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{"title"=>"Proton pump inhibitor usage and the risk of myocardial infarction in the general population", "type"=>"journal", "authors"=>[{"first_name"=>"Nigam H.", "last_name"=>"Shah", "scopus_author_id"=>"7401823709"}, {"first_name"=>"Paea", "last_name"=>"LePendu", "scopus_author_id"=>"13605247200"}, {"first_name"=>"Anna", "last_name"=>"Bauer-Mehren", "scopus_author_id"=>"35572639000"}, {"first_name"=>"Yohannes T.", "last_name"=>"Ghebremariam", "scopus_author_id"=>"10639679600"}, {"first_name"=>"Srinivasan V.", "last_name"=>"Iyer", "scopus_author_id"=>"55643743800"}, {"first_name"=>"Jake", "last_name"=>"Marcus", "scopus_author_id"=>"56715021900"}, {"first_name"=>"Kevin T.", "last_name"=>"Nead", "scopus_author_id"=>"24339007700"}, {"first_name"=>"John P.", "last_name"=>"Cooke", "scopus_author_id"=>"7202378672"}, {"first_name"=>"Nicholas J.", "last_name"=>"Leeper", "scopus_author_id"=>"55882699900"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84936774522", "pmid"=>"26061035", "pui"=>"605092304", "issn"=>"19326203", "isbn"=>"1932-6203", "scopus"=>"2-s2.0-84936774522", "doi"=>"10.1371/journal.pone.0124653"}, "id"=>"98dbc1d9-2244-3509-af8b-25837b85d700", "abstract"=>"BACKGROUND AND AIMS Proton pump inhibitors (PPIs) have been associated with adverse clinical outcomes amongst clopidogrel users after an acute coronary syndrome. Recent pre-clinical results suggest that this risk might extend to subjects without any prior history of cardiovascular disease. We explore this potential risk in the general population via data-mining approaches. METHODS Using a novel approach for mining clinical data for pharmacovigilance, we queried over 16 million clinical documents on 2.9 million individuals to examine whether PPI usage was associated with cardiovascular risk in the general population. RESULTS In multiple data sources, we found gastroesophageal reflux disease (GERD) patients exposed to PPIs to have a 1.16 fold increased association (95% CI 1.09-1.24) with myocardial infarction (MI). Survival analysis in a prospective cohort found a two-fold (HR = 2.00; 95% CI 1.07-3.78; P = 0.031) increase in association with cardiovascular mortality. We found that this association exists regardless of clopidogrel use. We also found that H2 blockers, an alternate treatment for GERD, were not associated with increased cardiovascular risk; had they been in place, such pharmacovigilance algorithms could have flagged this risk as early as the year 2000. CONCLUSIONS Consistent with our pre-clinical findings that PPIs may adversely impact vascular function, our data-mining study supports the association of PPI exposure with risk for MI in the general population. These data provide an example of how a combination of experimental studies and data-mining approaches can be applied to prioritize drug safety signals for further investigation.", "link"=>"http://www.mendeley.com/research/proton-pump-inhibitor-usage-risk-myocardial-infarction-general-population", "reader_count"=>149, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>9, "Librarian"=>1, "Researcher"=>29, "Student > Doctoral Student"=>13, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>14, "Other"=>28, "Student > Master"=>12, "Student > Bachelor"=>16, "Lecturer"=>5, "Professor"=>7}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>9, "Librarian"=>1, "Researcher"=>29, "Student > Doctoral Student"=>13, "Student > Ph. D. 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Article Coverage Curated

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Journal Comments | Further Information

• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/eff6d71c-6a5a-418b-8c8c-6c5558a0dd24", "title"=>"Obstructive sleep apnea as the PPI-ACS connection", "body"=>"I would suggest that the modest link between coronary disease and use of proton pump inhibitors is explained by obstructive sleep apnea (OSA). OSA is well known to cause gastro-esophageal reflux, hence PPI use. And OSA is strongly linked to obesity and hypertension, both of which are coronary risk factors and, at higher severity, to coronary disease itself.", "isRemoved"=>false, "created"=>"2015-06-11T07:34:27Z", "lastModified"=>"2015-06-11T07:34:27Z", "creator"=>{"userId"=>"510469"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0124653", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2015-06-11T07:34:27Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/07b84b69-7b0b-44d7-b767-ee38b2fb94d7", "title"=>"Reverse causality may have play a role", "body"=>"Given the uncertainties regarding time periods of exposure before the event and regarding the accuracy of the diagnosis of gastroesophageal reflux, the effect of a protopathic bias (reverse causality) cannot be neglected. Indeed, PPI could have been prescribed for symptoms of angor or early symptoms of myocardial infarction which have been taken as a gastroesophageal reflux. This potential bias could have contributed to the association between PPI use and myocardial infarction.", "isRemoved"=>false, "created"=>"2015-06-15T08:03:09Z", "lastModified"=>"2015-06-15T08:03:09Z", "creator"=>{"userId"=>"510881"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0124653", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>1, "mostRecentActivity"=>"2015-06-15T10:47:15Z", "replies"=>[{"type"=>"REPLY", "parentID"=>86469, "annotationUri"=>"info:doi/10.1371/reply/bf4cfc20-a7cc-46d2-a16d-cdd1558ab22f", "title"=>"RE: Reverse causality may have play a role", "body"=>"The authors address that idea in the limitations section in the Discussion: \"it may be that in some individuals PPIs were prescribed for angina that was misidentified as acid reflux. However, the observation that alternative heartburn medications such as H2 blockers were not associated with harm lends support to the concept that PPIs may specifically promote risk.