A microRNA Signature Associated with Early Recurrence in Breast Cancer
- Publication Date
- March 14, 2014
- Journal
- PLOS ONE
- Authors
- Luis G. Pérez Rivas, José M. Jerez, Rosario Carmona, Vanessa De Luque, et al
- Volume
- 9
- Issue
- 3
- Pages
- e91884
- DOI
- https://dx.plos.org/10.1371/journal.pone.0091884
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0091884
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/24632820
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954835
- Europe PMC
- http://europepmc.org/abstract/MED/24632820
- Web of Science
- 000332858400115
- Scopus
- 84898441297
- Mendeley
- http://www.mendeley.com/research/microrna-signature-associated-early-recurrence-breast-cancer-10
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Mendeley | Further Information
{"title"=>"A microRNA Signature Associated with Early Recurrence in Breast Cancer", "type"=>"journal", "authors"=>[{"first_name"=>"Luis G.", "last_name"=>"Pérez-Rivas"}, {"first_name"=>"José M.", "last_name"=>"Jerez"}, {"first_name"=>"Rosario", "last_name"=>"Carmona"}, {"first_name"=>"Vanessa", "last_name"=>"de Luque"}, {"first_name"=>"Luis", "last_name"=>"Vicioso"}, {"first_name"=>"M. Gonzalo", "last_name"=>"Claros"}, {"first_name"=>"Enrique", "last_name"=>"Viguera"}, {"first_name"=>"Bella", "last_name"=>"Pajares"}, {"first_name"=>"Alfonso", "last_name"=>"Sánchez"}, {"first_name"=>"Nuria", "last_name"=>"Ribelles"}, {"first_name"=>"Emilio", "last_name"=>"Alba"}, {"first_name"=>"José", "last_name"=>"Lozano"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"1932-6203", "pmid"=>"24632820", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0091884"}, "id"=>"537152b0-66ab-3223-8062-4beed0ffe392", "abstract"=>"Recurrent breast cancer occurring after the initial treatment is associated with poor outcome. A bimodal relapse pattern after surgery for primary tumor has been described with peaks of early and late recurrence occurring at about 2 and 5 years, respectively. Although several clinical and pathological features have been used to discriminate between low- and high-risk patients, the identification of molecular biomarkers with prognostic value remains an unmet need in the current management of breast cancer. Using microarray-based technology, we have performed a microRNA expression analysis in 71 primary breast tumors from patients that either remained disease-free at 5 years post-surgery (group A) or developed early (group B) or late (group C) recurrence. Unsupervised hierarchical clustering of microRNA expression data segregated tumors in two groups, mainly corresponding to patients with early recurrence and those with no recurrence. Microarray data analysis and RT-qPCR validation led to the identification of a set of 5 microRNAs (the 5-miRNA signature) differentially expressed between these two groups: miR-149, miR-10a, miR-20b, miR-30a-3p and miR-342-5p. All five microRNAs were down-regulated in tumors from patients with early recurrence. We show here that the 5-miRNA signature defines a high-risk group of patients with shorter relapse-free survival and has predictive value to discriminate non-relapsing versus early-relapsing patients (AUC = 0.993, p-value<0.05). Network analysis based on miRNA-target interactions curated by public databases suggests that down-regulation of the 5-miRNA signature in the subset of early-relapsing tumors would result in an overall increased proliferative and angiogenic capacity. In summary, we have identified a set of recurrence-related microRNAs with potential prognostic value to identify patients who will likely develop metastasis early after primary breast surgery.", "link"=>"http://www.mendeley.com/research/microrna-signature-associated-early-recurrence-breast-cancer-10", "reader_count"=>34, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>9, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>6, "Student > Bachelor"=>8}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>9, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>6, "Student > Bachelor"=>8}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>6, "Medicine and Dentistry"=>9, "Agricultural and Biological Sciences"=>16, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Hong Kong"=>1, "Egypt"=>1, "Brazil"=>1, "Italy"=>1, "Spain"=>2}, "group_count"=>3}CrossRef
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Europe PMC Database Citations | Further Information
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Relative Metric
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