osteocyte lacunar properties at the sub-micrometer scale in human bone samples from the jaw, femur and tibia. First, we compared healthy human jaw bone to human tibia and femur in order to assess the specific differences and address potential explanations of why the jaw bone is exclusively targeted by the necrosis as a side effect of BP treatment. Second, we investigated the differences between BRONJ and control jaw bone samples to detect potential differences which could aid an improved understanding of the course of BRONJ. We found that the apparent mass density of jaw bone was significantly smaller compared to that of tibia, consistent with a higher bone turnover in the jaw bone. The variance of the lacunar volume distribution was significantly different depending on the anatomical site. The comparison between BRONJ and control jaw specimens revealed no significant increase in mineralization after BP. We found a significant decrease in osteocyte-lacunar density in the BRONJ group compared to the control jaw. Interestingly, the osteocyte-lacunar volume distribution was not altered after BP treatment.", "link"=>"http://www.mendeley.com/research/alterations-mass-density-3d-osteocyte-lacunar-properties-bisphosphonaterelated-osteonecrotic-human-j", "reader_count"=>27, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>3, "Student > Master"=>4, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>3, "Student > Master"=>4, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>5, "Unspecified"=>4, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>6, "Physics and Astronomy"=>3, "Chemical Engineering"=>1, "Social Sciences"=>1, "Computer Science"=>4}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>5}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Computer Science"=>{"Computer Science"=>4}, "Unspecified"=>{"Unspecified"=>4}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "reader_count_by_country"=>{"Belgium"=>1, "France"=>3}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1394340"], "description"=>"<p>The white dashed lines in A and B indicate where A is located in B and vice versa. C shows a minimum intensity projection, the projection range is 30 pixels (10.5 µm). D shows the lacunae mask corresponding to C, also in the form of an intensity projection (z-range = 30 pixels). Color bar in mass density of a.u.</p>", "links"=>[], "tags"=>["Radiobiology", "Bioengineering", "Biological systems engineering", "Material properties", "Mechanical properties", "Anatomy and physiology", "Musculoskeletal system", "biomechanics", "bone", "Musculoskeletal anatomy", "Cell physiology", "Sensory systems", "Drugs and devices", "Drug interactions", "Oral medicine", "radiology", "Diagnostic radiology", "Computed tomography", "Electromagnetic radiation", "x-rays", "Medical physics", "reconstructed", "corresponding", "specimen"], "article_id"=>941133, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Bernhard Hesse", "Max Langer", "Peter Varga", "Alexandra Pacureanu", "Pei Dong", "Susanne Schrof", "Nils Männicke", "Heikki Suhonen", "Cécile Olivier", "Peter Maurer", "Galateia J. Kazakia", "Kay Raum", "Françoise Peyrin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088481.g001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Slides_of_a_reconstructed_volume_corresponding_to_a_control_jaw_specimen_are_shown_in_A_x_y_plane_and_B_x_z_plane_/941133", "title"=>"Slides of a reconstructed volume corresponding to a control jaw specimen are shown in A (x-y-plane) and B (x-z-plane).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-21 02:45:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394348"], "description"=>"<p>Ca.V: canal volume, BV: bone volume, Ca.S: canal surface.