\"\nhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124653#sec021\n\nThe idea that PPI use could be due to misdiagnosis of myocardial infarction was the conclusion of another recent study: \"the previously reported increase in risk of adverse cardiac events in patients using PPIs may reflect the fact that an AMI may be misinterpreted as dyspepsia.\"\nAleksandra Turkiewicz, Raquel Perez Vicente, Henrik Ohlsson, Patrik Tyden, Juan Merlo: Revising the link between proton-pump inhibitors and risk of acute myocardial infarction—a case-crossover analysis. European Journal of Clinical Pharmacology January 2015, Volume 71, Issue 1, pp 125-129 http://link.springer.com/article/10.1007%2Fs00228-014-1779-6\n ", "isRemoved"=>false, "created"=>"2015-06-15T10:47:15Z", "lastModified"=>"2015-06-15T10:47:15Z", "creator"=>{"userId"=>"138353"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"I am a PLOS ONE staff Senior Editor"}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0124653", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2015-06-15T10:47:15Z", "replies"=>[]}]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/115c0d21-1ab7-4d30-864b-7b610f2e34d7", "title"=>"Proton pump inhibitors and cardiovascular risk: unrevealed role of Magnesium?", "body"=>"It is very interesting the article of Shah NH et al[1] describing an association of proton pump inhibitors (PPIs) with increased myocardial infarction (MI) risk in the general population. The authors discussed that this effect may be due to an inhibitory effect of PPI on dimethylaminohydrolase (DDAH) activity, an enzyme which metabolizes asymmetric dimethylarginine (ADMA), an inhibitor of nitric oxide synthase. The increase in ADMA observed in experimental studies resulting in dysregulation of vascular NOS may be a possible mechanism for MI risk.[2]\n\nHowever, previous studies demonstrated the linkage between PPIs and hypomagnesemia.[3,4] Some case reports have show severe hypomagnesemia in individuals taking PPIs.[5-7] In 2011, the US Food and Drug Administration (FDA) released a drug safety communication warning clinicians about the risk of hypomanesemia following long term use of PPIs. Following the FDA warning, Danziger et al. published a large cohort study supporting the evidence of PPI-induced hypomagnesemia in ICU patients.[8] \n\nMagnesium is the second most common intracellular cation. Although its fundamental role in several important cell function and reactions, it has been seen as the forgotten cation over the years. Severe hypomagnesemia may induce convulsions, cardiac arrhythmias and death. It has been also shown that even mild hypomagnesemia has deleterious clinical consequences, such as hypertension, left ventricular hypertrophy, endothelial dysfunction and insulin resistance.[9-12] Reffelmann et al. demonstrated in over 4000 subjects that hypomagnesemia was associated with higher cardiovascular and all-cause mortality.[12]\n\nMagnesium homeostasis is determined by gastrointestinal absorption and renal excretion of magnesium.[13] Basically, gastrointestinal absorption of magnesium occurs by passive paracellular and active transport. Magnesium channels located in the apical membrane of enterocytes (transient receptor potential melastatin-6 and -7, TRPM6/7) have been held responsible for active transcellular transport. Althought the mechanisms of PPI-induced hypomagnesemia are not completely clear, it has been postulated that PPI impairs TRPM-6 and -7 intestinal absorption by decreasing intraluminal pH and, consequently, reducing the affinity of these channels for Mg++.[13,14] \n\nThus, we believe that hypomagnesemia might be another important mechanism involved in the association of PPI use and MI. It would be very interesting, if the authors could evaluate serum magnesium levels in patients with MI using PPI in order to reveal its role in this association.\n\n1 Shah NH, LePendu P, Bauer-Mehren A, Ghebremariam YT, Iyer SV, Marcus J, Nead KT, Cooke JP, Leeper NJ.: Proton pump inhibitor usage and the risk of myocardial infarction in the general population. PLoS One. 2015; 10(6): e0124653. \n2 Ghebremariam YT, LePendu P, Lee JC, Erlanson DA, Slaviero A, Shah NH, Leiper J, Cooke JP.: Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine. Circulation. 2013; 128(8): 845-53.\n3 Famularo G, Gasbarrone L, Minisola G: Hypomagnesemia and proton-pump inhibitors. Expert Opin Drug Saf. 2013; 12(5): 709-16.\n4 Markovits N, Loebstein R, Halkin H, Bialik M, Landes-Westerman J, Lomnicky J, Kurnik D. The association of proton pump inhibitors and hypomagnesemia in the community setting. J Clin Pharmacol. 2014; 54(8): 889-95.\n5.Shabajee N, Lamb EJ, Sturgess I et al. Omeprazole and refractory hypomagnesaemia. BMJ. 2008; 337: a425.\n6.Cundy T, Dissanayake A. Severe hypomagnesaemia in long-term users of proton-pump inhibitors. Clin Endocrinol (Oxf) 2008; 69: 338–341.\n7.Hoorn EJ, van der Hoek J, de Man RA et al. A case series of proton pump inhibitor-induced hypomagnesemia. Am J Kidney Dis 2010; 56: 112–116. \n8. Danziger J, William JH, Scott DJ et al. Proton-pump inhibitor use is associated with low serum magnesium concentrations. Kidney International. 2013; 83: 692–699.\n9. Sontia B, Touyz RM. Role of magnesium in hypertension. Arch Biochem Biophys. 2007; 458: 33–39.\n10. Barbagallo M, Dominguez LJ. Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance. Arch Biochem Biophys. 2007; 458: 40–47. \n11. Barbagallo M, Dominguez LJ, Galioto A et al. Oral magnesium supplementation improves vascular function in elderly diabetic patients. Magnes Res 2010; 23: 131–137.\n12. Reffelmann T, Ittermann T, Dorr M et al. Low serum magnesium concentrations predict cardiovascular and all-cause mortality. Atherosclerosis 2011; 219: 280–284. \n13. Perazella MA. Proton pump inhibitors and hypomagnesemia: a rare but serious complication. Kidney International (2013) 83, 553–556.\n14. Rondón LJ, Tiel Groenestege WM, Rayssiguier Y, Mazur A. Relationship between low magnesium status and TRPM6 expression in the kidney and large intestine. Am J Physiol Regul Integr Comp Physiol. 2008; 294: R2001–R2007. \n\n\nPedro Henrique França Gois MD, PhD\nAntonio Carlos Seguro MD, PhD ( Academic Editor PLoS One)\n\nLaboratory Investigation (LIM12) Clinical Hospital, Faculty of Medicine of University of São Paulo, Brazil.