Sphingosine 1-Phosphate (S1P) Induced Interleukin-8 (IL-8) Release Is Mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS-2B Cells
- Publication Date
- April 17, 2014
- Journal
- PLOS ONE
- Authors
- Michael J. O’sullivan, Nobuaki Hirota & James G. Martin
- Volume
- 9
- Issue
- 4
- Pages
- e95566
- DOI
- https://dx.plos.org/10.1371/journal.pone.0095566
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0095566
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/24743449
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990666
- Europe PMC
- http://europepmc.org/abstract/MED/24743449
- Web of Science
- 000335309100140
- Scopus
- 84899738610
- Mendeley
- http://www.mendeley.com/research/sphingosine-1phosphate-s1p-induced-interleukin8-il8-release-mediated-s1p-receptor-2-nuclear-factor-k
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Mendeley | Further Information
{"title"=>"Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor kB in BEAS-2B cells", "type"=>"journal", "authors"=>[{"first_name"=>"Michael J.", "last_name"=>"O'Sullivan", "scopus_author_id"=>"55792149200"}, {"first_name"=>"Nobuaki", "last_name"=>"Hirota", "scopus_author_id"=>"14045011200"}, {"first_name"=>"James G.", "last_name"=>"Martin", "scopus_author_id"=>"35493942900"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24743449", "doi"=>"10.1371/journal.pone.0095566", "pui"=>"372999731", "issn"=>"19326203", "sgr"=>"84899738610", "scopus"=>"2-s2.0-84899738610"}, "id"=>"4e3b167e-5eea-3985-b49c-74a6afb20ccd", "abstract"=>"The airway epithelium may release pro-inflammatory cytokines and chemokines in the asthmatic airway. Sphingosine 1-phosphate (S1P) is a bioactive lipid, increased in the airways of asthmatics, that may trigger the release of the potent neutrophil chemoattractant Interleukin-8 (IL-8) by epithelial cells. S1P is a ligand for 5 G protein-coupled receptors, S1PR1-5. We wished to explore the mechanisms of S1P induced IL-8 secretion with regard to the receptor(s) and downstream signaling events involved. Our results indicate that S1P induced IL-8 release is mediated by S1PR2 and the transcription factor NF-kB. Since the Epidermal Growth Factor Receptor (EGFR) and reactive oxygen species (ROS) have been implicated in IL-8 release in response to activation of other G protein-coupled receptors, we examined their importance in S1P induced IL-8 release and established that they are not involved. This study reveals S1PR2 and NF-kB as potential therapeutic targets in neutrophilic airway diseases such as severe asthma.", "link"=>"http://www.mendeley.com/research/sphingosine-1phosphate-s1p-induced-interleukin8-il8-release-mediated-s1p-receptor-2-nuclear-factor-k", "reader_count"=>6, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>2, "Other"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>2, "Other"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Iran"=>1}, "group_count"=>0}CrossRef
- http://doi.org/10.1128/MCB.00554-15
- http://doi.org/10.1186/s12866-017-1081-8
- http://doi.org/10.18632/oncotarget.24102
- http://doi.org/10.3390/ijms21134758
- http://doi.org/10.1016/j.prostaglandins.2019.106365
- http://doi.org/10.3389/fphar.2016.00167
- http://doi.org/10.3390/ijms19010112
- http://doi.org/10.1002/jcla.22927
- http://doi.org/10.1371/journal.pone.0119005
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- http://doi.org/10.1016/j.pharmthera.2018.07.006
- http://doi.org/10.1016/j.placenta.2015.08.010
- http://doi.org/10.1371/journal.pone.0203211
Scopus | Further Information
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Relative Metric
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