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{"title"=>"Plasma soluble prion protein, a potential biomarker for sport-related concussions: A pilot study", "type"=>"journal", "authors"=>[{"first_name"=>"Nam", "last_name"=>"Pham", "scopus_author_id"=>"56370952600"}, {"first_name"=>"Hungbo", "last_name"=>"Akonasu", "scopus_author_id"=>"56507520900"}, {"first_name"=>"Rhonda", "last_name"=>"Shishkin", "scopus_author_id"=>"56507227600"}, {"first_name"=>"Changiz", "last_name"=>"Taghibiglou", "scopus_author_id"=>"6603413533"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84922376865", "doi"=>"10.1371/journal.pone.0117286", "issn"=>"19326203", "pui"=>"601976189", "isbn"=>"19326203", "pmid"=>"25643046", "scopus"=>"2-s2.0-84922376865"}, "id"=>"8fb720b3-81df-3ec4-a08e-670fa97dc3c8", "abstract"=>"Sport-related mild traumatic brain injury (mTBI) or concussion is a significant health concern to athletes with potential long-term consequences. The diagnosis of sport concussion and return to sport decision making is one of the greatest challenges facing health care clinicians working in sports. Blood biomarkers have recently demonstrated their potential in assisting the detection of brain injury particularly, in those cases with no obvious physical injury. We have recently dis-covered plasma soluble cellular prion protein (PrP C) as a potential reliable biomarker for blast in-duced TBI (bTBI) in a rodent animal model. In order to explore the application of this novel TBI biomarker to sport-related concussion, we conducted a pilot study at the University of Saskatch-ewan (U of S) by recruiting athlete and non-athlete 18 to 30 year-old students. Using a modified quantitative ELISA method, we first established normal values for the plasma soluble PrP C in male and female students. The measured plasma soluble PrP C in confirmed concussion cases demonstrated a significant elevation of this analyte in post-concussion samples. Data collected from our pilot study indicates that the plasma soluble PrP C is a potential biomarker for sport-related concussion, which may be further developed into a clinical diagnostic tool to assist clini-cians in the assessment of sport concussion and return-to-play decision making.", "link"=>"http://www.mendeley.com/research/plasma-soluble-prion-protein-potential-biomarker-sportrelated-concussions-pilot-study-7", "reader_count"=>34, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>5, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>5, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>9, "Agricultural and Biological Sciences"=>6, "Neuroscience"=>3, "Sports and Recreations"=>4, "Psychology"=>2, "Chemistry"=>1, "Social Sciences"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Neuroscience"=>{"Neuroscience"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>4}, "Sports and Recreations"=>{"Sports and Recreations"=>4}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Mexico"=>1}, "group_count"=>4}

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• http://doi.org/10.1080/19336896.2020.1761514
• http://doi.org/10.1111/ejn.14390
• http://doi.org/10.1089/neu.2018.5918
• http://doi.org/10.1080/02699052.2018.1429662
• http://doi.org/10.1016/j.jocn.2018.07.002
• http://doi.org/10.1111/nan.12573
• http://doi.org/10.1016/j.bbr.2016.04.041
• http://doi.org/10.1136/jramc-2015-000517
• http://doi.org/10.1172/jci.insight.97105
• http://doi.org/10.1007/s40141-016-0121-x
• http://doi.org/10.1089/neu.2019.6884
• http://doi.org/10.1089/neu.2018.29017
• http://doi.org/10.3390/antiox9040297
• http://doi.org/10.1016/j.bbrc.2016.01.074
• http://doi.org/10.12688/f1000research.12025.1
• http://doi.org/10.1136/bjsports-2016-097447
• http://doi.org/10.1016/j.neubiorev.2016.09.014

