CiteULike

Mendeley | Further Information

{"title"=>"A highly accurate inclusive cancer screening test using Caenorhabditis elegans scent detection", "type"=>"journal", "authors"=>[{"first_name"=>"Takaaki", "last_name"=>"Hirotsu", "scopus_author_id"=>"8514028800"}, {"first_name"=>"Hideto", "last_name"=>"Sonoda", "scopus_author_id"=>"7004958687"}, {"first_name"=>"Takayuki", "last_name"=>"Uozumi", "scopus_author_id"=>"55312932200"}, {"first_name"=>"Yoshiaki", "last_name"=>"Shinden", "scopus_author_id"=>"55917767700"}, {"first_name"=>"Koshi", "last_name"=>"Mimori", "scopus_author_id"=>"35414017500"}, {"first_name"=>"Yoshihiko", "last_name"=>"Maehara", "scopus_author_id"=>"35371979200"}, {"first_name"=>"Naoko", "last_name"=>"Ueda", "scopus_author_id"=>"56542628000"}, {"first_name"=>"Masayuki", "last_name"=>"Hamakawa", "scopus_author_id"=>"56543367400"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84924368185", "doi"=>"10.1371/journal.pone.0118699", "pui"=>"602884919", "issn"=>"19326203", "pmid"=>"25760772", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "scopus"=>"2-s2.0-84924368185"}, "id"=>"5fc4bc9c-33b6-38be-a929-4a79f649ff0e", "abstract"=>"Early detection and treatment are of vital importance to the successful eradication of various cancers, and development of economical and non-invasive novel cancer screening systems is critical. Previous reports using canine scent detection demonstrated the existence of cancer-specific odours. However, it is difficult to introduce canine scent recognition into clinical practice because of the need to maintain accuracy. In this study, we developed a Nematode Scent Detection Test (NSDT) using Caenorhabditis elegans to provide a novel highly accurate cancer detection system that is economical, painless, rapid and convenient. We demonstrated wild-type C. elegans displayed attractive chemotaxis towards human cancer cell secretions, cancer tissues and urine from cancer patients but avoided control urine; in parallel, the response of the olfactory neurons of C. elegans to the urine from cancer patients was significantly stronger than to control urine. In contrast, G protein α mutants and olfactory neurons-ablated animals were not attracted to cancer patient urine, suggesting that C. elegans senses odours in urine. We tested 242 samples to measure the performance of the NSDT, and found the sensitivity was 95.8%; this is markedly higher than that of other existing tumour markers. Furthermore, the specificity was 95.0%. Importantly, this test was able to diagnose various cancer types tested at the early stage (stage 0 or 1). To conclude, C. elegans scent-based analyses might provide a new strategy to detect and study disease-associated scents.", "link"=>"http://www.mendeley.com/research/highly-accurate-inclusive-cancer-screening-test-using-caenorhabditis-elegans-scent-detection", "reader_count"=>141, "reader_count_by_academic_status"=>{"Unspecified"=>6, "Professor > Associate Professor"=>8, "Student > Doctoral Student"=>11, "Researcher"=>35, "Student > Ph. D. Student"=>26, "Student > Postgraduate"=>3, "Student > Master"=>12, "Other"=>7, "Student > Bachelor"=>28, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>6, "Professor > Associate Professor"=>8, "Student > Doctoral Student"=>11, "Researcher"=>35, "Student > Ph. D. Student"=>26, "Student > Postgraduate"=>3, "Student > Master"=>12, "Other"=>7, "Student > Bachelor"=>28, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Agricultural and Biological Sciences"=>49, "Philosophy"=>1, "Veterinary Science and Veterinary Medicine"=>2, "Chemistry"=>4, "Computer Science"=>2, "Engineering"=>12, "Biochemistry, Genetics and Molecular Biology"=>19, "Nursing and Health Professions"=>2, "Materials Science"=>1, "Medicine and Dentistry"=>29, "Neuroscience"=>6, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Physics and Astronomy"=>1, "Psychology"=>3, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>29}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>3}, "Unspecified"=>{"Unspecified"=>7}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Engineering"=>{"Engineering"=>12}, "Chemistry"=>{"Chemistry"=>4}, "Neuroscience"=>{"Neuroscience"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>49}, "Computer Science"=>{"Computer Science"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>19}, "Philosophy"=>{"Philosophy"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"Canada"=>1, "United States"=>4, "Japan"=>6, "United Kingdom"=>1, "Indonesia"=>1}, "group_count"=>5}

ORCID

CrossRef

• http://doi.org/10.1016/j.bpc.2019.106264
• http://doi.org/10.1016/j.cca.2019.08.011
• http://doi.org/10.1016/j.ejphar.2017.09.017
• http://doi.org/10.1016/j.jveb.2017.05.002
• http://doi.org/10.1246/bcsj.20180136
• http://doi.org/10.1248/yakushi.18-00185-4
• http://doi.org/10.1183/13993003.00965-2016
• http://doi.org/10.3390/diagnostics10060392
• http://doi.org/10.1016/j.proeng.2016.11.414
• http://doi.org/10.1590/0037-8682-0300-2018
• http://doi.org/10.1177/1179299X19896551
• http://doi.org/10.1016/j.mrrev.2016.09.002
• http://doi.org/10.2171/jao.46.191
• http://doi.org/10.1371/journal.pone.0181469
• http://doi.org/10.1038/s41388-020-1381-6
• http://doi.org/10.1111/pim.12349
• http://doi.org/10.1074/mcp.M116.062273
• http://doi.org/10.18632/oncotarget.27124
• http://doi.org/10.1007/s12328-017-0783-7
• http://doi.org/10.3390/cancers12113291

DataCite

Europe PMC Citations

Europe PMC Database Citations

PubMed Central

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84924368185"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84924368185?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84924368185&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84924368185&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84924368185", "dc:identifier"=>"SCOPUS_ID:84924368185", "eid"=>"2-s2.0-84924368185", "dc:title"=>"A highly accurate inclusive cancer screening test using Caenorhabditis elegans scent detection", "dc:creator"=>"Hirotsu T.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"10", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2015-03-11", "prism:coverDisplayDate"=>"11 March 2015", "prism:doi"=>"10.1371/journal.pone.0118699", "citedby-count"=>"27", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Kyushu University", "affiliation-city"=>"Fukuoka", "affiliation-country"=>"Japan"}, {"@_fa"=>"true", "affilname"=>"Kyushu University, Faculty of Medical Sciences", "affiliation-city"=>"Fukuoka", "affiliation-country"=>"Japan"}], "pubmed-id"=>"25760772", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0118699", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}, {"$"=>"repositoryam"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}

