Phenotypic Profiling of Scedosporium aurantiacum, an Opportunistic Pathogen Colonizing Human Lungs
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{"title"=>"Phenotypic profiling of Scedosporium aurantiacum, an opportunistic pathogen colonizing human lungs", "type"=>"journal", "authors"=>[{"first_name"=>"Jashanpreet", "last_name"=>"Kaur", "scopus_author_id"=>"56516181100"}, {"first_name"=>"Shu Yao", "last_name"=>"Duan", "scopus_author_id"=>"56585352500"}, {"first_name"=>"Lea A.I.", "last_name"=>"Vaas", "scopus_author_id"=>"37038632200"}, {"first_name"=>"Anahit", "last_name"=>"Penesyan", "scopus_author_id"=>"55964024000"}, {"first_name"=>"Wieland", "last_name"=>"Meyer", "scopus_author_id"=>"7401606137"}, {"first_name"=>"Ian T.", "last_name"=>"Paulsen", "scopus_author_id"=>"7006799662"}, {"first_name"=>"Helena", "last_name"=>"Nevalainen", "scopus_author_id"=>"6603919303"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"603466506", "pmid"=>"25811884", "doi"=>"10.1371/journal.pone.0122354", "scopus"=>"2-s2.0-84926683527", "issn"=>"19326203", "sgr"=>"84926683527"}, "id"=>"d29b953a-5ebd-3637-81dd-1455e7884585", "abstract"=>"Genotyping studies of Australian Scedosporium isolates have revealed the strong prevalence of a recently described species: Scedosporium aurantiacum. In addition to occurring in the environment, this fungus is also known to colonise the respiratory tracts of cystic fibrosis (CF) patients. A high throughput Phenotype Microarray (PM) analysis using 94 assorted substrates (sugars, amino acids, hexose-acids and carboxylic acids) was carried out for four isolates exhibiting different levels of virulence, determined using a Galleria mellonella infection model. A significant difference was observed in the substrate utilisation patterns of strains displaying differential virulence. For example, certain sugars such as sucrose (saccharose) were utilised only by low virulence strains whereas some sugar derivatives such as D-turanose promoted respiration only in the more virulent strains. Strains with a higher level of virulence also displayed flexibility and metabolic adaptability at two different temperature conditions tested (28 and 37 degrees C). Phenotype microarray data were integrated with the whole-genome sequence data of S. aurantiacum to reconstruct a pathway map for the metabolism of selected substrates to further elucidate differences between the strains.", "link"=>"http://www.mendeley.com/research/phenotypic-profiling-scedosporium-aurantiacum-opportunistic-pathogen-colonizing-human-lungs", "reader_count"=>14, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Researcher"=>3, "Other"=>1, "Student > Master"=>3, "Student > Bachelor"=>1, "Lecturer"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Researcher"=>3, "Other"=>1, "Student > Master"=>3, "Student > Bachelor"=>1, "Lecturer"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Environmental Science"=>1, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Spain"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1989257"], "description"=>"<p>Colony morphology of the four different strains of <i>S</i>. <i>aurantiacum</i> growing on Sabouraud dextrose agar plates after 14 days of incubation.</p>", "links"=>[], "tags"=>["throughput Phenotype Microarray", "acid", "Scedosporium aurantiacum", "pm", "Opportunistic Pathogen Colonizing Human Lungs Genotyping studies", "cf", "virulence", "substrate utilisation patterns", "Galleria mellonella infection model", "strain", "Phenotype microarray data"], "article_id"=>1356448, "categories"=>["Biological Sciences"], "users"=>["Jashanpreet Kaur", "Shu Yao Duan", "Lea A. I. Vaas", "Anahit Penesyan", "Wieland Meyer", "Ian T. Paulsen", "Helena Nevalainen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122354.g001", "stats"=>{"downloads"=>1, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Colony_morphology_of_the_four_different_strains_of_S_aurantiacum_growing_on_Sabouraud_dextrose_agar_plates_after_14_days_of_incubation_/1356448", "title"=>"Colony morphology of the four different strains of <i>S</i>. <i>aurantiacum</i> growing on Sabouraud dextrose agar plates after 14 days of incubation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 02:53:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1989260"], "description"=>"<p><b>A) WM 06.482, B) WM 08.202, C) WM 09.24 and D) WM 10.136.</b> Each experiment was repeated in triplicate, with bars representing ±1.25 standard errors, and 95% confidence interval.