\n \n", "isRemoved"=>false, "created"=>"2015-06-17T19:01:41Z", "lastModified"=>"2015-06-17T19:01:41Z", "creator"=>{"userId"=>"174237"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0124653", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2015-06-17T19:01:41Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/a1041dee-f3e3-48cb-9e1f-9a68ecb272f4", "title"=>"Definition of study groups", "body"=>"The methodology used is quite interesting and, though causation is not ascertained, makes a remarkably strong case in favour of the authors' hypothesis. \n\nHowever, the study groups appear unclearly defined (unless I missed something), in particular regarding polytherapy: is it possible patients in the PPI group were also treated with H2 blockers (prior or during PPI therapy) and conversely could H2 blockers patients also have been prescribed PPI in the past or during their defining prescription? \nIf PPI patients include patients previously (or currently) treated by H2B, the association that is identified could also be linked to patients' clinical profile (hard to adequately describe in healthcare databases). \n\nAnd also, what of potential immeasurable time bias (http://aje.oxfordjournals.org/content/168/3/329.full)? Would it be possible patients with MI have higher hospitalisation rate which would in fact account for the MI rates rather than PPI prescriptions? Have hospitalisation rates between groups been measured? In particular in specific wards?", "isRemoved"=>false, "created"=>"2015-06-18T19:34:27Z", "lastModified"=>"2015-06-18T19:34:27Z", "creator"=>{"userId"=>"511424"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0124653", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>2, "mostRecentActivity"=>"2015-06-20T10:26:41Z", "replies"=>[{"type"=>"REPLY", "parentID"=>86499, "annotationUri"=>"info:doi/10.1371/reply/0b76d88a-8751-4b3e-b2a8-2a02f9f1ec00", "title"=>"RE: Definition of study groups", "body"=>"The patients are not concurrently on PPIs and H2B drugs based on the data we have, however prior usage of H2B can not be ruled out because they are over the counter drugs, and given the data-mining approach, we did not have a way of determining that. Concurrent, undocumented use can also not be ruled out. The exposed and non-exposed patients are matched for their number of co-morbidities and number of unique drugs to account fot their clinical profile. Again, given the nature of the data, that is the best approximation of their clinical profile that does not need manual review.\n\nOn the point of higher hospitalizations, that could affect the Stanford data, but the Practice Fusion data is from out patient clinics, which are unlikely to be affected by that. We did not compare hospitalization rates.\n\nOur analysis is not a classical epidemiological study. As noted in the methods, in a data-mining mindset, we focus on learning a valid function f(x)—which is modeled as an algorithm that operates on variables (x) to predict the responses (y). The linking function f(x) in a data-mining study can be a regression, but cannot, and should not, be interpreted as a causal regression model. The way to assess the association is via discrimination ability, which was determined using a gold standard set of 28 true positive and 165 negative associations spanning 78 drugs and 12 different outcomes, and was estimated to have 97.5% specificity and 39% sensitivity in discerning a true association from a false one. For the association between the different PPIs and myocardial infarction, in the population of people with acid reflux, when we obtain association of > 1, in two separate datasets and H2 blockers do not, that supports our hypothesis (particularly, given the mechanism). \n\nFinally, as we note, the absolute effect size is small (as reported by http://www.ncbi.nlm.nih.gov/pubmed/25499395).", "isRemoved"=>false, "created"=>"2015-06-20T00:09:26Z", "lastModified"=>"2015-06-20T00:09:26Z", "creator"=>{"userId"=>"495062"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0124653", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>1, "mostRecentActivity"=>"2015-06-20T10:26:41Z", "replies"=>[{"type"=>"REPLY", "parentID"=>86508, "annotationUri"=>"info:doi/10.1371/reply/f59c7728-74cd-419b-a0c8-9210137d219a", "title"=>"RE: RE: Definition of study groups", "body"=>"Thank you for your answer.", "isRemoved"=>false, "created"=>"2015-06-20T10:26:41Z", "lastModified"=>"2015-06-20T10:26:41Z", "creator"=>{"userId"=>"511424"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0124653", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2015-06-20T10:26:41Z", "replies"=>[]}]}]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/ef9a352d-080f-46c7-9183-79050003b0af", "title"=>"ASA as a possible confounding factor", "body"=>"This study, through a mining methodology, shows in patients with gastroesophageal reflux disease (GERD) a positive association between risk of myocardial infarction and the proton pump inhibitors (PPI), unlike the H2-blockers. However, the PPI are the drugs far also used for the prevention of the gastric damage by NSAIDS, including acetylsalicylic acid (ASA), showing a clinical superiority in this field with respect to the H2-blockers. For this reason, in patients with GERD and ischemic heart disease requiring of ASA (and then to be considered at greater cardiovascular risk), doctors might have preferred the PPI compared to H2-blockers by creating a selection bias. In the study, while it is assessed the possible effect of the patients assuming clopidogrel, is not mentioned and specified the role of the concurrent use of ASA. It is relevant to observe that the possible selection bias due to the clopidogrel might be attenuated from the evaluation of the pharmacological interference of PPI on clopidogrel that might have induced the prescription of H2-blockers, allowing an almost equal distribution of the clopidogrel in the patients treated with PPI