Web of Science® | Further Information

Article Coverage

• {"referral"=>"http://www.newscientist.com/article/dn27224-sushi-parasite-inspires-worm-test-for-cancer.html", "language"=>"English", "title"=>"Sushi parasite inspires worm test for cancer - health - 23 March 2015 - New Scientist", "type"=>"News", "publication"=>"New Scientist ", "published_on"=>"2015-03-23T00:00:00Z", "link_state"=>"APPROVED"}
• {"referral"=>"http://www.ncbi.nlm.nih.gov/pubmed/25760772/", "language"=>"English", "title"=>"A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection. - PubMed - NCBI", "type"=>"Discussion board", "publication"=>"Hirotsu T , et al.", "published_on"=>"2015-04-02T00:00:00Z", "link_state"=>"REJECTED"}
• {"referral"=>"http://www.ncbi.nlm.nih.gov/pubmed/25760772", "language"=>"English", "title"=>"A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection. - PubMed - NCBI", "type"=>"Discussion board", "publication"=>"Hirotsu T , et al.", "published_on"=>"2015-04-02T00:00:00Z", "link_state"=>"REJECTED"}
• {"referral"=>"http://news.sci.kyushu-u.ac.jp/?p=5365", "language"=>"", "title"=>"線虫で１００円がん検査", "type"=>"Discussion board", "publication"=>"", "published_on"=>"", "link_state"=>""}
• {"referral"=>"http://news.sci.kyushu-u.ac.jp/biol/%E7%B7%9A%E8%99%AB%E3%81%A7%EF%BC%91%EF%BC%90%EF%BC%90%E5%86%86%E3%81%8C%E3%82%93%E6%A4%9C%E6%9F%BB/", "language"=>"", "title"=>"線虫で１００円がん検査 | 生物 | 九大理学部ニュース", "type"=>"Discussion board", "publication"=>"", "published_on"=>"", "link_state"=>""}
• {"referral"=>"http://www.smartcelegans.com/index_j.html", "language"=>"", "title"=>"SmartCelegans -- Revolutoinary Cancer Screening Technology", "type"=>"Discussion board", "publication"=>"Taku Nakahara", "published_on"=>"", "link_state"=>""}

Article Coverage Curated

• {"referral"=>"http://www.newscientist.com/article/dn27224-sushi-parasite-inspires-worm-test-for-cancer.html", "language"=>"English", "title"=>"Sushi parasite inspires worm test for cancer - health - 23 March 2015 - New Scientist", "type"=>"News", "publication"=>"New Scientist ", "published_on"=>"2015-03-23T00:00:00.000Z", "link_state"=>"APPROVED", "id"=>33356, "created"=>"2015-03-25T22:38:50.000Z", "crowdsourced"=>false, "article"=>{"id"=>10642, "doi"=>"10.1371/journal.pone.0118699", "title"=>"A Highly Accurate Inclusive Cancer Screening Test Using <italic>Caenorhabditis elegans</italic> Scent Detection", "published_on"=>"2015-03-11T00:00:00.000Z"}}

Facebook

• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0118699", "share_count"=>59, "like_count"=>448, "comment_count"=>120, "click_count"=>0, "total_count"=>627}

Journal Comments | Further Information

• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/ac1105dc-0f3d-484f-8fcd-819b9da31a37", "title"=>"Exciting results - what about moving from the nematode to the receptor?", "body"=>"These are very exciting results.\n\nOur lab is working to engineer biosensors from the nematode receptor genes that lie behind these responses. These two publications show how that might be achieved:\n\nhttp://www.sciencedirect.com/science/article/pii/S0956566311005288\n\nhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111429\n\n", "isRemoved"=>false, "created"=>"2015-03-26T23:28:52Z", "lastModified"=>"2015-03-26T23:28:52Z", "creator"=>{"userId"=>"148347"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"I am an author of the two papers cited above."}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0118699", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2015-03-26T23:28:52Z", "replies"=>[]}

