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{"title"=>"Dysregulation in microRNA expression is associated with alterations in immune functions in combat veterans with post-traumatic stress disorder", "type"=>"journal", "authors"=>[{"first_name"=>"Juhua", "last_name"=>"Zhou", "scopus_author_id"=>"7405549112"}, {"first_name"=>"Prakash", "last_name"=>"Nagarkatti", "scopus_author_id"=>"7005792287"}, {"first_name"=>"Yin", "last_name"=>"Zhong", "scopus_author_id"=>"36119571500"}, {"first_name"=>"Jay P.", "last_name"=>"Ginsberg", "scopus_author_id"=>"8912499500"}, {"first_name"=>"Narendra P.", "last_name"=>"Singh", "scopus_author_id"=>"35557422100"}, {"first_name"=>"Jiajia", "last_name"=>"Zhang", "scopus_author_id"=>"16204460500"}, {"first_name"=>"Mitzi", "last_name"=>"Nagarkatti", "scopus_author_id"=>"7005891809"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84899724278", "sgr"=>"84899724278", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0094075", "pmid"=>"24759737", "isbn"=>"1932-6203", "pui"=>"373007571"}, "id"=>"ca6d65a4-6037-37fb-889d-9f3c15ea238c", "abstract"=>"While the immunological dysfunction in combat Veterans with post-traumatic stress disorder (PTSD) has been well documented, the precise mechanisms remain unclear. The current study evaluated the role of microRNA (miR) in immunological dysfunction associated with PTSD. The presence of peripheral blood mononuclear cells (PBMC) and various lymphocyte subsets in blood collected from PTSD patients were analyzed. Our studies demonstrated that the numbers of both PBMC and various lymphocyte subsets increased significantly in PTSD patients. When T cells were further analyzed, the percentage of Th1 cells and Th17 cells increased, regulatory T cells(Tregs) decreased, while Th2 cells remained unaltered in PTSD patients. These data correlated with increased plasma levels of IFN-γ and IL-17 while IL-4 showed no significant change. The increase in PBMC counts, Th1 and Th17 cells seen in PTSD patients correlated with the clinical scores. High-throughput analysis of PBMCs for 1163 miRs showed that the expression of a significant number of miRs was altered in PTSD patients. Pathway analysis of dysregulated miRs seen in PTSD patients revealed relationship between selected miRNAs and genes that showed direct/indirect role in immunological signaling pathways consistent with the immunological changes seen in these patients. Of interest was the down-regulation of miR-125a in PTSD, which specifically targeted IFN-γ production. Together, the current study demonstrates for the first time that PTSD was associated with significant alterations in miRNAs, which may promote pro-inflammatory cytokine profile. Such epigenetic events may provide useful tools to identify potential biomarkers for diagnosis, and facilitate therapy of PTSD.", "link"=>"http://www.mendeley.com/research/dysregulation-microrna-expression-associated-alterations-immune-functions-combat-veterans-posttrauma-3", "reader_count"=>38, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>4, "Student > Doctoral Student"=>2, "Researcher"=>7, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>2, "Student > Master"=>7, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>4, "Student > Doctoral Student"=>2, "Researcher"=>7, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>2, "Student > Master"=>7, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>9, "Agricultural and Biological Sciences"=>12, "Sports and Recreations"=>1, "Psychology"=>6, "Social Sciences"=>1, "Computer Science"=>2, "Immunology and Microbiology"=>1, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>6}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>12}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"United States"=>1, "Brazil"=>1, "Australia"=>1, "Croatia"=>1}, "group_count"=>3}

CrossRef

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• http://doi.org/10.1016/j.phrs.2018.12.007

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• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/edf25c52-b7c1-4437-b181-76334d0f62d7", "title"=>"Incomplete Materials and Methods", "body"=>"Very interesting paper. However, in order to reproduce the results, it would be helpful to know the method or kit used to label the RNA samples that were hybridized to the Affymetrix miRNA arrays. In addition, identification of the miRNA target gene prediction databases and the prediction thresholds used for pathway analysis would also be in order.", "isRemoved"=>false, "created"=>"2015-11-23T21:41:30Z", "lastModified"=>"2015-11-23T21:41:30Z", "creator"=>{"userId"=>"529998"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0094075", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2015-11-23T21:41:30Z", "replies"=>[]}

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• {"id"=>"461918120014524416", "text"=>"Inflammation in those with PTSD linked to changes in microRNA via @PLOSONE http://t.co/Qrppfz06Fi", "created_at"=>"2014-05-01T17:20:36Z", "user"=>"MU_Peter", "user_name"=>"MU - Peter Shimon", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000677936861/76bd53263367cb69276056728a91a1c1_normal.jpeg"}
• {"id"=>"840076115255336960", "text"=>"#ptsd is associated with increased inflammatory T cells and decreased T regulatory cells https://t.co/rpEG7JyA3v… https://t.co/jxfOKA4gaU", "created_at"=>"2017-03-10T05:45:28Z", "user"=>"NobilisTx", "user_name"=>"Nobilis Therapeutics", "user_profile_image"=>"http://pbs.twimg.com/profile_images/638273044608217088/yNvGzopO_normal.png"}
• {"id"=>"912857255284023296", "text"=>"https://t.co/qQAcS2pdPV Stop pretending serious scientists do not know how to prevent suicide. https://t.co/1vSNqHl0HK", "created_at"=>"2017-09-27T01:51:44Z", "user"=>"jvkohl", "user_name"=>"James V. Kohl", "user_profile_image"=>"http://pbs.twimg.com/profile_images/567084118/alabedit4_normal.jpg"}

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F1000Prime