Involvement of CX3CL1/CX3CR1 Signaling in Spinal Long Term Potentiation
- Publication Date
- March 13, 2015
- Journal
- PLOS ONE
- Authors
- Chao Bian, Zhi Qi Zhao, Yu Qiu Zhang & Ning Lü
- Volume
- 10
- Issue
- 3
- Pages
- e0118842
- DOI
- https://dx.plos.org/10.1371/journal.pone.0118842
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0118842
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/25768734
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358970
- Europe PMC
- http://europepmc.org/abstract/MED/25768734
- Web of Science
- 000351277500049
- Scopus
- 84929497582
- Mendeley
- http://www.mendeley.com/research/involvement-cx3cl1cx3cr1-signaling-spinal-long-term-potentiation
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Mendeley | Further Information
{"title"=>"Involvement of CX3CL1/CX3CR1 signaling in spinal long term potentiation", "type"=>"journal", "authors"=>[{"first_name"=>"Chao", "last_name"=>"Bian", "scopus_author_id"=>"56079852600"}, {"first_name"=>"Zhi Qi", "last_name"=>"Zhao", "scopus_author_id"=>"7404148138"}, {"first_name"=>"Yu Qiu", "last_name"=>"Zhang", "scopus_author_id"=>"55978429900"}, {"first_name"=>"Ning", "last_name"=>"Lü", "scopus_author_id"=>"35311283300"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84929497582", "pui"=>"604114652", "doi"=>"10.1371/journal.pone.0118842", "sgr"=>"84929497582", "pmid"=>"25768734"}, "id"=>"1aa0e25b-fff3-3b12-9329-c09e7062cb62", "abstract"=>"The long-term potentiation (LTP) of spinal C-fiber-evoked field potentials is considered as a fundamental mechanism of central sensitization in the spinal cord. Accumulating evidence has showed the contribution of spinal microglia to spinal LTP and pathological pain. As a key signaling of neurons-microglia interactions, the involvement of CX3CL1/CX3CR1 signaling in pathological pain has also been investigated extensively. The present study examined whether CX3CL1/CX3CR1 signaling plays a role in spinal LTP. The results showed that 10-trains tetanic stimulation (100 Hz, 2s) of the sciatic nerve (TSS) produced a significant LTP of C-fiber-evoked field potentials lasting for over 3 h in the rat spinal dorsal horn. Blockade of CX3CL1/CX3CR1 signaling with an anti-CX3CR1 neutralizing antibody (CX3CR1 AB) markedly suppressed TSS-induced LTP. Exogenous CX3CL1 significantly potentiated 3-trains TSS-induced LTP in rats. Consistently, spinal LTP of C-fiber-evoked field potentials was also induced by TSS (100 Hz, 1s, 4 trains) in all C57BL/6 wild type (WT) mice. However, in CX3CR1-/- mice, TSS failed to induce LTP and behavioral hypersensitivity, confirming an essential role of CX3CR1 in spinal LTP induction. Furthermore, blockade of IL-18 or IL-23, the potential downstream factors of CX3CL1/CX3CR1 signaling, with IL-18 BP or anti-IL-23 neutralizing antibody (IL-23 AB), obviously suppressed spinal LTP in rats. These results suggest that CX3CL1/CX3CR1 signaling is involved in LTP of C-fiber-evoked field potentials in the rodent spinal dorsal horn.", "link"=>"http://www.mendeley.com/research/involvement-cx3cl1cx3cr1-signaling-spinal-long-term-potentiation", "reader_count"=>19, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>3, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>3, "Professor"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>4, "Neuroscience"=>6, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>6}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Spain"=>1}, "group_count"=>1}CrossRef
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Europe PMC Database Citations | Further Information
{"UNIPROT"=>4}Scopus | Further Information
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Relative Metric
{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}Loading … 

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