Nature

Reddit

Twitter

• {"id"=>"1234475085903417344", "text"=>"#PLOSONE: A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection https://t.co/RYwRBbVar3", "created_at"=>"2020-03-02T13:46:10Z", "user"=>"seyd__", "user_name"=>"seyda", "user_profile_image"=>"http://pbs.twimg.com/profile_images/878266880347262976/l88TDCBC_normal.jpg"}
• {"id"=>"575738528929353728", "text"=>"First, we peed on frogs for pregnancy test, now pee on a worm for cancer test. MT @PLOSONE: Screening Using C elegans http://t.co/wldp9DM6Ms", "created_at"=>"2015-03-11T19:22:16Z", "user"=>"TenleyArcher", "user_name"=>"Tenley Archer", "user_profile_image"=>"http://pbs.twimg.com/profile_images/508732075848261633/eANrH8tu_normal.jpeg"}
• {"id"=>"575743876746625024", "text"=>"RT @PLOSONE: A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection http://t.co/qpggQOzIr5", "created_at"=>"2015-03-11T19:43:31Z", "user"=>"MediTech_Media", "user_name"=>"MediTech Media", "user_profile_image"=>"http://pbs.twimg.com/profile_images/452084908488273920/nKH0BisE_normal.png"}
• {"id"=>"575782356813926400", "text"=>"RT @PLOSONE: A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection http://t.co/qpggQOzIr5", "created_at"=>"2015-03-11T22:16:26Z", "user"=>"ShotaOkabe", "user_name"=>"おかべしょうた", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000764782859/522bd039f83ac307552a3dcf373c5966_normal.jpeg"}
• {"id"=>"575790405037350912", "text"=>"がん診断、尿1滴で＝線虫の習性利用―10年後の実用化目指す・九大など（時事通信）\nhttp://t.co/Bi5sgncAm7\n\n原著論文はこちら（Free)\nhttp://t.co/XaL4Xyu2Y5\n\nhttp://t.co/JZyen6TzMw", "created_at"=>"2015-03-11T22:48:24Z", "user"=>"passage_blanc", "user_name"=>"パサージュ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/465736474000769024/5Aiibekm_normal.jpeg"}
• {"id"=>"575804706980818944", "text"=>"RT @PLOSONE: A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection http://t.co/qpggQOzIr5", "created_at"=>"2015-03-11T23:45:14Z", "user"=>"Chitananda_NM", "user_name"=>"Nathalie Martinek", "user_profile_image"=>"http://pbs.twimg.com/profile_images/440077843242835970/C7lAmv3V_normal.jpeg"}
• {"id"=>"575819888867995648", "text"=>"これだ　：PLOS ONE: A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection http://t.co/XEZQUjw84F", "created_at"=>"2015-03-12T00:45:34Z", "user"=>"riotoqll", "user_name"=>"刂才ッ卜", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000541512604/08fa29830bef716ba6257e8422160350_normal.png"}
• {"id"=>"575823528919896064", "text"=>"#PLOSONE: A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection http://t.co/r9BspKChmI 九州大・広津崇亮助教ら", "created_at"=>"2015-03-12T01:00:02Z", "user"=>"norioNY", "user_name"=>"ノリオ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/557347038442975233/s7t6Mp___normal.jpeg"}
• {"id"=>"575825783924510720", "text"=>"#PLOSONE: A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection http://t.co/vLgI8mcLsv", "created_at"=>"2015-03-12T01:08:59Z", "user"=>"MARKINSURE", "user_name"=>"Mark Volkov", "user_profile_image"=>"http://abs.twimg.com/sticky/default_profile_images/default_profile_2_normal.png"}
• {"id"=>"575828328302571520", "text"=>"RT @PLOSONE: A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection http://t.co/qpggQOzIr5", "created_at"=>"2015-03-12T01:19:06Z", "user"=>"tsurune64", "user_name"=>"Royce", "user_profile_image"=>"http://pbs.twimg.com/profile_images/564136439437197312/6kR19icZ_normal.jpeg"}
• {"id"=>"575864899898736640", "text"=>"@disat15 その辺についても多分論文本体の中にあるはず（自分も気になったから読む）つ http://t.co/T4vQP4rGDV", "created_at"=>"2015-03-12T03:44:25Z", "user"=>"0_Add_astraaa_1", "user_name"=>"harat", "user_profile_image"=>"http://pbs.twimg.com/profile_images/561909510806065152/DHLiK8o5_normal.jpeg"}
• {"id"=>"575869171512139776", "text"=>"http://t.co/ZO8gWLF9pu これが線虫でガンをかぎ分けるという PLOS ONE に載っている文。", "created_at"=>"2015-03-12T04:01:24Z", "user"=>"Blanka_Meduzo", "user_name"=>"Blanka_Meduzo", "user_profile_image"=>"http://pbs.twimg.com/profile_images/498043973672267776/x45m3aGa_normal.jpeg"}
• {"id"=>"575874216983048192", "text"=>"素晴らしい！\nPLOSONEてことは、これですね。↓\nhttp://t.co/2aFiEz5G6U\nオンラインジャーナルなんだから、朝日もURL載せればいいのに。\n\n〈寄生虫でがん診断？　患者の尿のにおい好み、精度９５％〉（朝日新聞）\nhttp://t.co/zWuBARBNZZ", "created_at"=>"2015-03-12T04:21:27Z", "user"=>"59224", "user_name"=>"まんがの山", "user_profile_image"=>"http://pbs.twimg.com/profile_images/575716338221502464/09TIIhMd_normal.jpeg"}
• {"id"=>"575887360992280578", "text"=>"飼育方法からライフサイクルまでよく調べられてるモデル生物（C. elegans）で出来たというのがキモだと思うけど、「寄生虫」って書いたら誤解されるんでは？　http://t.co/628CYXMl3o　PLOS ONEの論文: http://t.co/7qf2AKukbO", "created_at"=>"2015-03-12T05:13:40Z", "user"=>"c_z", "user_name"=>"Keiichiro Ono", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1621738038/ko1_normal.jpg"}
• {"id"=>"576005660258631680", "text"=>"@kei_chandler これですかね。 http://t.co/Y2JaauUTh1", "created_at"=>"2015-03-12T13:03:45Z", "user"=>"monstar81053", "user_name"=>"toumei-unicorn", "user_profile_image"=>"http://pbs.twimg.com/profile_images/569508643427450880/C5nMzEfO_normal.png"}
