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Phenotypic Profiling of Scedosporium aurantiacum, an Opportunistic Pathogen Colonizing Human Lungs

Publication Date: March 26, 2015
Journal: PLOS ONE
Authors: Jashanpreet Kaur, Shu Yao Duan, Lea A. I. Vaas, Anahit Penesyan, et al
Volume: 10
Issue: 3
Pages: e0122354
DOI: https://dx.plos.org/10.1371/journal.pone.0122354
Publisher URL: http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0122354
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25811884
PubMed Central: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374879
Europe PMC: http://europepmc.org/abstract/MED/25811884
Web of Science: 000356353700186
Scopus: 84926683527
Mendeley: http://www.mendeley.com/research/phenotypic-profiling-scedosporium-aurantiacum-opportunistic-pathogen-colonizing-human-lungs

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CiteULike06 May 08:08 UTC

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Mendeley 1621 Apr 16:08 UTC

Mendeley | Further Information

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ORCID 203 May 19:48 UTC

Scopus | Further Information

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Web of Science®07 Jan 19:00 UTC

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Journal Comments22 Oct 19:12 UTC

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Figshare 11504 May 08:37 UTC

Figshare

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{"files"=>["https://ndownloader.figshare.com/files/1989268"], "description"=>"Cell biomass was calculated for all the strains grown in sucrose and turanose supplemented minimal media and plotted against the respiration rates (OmniLog units). a) 1mM sucrose; b) 1mM turanose.", "links"=>[], "tags"=>["throughput Phenotype Microarray", "acid", "Scedosporium aurantiacum", "pm", "Opportunistic Pathogen Colonizing Human Lungs Genotyping studies", "cf", "virulence", "substrate utilisation patterns", "Galleria mellonella infection model", "strain", "Phenotype microarray data"], "article_id"=>1356458, "categories"=>["Biological Sciences"], "users"=>["Jashanpreet Kaur", "Shu Yao Duan", "Lea A. I. Vaas", "Anahit Penesyan", "Wieland Meyer", "Ian T. Paulsen", "Helena Nevalainen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122354.g006", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_between_cell_growth_and_cell_respiration_for_sucrose_and_turanose_for_S_aurantiacum_at_37_C_/1356458", "title"=>"Correlation between cell growth and cell respiration for sucrose and turanose for S. aurantiacum at 37°C.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 02:53:47"}
{"files"=>["https://ndownloader.figshare.com/files/1989271"], "description"=>"Schematic overview of various metabolic pathways present in S. aurantiacum obtained after superimposition of PM data with the assembled genome.", "links"=>[], "tags"=>["throughput Phenotype Microarray", "acid", "Scedosporium aurantiacum", "pm", "Opportunistic Pathogen Colonizing Human Lungs Genotyping studies", "cf", "virulence", "substrate utilisation patterns", "Galleria mellonella infection model", "strain", "Phenotype microarray data"], "article_id"=>1356461, "categories"=>["Biological Sciences"], "users"=>["Jashanpreet Kaur", "Shu Yao Duan", "Lea A. I. Vaas", "Anahit Penesyan", "Wieland Meyer", "Ian T. Paulsen", "Helena Nevalainen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122354.g007", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_overview_of_various_metabolic_pathways_present_in_S_aurantiacum_obtained_after_superimposition_of_PM_data_with_the_assembled_genome_/1356461", "title"=>"Schematic overview of various metabolic pathways present in S. aurantiacum obtained after superimposition of PM data with the assembled genome.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 02:53:47"}
{"files"=>["https://ndownloader.figshare.com/files/1989276"], "description"=>"<div>Genotyping studies of Australian Scedosporium isolates have revealed the strong prevalence of a recently described species: Scedosporium aurantiacum. In addition to occurring in the environment, this fungus is also known to colonise the respiratory tracts of cystic fibrosis (CF) patients. A high throughput Phenotype Microarray (PM) analysis using 94 assorted substrates (sugars, amino acids, hexose-acids and carboxylic acids) was carried out for four isolates exhibiting different levels of virulence, determined using a Galleria mellonella infection model. A significant difference was observed in the substrate utilisation patterns of strains displaying differential virulence. For example, certain sugars such as sucrose (saccharose) were utilised only by low virulence strains whereas some sugar derivatives such as D-turanose promoted respiration only in the more virulent strains. Strains with a higher level of virulence also displayed flexibility and metabolic adaptability at two different temperature conditions tested (28 and 37°C). Phenotype microarray data were integrated with the whole-genome sequence data of S. aurantiacum to reconstruct a pathway map for the metabolism of selected substrates to further elucidate differences between the strains.</div>", "links"=>[], "tags"=>["throughput Phenotype Microarray", "acid", "Scedosporium aurantiacum", "pm", "Opportunistic Pathogen Colonizing Human Lungs Genotyping studies", "cf", "virulence", "substrate utilisation patterns", "Galleria mellonella infection model", "strain", "Phenotype microarray data"], "article_id"=>1356466, "categories"=>["Biological Sciences"], "users"=>["Jashanpreet Kaur", "Shu Yao Duan", "Lea A. I. Vaas", "Anahit Penesyan", "Wieland Meyer", "Ian T. Paulsen", "Helena Nevalainen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122354", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Phenotypic_Profiling_of_Scedosporium_aurantiacum_an_Opportunistic_Pathogen_Colonizing_Human_Lungs/1356466", "title"=>"Phenotypic Profiling of Scedosporium aurantiacum, an Opportunistic Pathogen Colonizing Human Lungs", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 02:53:47"}

PMC Usage Stats 69617 Jan 21:59 UTC

PMC Usage Stats | Further Information

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Relative Metric10 May 17:58 UTC

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}

F1000Prime20 Jan 13:37 UTC

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