Two Urinary Peptides Associated Closely With Type 2 Diabetes Mellitus
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{"title"=>"Two urinary peptides associated closely with type 2 diabetes mellitus", "type"=>"journal", "authors"=>[{"first_name"=>"Man", "last_name"=>"Zhang", "scopus_author_id"=>"55497114000"}, {"first_name"=>"Guangzhen", "last_name"=>"Fu", "scopus_author_id"=>"55758044400"}, {"first_name"=>"Ting", "last_name"=>"Lei", "scopus_author_id"=>"55654234300"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"604612826", "doi"=>"10.1371/journal.pone.0122950", "sgr"=>"84930638985", "scopus"=>"2-s2.0-84930638985", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"25902048"}, "id"=>"cf84c3b1-6cee-395d-acaa-53a640f3aca9", "abstract"=>"OBJECTIVE: To monitor of type 2 diabetes more simply, conveniently and noninvasively, we are trying to identify the potential urinary peptides that associated with different stages of glucose control in type 2 diabetes mellitus.\\n\\nMETHODS: Firstly, we collected urine samples from type 2 diabetic patients and normal controls. These type 2 diabetic patients were divided into two groups according to fasting plasma glucose (FPG) and hemoglobin A1c% (HbA1c), respectively. Magnetic beads based weak cation exchange chromatography (MB-WCX) was used to condense urinary peptides. The eluates were then analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). Subsequently, ClinProt was used to profile and screen the polypeptide patterns based on different methods of grouping in diabetic patients and normal controls. Finally, the amino acid sequences of differentially expressed peptides were identified by nano-liquid chromatography-tandem mass spectrometry and the protein sources of the corresponding peptide were matched in IPI Human database.\\n\\nRESULTS: Proteomics analysis found two up-regulated peptide (m/z 2756.1 and m/z 3223.2) representations in diabetic subjects, and the two peptides increased with increases in the amount of glycosylated hemoglobin. Further, the parallelism between m/z 3223.2 and glycosylated hemoglobin was better than the parallelism between m/z 2756.1 and glycosylated hemoglobin. Area under the receiver operating characteristic of the two peptides was 0.722 and 0.661, respectively. The above-mentioned peptide m/z 2756.1 was further identified as fragment of fibrinogen alpha chain precursor and m/z 3223.2 was fragment of prothrombin precursor.\\n\\nCONCLUSION: These results suggested the two urinary biomarkers enable monitor of type 2 diabetes patients with different stages of glucose control.", "link"=>"http://www.mendeley.com/research/two-urinary-peptides-associated-closely-type-2-diabetes-mellitus", "reader_count"=>12, "reader_count_by_academic_status"=>{"Librarian"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>4, "Student > Bachelor"=>2, "Student > Postgraduate"=>1}, "reader_count_by_user_role"=>{"Librarian"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>4, "Student > Bachelor"=>2, "Student > Postgraduate"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>5, "Chemistry"=>3, "Computer Science"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Chemistry"=>{"Chemistry"=>3}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Canada"=>1, "Portugal"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2035597"], "description"=>"<p>(A) The distribution of the average peak area from the three groups and arrows indicating peaks that had statistically significant difference among three groups (p<0.05). (B) The peak area distributions of m/z 2756.1and m/z 3223.2 in all samples. Throughout comparison between two groups of the three, m/z 2756.1 and m/z 3223.2 had no significant difference (p>0.05) between GM1 and GM2.</p>", "links"=>[], "tags"=>["peptide", "fasting plasma glucose", "glucose control", "type 2", "prothrombin precursor.ConclusionThese results", "2756.1", "type 2 diabetes", "Type 2 Diabetes Patients", "Urinary Peptides Associated", "IPI Human database.ResultsProteomics analysis", "cation exchange chromatography", "Type 2 Diabetes Mellitus ObjectiveTo", "glycosylated hemoglobin", "type 2 diabetes mellitus.MethodsFirstly", "fpg"], "article_id"=>1391258, "categories"=>["Biological Sciences"], "users"=>["Man Zhang", "Guangzhen Fu", "Ting Lei"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122950.g001", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analysis_and_comparison_of_urinary_peptide_peaks_based_on_fasting_plasma_glucose_of_type_2_diabetes_mellitus_/1391258", "title"=>"Analysis and comparison of urinary peptide peaks based on fasting plasma glucose of type 2 diabetes mellitus.