</p>", "links"=>[], "tags"=>["throughput Phenotype Microarray", "acid", "Scedosporium aurantiacum", "pm", "Opportunistic Pathogen Colonizing Human Lungs Genotyping studies", "cf", "virulence", "substrate utilisation patterns", "Galleria mellonella infection model", "strain", "Phenotype microarray data"], "article_id"=>1356450, "categories"=>["Biological Sciences"], "users"=>["Jashanpreet Kaur", "Shu Yao Duan", "Lea A. I. Vaas", "Anahit Penesyan", "Wieland Meyer", "Ian T. Paulsen", "Helena Nevalainen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122354.g002", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Growth_of_the_S_aurantiacum_strains_in_liquid_culture_in_Sabouraud_s_broth_measured_as_change_in_the_mycelial_dry_weight_mg_ml_over_time_/1356450", "title"=>"Growth of the <i>S</i>. <i>aurantiacum</i> strains in liquid culture in Sabouraud’s broth, measured as change in the mycelial dry weight (mg/ml) over time.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 02:53:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1989262"], "description"=>"<p>Survival of <i>G</i>. <i>mellonella</i> larvae infected with different strains of <i>S</i>. <i>aurantiacum</i>.</p>", "links"=>[], "tags"=>["throughput Phenotype Microarray", "acid", "Scedosporium aurantiacum", "pm", "Opportunistic Pathogen Colonizing Human Lungs Genotyping studies", "cf", "virulence", "substrate utilisation patterns", "Galleria mellonella infection model", "strain", "Phenotype microarray data"], "article_id"=>1356452, "categories"=>["Biological Sciences"], "users"=>["Jashanpreet Kaur", "Shu Yao Duan", "Lea A. I. Vaas", "Anahit Penesyan", "Wieland Meyer", "Ian T. Paulsen", "Helena Nevalainen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122354.g003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Survival_of_G_mellonella_larvae_infected_with_different_strains_of_S_aurantiacum_/1356452", "title"=>"Survival of <i>G</i>. <i>mellonella</i> larvae infected with different strains of <i>S</i>. <i>aurantiacum</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 02:53:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1989264"], "description"=>"<p>OmniLog units with a minimum value of 100 depict a positive phenotype.</p>", "links"=>[], "tags"=>["throughput Phenotype Microarray", "acid", "Scedosporium aurantiacum", "pm", "Opportunistic Pathogen Colonizing Human Lungs Genotyping studies", "cf", "virulence", "substrate utilisation patterns", "Galleria mellonella infection model", "strain", "Phenotype microarray data"], "article_id"=>1356454, "categories"=>["Biological Sciences"], "users"=>["Jashanpreet Kaur", "Shu Yao Duan", "Lea A. I. Vaas", "Anahit Penesyan", "Wieland Meyer", "Ian T. Paulsen", "Helena Nevalainen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122354.g004", "stats"=>{"downloads"=>1, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Different_sugar_utilization_patterns_of_low_and_high_virulent_strains_/1356454", "title"=>"Different sugar utilization patterns of low and high virulent strains.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 02:53:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1989265"], "description"=>"<p>A different pattern is assigned to each strain as shown in the key below. The graphs clearly distinguish between the growth patterns of high and low virulent strains on selected carbon sources at both temperatures. (Weight of the inoculum was 10 mg/ml. Therefore biomass value above this limit was considered as significant growth). Each experiment was repeated in triplicate, with bars representing ±1.25 standard errors, and 95% confidence interval.</p>", "links"=>[], "tags"=>["throughput Phenotype Microarray", "acid", "Scedosporium aurantiacum", "pm", "Opportunistic Pathogen Colonizing Human Lungs Genotyping studies", "cf", "virulence", "substrate utilisation patterns", "Galleria mellonella infection model", "strain", "Phenotype microarray data"], "article_id"=>1356455, "categories"=>["Biological Sciences"], "users"=>["Jashanpreet Kaur", "Shu Yao Duan", "Lea A. I. Vaas", "Anahit Penesyan", "Wieland Meyer", "Ian T. Paulsen", "Helena Nevalainen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122354.g005", "stats"=>{"downloads"=>2, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relative_growth_of_S_aurantiacum_in_minimal_medium_with_different_carbon_sources_measured_as_average_dry_weight_of_mycelia_at_a_28_C_and_b_37_C_/1356455", "title"=>"Relative growth of <i>S</i>. <i>aurantiacum</i> in minimal medium with different carbon sources, measured as average dry weight of mycelia at a) 28°C and b) 37°C.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 02:53:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1989268"], "description"=>"<p>Cell biomass was calculated for all the strains grown in sucrose and turanose supplemented minimal media and plotted against the respiration rates (OmniLog units). a) 1mM sucrose; b) 1mM turanose.