• {"id"=>"576285003920756736", "text"=>"#PLOSONE: A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection http://t.co/VxhHLjis20", "created_at"=>"2015-03-13T07:33:46Z", "user"=>"MeisohBoy", "user_name"=>"迷走ぼーい", "user_profile_image"=>"http://pbs.twimg.com/profile_images/554857220702093312/x65iQ6Hz_normal.jpeg"}
• {"id"=>"576500135305338880", "text"=>"#PLOSONE: A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection http://t.co/x2ruBlANws", "created_at"=>"2015-03-13T21:48:37Z", "user"=>"JunJun697", "user_name"=>"SuperdimensionJunJun", "user_profile_image"=>"http://pbs.twimg.com/profile_images/654013273/jun4_normal.jpg"}
• {"id"=>"577258556342185985", "text"=>"#PLOSONE: A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection http://t.co/2SbSoGW5tB", "created_at"=>"2015-03-16T00:02:19Z", "user"=>"k____i", "user_name"=>"Kentaro Inoue", "user_profile_image"=>"http://abs.twimg.com/sticky/default_profile_images/default_profile_5_normal.png"}
• {"id"=>"673381556686204928", "text"=>"C.elegans is able to detect cancer in human urine, with 96% accuracy -RT @Nematology https://t.co/KjCf8MxERo https://t.co/ucoByFkpKm", "created_at"=>"2015-12-06T06:00:48Z", "user"=>"Data_360", "user_name"=>"Data", "user_profile_image"=>"http://abs.twimg.com/sticky/default_profile_images/default_profile_3_normal.png"}
• {"id"=>"673405521152487424", "text"=>"C.elegans is able to detect cancer in human urine, with 96% accuracy -RT @Nematology https://t.co/KjCf8MxERo https://t.co/ZxVpw7cRh4", "created_at"=>"2015-12-06T07:36:02Z", "user"=>"Data_360", "user_name"=>"Data", "user_profile_image"=>"http://abs.twimg.com/sticky/default_profile_images/default_profile_3_normal.png"}
• {"id"=>"673607641143332864", "text"=>"RT @Data_360: C.elegans is able to detect cancer in human urine, with 96% accuracy -RT @Nematology https://t.co/KjCf8MxERo https://t.co/ZxV…", "created_at"=>"2015-12-06T20:59:11Z", "user"=>"cMadan", "user_name"=>"Chris Madan", "user_profile_image"=>"http://pbs.twimg.com/profile_images/467152273894699008/phbQj1Ju_normal.jpeg"}
• {"id"=>"673609043043205120", "text"=>"Evolution drives neural systems to fine tune signal detection. The 302 neurons in C. elegans can detect cancer: https://t.co/tpVt1U8sh5", "created_at"=>"2015-12-06T21:04:45Z", "user"=>"BWJones", "user_name"=>"Bryan William Jones", "user_profile_image"=>"http://pbs.twimg.com/profile_images/673004226142801920/kbj_P20h_normal.jpg"}
• {"id"=>"673640849385869313", "text"=>"\"a novel highly accurate #cancer detection system that is economical, painless, rapid and convenient.\" in @PLOSONE https://t.co/y7CsXpoLCC", "created_at"=>"2015-12-06T23:11:08Z", "user"=>"gcabanac", "user_name"=>"Guillaume Cabanac", "user_profile_image"=>"http://pbs.twimg.com/profile_images/590129776033136640/9jZYAwlL_normal.jpg"}
• {"id"=>"673645245465305093", "text"=>"RT @Data_360: C.elegans is able to detect cancer in human urine, with 96% accuracy -RT @Nematology https://t.co/KjCf8MxERo https://t.co/ZxV…", "created_at"=>"2015-12-06T23:28:36Z", "user"=>"SandrineGrillon", "user_name"=>"Sandrine Grillon", "user_profile_image"=>"http://pbs.twimg.com/profile_images/538015371089809409/mngDvth9_normal.png"}
• {"id"=>"677884994451202048", "text"=>"C.elegans is able to detect cancer in human urine, with 96% accuracy https://t.co/hqhlPu9GWZ https://t.co/WsnZUdNpL4", "created_at"=>"2015-12-18T16:15:51Z", "user"=>"Cookblog", "user_name"=>"Cook Journal", "user_profile_image"=>"http://abs.twimg.com/sticky/default_profile_images/default_profile_1_normal.png"}
• {"id"=>"686015984847708160", "text"=>"#PLOSONE: A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection https://t.co/NhnhBIBEq7 - good job!", "created_at"=>"2016-01-10T02:45:31Z", "user"=>"e_k_brinkman", "user_name"=>"eriko", "user_profile_image"=>"http://pbs.twimg.com/profile_images/653100567812636672/nhrAfcH3_normal.jpg"}
• {"id"=>"719010216432406528", "text"=>"??????????????\n????A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection \nhttps://t.co/wwYoIs1RZI", "created_at"=>"2016-04-10T03:52:48Z", "user"=>"kokikokiya", "user_name"=>"???????????", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3551738701/a673a16e72d4715ee973b7d8b1a3bbf0_normal.jpeg"}
• {"id"=>"719357207389679617", "text"=>"@PKAnzug ?????????????????????????\n?A Highly Accurate Inclusive Cancer Screening Test Using C. elegans …\nhttps://t.co/zRJdcHni9N", "created_at"=>"2016-04-11T02:51:37Z", "user"=>"Ra_koyama", "user_name"=>"??????", "user_profile_image"=>"http://abs.twimg.com/sticky/default_profile_images/default_profile_1_normal.png"}
• {"id"=>"738126110064443392", "text"=>"C?elegance can find cancer :https://t.co/PfvTJl618K", "created_at"=>"2016-06-01T21:52:33Z", "user"=>"chikamidoco", "user_name"=>"risatired", "user_profile_image"=>"http://pbs.twimg.com/profile_images/729576424055541760/AaOit3sb_normal.jpg"}
• {"id"=>"890186637195354113", "text"=>"?????C.elegans????????????????????????2015??????????PLOS ONE???\nhttps://t.co/qLIJDU8YFJ", "created_at"=>"2017-07-26T12:26:47Z", "user"=>"pooh_kirin", "user_name"=>"???-like receptor", "user_profile_image"=>"http://pbs.twimg.com/profile_images/890108030544744448/8EU9zyPu_normal.jpg"}