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-22 03:39:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2035598"], "description"=>"<p>(A) The distribution of average peak area from the three groups and arrows indicate peaks that had significant difference among the three groups (p<0.05). (B) The peak area distributions of m/z 2756.1and m/z 3223.2 in all samples. Throughout comparison between two groups of the three, m/z 2756.1 and m/z 3223.2 had significant difference (p<0.05).</p>", "links"=>[], "tags"=>["peptide", "fasting plasma glucose", "glucose control", "type 2", "prothrombin precursor.ConclusionThese results", "2756.1", "type 2 diabetes", "Type 2 Diabetes Patients", "Urinary Peptides Associated", "IPI Human database.ResultsProteomics analysis", "cation exchange chromatography", "Type 2 Diabetes Mellitus ObjectiveTo", "glycosylated hemoglobin", "type 2 diabetes mellitus.MethodsFirstly", "fpg"], "article_id"=>1391259, "categories"=>["Biological Sciences"], "users"=>["Man Zhang", "Guangzhen Fu", "Ting Lei"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122950.g002", "stats"=>{"downloads"=>0, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analysis_and_comparison_of_urinary_peptide_peaks_based_on_glycosylated_haemoglobin_A1c_of_type_2_diabetes_mellitus_/1391259", "title"=>"Analysis and comparison of urinary peptide peaks based on glycosylated haemoglobin A1c of type 2 diabetes mellitus.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-22 03:39:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2035600"], "description"=>"<p>(A) Association between m/z 2756.1, m/z 3223.2 and fasting plasma glucose. (B) Association between m/z 2756.1, m/z 3223.2 and glycosylated haemoglobin A1c.</p>", "links"=>[], "tags"=>["peptide", "fasting plasma glucose", "glucose control", "type 2", "prothrombin precursor.ConclusionThese results", "2756.1", "type 2 diabetes", "Type 2 Diabetes Patients", "Urinary Peptides Associated", "IPI Human database.ResultsProteomics analysis", "cation exchange chromatography", "Type 2 Diabetes Mellitus ObjectiveTo", "glycosylated hemoglobin", "type 2 diabetes mellitus.MethodsFirstly", "fpg"], "article_id"=>1391261, "categories"=>["Biological Sciences"], "users"=>["Man Zhang", "Guangzhen Fu", "Ting Lei"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122950.g003", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_changes_trend_between_the_differently_expressed_peaks_and_glycemic_control_/1391261", "title"=>"The changes trend between the differently expressed peaks and glycemic control.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-22 03:39:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2035601"], "description"=>"<p>Receiver operated curve (ROC) and area under the curve (AUC) of the two urinary peptides based on glycosylated haemoglobin A1c of type 2 diabetes mellitus.</p>", "links"=>[], "tags"=>["peptide", "fasting plasma glucose", "glucose control", "type 2", "prothrombin precursor.ConclusionThese results", "2756.1", "type 2 diabetes", "Type 2 Diabetes Patients", "Urinary Peptides Associated", "IPI Human database.ResultsProteomics analysis", "cation exchange chromatography", "Type 2 Diabetes Mellitus ObjectiveTo", "glycosylated hemoglobin", "type 2 diabetes mellitus.MethodsFirstly", "fpg"], "article_id"=>1391262, "categories"=>["Biological Sciences"], "users"=>["Man Zhang", "Guangzhen Fu", "Ting Lei"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122950.g004", "stats"=>{"downloads"=>3, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Receiver_operated_curve_ROC_and_area_under_the_curve_AUC_of_the_two_urinary_peptides_based_on_glycosylated_haemoglobin_A1c_of_type_2_diabetes_mellitus_/1391262", "title"=>"Receiver operated curve (ROC) and area under the curve (AUC) of the two urinary peptides based on glycosylated haemoglobin A1c of type 2 diabetes mellitus.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-22 03:39:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2035602"], "description"=>"<p>Identified peptides sequences of two elevated peaks.</p>", "links"=>[], "tags"=>["peptide", "fasting plasma glucose", "glucose control", "type 2", "prothrombin precursor.ConclusionThese results", "2756.1", "type 2 diabetes", "Type 2 Diabetes Patients", "Urinary Peptides Associated", "IPI Human database.ResultsProteomics analysis", "cation exchange chromatography", "Type 2 Diabetes Mellitus ObjectiveTo", "glycosylated hemoglobin", "type 2 diabetes mellitus.MethodsFirstly", "fpg"], "article_id"=>1391263, "categories"=>["Biological Sciences"], "users"=>["Man Zhang", "Guangzhen Fu", "Ting Lei"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122950.t002", "stats"=>{"downloads"=>3, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Identified_peptides_sequences_of_two_elevated_peaks_/1391263", "title"=>"Identified peptides sequences of two elevated peaks.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-04-22 03:39:31"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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