</p>", "links"=>[], "tags"=>["throughput Phenotype Microarray", "acid", "Scedosporium aurantiacum", "pm", "Opportunistic Pathogen Colonizing Human Lungs Genotyping studies", "cf", "virulence", "substrate utilisation patterns", "Galleria mellonella infection model", "strain", "Phenotype microarray data"], "article_id"=>1356458, "categories"=>["Biological Sciences"], "users"=>["Jashanpreet Kaur", "Shu Yao Duan", "Lea A. I. Vaas", "Anahit Penesyan", "Wieland Meyer", "Ian T. Paulsen", "Helena Nevalainen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122354.g006", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_between_cell_growth_and_cell_respiration_for_sucrose_and_turanose_for_S_aurantiacum_at_37_C_/1356458", "title"=>"Correlation between cell growth and cell respiration for sucrose and turanose for <i>S</i>. <i>aurantiacum</i> at 37°C.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 02:53:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1989271"], "description"=>"<p>Schematic overview of various metabolic pathways present in <i>S</i>. <i>aurantiacum</i> obtained after superimposition of PM data with the assembled genome.</p>", "links"=>[], "tags"=>["throughput Phenotype Microarray", "acid", "Scedosporium aurantiacum", "pm", "Opportunistic Pathogen Colonizing Human Lungs Genotyping studies", "cf", "virulence", "substrate utilisation patterns", "Galleria mellonella infection model", "strain", "Phenotype microarray data"], "article_id"=>1356461, "categories"=>["Biological Sciences"], "users"=>["Jashanpreet Kaur", "Shu Yao Duan", "Lea A. I. Vaas", "Anahit Penesyan", "Wieland Meyer", "Ian T. Paulsen", "Helena Nevalainen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122354.g007", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_overview_of_various_metabolic_pathways_present_in_S_aurantiacum_obtained_after_superimposition_of_PM_data_with_the_assembled_genome_/1356461", "title"=>"Schematic overview of various metabolic pathways present in <i>S</i>. <i>aurantiacum</i> obtained after superimposition of PM data with the assembled genome.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 02:53:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1989276"], "description"=>"<div><p>Genotyping studies of Australian <i>Scedosporium</i> isolates have revealed the strong prevalence of a recently described species: <i>Scedosporium aurantiacum</i>. In addition to occurring in the environment, this fungus is also known to colonise the respiratory tracts of cystic fibrosis (CF) patients. A high throughput Phenotype Microarray (PM) analysis using 94 assorted substrates (sugars, amino acids, hexose-acids and carboxylic acids) was carried out for four isolates exhibiting different levels of virulence, determined using a <i>Galleria mellonella</i> infection model. A significant difference was observed in the substrate utilisation patterns of strains displaying differential virulence. For example, certain sugars such as sucrose (saccharose) were utilised only by low virulence strains whereas some sugar derivatives such as D-turanose promoted respiration only in the more virulent strains. Strains with a higher level of virulence also displayed flexibility and metabolic adaptability at two different temperature conditions tested (28 and 37°C). Phenotype microarray data were integrated with the whole-genome sequence data of <i>S</i>. <i>aurantiacum</i> to reconstruct a pathway map for the metabolism of selected substrates to further elucidate differences between the strains.</p></div>", "links"=>[], "tags"=>["throughput Phenotype Microarray", "acid", "Scedosporium aurantiacum", "pm", "Opportunistic Pathogen Colonizing Human Lungs Genotyping studies", "cf", "virulence", "substrate utilisation patterns", "Galleria mellonella infection model", "strain", "Phenotype microarray data"], "article_id"=>1356466, "categories"=>["Biological Sciences"], "users"=>["Jashanpreet Kaur", "Shu Yao Duan", "Lea A. I. Vaas", "Anahit Penesyan", "Wieland Meyer", "Ian T. Paulsen", "Helena Nevalainen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122354", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Phenotypic_Profiling_of_Scedosporium_aurantiacum_an_Opportunistic_Pathogen_Colonizing_Human_Lungs/1356466", "title"=>"Phenotypic Profiling of <i>Scedosporium aurantiacum</i>, an Opportunistic Pathogen Colonizing Human Lungs", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 02:53:47"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"25", "full-text"=>"21", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
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  • {"unique-ip"=>"22", "full-text"=>"18", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
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  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
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  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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