</p>", "links"=>[], "tags"=>["Radiobiology", "Bioengineering", "Biological systems engineering", "Material properties", "Mechanical properties", "Anatomy and physiology", "Musculoskeletal system", "biomechanics", "bone", "Musculoskeletal anatomy", "Cell physiology", "Sensory systems", "Drugs and devices", "Drug interactions", "Oral medicine", "radiology", "Diagnostic radiology", "Computed tomography", "Electromagnetic radiation", "x-rays", "Medical physics", "deviation", "investigated", "morphometric", "segmented", "vessel-pores", "anatomical", "sites", "pathology"], "article_id"=>941141, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Bernhard Hesse", "Max Langer", "Peter Varga", "Alexandra Pacureanu", "Pei Dong", "Susanne Schrof", "Nils Männicke", "Heikki Suhonen", "Cécile Olivier", "Peter Maurer", "Galateia J. Kazakia", "Kay Raum", "Françoise Peyrin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088481.t003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_and_standard_deviation_of_the_investigated_morphometric_properties_of_the_segmented_vessel_pores_for_the_different_anatomical_sites_and_pathology_are_summarized_/941141", "title"=>"Mean and standard deviation of the investigated morphometric properties of the segmented vessel-pores for the different anatomical sites and pathology are summarized.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-21 02:45:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394344"], "description"=>"<p>Significant differences between groups are indicated by a horizontal bar. If the significance level was reached, the p-Value and the F-Value are reported.</p>", "links"=>[], "tags"=>["Radiobiology", "Bioengineering", "Biological systems engineering", "Material properties", "Mechanical properties", "Anatomy and physiology", "Musculoskeletal system", "biomechanics", "bone", "Musculoskeletal anatomy", "Cell physiology", "Sensory systems", "Drugs and devices", "Drug interactions", "Oral medicine", "radiology", "Diagnostic radiology", "Computed tomography", "Electromagnetic radiation", "x-rays", "Medical physics", "differences", "anatomical", "variance", "followed", "hoc", "bonferroni"], "article_id"=>941137, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Bernhard Hesse", "Max Langer", "Peter Varga", "Alexandra Pacureanu", "Pei Dong", "Susanne Schrof", "Nils Männicke", "Heikki Suhonen", "Cécile Olivier", "Peter Maurer", "Galateia J. Kazakia", "Kay Raum", "Françoise Peyrin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088481.g005", "stats"=>{"downloads"=>0, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Investigated_differences_with_respect_to_anatomical_sites_assessed_by_analyses_of_variance_ANOVA_followed_by_post_hoc_multiple_comparison_Bonferroni_tests_are_summarized_/941137", "title"=>"Investigated differences with respect to anatomical sites, assessed by analyses of variance (ANOVA), followed by post hoc multiple comparison Bonferroni tests are summarized.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-21 02:45:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394342"], "description"=>"<p>The volumes of the lacunae are color-coded in units of µm<sup>3</sup>.</p>", "links"=>[], "tags"=>["Radiobiology", "Bioengineering", "Biological systems engineering", "Material properties", "Mechanical properties", "Anatomy and physiology", "Musculoskeletal system", "biomechanics", "bone", "Musculoskeletal anatomy", "Cell physiology", "Sensory systems", "Drugs and devices", "Drug interactions", "Oral medicine", "radiology", "Diagnostic radiology", "Computed tomography", "Electromagnetic radiation", "x-rays", "Medical physics", "renderings", "subsections", "originating", "femur", "lacunae", "canals"], "article_id"=>941135, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Bernhard Hesse", "Max Langer", "Peter Varga", "Alexandra Pacureanu", "Pei Dong", "Susanne Schrof", "Nils Männicke", "Heikki Suhonen", "Cécile Olivier", "Peter Maurer", "Galateia J. Kazakia", "Kay Raum", "Françoise Peyrin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088481.g003", "stats"=>{"downloads"=>1, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Volume_renderings_of_two_subsections_originating_from_the_jaw_A_B_and_the_femur_C_D_A_and_C_show_the_lacunae_and_canals_from_a_8220_top_down_8221_perspective_while_B_and_D_are_shown_from_a_8220_front_on_8221_perspective_/941135", "title"=>"Volume renderings of two subsections originating from the jaw (A, B) and the femur (C, D. A and C show the lacunae and canals from a “top-down” perspective while B and D are shown from a “front-on” perspective.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-21 02:45:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394343"], "description"=>"<p>The are shown for the three regions, with region 1, region 2, and region 3 being the top, the middle, and the lower sub-section of one specimen scanned, respectively.