Wikipedia | Further Information

• {"title"=>"カエノラブディティス・エレガンス", "url"=>"http://ja.wikipedia.org/wiki/カエノラブディティス・エレガンス", "timestamp"=>"2018-10-25T08:06:55Z"}
• {"title"=>"File:A-Highly-Accurate-Inclusive-Cancer-Screening-Test-Using-Caenorhabditis-elegans-Scent-Detection-pone.0118699.s008.ogv", "url"=>"http://commons.wikimedia.org/wiki/File:A-Highly-Accurate-Inclusive-Cancer-Screening-Test-Using-Caenorhabditis-elegans-Scent-Detection-pone.0118699.s008.ogv", "timestamp"=>"2017-11-15T11:31:48Z"}

Counter

• {"month"=>"3", "year"=>"2015", "pdf_views"=>"2229", "xml_views"=>"18", "html_views"=>"10976"}
• {"month"=>"4", "year"=>"2015", "pdf_views"=>"459", "xml_views"=>"4", "html_views"=>"3139"}
• {"month"=>"5", "year"=>"2015", "pdf_views"=>"263", "xml_views"=>"0", "html_views"=>"1575"}
• {"month"=>"6", "year"=>"2015", "pdf_views"=>"172", "xml_views"=>"0", "html_views"=>"1056"}
• {"month"=>"7", "year"=>"2015", "pdf_views"=>"121", "xml_views"=>"0", "html_views"=>"722"}
• {"month"=>"8", "year"=>"2015", "pdf_views"=>"86", "xml_views"=>"0", "html_views"=>"474"}
• {"month"=>"9", "year"=>"2015", "pdf_views"=>"95", "xml_views"=>"2", "html_views"=>"668"}
• {"month"=>"10", "year"=>"2015", "pdf_views"=>"84", "xml_views"=>"0", "html_views"=>"575"}
• {"month"=>"11", "year"=>"2015", "pdf_views"=>"81", "xml_views"=>"0", "html_views"=>"594"}
• {"month"=>"12", "year"=>"2015", "pdf_views"=>"52", "xml_views"=>"0", "html_views"=>"642"}
• {"month"=>"1", "year"=>"2016", "pdf_views"=>"87", "xml_views"=>"0", "html_views"=>"471"}
• {"month"=>"2", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"374"}
• {"month"=>"3", "year"=>"2016", "pdf_views"=>"63", "xml_views"=>"0", "html_views"=>"351"}
• {"month"=>"4", "year"=>"2016", "pdf_views"=>"76", "xml_views"=>"0", "html_views"=>"392"}
• {"month"=>"5", "year"=>"2016", "pdf_views"=>"116", "xml_views"=>"0", "html_views"=>"410"}
• {"month"=>"6", "year"=>"2016", "pdf_views"=>"81", "xml_views"=>"0", "html_views"=>"464"}
• {"month"=>"7", "year"=>"2016", "pdf_views"=>"61", "xml_views"=>"0", "html_views"=>"291"}
• {"month"=>"8", "year"=>"2016", "pdf_views"=>"74", "xml_views"=>"0", "html_views"=>"276"}
• {"month"=>"9", "year"=>"2016", "pdf_views"=>"37", "xml_views"=>"0", "html_views"=>"343"}
• {"month"=>"10", "year"=>"2016", "pdf_views"=>"83", "xml_views"=>"0", "html_views"=>"686"}
• {"month"=>"11", "year"=>"2016", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"452"}
• {"month"=>"12", "year"=>"2016", "pdf_views"=>"59", "xml_views"=>"2", "html_views"=>"409"}
• {"month"=>"1", "year"=>"2017", "pdf_views"=>"58", "xml_views"=>"1", "html_views"=>"396"}
• {"month"=>"2", "year"=>"2017", "pdf_views"=>"66", "xml_views"=>"2", "html_views"=>"516"}
• {"month"=>"3", "year"=>"2017", "pdf_views"=>"49", "xml_views"=>"1", "html_views"=>"395"}
• {"month"=>"4", "year"=>"2017", "pdf_views"=>"166", "xml_views"=>"1", "html_views"=>"902"}
• {"month"=>"5", "year"=>"2017", "pdf_views"=>"168", "xml_views"=>"4", "html_views"=>"679"}
• {"month"=>"6", "year"=>"2017", "pdf_views"=>"137", "xml_views"=>"5", "html_views"=>"492"}
• {"month"=>"7", "year"=>"2017", "pdf_views"=>"107", "xml_views"=>"3", "html_views"=>"361"}
• {"month"=>"8", "year"=>"2017", "pdf_views"=>"78", "xml_views"=>"3", "html_views"=>"380"}
• {"month"=>"9", "year"=>"2017", "pdf_views"=>"69", "xml_views"=>"6", "html_views"=>"373"}
• {"month"=>"10", "year"=>"2017", "pdf_views"=>"70", "xml_views"=>"7", "html_views"=>"674"}
• {"month"=>"11", "year"=>"2017", "pdf_views"=>"56", "xml_views"=>"3", "html_views"=>"508"}
• {"month"=>"12", "year"=>"2017", "pdf_views"=>"75", "xml_views"=>"3", "html_views"=>"480"}
• {"month"=>"1", "year"=>"2018", "pdf_views"=>"55", "xml_views"=>"4", "html_views"=>"389"}
• {"month"=>"2", "year"=>"2018", "pdf_views"=>"62", "xml_views"=>"2", "html_views"=>"241"}
• {"month"=>"3", "year"=>"2018", "pdf_views"=>"64", "xml_views"=>"1", "html_views"=>"279"}
• {"month"=>"4", "year"=>"2018", "pdf_views"=>"81", "xml_views"=>"5", "html_views"=>"313"}
• {"month"=>"5", "year"=>"2018", "pdf_views"=>"53", "xml_views"=>"3", "html_views"=>"203"}
• {"month"=>"6", "year"=>"2018", "pdf_views"=>"59", "xml_views"=>"5", "html_views"=>"172"}
• {"month"=>"7", "year"=>"2018", "pdf_views"=>"89", "xml_views"=>"10", "html_views"=>"333"}
• {"month"=>"8", "year"=>"2018", "pdf_views"=>"57", "xml_views"=>"3", "html_views"=>"169"}
• {"month"=>"9", "year"=>"2018", "pdf_views"=>"102", "xml_views"=>"2", "html_views"=>"169"}
• {"month"=>"10", "year"=>"2018", "pdf_views"=>"145", "xml_views"=>"5", "html_views"=>"927"}
• {"month"=>"11", "year"=>"2018", "pdf_views"=>"64", "xml_views"=>"2", "html_views"=>"351"}
• {"month"=>"12", "year"=>"2018", "pdf_views"=>"55", "xml_views"=>"3", "html_views"=>"194"}
• {"month"=>"1", "year"=>"2019", "pdf_views"=>"56", "xml_views"=>"0", "html_views"=>"164"}
• {"month"=>"2", "year"=>"2019", "pdf_views"=>"50", "xml_views"=>"0", "html_views"=>"104"}
• {"month"=>"3", "year"=>"2019", "pdf_views"=>"161", "xml_views"=>"0", "html_views"=>"119"}
• {"month"=>"4", "year"=>"2019", "pdf_views"=>"64", "xml_views"=>"1", "html_views"=>"133"}
• {"month"=>"5", "year"=>"2019", "pdf_views"=>"65", "xml_views"=>"3", "html_views"=>"181"}
• {"month"=>"6", "year"=>"2019", "pdf_views"=>"70", "xml_views"=>"1", "html_views"=>"199"}
• {"month"=>"7", "year"=>"2019", "pdf_views"=>"91", "xml_views"=>"1", "html_views"=>"219"}
• {"month"=>"8", "year"=>"2019", "pdf_views"=>"40", "xml_views"=>"0", "html_views"=>"115"}
• {"month"=>"9", "year"=>"2019", "pdf_views"=>"47", "xml_views"=>"0", "html_views"=>"118"}
• {"month"=>"10", "year"=>"2019", "pdf_views"=>"508", "xml_views"=>"6", "html_views"=>"1577"}
• {"month"=>"11", "year"=>"2019", "pdf_views"=>"109", "xml_views"=>"1", "html_views"=>"495"}
• {"month"=>"12", "year"=>"2019", "pdf_views"=>"291", "xml_views"=>"2", "html_views"=>"642"}
• {"month"=>"1", "year"=>"2020", "pdf_views"=>"368", "xml_views"=>"3", "html_views"=>"407"}
• {"month"=>"2", "year"=>"2020", "pdf_views"=>"125", "xml_views"=>"3", "html_views"=>"249"}
• {"month"=>"3", "year"=>"2020", "pdf_views"=>"127", "xml_views"=>"0", "html_views"=>"211"}
• {"month"=>"4", "year"=>"2020", "pdf_views"=>"91", "xml_views"=>"1", "html_views"=>"158"}
• {"month"=>"5", "year"=>"2020", "pdf_views"=>"132", "xml_views"=>"3", "html_views"=>"143"}
• {"month"=>"6", "year"=>"2020", "pdf_views"=>"71", "xml_views"=>"2", "html_views"=>"161"}
• {"month"=>"7", "year"=>"2020", "pdf_views"=>"70", "xml_views"=>"3", "html_views"=>"143"}
• {"month"=>"8", "year"=>"2020", "pdf_views"=>"46", "xml_views"=>"0", "html_views"=>"152"}
• {"month"=>"9", "year"=>"2020", "pdf_views"=>"60", "xml_views"=>"1", "html_views"=>"138"}
• {"month"=>"10", "year"=>"2020", "pdf_views"=>"82", "xml_views"=>"4", "html_views"=>"185"}
• {"month"=>"11", "year"=>"2020", "pdf_views"=>"75", "xml_views"=>"1", "html_views"=>"182"}
• {"month"=>"12", "year"=>"2020", "pdf_views"=>"69", "xml_views"=>"2", "html_views"=>"269"}
• {"month"=>"1", "year"=>"2021", "pdf_views"=>"51", "xml_views"=>"2", "html_views"=>"149"}
• {"month"=>"2", "year"=>"2021", "pdf_views"=>"70", "xml_views"=>"2", "html_views"=>"204"}

