The Anoikis Effector Bit1 Displays Tumor Suppressive Function in Lung Cancer Cells
- Publication Date
- July 08, 2014
- Journal
- PLOS ONE
- Authors
- Xin Yao, Scott Jennings, Shubha Kale Ireland, Tri Pham, et al
- Volume
- 9
- Issue
- 7
- Pages
- e101564
- DOI
- https://dx.plos.org/10.1371/journal.pone.0101564
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0101564
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/25003198
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086906
- Europe PMC
- http://europepmc.org/abstract/MED/25003198
- Web of Science
- 000339242700039
- Scopus
- 84903986903
- Mendeley
- http://www.mendeley.com/research/anoikis-effector-bit1-displays-tumor-suppressive-function-lung-cancer-cells-1
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Mendeley | Further Information
{"title"=>"The anoikis effector Bit1 displays tumor suppressive function in lung cancer cells", "type"=>"journal", "authors"=>[{"first_name"=>"Xin", "last_name"=>"Yao", "scopus_author_id"=>"56258926800"}, {"first_name"=>"Scott", "last_name"=>"Jennings", "scopus_author_id"=>"57194714207"}, {"first_name"=>"Shubha Kale", "last_name"=>"Ireland", "scopus_author_id"=>"50061118800"}, {"first_name"=>"Tri", "last_name"=>"Pham", "scopus_author_id"=>"55599935300"}, {"first_name"=>"Brandi", "last_name"=>"Temple", "scopus_author_id"=>"56257802700"}, {"first_name"=>"Mya", "last_name"=>"Davis", "scopus_author_id"=>"55475321900"}, {"first_name"=>"Renwei", "last_name"=>"Chen", "scopus_author_id"=>"16027672200"}, {"first_name"=>"Ian", "last_name"=>"Davenport", "scopus_author_id"=>"35083260200"}, {"first_name"=>"Hector", "last_name"=>"Biliran", "scopus_author_id"=>"6508285955"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84903986903", "pui"=>"373489158", "doi"=>"10.1371/journal.pone.0101564", "pmid"=>"25003198", "scopus"=>"2-s2.0-84903986903", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"9560eaf9-8258-36d1-8d4b-0e69300f73b8", "abstract"=>"The mitochondrial Bit1 (Bcl-2 inhibitor of transcription 1) protein is a part of an apoptotic pathway that is uniquely regulated by integrin-mediated attachment. As an anoikis effector, Bit1 is released into the cytoplasm following loss of cell attachment and induces a caspase-independent form of apoptosis. Considering that anoikis resistance is a critical determinant of transformation, we hypothesized that cancer cells may circumvent the Bit1 apoptotic pathway to attain anchorage-independence and tumorigenic potential. Here, we provide the first evidence of the tumor suppressive effect of Bit1 through a mechanism involving anoikis induction in human lung adenocarcinoma derived A549 cells. Restitution of Bit1 in anoikis resistant A549 cells is sufficient to induce detachment induced-apoptosis despite defect in caspase activation and impairs their anchorage-independent growth. Conversely, stable downregulation of Bit1 in these cells significantly enhances their anoikis resistance and anchorage-independent growth. The Bit1 knockdown cells exhibit significantly enhanced tumorigenecity in vivo. It has been previously shown that the nuclear TLE1 corepressor is a putative oncogene in lung cancer, and we show here that TLE1 blocks Bit1 mediated anoikis in part by sequestering the pro-apoptotic partner of Bit1, the Amino-terminal Enhancer of Split (AES) protein, in the nucleus. Taken together, these findings suggest a tumor suppressive role of the caspase-independent anoikis effector Bit1 in lung cancer. Consistent with its role as a tumor suppressor, we have found that Bit1 is downregulated in human non-small cell lung cancer (NSCLC) tissues.", "link"=>"http://www.mendeley.com/research/anoikis-effector-bit1-displays-tumor-suppressive-function-lung-cancer-cells-1", "reader_count"=>7, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}CrossRef
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Europe PMC Database Citations | Further Information
{"UNIPROT"=>3}Scopus | Further Information
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Relative Metric
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