</p>", "links"=>[], "tags"=>["Radiobiology", "Bioengineering", "Biological systems engineering", "Material properties", "Mechanical properties", "Anatomy and physiology", "Musculoskeletal system", "biomechanics", "bone", "Musculoskeletal anatomy", "Cell physiology", "Sensory systems", "Drugs and devices", "Drug interactions", "Oral medicine", "radiology", "Diagnostic radiology", "Computed tomography", "Electromagnetic radiation", "x-rays", "Medical physics", "sub-section", "specimen"], "article_id"=>941136, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Bernhard Hesse", "Max Langer", "Peter Varga", "Alexandra Pacureanu", "Pei Dong", "Susanne Schrof", "Nils Männicke", "Heikki Suhonen", "Cécile Olivier", "Peter Maurer", "Galateia J. Kazakia", "Kay Raum", "Françoise Peyrin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088481.g004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_are_shown_for_the_three_regions_with_region_1_region_2_and_region_3_being_the_top_the_middle_and_the_lower_sub_section_of_one_specimen_scanned_respectively_/941136", "title"=>"The are shown for the three regions, with region 1, region 2, and region 3 being the top, the middle, and the lower sub-section of one specimen scanned, respectively.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-21 02:45:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394341"], "description"=>"<p>The peak at around −100 is due to the air outside the sample, and the broad peak at about 200 is due to the glue used to attach the sample that managed to travel up the sample. In (B) the after segmentation is shown, and the parameters derived from it are indicated.</p>", "links"=>[], "tags"=>["Radiobiology", "Bioengineering", "Biological systems engineering", "Material properties", "Mechanical properties", "Anatomy and physiology", "Musculoskeletal system", "biomechanics", "bone", "Musculoskeletal anatomy", "Cell physiology", "Sensory systems", "Drugs and devices", "Drug interactions", "Oral medicine", "radiology", "Diagnostic radiology", "Computed tomography", "Electromagnetic radiation", "x-rays", "Medical physics"], "article_id"=>941134, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Bernhard Hesse", "Max Langer", "Peter Varga", "Alexandra Pacureanu", "Pei Dong", "Susanne Schrof", "Nils Männicke", "Heikki Suhonen", "Cécile Olivier", "Peter Maurer", "Galateia J. Kazakia", "Kay Raum", "Françoise Peyrin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088481.g002", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_A_a_relative_mass_density_distribution_is_shown_/941134", "title"=>"In (A) a relative mass density distribution is shown.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-21 02:45:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394350"], "description"=>"<p>‘Z’: intravenous administration of Zoledronate, ‘A’: oral administration of Alendronate, ‘n.k.’: not known.</p>", "links"=>[], "tags"=>["Radiobiology", "Bioengineering", "Biological systems engineering", "Material properties", "Mechanical properties", "Anatomy and physiology", "Musculoskeletal system", "biomechanics", "bone", "Musculoskeletal anatomy", "Cell physiology", "Sensory systems", "Drugs and devices", "Drug interactions", "Oral medicine", "radiology", "Diagnostic radiology", "Computed tomography", "Electromagnetic radiation", "x-rays", "Medical physics", "details", "anatomical", "bp", "duration"], "article_id"=>941143, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Bernhard Hesse", "Max Langer", "Peter Varga", "Alexandra Pacureanu", "Pei Dong", "Susanne Schrof", "Nils Männicke", "Heikki Suhonen", "Cécile Olivier", "Peter Maurer", "Galateia J. Kazakia", "Kay Raum", "Françoise Peyrin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088481.t001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sample_details_such_as_age_gender_anatomical_region_BP_treatment_and_duration_of_the_BP_treatment_are_listed_/941143", "title"=>"Sample details such as age, gender, anatomical region, BP treatment and duration of the BP treatment are listed.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-21 02:45:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394349"], "description"=>"<p>The * indicates that those properties are statistically significantly different between the BRONJ and control jaw.