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{"UNIPROT"=>23}

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• {"id"=>"562805782786637824", "text"=>"More evidence for potential blood biomarkers of #concussion http://t.co/Tj1uXsVXS1 @PLOSONE", "created_at"=>"2015-02-04T02:52:09Z", "user"=>"DrvanDonkelaar", "user_name"=>"Paul van Donkelaar", "user_profile_image"=>"http://pbs.twimg.com/profile_images/552686061587943424/vipz-IF3_normal.jpeg"}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/1878651"], "description"=>"<p><b>A)</b> Two-tailed unpaired student’s t-test shows post-TBI PrP^C concentrations (n = 6; 2.96 ng/mL <b>±</b> 0.37 SEM) are significantly elevated compared with either offseason athlete baseline concentration (n = 76’ 1.59 ng/mL <b>±</b> 0.07 SEM)(<i>p< 0</i>.<i>0001</i>), or both athletes and non-athletes combined (n = 103; 1.70 ng/mL <b>±</b> 0.07 SEM)(<i>p<0</i>.<i>0001</i>). <b>B)</b> Two-tailed paired t-test shows there was no significant difference between three sets of pre- and post-TBI PrP^C values (<i>p = 0</i>.<i>1666</i>).</p>", "links"=>[], "tags"=>["sport concussion", "pilot study", "novel TBI biomarker", "plasma", "rodent animal model", "prpc", "Plasma Soluble Prion Protein", "health care clinicians", "elisa", "brain injury"], "article_id"=>1299864, "categories"=>["Uncategorised"], "users"=>["Nam Pham", "Hungbo Akonasu", "Rhonda Shishkin", "Changiz Taghibiglou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0117286.g004", "stats"=>{"downloads"=>1, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_between_Normal_and_Post_Concussion_/1299864", "title"=>"Comparison between Normal and Post-Concussion.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-02 03:11:22"}
• {"files"=>["https://ndownloader.figshare.com/files/1878648"], "description"=>"<p>Two-tailed unpaired student’s t-test shows no significant difference between male (n = 54; 1.63 ng/mL <b>±</b> 0.10 SEM) and female (n = 49; 1.79 ng/mL <b>±</b> 0.10 SEM) (<i>p>0</i>.<i>05</i>). <i>T</i> test of athletes (n = 76, 1.59 ng/mL <b>±</b> 0.07 SEM) vs. the normal non-athlete population (n = 27; 2.02 ng/mL <b>±</b> 0.15 SEM) shows significant difference between mean PrP^C concentrations (<i>p<0</i>.<i>01</i>).</p>", "links"=>[], "tags"=>["sport concussion", "pilot study", "novel TBI biomarker", "plasma", "rodent animal model", "prpc", "Plasma Soluble Prion Protein", "health care clinicians", "elisa", "brain injury"], "article_id"=>1299861, "categories"=>["Uncategorised"], "users"=>["Nam Pham", "Hungbo Akonasu", "Rhonda Shishkin", "Changiz Taghibiglou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0117286.g002", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Group_Comparison_of_Plasma_PrP_C_/1299861", "title"=>"Group Comparison of Plasma PrP^C.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-02 03:11:22"}
• {"files"=>["https://ndownloader.figshare.com/files/1878649"], "description"=>"<p>One-way ANOVA of PrP^C concentrations for different age groups shows there is no significant difference between mean concentrations for subjects between the ages of 18–20 (n = 51; 1.66 ng/mL ± 0.68 SD), 21–33 (n = 33; 1.61 ng/L ± 0.58 SD), 24–26 (n = 14; 1.89 ng/mL ± 0.78 SD), 27–29 (n = 4; 2.13 ng/mL ± 0.51 SD), and those 30 and over (n = 9; 1.73 ng/mL ± 0.90 SD) (<i>p = 0</i>.<i>4702</i>).</p>", "links"=>[], "tags"=>["sport concussion", "pilot study", "novel TBI biomarker", "plasma", "rodent animal model", "prpc", "Plasma Soluble Prion Protein", "health care clinicians", "elisa", "brain injury"], "article_id"=>1299862, "categories"=>["Uncategorised"], "users"=>["Nam Pham", "Hungbo Akonasu", "Rhonda Shishkin", "Changiz Taghibiglou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0117286.g003", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_Plasma_PrP_C_with_Age_/1299862", "title"=>"Comparison of Plasma PrP^C with Age.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-02 03:11:22"}
• {"files"=>["https://ndownloader.figshare.com/files/1878646"], "description"=>"<p>Semi-quantitative band density analysis determined that both GFAP and PrP^C protein content were significantly elevated in post-TBI samples (n = 4) in comparison to randomly selected controls (n = 8). All bands were normalized to housekeeping protein actin. Mean post-TBI GFAP band intensity was higher (180.0% ± 31.4% SEM) than in controls (100% ± 13.0%) (two-tailed t-test, <i>p<0</i>.<i>034</i>). Mean post-TBI PrP^C band intensity was also higher (171.9% ± 18.0%) than in controls (100.0% ± 11.0%) (two-tailed t-test, <i>p<0</i>.<i>0025</i>).</p>", "links"=>[], "tags"=>["sport concussion", "pilot study", "novel TBI biomarker", "plasma", "rodent animal model", "prpc", "Plasma Soluble Prion Protein", "health care clinicians", "elisa", "brain injury"], "article_id"=>1299859, "categories"=>["Uncategorised"], "users"=>["Nam Pham", "Hungbo Akonasu", "Rhonda Shishkin", "Changiz Taghibiglou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0117286.g001", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Western_blot_for_protein_biomarkers_/1299859", "title"=>"Western blot for protein biomarkers.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-02 03:11:22"}
• {"files"=>["https://ndownloader.figshare.com/files/1878652"], "description"=>"<p>Study participants’ description.</p>", "links"=>[], "tags"=>["sport concussion", "pilot study", "novel TBI biomarker", "plasma", "rodent animal model", "prpc", "Plasma Soluble Prion Protein", "health care clinicians", "elisa", "brain injury"], "article_id"=>1299865, "categories"=>["Uncategorised"], "users"=>["Nam Pham", "Hungbo Akonasu", "Rhonda Shishkin", "Changiz Taghibiglou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0117286.t001", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_participants_8217_description_/1299865", "title"=>"Study participants’ description.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-02 03:11:22"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}

F1000Prime | Further Information

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• {"year"=>2018, "month"=>11, "doi"=>"10.1371/journal.pone.0117286", "f1000_id"=>"725335868", "url"=>"https://f1000.com/prime/725335868", "score"=>3, "classifications"=>["new_finding", "novel_drug_target", "technical_advance"], "updated_at"=>"2018-11-26T09:41:16Z"}
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• {"year"=>2019, "month"=>8, "doi"=>"10.1371/journal.pone.0117286", "f1000_id"=>"725335868", "url"=>"https://f1000.com/prime/725335868", "score"=>3, "classifications"=>["new_finding", "novel_drug_target", "technical_advance"], "updated_at"=>"2019-08-26T08:41:22Z"}
• {"year"=>2019, "month"=>9, "doi"=>"10.1371/journal.pone.0117286", "f1000_id"=>"725335868", "url"=>"https://f1000.com/prime/725335868", "score"=>3, "classifications"=>["new_finding", "novel_drug_target", "technical_advance"], "updated_at"=>"2019-09-30T08:41:21Z"}
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