or H2-blockers. I think that an analysis of the concomitant prescription of ASA in GERD patients is essential for proper clinical evaluation of the data emerging from this study", "isRemoved"=>false, "created"=>"2015-07-04T07:33:13Z", "lastModified"=>"2015-07-04T07:33:13Z", "creator"=>{"userId"=>"513282"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0124653", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2015-07-04T07:33:13Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/c604b3e3-b87f-4a27-84f5-f5f9b9b620bd", "title"=>"Expand on Study Group Populations", "body"=>"Hello there, I am putting a presentation together using this study and there was one piece that I found confusing. If further clarification could be made, that would be greatly appreciated. \n\nIn Table 1 there is the population size on PPIs (32,363) for this study and then it is broken down into the five main PPIs and the number of people who were on them. Those numbers don't add up to 32,363. Even if dexlansoprazole were included in this number, it still doesn't add up. Is there something I'm not seeing that gets that number to 32,363? I have the same question for Table 4. ", "isRemoved"=>false, "created"=>"2015-07-21T05:33:27Z", "lastModified"=>"2015-07-21T05:33:27Z", "creator"=>{"userId"=>"515240"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0124653", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>1, "mostRecentActivity"=>"2015-07-21T16:41:02Z", "replies"=>[{"type"=>"REPLY", "parentID"=>86726, "annotationUri"=>"info:doi/10.1371/reply/cbca4e9a-01f0-4b00-99bd-4d13a997c719", "title"=>"RE: Expand on Study Group Populations", "body"=>"The numbers for individual drugs don't add up to 32,363 because for the individual drug counts, we require that the patient record has no mention of any other PPI at all. So for the difference you see between the 32,363 and the sum of all the individual drug counts is due to patients that had more than one PPI mentioned in their record. Same thing applies to table 4.", "isRemoved"=>false, "created"=>"2015-07-21T16:41:02Z", "lastModified"=>"2015-07-21T16:41:02Z", "creator"=>{"userId"=>"515331"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0124653", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2015-07-21T16:41:02Z", "replies"=>[]}]}

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• {"id"=>"1001657294931705857", "text"=>"@SeeFisch MI!\n\nhttps://t.co/pZKicL2nDA\n\nDementia!\n\nhttps://t.co/EMKY1ZrRot", "created_at"=>"2018-05-30T02:51:23Z", "user"=>"RyanGamlin", "user_name"=>"Ryan Gamlin", "user_profile_image"=>"http://pbs.twimg.com/profile_images/920702950678433793/NWCB89La_normal.jpg"}
• {"id"=>"608710600382795776", "text"=>"Inhibidores de bomba de protones y riesgo de enf. CV. http://t.co/x4S3OS87H1", "created_at"=>"2015-06-10T19:01:31Z", "user"=>"maxididomenico", "user_name"=>"Max", "user_profile_image"=>"http://pbs.twimg.com/profile_images/513785184920293376/hFJGno7P_normal.jpeg"}
• {"id"=>"608734213404098560", "text"=>"#PLOSONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/77VNDjSOwQ", "created_at"=>"2015-06-10T20:35:20Z", "user"=>"Sere_Sector", "user_name"=>"Drifting", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1441702805/red_medic_tribe_normal.png"}
• {"id"=>"608746757514665984", "text"=>"Favorites http://t.co/OeU93KxUs9", "created_at"=>"2015-06-10T21:25:11Z", "user"=>"drpalaciosboix", "user_name"=>"Albert P. Boix", "user_profile_image"=>"http://pbs.twimg.com/profile_images/603321309100052480/T7prgQnp_normal.jpg"}
• {"id"=>"608762802401087488", "text"=>"@RaulCalvoRico el artículo: mucha metodología nueva, viejo error: sesgo de población más enferma incontrolable http://t.co/58d1ZhlsVq", "created_at"=>"2015-06-10T22:28:57Z", "user"=>"fgomollon", "user_name"=>"Fernando Gomollón", "user_profile_image"=>"http://pbs.twimg.com/profile_images/523466972433219584/FrKRiWgp_normal.jpeg"}
• {"id"=>"608796610152247296", "text"=>"Thx @nsmartinworld:: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population: http://t.co/XAX6bhU9Nf", "created_at"=>"2015-06-11T00:43:17Z", "user"=>"hhask", "user_name"=>"Helen Haskell", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1097944071/IMG_1593__2__-_Copy_normal.JPG"}
• {"id"=>"608796941296783360", "text"=>"PPI's and heart attack risk http://t.co/IJNdHlwMt2", "created_at"=>"2015-06-11T00:44:36Z", "user"=>"grahamcmackenzi", "user_name"=>"Graham MacKenzie PhC", "user_profile_image"=>"http://pbs.twimg.com/profile_images/578284368017408000/1GX5MnvD_normal.jpeg"}
• {"id"=>"608813037437329409", "text"=>"PPIs are associated with MI. Always will be. It’s confounding. http://t.co/b4sfsjsiss @PLOSONE", "created_at"=>"2015-06-11T01:48:33Z", "user"=>"DavidJuurlink", "user_name"=>"David Juurlink", "user_profile_image"=>"http://pbs.twimg.com/profile_images/480395377992945664/vNkYkvoj_normal.jpeg"}
• {"id"=>"608815626812035072", "text"=>"RT @DavidJuurlink: PPIs are associated with MI. Always will be. It’s confounding. http://t.co/b4sfsjsiss @PLOSONE", "created_at"=>"2015-06-11T01:58:51Z", "user"=>"cabreraERDR", "user_name"=>"Daniel Cabrera", "user_profile_image"=>"http://pbs.twimg.com/profile_images/533348774928592896/tyLF1T0d_normal.jpeg"}
• {"id"=>"608817466513440768", "text"=>"RT @DavidJuurlink: PPIs are associated with MI. Always will be. It’s confounding. http://t.co/b4sfsjsiss @PLOSONE", "created_at"=>"2015-06-11T02:06:09Z", "user"=>"apleblan", "user_name"=>"Tony LeBlanc", "user_profile_image"=>"http://pbs.twimg.com/profile_images/583829572074020864/gBm9kfWw_normal.jpg"}
• {"id"=>"608819527548346368", "text"=>"RT @DavidJuurlink: PPIs are associated with MI. Always will be. It’s confounding. http://t.co/b4sfsjsiss @PLOSONE", "created_at"=>"2015-06-11T02:14:21Z", "user"=>"mfbellolio", "user_name"=>"Fernanda Bellolio", "user_profile_image"=>"http://pbs.twimg.com/profile_images/526425694516301824/KSDseKSl_normal.jpeg"}