</p>", "links"=>[], "tags"=>["Radiobiology", "Bioengineering", "Biological systems engineering", "Material properties", "Mechanical properties", "Anatomy and physiology", "Musculoskeletal system", "biomechanics", "bone", "Musculoskeletal anatomy", "Cell physiology", "Sensory systems", "Drugs and devices", "Drug interactions", "Oral medicine", "radiology", "Diagnostic radiology", "Computed tomography", "Electromagnetic radiation", "x-rays", "Medical physics", "deviation", "investigated", "anatomical", "sites", "pathology"], "article_id"=>941142, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Bernhard Hesse", "Max Langer", "Peter Varga", "Alexandra Pacureanu", "Pei Dong", "Susanne Schrof", "Nils Männicke", "Heikki Suhonen", "Cécile Olivier", "Peter Maurer", "Galateia J. Kazakia", "Kay Raum", "Françoise Peyrin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088481.t002", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_and_standard_deviation_of_the_investigated_properties_for_the_different_anatomical_sites_and_pathology_are_summarized_/941142", "title"=>"Mean and standard deviation of the investigated properties for the different anatomical sites and pathology are summarized.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-21 02:45:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394346"], "description"=>"<p>The shaded areas correspond to the standard error based on the different samples. Histograms are normalized to the absolute amount of lacunae, bin size is 50 µm<sup>3</sup>. It should be noted that even though the histograms of the two groups look very similar, there are differences between the histograms of individual donors.</p>", "links"=>[], "tags"=>["Radiobiology", "Bioengineering", "Biological systems engineering", "Material properties", "Mechanical properties", "Anatomy and physiology", "Musculoskeletal system", "biomechanics", "bone", "Musculoskeletal anatomy", "Cell physiology", "Sensory systems", "Drugs and devices", "Drug interactions", "Oral medicine", "radiology", "Diagnostic radiology", "Computed tomography", "Electromagnetic radiation", "x-rays", "Medical physics", "lacunae", "grouped", "bronj"], "article_id"=>941139, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Bernhard Hesse", "Max Langer", "Peter Varga", "Alexandra Pacureanu", "Pei Dong", "Susanne Schrof", "Nils Männicke", "Heikki Suhonen", "Cécile Olivier", "Peter Maurer", "Galateia J. Kazakia", "Kay Raum", "Françoise Peyrin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088481.g007", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histograms_of_all_jaw_lacunae_grouped_in_either_BRONJ_or_healthy_bone_/941139", "title"=>"Histograms of all jaw lacunae grouped in either BRONJ or healthy bone.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-21 02:45:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394345"], "description"=>"<p>Histograms are normalized to the area under the total number of lacunae for each site. Bin size is set to 50 µm<sup>3</sup>. The transparent areas indicate the standard error for each site based on the individual samples.</p>", "links"=>[], "tags"=>["Radiobiology", "Bioengineering", "Biological systems engineering", "Material properties", "Mechanical properties", "Anatomy and physiology", "Musculoskeletal system", "biomechanics", "bone", "Musculoskeletal anatomy", "Cell physiology", "Sensory systems", "Drugs and devices", "Drug interactions", "Oral medicine", "radiology", "Diagnostic radiology", "Computed tomography", "Electromagnetic radiation", "x-rays", "Medical physics", "lacunar", "volumes", "sites"], "article_id"=>941138, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Bernhard Hesse", "Max Langer", "Peter Varga", "Alexandra Pacureanu", "Pei Dong", "Susanne Schrof", "Nils Männicke", "Heikki Suhonen", "Cécile Olivier", "Peter Maurer", "Galateia J. Kazakia", "Kay Raum", "Françoise Peyrin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088481.g006", "stats"=>{"downloads"=>3, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histograms_of_the_lacunar_volumes_for_the_three_different_sites_are_shown_/941138", "title"=>"Histograms of the lacunar volumes for the three different sites are shown.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-21 02:45:28"}

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