Figshare

• {"files"=>["https://ndownloader.figshare.com/files/1944883"], "description"=>"<p>Box plots (A) and dot plots (B) of chemotactic responses of wild-type <i>C</i>. <i>elegans</i> to urine samples from control subjects (n = 218) or cancer patients (n = 24). Whiskers indicate 10th and 90th percentiles.</p>", "links"=>[], "tags"=>["elegans senses odours", "novel cancer screening systems", "cancer patient urine", "cancer patients", "NSDT", "Caenorhabditis elegans Scent Detection", "cancer detection system", "Accurate Inclusive Cancer Screening Test", "Nematode Scent Detection Test", "G protein α mutants", "cancer cell secretions", "control urine"], "article_id"=>1332829, "categories"=>["Biological Sciences"], "users"=>["Takaaki Hirotsu", "Hideto Sonoda", "Takayuki Uozumi", "Yoshiaki Shinden", "Koshi Mimori", "Yoshihiko Maehara", "Naoko Ueda", "Masayuki Hamakawa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118699.g003", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_NSDT_of_242_urine_samples_/1332829", "title"=>"NSDT of 242 urine samples.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-11 02:46:25"}
• {"files"=>["https://ndownloader.figshare.com/files/1944884"], "description"=>"<p>The type and stage of cancer from which serum CEA, serum anti-p53 antibody, urinary DiAcSpm/Cre, some TMs and NSDT were measured or detected in 24 cancer patients are shown. Some TMs indicate that positive results were found for at least one tumour marker: CEA, Anti-p53 Ab or DiAcSpm. Sensitivity, specificity, positive predictive value and efficiency are also demonstrated. Such values of the NSDT were markedly higher than those of other existing tumour markers.</p><p>Accuracy of tumour markers in extended characterization.</p>", "links"=>[], "tags"=>["elegans senses odours", "novel cancer screening systems", "cancer patient urine", "cancer patients", "NSDT", "Caenorhabditis elegans Scent Detection", "cancer detection system", "Accurate Inclusive Cancer Screening Test", "Nematode Scent Detection Test", "G protein α mutants", "cancer cell secretions", "control urine"], "article_id"=>1332830, "categories"=>["Biological Sciences"], "users"=>["Takaaki Hirotsu", "Hideto Sonoda", "Takayuki Uozumi", "Yoshiaki Shinden", "Koshi Mimori", "Yoshihiko Maehara", "Naoko Ueda", "Masayuki Hamakawa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118699.t001", "stats"=>{"downloads"=>7, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Accuracy_of_tumour_markers_in_extended_characterization_/1332830", "title"=>"Accuracy of tumour markers in extended characterization.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-11 02:46:25"}
• {"files"=>["https://ndownloader.figshare.com/files/1944882"], "description"=>"<p>(A) Chemotaxis to urine from controls (c5 and c10) or cancer patients (p5, p8 and p18) in wild-type animals with AWC, AWA, ASH or AWB neuron ablation (n ≥ 5 assays). (B) Chemotaxis of wild-type <i>C</i>. <i>elegans</i> to urine samples from controls (A and B) or cancer patients (C and D) with or without filtration that were used in imaging experiments (n ≥ 5 assays). Filtration of urine had no significant effect. (C) Calcium responses of AWC olfactory neurons on removal of control or cancer patient urine. (D) Average fluorescence changes in AWC for 10 s following urine removal (n ≥ 8 animals). Values are normalized to the average change in ratio of Control-A. (E) Calcium responses of AWA olfactory neurons after addition of urine from controls or cancer patients. (F) Average fluorescence changes in AWA for 10 s after urine stimulation (n ≥ 8 animals). Values are normalized to the average change in ratio of Control-A. The brown shading indicates that urine was present. Error bars and shaded regions around the curves represent SEM. Significant differences from control samples are indicated by * (<i>P</i> < 0.05); ** (<i>P</i> < 0.01); *** (<i>P</i> < 0.001) as calculated by Dunnett’s tests (A, D, F).</p>", "links"=>[], "tags"=>["elegans senses odours", "novel cancer screening systems", "cancer patient urine", "cancer patients", "NSDT", "Caenorhabditis elegans Scent Detection", "cancer detection system", "Accurate Inclusive Cancer Screening Test", "Nematode Scent Detection Test", "G protein α mutants", "cancer cell secretions", "control urine"], "article_id"=>1332828, "categories"=>["Biological Sciences"], "users"=>["Takaaki Hirotsu", "Hideto Sonoda", "Takayuki Uozumi", "Yoshiaki Shinden", "Koshi Mimori", "Yoshihiko Maehara", "Naoko Ueda", "Masayuki Hamakawa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118699.g002", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Olfactory_neurons_of_C_elegans_respond_to_urine_from_cancer_patients_/1332828", "title"=>"Olfactory neurons of <i>C</i>. <i>elegans</i> respond to urine from cancer patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-11 02:46:25"}
