Gene Silencing of SOCS3 by siRNA Intranasal Delivery Inhibits Asthma Phenotype in Mice
- Publication Date
- March 17, 2014
- Journal
- PLOS ONE
- Authors
- M A Paz Zafra, Carla Mazzeo, Cristina Gámez, Ainara Rodriguez Marco, et al
- Volume
- 9
- Issue
- 3
- Pages
- e91996
- DOI
- https://dx.plos.org/10.1371/journal.pone.0091996
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0091996
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/24637581
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956882
- Europe PMC
- http://europepmc.org/abstract/MED/24637581
- Web of Science
- 000333254100099
- Scopus
- 84898669702
- Mendeley
- http://www.mendeley.com/research/gene-silencing-socs3-sirna-intranasal-delivery-inhibits-asthma-phenotype-mice
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Mendeley | Further Information
{"title"=>"Gene silencing of SOCS3 by siRNA intranasal delivery inhibits asthma phenotype in mice", "type"=>"journal", "authors"=>[{"first_name"=>"Ma Paz", "last_name"=>"Zafra", "scopus_author_id"=>"37098297400"}, {"first_name"=>"Carla", "last_name"=>"Mazzeo", "scopus_author_id"=>"35074587000"}, {"first_name"=>"Cristina", "last_name"=>"Gámez", "scopus_author_id"=>"57196998549"}, {"first_name"=>"Ainara Rodriguez", "last_name"=>"Marco", "scopus_author_id"=>"56881742900"}, {"first_name"=>"Ana", "last_name"=>"De Zulueta", "scopus_author_id"=>"56115383900"}, {"first_name"=>"Veronica", "last_name"=>"Sanz", "scopus_author_id"=>"55552164000"}, {"first_name"=>"Izaskun", "last_name"=>"Bilbao", "scopus_author_id"=>"24402931700"}, {"first_name"=>"Jesús", "last_name"=>"Ruiz-Cabello", "scopus_author_id"=>"7003625720"}, {"first_name"=>"Jose M.", "last_name"=>"Zubeldia", "scopus_author_id"=>"6503871740"}, {"first_name"=>"Victoria", "last_name"=>"Del Pozo", "scopus_author_id"=>"7003488867"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84898669702", "pui"=>"372838413", "doi"=>"10.1371/journal.pone.0091996", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84898669702", "pmid"=>"24637581"}, "id"=>"ebb14fee-6cf7-39db-93dc-e637a36563fc", "abstract"=>"Suppresors of cytokine signaling (SOCS) proteins regulate cytokine responses and control immune balance. Several studies have confirmed that SOCS3 is increased in asthmatic patients, and SOCS3 expression is correlated with disease severity. The objective of this study was to evaluate if delivering of SOCS3 short interfering RNA (siRNA) intranasally in lungs could be a good therapeutic approach in an asthma chronic mouse model. Our results showed that intranasal treatment with SOCS3-siRNA led to an improvement in the eosinophil count and the normalization of hyperresponsiveness to methacholine. Concomitantly, this treatment resulted in an improvement in mucus secretion, a reduction in lung collagen, which are prominent features of airway remodeling. The mechanism implies JAK/STAT and RhoA/Rho-kinase signaling pathway, because we found a decreasing in STAT3 phosphorylation status and down regulation of RhoA/Rho-kinase protein expression. These results might lead to a new therapy for the treatment of chronic asthma.", "link"=>"http://www.mendeley.com/research/gene-silencing-socs3-sirna-intranasal-delivery-inhibits-asthma-phenotype-mice", "reader_count"=>29, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>6, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>6, "Other"=>2, "Student > Master"=>4, "Student > Bachelor"=>2, "Professor"=>1, "Student > Postgraduate"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>6, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>6, "Other"=>2, "Student > Master"=>4, "Student > Bachelor"=>2, "Professor"=>1, "Student > Postgraduate"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>4, "Materials Science"=>2, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>12, "Immunology and Microbiology"=>1, "Engineering"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Materials Science"=>{"Materials Science"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>12}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>4}}, "group_count"=>1}CrossRef
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Europe PMC Database Citations | Further Information
{"UNIPROT"=>2}Scopus | Further Information
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Relative Metric
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