• {"id"=>"608829470234013696", "text"=>"10 yrs too late for me, #ProtonPumpInhibitor Usage, Risk of Myocardial Infarction http://t.co/Q3RXxIjgQ4", "created_at"=>"2015-06-11T02:53:51Z", "user"=>"digitalisum", "user_name"=>"andrew mccance", "user_profile_image"=>"http://pbs.twimg.com/profile_images/597124161866244097/DaSD-fAu_normal.jpg"}
• {"id"=>"608840193303400448", "text"=>"RT @DavidJuurlink: PPIs are associated with MI. Always will be. It’s confounding. http://t.co/b4sfsjsiss @PLOSONE", "created_at"=>"2015-06-11T03:36:28Z", "user"=>"EMCases", "user_name"=>"Anton Helman", "user_profile_image"=>"http://pbs.twimg.com/profile_images/471363855218511874/qmSjzpr__normal.png"}
• {"id"=>"608844194514366464", "text"=>"RT @DavidJuurlink: PPIs are associated with MI. Always will be. It’s confounding. http://t.co/b4sfsjsiss @PLOSONE", "created_at"=>"2015-06-11T03:52:22Z", "user"=>"Toad", "user_name"=>"Toad", "user_profile_image"=>"http://pbs.twimg.com/profile_images/406759102/MOSS_normal.jpeg"}
• {"id"=>"608845657361686528", "text"=>"RT @DavidJuurlink: PPIs are associated with MI. Always will be. It’s confounding. http://t.co/b4sfsjsiss @PLOSONE", "created_at"=>"2015-06-11T03:58:11Z", "user"=>"Smileen02", "user_name"=>"Eileen Smith", "user_profile_image"=>"http://pbs.twimg.com/profile_images/605969314810716160/lplTfTku_normal.jpg"}
• {"id"=>"608855883116716032", "text"=>"【FOX NEWS】\nStudy links common heartburn drug to increased heart attack risk\nhttp://t.co/m0kkFTILTb\n【PLoS ONE】\nhttp://t.co/CfirT3MAHh", "created_at"=>"2015-06-11T04:38:49Z", "user"=>"kojima_aponet", "user_name"=>"小嶋 慎二＠アポネット", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1864221167/aponet_profile_normal.jpg"}
• {"id"=>"608858710404784128", "text"=>"【PLoS ONE】\nProton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population\nhttp://t.co/CfirT3MAHh", "created_at"=>"2015-06-11T04:50:03Z", "user"=>"kojima_aponet", "user_name"=>"小嶋 慎二＠アポネット", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1864221167/aponet_profile_normal.jpg"}
• {"id"=>"608859068824846337", "text"=>"RT @kojima_aponet: 【PLoS ONE】\nProton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population\nhttp://t.co/CfirT…", "created_at"=>"2015-06-11T04:51:28Z", "user"=>"syuichiao", "user_name"=>"青島周一", "user_profile_image"=>"http://pbs.twimg.com/profile_images/457290297983000576/mdcPzdKN_normal.jpeg"}
• {"id"=>"608866044883537920", "text"=>"#PLOSONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/EztlPq7OgA", "created_at"=>"2015-06-11T05:19:11Z", "user"=>"edouriez", "user_name"=>"Eric DOURIEZ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1416830024/Twitter_profil_normal.jpg"}
• {"id"=>"608883598029111296", "text"=>"RT @DavidJuurlink: PPIs are associated with MI. Always will be. It’s confounding. http://t.co/b4sfsjsiss @PLOSONE", "created_at"=>"2015-06-11T06:28:56Z", "user"=>"drarcox", "user_name"=>"Anthony Cox", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3735691828/48104771104bbcfb17e8d6cb24d35469_normal.jpeg"}
• {"id"=>"608906035793948672", "text"=>"Downside Big Data: media die berichten over data-mining studies met RR=1.16 (CI 1.09-1.24) voor PPIs op hartinfarct http://t.co/zSvJ0Levb8", "created_at"=>"2015-06-11T07:58:06Z", "user"=>"HenkJanOut", "user_name"=>"Henk Jan Out", "user_profile_image"=>"http://pbs.twimg.com/profile_images/543348665801134081/qhy6JOo5_normal.jpeg"}
• {"id"=>"608906963976601600", "text"=>"PPI use and risk of cardiovascular mortality http://t.co/0V4AmJ5AGu", "created_at"=>"2015-06-11T08:01:47Z", "user"=>"Aiims1742", "user_name"=>"Anirban Maitra", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1378843647/01_normal.jpg"}
• {"id"=>"608944343840362496", "text"=>"Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population\n\nhttp://t.co/qxUFxW0aa5", "created_at"=>"2015-06-11T10:30:19Z", "user"=>"asymptoticstat", "user_name"=>"Edgar Simard PhD MPH", "user_profile_image"=>"http://pbs.twimg.com/profile_images/573580225436495873/vtnLlXPh_normal.png"}
• {"id"=>"608965812465102848", "text"=>"@SkepticalDDS http://t.co/x7AJjV6O6g, pretty solid study (IMO) from a design and interpretation perspective, matched for what they could etc", "created_at"=>"2015-06-11T11:55:38Z", "user"=>"MCBazacoPhD", "user_name"=>"Michael Bazaco", "user_profile_image"=>"http://pbs.twimg.com/profile_images/604692045228322816/DFp70tI0_normal.jpg"}
• {"id"=>"608987081407348737", "text"=>"#PPI use linked to heart attacks http://t.co/n3P1ElEqAL http://t.co/AxLgpohMgF", "created_at"=>"2015-06-11T13:20:09Z", "user"=>"DrMazMD", "user_name"=>"Maziar Rezvani, M.D.", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000056578234/cf5f1cc6c1ef724cf4c2619b5d0dba0f_normal.jpeg"}
• {"id"=>"608989124557701120", "text"=>"Proton pump inhibitors may increase heart attack risk. http://t.co/YvsuPPLiNM @PLOSONE http://t.co/IrMWifY9cR @nytimes", "created_at"=>"2015-06-11T13:28:16Z", "user"=>"ijusue", "user_name"=>"I. Jusué-Torres, MD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000129408388/e8bfcf56ef7febfb9059bfa6eef7a174_normal.jpeg"}
• {"id"=>"608993696495845376", "text"=>"http://t.co/A47tEFam0Y", "created_at"=>"2015-06-11T13:46:26Z", "user"=>"MassTortMan", "user_name"=>"Advocate", "user_profile_image"=>"http://pbs.twimg.com/profile_images/606861891445485568/mYzQ_gnH_normal.png"}
• {"id"=>"608993883582820352", "text"=>"Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population\n\nhttp://t.co/A47tEFam0Y", "created_at"=>"2015-06-11T13:47:11Z", "user"=>"MassTortMan", "user_name"=>"Advocate", "user_profile_image"=>"http://pbs.twimg.com/profile_images/606861891445485568/mYzQ_gnH_normal.png"}
• {"id"=>"609005360402296832", "text"=>"Correlation, but not causation, right? “PPI Usage and the Risk of Myocardial Infarction in the General Population” http://t.co/pQ88Orv6iB", "created_at"=>"2015-06-11T14:32:47Z", "user"=>"JoshIsserman", "user_name"=>"Joshua Isserman", "user_profile_image"=>"http://pbs.twimg.com/profile_images/573271034377326592/0sYpi3hx_normal.jpeg"}
• {"id"=>"609024627554148353", "text"=>"Another benefit versus risk scenario!! Take the proton inhibitor or don't take the proton inhibitor. It's never easy! http://t.co/p5p3Iyf7Au", "created_at"=>"2015-06-11T15:49:20Z", "user"=>"ecafortcollins", "user_name"=>"Eyecare Associates", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000851098494/2623548369907380cf4fcefca50b6103_normal.jpeg"}