• {"files"=>["https://ndownloader.figshare.com/files/1944887", "https://ndownloader.figshare.com/files/1944888", "https://ndownloader.figshare.com/files/1944889", "https://ndownloader.figshare.com/files/1944890", "https://ndownloader.figshare.com/files/1944891", "https://ndownloader.figshare.com/files/1944892", "https://ndownloader.figshare.com/files/1944893", "https://ndownloader.figshare.com/files/1944894", "https://ndownloader.figshare.com/files/1944895", "https://ndownloader.figshare.com/files/1944896", "https://ndownloader.figshare.com/files/1944897"], "description"=>"<div><p>Early detection and treatment are of vital importance to the successful eradication of various cancers, and development of economical and non-invasive novel cancer screening systems is critical. Previous reports using canine scent detection demonstrated the existence of cancer-specific odours. However, it is difficult to introduce canine scent recognition into clinical practice because of the need to maintain accuracy. In this study, we developed a Nematode Scent Detection Test (NSDT) using <i>Caenorhabditis elegans</i> to provide a novel highly accurate cancer detection system that is economical, painless, rapid and convenient. We demonstrated wild-type <i>C</i>. <i>elegans</i> displayed attractive chemotaxis towards human cancer cell secretions, cancer tissues and urine from cancer patients but avoided control urine; in parallel, the response of the olfactory neurons of <i>C</i>. <i>elegans</i> to the urine from cancer patients was significantly stronger than to control urine. In contrast, G protein α mutants and olfactory neurons-ablated animals were not attracted to cancer patient urine, suggesting that <i>C</i>. <i>elegans</i> senses odours in urine. We tested 242 samples to measure the performance of the NSDT, and found the sensitivity was 95.8%; this is markedly higher than that of other existing tumour markers. Furthermore, the specificity was 95.0%. Importantly, this test was able to diagnose various cancer types tested at the early stage (stage 0 or 1). To conclude, <i>C</i>. <i>elegans</i> scent-based analyses might provide a new strategy to detect and study disease-associated scents.</p></div>", "links"=>[], "tags"=>["elegans senses odours", "novel cancer screening systems", "cancer patient urine", "cancer patients", "NSDT", "Caenorhabditis elegans Scent Detection", "cancer detection system", "Accurate Inclusive Cancer Screening Test", "Nematode Scent Detection Test", "G protein α mutants", "cancer cell secretions", "control urine"], "article_id"=>1332833, "categories"=>["Biological Sciences"], "users"=>["Takaaki Hirotsu", "Hideto Sonoda", "Takayuki Uozumi", "Yoshiaki Shinden", "Koshi Mimori", "Yoshihiko Maehara", "Naoko Ueda", "Masayuki Hamakawa"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0118699.s001", "https://dx.doi.org/10.1371/journal.pone.0118699.s002", "https://dx.doi.org/10.1371/journal.pone.0118699.s003", "https://dx.doi.org/10.1371/journal.pone.0118699.s004", "https://dx.doi.org/10.1371/journal.pone.0118699.s005", "https://dx.doi.org/10.1371/journal.pone.0118699.s006", "https://dx.doi.org/10.1371/journal.pone.0118699.s007", "https://dx.doi.org/10.1371/journal.pone.0118699.s008", "https://dx.doi.org/10.1371/journal.pone.0118699.s009", "https://dx.doi.org/10.1371/journal.pone.0118699.s010", "https://dx.doi.org/10.1371/journal.pone.0118699.s011"], "stats"=>{"downloads"=>18, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_Highly_Accurate_Inclusive_Cancer_Screening_Test_Using_Caenorhabditis_elegans_Scent_Detection/1332833", "title"=>"A Highly Accurate Inclusive Cancer Screening Test Using <i>Caenorhabditis elegans</i> Scent Detection", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-03-11 02:46:25"}
• {"files"=>["https://ndownloader.figshare.com/files/1944880"], "description"=>"<p>(A) Chemotaxis of wild-type <i>C</i>. <i>elegans</i> to 10^-6 and 10^-7 dilutions of MEM, EMEM or RPMI medium only, or culture medium from fibroblast (KMST-6 and CCD-112CoN), colorectal cancer (SW480, COLO201 and COLO205), breast cancer (MCF7) or gastric cancer (NUGC4, MKN1 and MKN7) cells (n ≥ 5 assays). (B) Chemotaxis of wild type and <i>odr-3</i> mutants (n ≥ 5 assays) in response to a 10^-6 dilution of conditioned culture medium from colorectal, breast or gastric cancer cells. (C) Chemotaxis of wild type to 10^-2, 10^-3 and 10^-4 dilutions of saline with normal and cancer tissue (n ≥ 5 assays). (D) Chemotaxis to normal and cancer tissue by wild-type and <i>odr-3</i> mutants (n ≥ 5 assays). (E) Chemotaxis of wild type to human urine samples from control subjects (blue bars; c1–c10) or cancer patients (orange bars; p1–p20) at 10^-1 dilution (n = 5 assays). (F) Chemotaxis to urine from cancer patients by wild-type and <i>odr-3</i> mutants at 10^-1 dilution (n ≥ 6 assays). Error bars represent SEM. Significant differences from control samples are indicated by * (<i>P</i> < 0.05); ** (<i>P</i> < 0.01); *** (<i>P</i> < 0.001) by Dunnett’s tests (A) or Student’s <i>t</i>-tests (B, C, D, F). † indicates a significant difference (<i>P</i> < 0.05) by Student’s <i>t</i>-tests (A).</p>", "links"=>[], "tags"=>["elegans senses odours", "novel cancer screening systems", "cancer patient urine", "cancer patients", "NSDT", "Caenorhabditis elegans Scent Detection", "cancer detection system", "Accurate Inclusive Cancer Screening Test", "Nematode Scent Detection Test", "G protein α mutants", "cancer cell secretions", "control urine"], "article_id"=>1332826, "categories"=>["Biological Sciences"], "users"=>["Takaaki Hirotsu", "Hideto Sonoda", "Takayuki Uozumi", "Yoshiaki Shinden", "Koshi Mimori", "Yoshihiko Maehara", "Naoko Ueda", "Masayuki Hamakawa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118699.g001", "stats"=>{"downloads"=>0, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_C_elegans_can_respond_to_cancer_cell_culture_medium_and_cancer_tissue_and_detect_cancer_smells_in_human_urine_/1332826", "title"=>"<i>C</i>. <i>elegans</i> can respond to cancer cell culture medium and cancer tissue, and detect cancer smells in human urine.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-11 02:46:25"}

