Association between Low Serum Magnesium Level and Major Adverse Cardiac Events in Patients Treated with Drug-Eluting Stents for Acute Myocardial Infarction
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{"title"=>"Association between low serum magnesium level and major adverse cardiac events in patients treated with drug-eluting stents for acute myocardial infarction", "type"=>"journal", "authors"=>[{"first_name"=>"Guipeng", "last_name"=>"An", "scopus_author_id"=>"8276134400"}, {"first_name"=>"Zhongqi", "last_name"=>"Du", "scopus_author_id"=>"56157497100"}, {"first_name"=>"Xiao", "last_name"=>"Meng", "scopus_author_id"=>"35750487900"}, {"first_name"=>"Tao", "last_name"=>"Guo", "scopus_author_id"=>"56924341600"}, {"first_name"=>"Rui", "last_name"=>"Shang", "scopus_author_id"=>"56010445800"}, {"first_name"=>"Jifu", "last_name"=>"Li", "scopus_author_id"=>"16550272100"}, {"first_name"=>"Fengshuang", "last_name"=>"An", "scopus_author_id"=>"36887489500"}, {"first_name"=>"Wenjing", "last_name"=>"Li", "scopus_author_id"=>"56447335700"}, {"first_name"=>"Cheng", "last_name"=>"Zhang", "scopus_author_id"=>"56118477400"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84902530515", "sgr"=>"84902530515", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0098971", "pmid"=>"24901943", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"373326348"}, "id"=>"d7de5cc8-ad4a-34cb-ab77-d463ce233a98", "abstract"=>"OBJECTIVES: We investigated the association of serum magnesium (Mg) levels and major adverse cardiac events (MACEs) after drug-eluting stent (DES) implantation.\\n\\nBACKGROUND: Mg depletion plays a key role in the pathphysiologic features of diabetes mellitus, hypertension, thrombosis, arrhythmias and coronary artery disease. Whether the depletion is related to the long-term prognosis of DES implantation is not known.\\n\\nMETHODS: From 2008 to 2011, we enrolled 414 consecutive patients <50 years old who underwent DES implantation for acute coronary syndrome. Serum Mg level was analyzed and patients were followed up for a median of 24 months (interquartile range 14-32 months) for the occurrence of MACEs defined as death, myocardial infarction, stroke, and any revascularization.\\n\\nRESULTS: For patients with unstable angina, no significant association between serum Mg level and MACEs was found in the multivariate model. For patients with myocardial infarction, after adjusting for age, positive family history, smoking status, hypertension, hypercholesterolemia, and diabetes at baseline, the risk was 8.11-fold higher for patients with quartile 1 than 4 Mg level (95% confidence interval 1.7-38.75; P<0.01). In addition, when tested as a continuous variable, serum magnesium was a significant predictor for MACEs of acute myocardial infarction (HR [per 0.1 mM increase], 0.35 [95% CI, 0.19-0.63], p< 0.01), after adjustment for other confounders.\\n\\nCONCLUSIONS: Low serum level of Mg may be an important predictor of MACEs with DES implantation for acute myocardial infarction. Further research into the effectiveness of Mg supplementation for these patients is warranted.", "link"=>"http://www.mendeley.com/research/association-between-low-serum-magnesium-level-major-adverse-cardiac-events-patients-treated-drugelut", "reader_count"=>17, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>4, "Student > Bachelor"=>7}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>4, "Student > Bachelor"=>7}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>6, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>10}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>6}}, "reader_count_by_country"=>{"South Korea"=>1}, "group_count"=>1}

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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Medicine and health sciences/Cardiology", "average_usage"=>[246]}, {"subject_area"=>"/Medicine and health sciences/Vascular medicine", "average_usage"=>[248]}]}
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