• {"id"=>"609024896040071170", "text"=>"patients w GERD on PPIs vs XH2s had a 1.16 risk of MI, 2x mortality: retrospective, not randomized prospective. Ok? http://t.co/FVcLHUu9tD", "created_at"=>"2015-06-11T15:50:25Z", "user"=>"tedhouk", "user_name"=>"Theodore C Houk, M.D", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1550505999/IMG_1005_normal.JPG"}
• {"id"=>"609025566717657089", "text"=>"#PLOSONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/A0ggvHov1M", "created_at"=>"2015-06-11T15:53:04Z", "user"=>"aldosterone", "user_name"=>"Aldo Manresa", "user_profile_image"=>"http://pbs.twimg.com/profile_images/606955434830921728/DpwJMR4e_normal.jpg"}
• {"id"=>"609026884416905216", "text"=>"Proton pump inhibitors (PPIs), one of the most heavily prescribed medications in the U.S. linked to heart attack http://t.co/dfCJWJim86", "created_at"=>"2015-06-11T15:58:19Z", "user"=>"stopdamadnezz", "user_name"=>"Jon Ebbert", "user_profile_image"=>"http://pbs.twimg.com/profile_images/606801630479015936/L2KPZECh_normal.jpg"}
• {"id"=>"609036325660954624", "text"=>"RT @DavidJuurlink: PPIs are associated with MI. Always will be. It’s confounding. http://t.co/b4sfsjsiss @PLOSONE", "created_at"=>"2015-06-11T16:35:50Z", "user"=>"ArdenBarry", "user_name"=>"Arden Barry PharmD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/460556936073588738/TzlcoG-7_normal.png"}
• {"id"=>"609036736811954176", "text"=>"Another reason to judiciously use acid suppressive medications http://t.co/y2XXB2KbaQ", "created_at"=>"2015-06-11T16:37:28Z", "user"=>"ABC_PharmD", "user_name"=>"Amber B Clemmons", "user_profile_image"=>"http://pbs.twimg.com/profile_images/578297248368320512/MM_4SQ4h_normal.jpeg"}
• {"id"=>"609037852802846720", "text"=>"RT @ABC_PharmD: Another reason to judiciously use acid suppressive medications http://t.co/y2XXB2KbaQ", "created_at"=>"2015-06-11T16:41:54Z", "user"=>"KoontzOncology", "user_name"=>"Susannah E. Koontz", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1351256264/KoontzHOPA2010_normal.jpg"}
• {"id"=>"609041073990676480", "text"=>"RT @DavidJuurlink: PPIs are associated with MI. Always will be. It’s confounding. http://t.co/b4sfsjsiss @PLOSONE", "created_at"=>"2015-06-11T16:54:42Z", "user"=>"CommPharm", "user_name"=>"Mike Boivin", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1320122175/IMG_5660s_normal.jpg"}
• {"id"=>"609044071995305984", "text"=>"Proton Pump Inhibitors (Omperazole,et al) increase heart attack risk by 16-21%. No increase for H2 blockers. http://t.co/rQsTjqz8dM #bigdata", "created_at"=>"2015-06-11T17:06:36Z", "user"=>"AndyStringer", "user_name"=>"Andy Stringer", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1413059588/Andrew0505_c_ep_acb__208x234_normal.jpg"}
• {"id"=>"609044746913333248", "text"=>"Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/xO6kYKUpj2", "created_at"=>"2015-06-11T17:09:17Z", "user"=>"AnttiHeikkil2", "user_name"=>"Antti Heikkilä", "user_profile_image"=>"http://pbs.twimg.com/profile_images/605082356106596353/X2M4sraj_normal.jpg"}
• {"id"=>"609045253966974978", "text"=>"RT @AnttiHeikkil2: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/xO6kYKUpj2", "created_at"=>"2015-06-11T17:11:18Z", "user"=>"ianlane88", "user_name"=>"Ian lane", "user_profile_image"=>"http://pbs.twimg.com/profile_images/582343964038209536/dm-dezG6_normal.png"}
• {"id"=>"609059148144074753", "text"=>"Chronic use of PPIs Proton Pump Inhibitors may increase heart attacks Prevacid Protonix Prilosec Nexium Dexilant http://t.co/JvfsDORczJ", "created_at"=>"2015-06-11T18:06:31Z", "user"=>"jsequoia", "user_name"=>"JacquelineSequoia MD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/802868053/js_face_crop_normal.jpg"}
• {"id"=>"609059564764315648", "text"=>"@BezaMerid Link to the study: http://t.co/xTTrrSWye3", "created_at"=>"2015-06-11T18:08:10Z", "user"=>"BezaMerid", "user_name"=>"Beza Merid", "user_profile_image"=>"http://pbs.twimg.com/profile_images/561628591671091200/IxHq3Pp-_normal.jpeg"}
• {"id"=>"609059733388034048", "text"=>"RT @AnttiHeikkil2: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/xO6kYKUpj2", "created_at"=>"2015-06-11T18:08:50Z", "user"=>"TuulaKohonen", "user_name"=>"Tuula Kohonen", "user_profile_image"=>"http://pbs.twimg.com/profile_images/592019372748582912/sHBKD7ma_normal.jpg"}
• {"id"=>"609061665846534144", "text"=>"#PLOSONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/gYTqgOlCXF", "created_at"=>"2015-06-11T18:16:31Z", "user"=>"seittsa", "user_name"=>"Saara Seittenranta", "user_profile_image"=>"http://pbs.twimg.com/profile_images/548245446980677634/ujPeaypw_normal.jpeg"}
• {"id"=>"609069474537418753", "text"=>"1/2: Proton Pump Inhibitor Usage and the Risk of\rMyocardial Infarction in the General\rPopulation #PPI http://t.co/jZiODJx4hE", "created_at"=>"2015-06-11T18:47:33Z", "user"=>"Bristol_scaleMD", "user_name"=>"Constance", "user_profile_image"=>"http://pbs.twimg.com/profile_images/519655303755747330/kZZo0-pM_normal.jpeg"}
• {"id"=>"609086490413551618", "text"=>"ppi'lar ile kalp krizi riski ilişkisini inceleyen güncel (dün yayınlandı :D) bir çalışma:\nhttp://t.co/gRbHaRafgY\npdf: http://t.co/bvB6HnNS9c", "created_at"=>"2015-06-11T19:55:10Z", "user"=>"hafizaibeser", "user_name"=>"Sinan", "user_profile_image"=>"http://pbs.twimg.com/profile_images/549323263198121984/pch2Zg76_normal.jpeg"}
• {"id"=>"609120665887600641", "text"=>"RT @DavidJuurlink: PPIs are associated with MI. Always will be. It’s confounding. http://t.co/b4sfsjsiss @PLOSONE", "created_at"=>"2015-06-11T22:10:58Z", "user"=>"CAPhO_ACPhO", "user_name"=>"CAPhO", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1696966678/FBLogoV2_normal.JPG"}
• {"id"=>"609123067688808448", "text"=>"Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http://t.co/8wTxPbZ4FP", "created_at"=>"2015-06-11T22:20:30Z", "user"=>"Deprescribing", "user_name"=>"Deprescribing", "user_profile_image"=>"http://pbs.twimg.com/profile_images/605743263769755648/lxyAdbUL_normal.png"}