PMC Usage Stats | Further Information

• {"unique-ip"=>"248", "full-text"=>"268", "pdf"=>"180", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"44", "supp-data"=>"67", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
• {"unique-ip"=>"88", "full-text"=>"98", "pdf"=>"46", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"42", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
• {"unique-ip"=>"101", "full-text"=>"143", "pdf"=>"59", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"46", "supp-data"=>"49", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
• {"unique-ip"=>"60", "full-text"=>"69", "pdf"=>"28", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
• {"unique-ip"=>"220", "full-text"=>"282", "pdf"=>"193", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"88", "supp-data"=>"119", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
• {"unique-ip"=>"38", "full-text"=>"34", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
• {"unique-ip"=>"68", "full-text"=>"71", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"22", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
• {"unique-ip"=>"88", "full-text"=>"105", "pdf"=>"33", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"19", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
• {"unique-ip"=>"74", "full-text"=>"78", "pdf"=>"31", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
• {"unique-ip"=>"42", "full-text"=>"52", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
• {"unique-ip"=>"63", "full-text"=>"81", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"26", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
• {"unique-ip"=>"71", "full-text"=>"75", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"21", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
• {"unique-ip"=>"37", "full-text"=>"54", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
• {"unique-ip"=>"47", "full-text"=>"60", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
• {"unique-ip"=>"42", "full-text"=>"61", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
• {"unique-ip"=>"40", "full-text"=>"49", "pdf"=>"31", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
• {"unique-ip"=>"29", "full-text"=>"49", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
• {"unique-ip"=>"29", "full-text"=>"43", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
• {"unique-ip"=>"65", "full-text"=>"81", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
• {"unique-ip"=>"44", "full-text"=>"42", "pdf"=>"33", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
• {"unique-ip"=>"32", "full-text"=>"38", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
• {"unique-ip"=>"34", "full-text"=>"45", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
• {"unique-ip"=>"46", "full-text"=>"52", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
• {"unique-ip"=>"37", "full-text"=>"42", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
• {"unique-ip"=>"47", "full-text"=>"55", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
• {"unique-ip"=>"86", "full-text"=>"107", "pdf"=>"32", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"31", "supp-data"=>"6", "cited-by"=>"1", "year"=>"2017", "month"=>"4"}
• {"unique-ip"=>"75", "full-text"=>"94", "pdf"=>"40", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"35", "supp-data"=>"18", "cited-by"=>"2", "year"=>"2017", "month"=>"5"}
• {"unique-ip"=>"32", "full-text"=>"42", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
• {"unique-ip"=>"19", "full-text"=>"23", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
• {"unique-ip"=>"39", "full-text"=>"39", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
• {"unique-ip"=>"39", "full-text"=>"44", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
• {"unique-ip"=>"62", "full-text"=>"78", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"21", "cited-by"=>"1", "year"=>"2017", "month"=>"10"}
• {"unique-ip"=>"42", "full-text"=>"46", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
• {"unique-ip"=>"34", "full-text"=>"40", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
• {"unique-ip"=>"35", "full-text"=>"41", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
• {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
• {"unique-ip"=>"26", "full-text"=>"22", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
• {"unique-ip"=>"36", "full-text"=>"46", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
• {"unique-ip"=>"62", "full-text"=>"85", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"13", "cited-by"=>"1", "year"=>"2018", "month"=>"11"}
• {"unique-ip"=>"56", "full-text"=>"65", "pdf"=>"18", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"31", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
• {"unique-ip"=>"37", "full-text"=>"38", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"4"}
• {"unique-ip"=>"32", "full-text"=>"30", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"19", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
• {"unique-ip"=>"37", "full-text"=>"43", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"25", "cited-by"=>"1", "year"=>"2018", "month"=>"5"}
• {"unique-ip"=>"37", "full-text"=>"36", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
• {"unique-ip"=>"21", "full-text"=>"25", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
• {"unique-ip"=>"48", "full-text"=>"114", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
• {"unique-ip"=>"27", "full-text"=>"35", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
• {"unique-ip"=>"32", "full-text"=>"40", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"9", "cited-by"=>"2", "year"=>"2019", "month"=>"2"}
• {"unique-ip"=>"29", "full-text"=>"34", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2019", "month"=>"3"}
• {"unique-ip"=>"36", "full-text"=>"59", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
• {"unique-ip"=>"46", "full-text"=>"51", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
• {"unique-ip"=>"27", "full-text"=>"24", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
• {"unique-ip"=>"27", "full-text"=>"30", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
• {"unique-ip"=>"119", "full-text"=>"130", "pdf"=>"36", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"34", "supp-data"=>"18", "cited-by"=>"2", "year"=>"2019", "month"=>"10"}
• {"unique-ip"=>"86", "full-text"=>"95", "pdf"=>"22", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"23", "cited-by"=>"1", "year"=>"2019", "month"=>"12"}
• {"unique-ip"=>"33", "full-text"=>"32", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
• {"unique-ip"=>"28", "full-text"=>"34", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
• {"unique-ip"=>"31", "full-text"=>"36", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
• {"unique-ip"=>"29", "full-text"=>"29", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
• {"unique-ip"=>"29", "full-text"=>"30", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
• {"unique-ip"=>"30", "full-text"=>"34", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
• {"unique-ip"=>"24", "full-text"=>"32", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"8"}
• {"unique-ip"=>"27", "full-text"=>"25", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
• {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
• {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
• {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
• {"unique-ip"=>"21", "full-text"=>"19", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2021", "month"=>"1"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}

F1000Prime