Novel Anti-Microbial Peptide SR-0379 Accelerates Wound Healing via the PI3 Kinase/Akt/mTOR Pathway
- Publication Date
- March 27, 2014
- Journal
- PLOS ONE
- Authors
- Hideki Tomioka, Hironori Nakagami, Akiko Tenma, Yoshimi Saito, et al
- Volume
- 9
- Issue
- 3
- Pages
- e92597
- DOI
- https://dx.plos.org/10.1371/journal.pone.0092597
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0092597
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/24675668
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968008
- Europe PMC
- http://europepmc.org/abstract/MED/24675668
- Web of Science
- 000333677500027
- Scopus
- 84899878218
- Mendeley
- http://www.mendeley.com/research/novel-antimicrobial-peptide-sr0379-accelerates-wound-healing-via-pi3-kinaseaktmtor-pathway
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Mendeley | Further Information
{"title"=>"Novel anti-microbial peptide SR-0379 accelerates wound healing via the PI3 kinase/Akt/mTOR pathway", "type"=>"journal", "authors"=>[{"first_name"=>"Hideki", "last_name"=>"Tomioka", "scopus_author_id"=>"55658247700"}, {"first_name"=>"Hironori", "last_name"=>"Nakagami", "scopus_author_id"=>"7006290279"}, {"first_name"=>"Akiko", "last_name"=>"Tenma", "scopus_author_id"=>"56149337900"}, {"first_name"=>"Yoshimi", "last_name"=>"Saito", "scopus_author_id"=>"56151038700"}, {"first_name"=>"Toshihiro", "last_name"=>"Kaga", "scopus_author_id"=>"55027862600"}, {"first_name"=>"Toshihide", "last_name"=>"Kanamori", "scopus_author_id"=>"56149501800"}, {"first_name"=>"Nao", "last_name"=>"Tamura", "scopus_author_id"=>"55270446800"}, {"first_name"=>"Kazunori", "last_name"=>"Tomono", "scopus_author_id"=>"35352322800"}, {"first_name"=>"Yasufumi", "last_name"=>"Kaneda", "scopus_author_id"=>"7202736982"}, {"first_name"=>"Ryuichi", "last_name"=>"Morishita", "scopus_author_id"=>"7102241494"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84899878218", "sgr"=>"84899878218", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0092597", "pmid"=>"24675668", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"373030855"}, "id"=>"3d3347f7-ec05-36e5-aac0-a2824daa9a88", "abstract"=>"We developed a novel cationic antimicrobial peptide, AG30/5C, which demonstrates angiogenic properties similar to those of LL-37 or PR39. However, improvement of its stability and cost efficacy are required for clinical application. Therefore, we examined the metabolites of AG30/5C, which provided the further optimized compound, SR-0379. SR-0379 enhanced the proliferation of human dermal fibroblast cells (NHDFs) via the PI3 kinase-Akt-mTOR pathway through integrin-mediated interactions. Furthermore SR-0379 promoted the tube formation of human umbilical vein endothelial cells (HUVECs) in co-culture with NHDFs. This compound also displays antimicrobial activities against a number of bacteria, including drug-resistant microbes and fungi. We evaluated the effect of SR-0379 in two different would-healing models in rats, the full-thickness defects under a diabetic condition and an acutely infected wound with full-thickness defects and inoculation with Staphylococcus aureus. Treatment with SR-0379 significantly accelerated wound healing when compared to fibroblast growth factor 2 (FGF2). The beneficial effects of SR-0379 on wound healing can be explained by enhanced angiogenesis, granulation tissue formation, proliferation of endothelial cells and fibroblasts and antimicrobial activity. These results indicate that SR-0379 may have the potential for drug development in wound repair, even under especially critical colonization conditions.", "link"=>"http://www.mendeley.com/research/novel-antimicrobial-peptide-sr0379-accelerates-wound-healing-via-pi3-kinaseaktmtor-pathway", "reader_count"=>26, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>7, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>7, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>6, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>3, "Chemistry"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Chemistry"=>{"Chemistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>4}}, "reader_count_by_country"=>{"Denmark"=>1, "Spain"=>1}, "group_count"=>4}CrossRef
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Scopus | Further Information
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Relative Metric
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Net::HTTPInternalServerError
Source
ScopusTime
2020-11-11 20:17:37 UTCTarget URL
https://api.elsevier.com/content/search/index:SCOPUS?query=DOI(10.1371%2Fjournal.pone.0092597)Trace
/app/models/concerns/networkable.rb:21:in `get_result'
/app/models/source.rb:165:in `get_data'
/app/models/retrieval_status.rb:47:in `perform_get_data'
/app/jobs/source_job.rb:52:in `block (2 levels) in perform'
/app/jobs/source_job.rb:51:in `block in perform'
/app/jobs/source_job.rb:35:in `each'
/app/jobs/source_job.rb:35:in `perform'