• {"id"=>"609126851751968768", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-11T22:35:33Z", "user"=>"topherfreeman", "user_name"=>"Chris Freeman", "user_profile_image"=>"http://pbs.twimg.com/profile_images/471176594329858049/mOpkIn-M_normal.jpeg"}
• {"id"=>"609129342837239808", "text"=>"Del @PLOSONE de hoy: los inhibidores de bomba de protones aumentan el riesgo cardiovascular. http://t.co/62YQaXUTcG", "created_at"=>"2015-06-11T22:45:27Z", "user"=>"franciscogc", "user_name"=>"Francisco Guadarrama", "user_profile_image"=>"http://pbs.twimg.com/profile_images/563518116450168832/TqWOFpyP_normal.jpeg"}
• {"id"=>"609133013545304064", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-11T23:00:02Z", "user"=>"DRugby56", "user_name"=>"Debbie Rigby", "user_profile_image"=>"http://pbs.twimg.com/profile_images/537062667882483713/Y0WUf2Sd_normal.png"}
• {"id"=>"609133800103276545", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-11T23:03:09Z", "user"=>"ngsayago", "user_name"=>"Nory Gómez Sayago", "user_profile_image"=>"http://pbs.twimg.com/profile_images/527762905563811840/Zv8hvHyL_normal.jpeg"}
• {"id"=>"609135752304291841", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-11T23:10:55Z", "user"=>"IosuBJ", "user_name"=>"Iosu Barral Juez", "user_profile_image"=>"http://pbs.twimg.com/profile_images/598488689270992896/3EBo-W7f_normal.jpg"}
• {"id"=>"609136075186008064", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-11T23:12:12Z", "user"=>"0scar_PL", "user_name"=>"OscarPL", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2835170152/1cae7f417a9ed2b7b334fb93652d54fa_normal.jpeg"}
• {"id"=>"609137713770463232", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-11T23:18:42Z", "user"=>"the_shpa", "user_name"=>"SHPA", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000728692023/bf3bdf590d18566ffc80ebd5d41c712d_normal.jpeg"}
• {"id"=>"609155686619070464", "text"=>"PPIs linked with increased heart attack risk: http://t.co/FX51sXaSqx #rdchat #healthcare", "created_at"=>"2015-06-12T00:30:07Z", "user"=>"TaylorEatRight", "user_name"=>"Taylor Wolfram", "user_profile_image"=>"http://pbs.twimg.com/profile_images/462033825636155393/Y3QnBmNH_normal.jpeg"}
• {"id"=>"609158023752351745", "text"=>"Proton Pump Inhibitor Usage and the Risk of http://t.co/rmjP7ro0oY", "created_at"=>"2015-06-12T00:39:25Z", "user"=>"FrancoiseGeorge", "user_name"=>"Dr Françoise George", "user_profile_image"=>"http://pbs.twimg.com/profile_images/557574187414331392/rQKZI8yH_normal.jpeg"}
• {"id"=>"609177407363219457", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-12T01:56:26Z", "user"=>"hvdow", "user_name"=>"Helen Dowling", "user_profile_image"=>"http://pbs.twimg.com/profile_images/602413505866637312/IA_2W7wR_normal.jpg"}
• {"id"=>"609214244488241152", "text"=>"【AFPBB News】\n胸焼け抑える薬、心臓発作リスクに関連か\nhttp://t.co/ivUY00j9TA\n\n【PLoS ONE】\nhttp://t.co/CfirT3MAHh", "created_at"=>"2015-06-12T04:22:49Z", "user"=>"kojima_aponet", "user_name"=>"小嶋 慎二＠アポネット", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1864221167/aponet_profile_normal.jpg"}
• {"id"=>"609230632120643584", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-12T05:27:56Z", "user"=>"arranzcastella", "user_name"=>"M Teresa Arranz ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3682638370/c97e65edd087877ab93568db42e7a87c_normal.jpeg"}
• {"id"=>"609232484308545536", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-12T05:35:17Z", "user"=>"CasteloRosana", "user_name"=>"Rosana Castelo ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/574975481897947136/LCJ40N34_normal.jpeg"}
• {"id"=>"609239955102126080", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-12T06:04:59Z", "user"=>"victorpadilla21", "user_name"=>"victor padilla", "user_profile_image"=>"http://pbs.twimg.com/profile_images/512732350510145536/UMB8PCcw_normal.jpeg"}
• {"id"=>"609242274585776128", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-12T06:14:12Z", "user"=>"GCentinela", "user_name"=>"Ganglio Centinela", "user_profile_image"=>"http://pbs.twimg.com/profile_images/456652071974891520/_UBA2fvh_normal.jpeg"}
• {"id"=>"609249704724045824", "text"=>"(PLoS One) La minería de datos desvela una asociación entre la exposición a IBP y un > riesgo de sufrir un IAM http://t.co/xNSgqsF5OD", "created_at"=>"2015-06-12T06:43:43Z", "user"=>"rincondesisifo", "user_name"=>"Carlos F. Oropesa", "user_profile_image"=>"http://pbs.twimg.com/profile_images/600077430292914176/pdTXGpbW_normal.jpg"}
• {"id"=>"609250456255242240", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-12T06:46:42Z", "user"=>"lauradiego_", "user_name"=>"Laura Diego", "user_profile_image"=>"http://pbs.twimg.com/profile_images/494758110058131456/CNEeMKeG_normal.jpeg"}
• {"id"=>"609250499943116800", "text"=>"RT @rincondesisifo: (PLoS One) La minería de datos desvela una asociación entre la exposición a IBP y un > riesgo de sufrir un IAM http://t…", "created_at"=>"2015-06-12T06:46:53Z", "user"=>"SIETES7", "user_name"=>"Sietes.org", "user_profile_image"=>"http://pbs.twimg.com/profile_images/586093630030512128/mUToIj5w_normal.jpg"}
• {"id"=>"609264458783961088", "text"=>"RT @rincondesisifo: (PLoS One) La minería de datos desvela una asociación entre la exposición a IBP y un > riesgo de sufrir un IAM http://t…", "created_at"=>"2015-06-12T07:42:21Z", "user"=>"carmelprzrz", "user_name"=>"Carmelo", "user_profile_image"=>"http://pbs.twimg.com/profile_images/609023723325284352/QjcIOcvB_normal.jpg"}
• {"id"=>"609265465614069761", "text"=>"RT @rincondesisifo: (PLoS One) La minería de datos desvela una asociación entre la exposición a IBP y un > riesgo de sufrir un IAM http://t…", "created_at"=>"2015-06-12T07:46:21Z", "user"=>"cuidandoAJR", "user_name"=>"Antonio Jesús", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1944490905/foto_carnet_cinemascope_normal.jpg"}
• {"id"=>"609271419403419648", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-12T08:10:00Z", "user"=>"Franrolu", "user_name"=>"Fco Rodríguez Lucena", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3187754852/94564bb5ceb431ac1856d742ecf823bc_normal.jpeg"}
• {"id"=>"609275361948340224", "text"=>"RT @kojima_aponet: 【AFPBB News】\n胸焼け抑える薬、心臓発作リスクに関連か\nhttp://t.co/ivUY00j9TA\n\n【PLoS ONE】\nhttp://t.co/CfirT3MAHh", "created_at"=>"2015-06-12T08:25:40Z", "user"=>"UtamaruPhD", "user_name"=>"Utamaru.Pharm", "user_profile_image"=>"http://pbs.twimg.com/profile_images/536488519133196288/_aPNwTpr_normal.jpeg"}
• {"id"=>"609277100042899456", "text"=>"عدد من أدوية القرحةوالارتجاع(نكسيوم اموبرازول..)\nتضاعف معدل الاصابة بالأزمةالقلبية \nدراسة مهمة\nhttp://t.co/LcTOKWyEbG http://t.co/94Qn3C5rom", "created_at"=>"2015-06-12T08:32:35Z", "user"=>"DrAbdullahKhoja", "user_name"=>"د.عبدالله توفيق خوجة", "user_profile_image"=>"http://pbs.twimg.com/profile_images/595467026719576064/zjENSZHv_normal.jpg"}
• {"id"=>"609279051107274753", "text"=>"من أدوية الارتجاع\nما يضاعف وفيات القلبية ويزيد أزمات القلب\nأسأل طبيبك\nhttp://t.co/LcTOKWyEbG http://t.co/94Qn3C5rom http://t.co/gYdlBYHPEB", "created_at"=>"2015-06-12T08:40:20Z", "user"=>"DrAbdullahKhoja", "user_name"=>"د.عبدالله توفيق خوجة", "user_profile_image"=>"http://pbs.twimg.com/profile_images/595467026719576064/zjENSZHv_normal.jpg"}
• {"id"=>"609286881965142016", "text"=>"Heart attack risk increases 16-21% with use of common antacid drugs #PPIs, suggests new study http://t.co/HtNcTy8UOy http://t.co/uMYxHD0fUi", "created_at"=>"2015-06-12T09:11:27Z", "user"=>"phoebewonderlan", "user_name"=>"Dr Rob Beckwith", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1816880809/lane_normal.jpg"}
• {"id"=>"609311761548898304", "text"=>"MT @rincondesisifo BigData desvela asociación entre exposición a IBP y un > riesgo de sufrir un IAM http://t.co/CFHoGrf6Xt #SegPac", "created_at"=>"2015-06-12T10:50:19Z", "user"=>"EnferEvidente", "user_name"=>"X.M. Meijome", "user_profile_image"=>"http://pbs.twimg.com/profile_images/609250211500834817/RCKTo-91_normal.jpg"}
• {"id"=>"609313563593682945", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-12T10:57:28Z", "user"=>"LawersCuen", "user_name"=>"Guillermo", "user_profile_image"=>"http://pbs.twimg.com/profile_images/568162774081994752/eTH74mdb_normal.jpeg"}
• {"id"=>"609313567435792384", "text"=>"RT @EnferEvidente: MT @rincondesisifo BigData desvela asociación entre exposición a IBP y un > riesgo de sufrir un IAM http://t.co/CFHoGrf6…", "created_at"=>"2015-06-12T10:57:29Z", "user"=>"ThugMetricsNews", "user_name"=>"Thug Metrics News", "user_profile_image"=>"http://pbs.twimg.com/profile_images/555474607101071360/jy1EJZCF_normal.jpeg"}
• {"id"=>"609332843454574593", "text"=>"Uff, IBP OR PPIs and risk of MInfarction \nhttp://t.co/IPCdnKowYk", "created_at"=>"2015-06-12T12:14:05Z", "user"=>"estebanjodar", "user_name"=>"Esteban Jódar Gimeno", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000207978285/384f5ce5c1d3022391b2609574f75819_normal.jpeg"}
• {"id"=>"609333352517271553", "text"=>"#PLOSONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/ENFB7S0RYv", "created_at"=>"2015-06-12T12:16:06Z", "user"=>"robertfsiegmund", "user_name"=>"Robert F. Siegmund", "user_profile_image"=>"http://pbs.twimg.com/profile_images/601428052082565121/pfe-LMXX_normal.jpg"}
• {"id"=>"609339134629384192", "text"=>"@salehghonaim \nتفضل اخي الكريم\nبحثت عنها بالنيابة عنك\nاعتقد ان هذه هي الدراسة المعنية\n (لم اقرأها)\nhttp://t.co/q5sy4rMaGk", "created_at"=>"2015-06-12T12:39:05Z", "user"=>"AzAlRajhi", "user_name"=>"عبدالعزيز الراجحي", "user_profile_image"=>"http://pbs.twimg.com/profile_images/600793833635348480/hIT4gLGN_normal.jpg"}
• {"id"=>"609356677654159360", "text"=>"Could your #PPI med for #Heartburn increase your risk of a #HeartAttack? @JWatch \n\nhttp://t.co/RkXyY2dOJc", "created_at"=>"2015-06-12T13:48:47Z", "user"=>"DrDooleyMD", "user_name"=>"Dr. Victoria Dooley", "user_profile_image"=>"http://pbs.twimg.com/profile_images/591333081904062465/sBSZgs0G_normal.jpg"}
• {"id"=>"609360598057377792", "text"=>"Common anti-acids appear to increase risk of heart attack in the General Population\n#lifestyle eat bad, take pills\nhttp://t.co/XtXVEuyvny", "created_at"=>"2015-06-12T14:04:22Z", "user"=>"DrShlain", "user_name"=>"Jordan Shlain MD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/579061264296456193/0FleLCCA_normal.jpg"}
• {"id"=>"609361539800264704", "text"=>"Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/CaMQ2gMpZJ", "created_at"=>"2015-06-12T14:08:07Z", "user"=>"HaymanBuwan", "user_name"=>"Hayman Buwan", "user_profile_image"=>"http://pbs.twimg.com/profile_images/558437686344970240/om69bMMp_normal.jpeg"}
• {"id"=>"609363099515252736", "text"=>"Inhibidores bomba de protones asociados a mayor riesgo IAM en población general. En PLoS One. http://t.co/Ah6lzHHV7i", "created_at"=>"2015-06-12T14:14:19Z", "user"=>"ConsEspRCP", "user_name"=>"Consejo Español RCP", "user_profile_image"=>"http://pbs.twimg.com/profile_images/524260467481395200/sOEw1yPN_normal.jpeg"}
• {"id"=>"609363281267060736", "text"=>"RT @ConsEspRCP: Inhibidores bomba de protones asociados a mayor riesgo IAM en población general. En PLoS One. http://t.co/Ah6lzHHV7i", "created_at"=>"2015-06-12T14:15:02Z", "user"=>"alfchus", "user_name"=>"Alf Serrano Moraza", "user_profile_image"=>"http://pbs.twimg.com/profile_images/543851208343969792/ufNde9Ag_normal.png"}
• {"id"=>"609364170019110912", "text"=>"RT @ConsEspRCP: Inhibidores bomba de protones asociados a mayor riesgo IAM en población general. En PLoS One. http://t.co/Ah6lzHHV7i", "created_at"=>"2015-06-12T14:18:34Z", "user"=>"TGijonConde", "user_name"=>"Teresa Gijon Conde", "user_profile_image"=>"http://pbs.twimg.com/profile_images/544209446151266304/n7ZRSLE4_normal.jpeg"}
• {"id"=>"609364974348161024", "text"=>"RT @ConsEspRCP: Inhibidores bomba de protones asociados a mayor riesgo IAM en población general. En PLoS One. http://t.co/Ah6lzHHV7i", "created_at"=>"2015-06-12T14:21:45Z", "user"=>"antibar_ibanez", "user_name"=>"Antonio Ibáñez", "user_profile_image"=>"http://pbs.twimg.com/profile_images/593422917821714432/Myto-3mq_normal.jpg"}
• {"id"=>"609365301810085888", "text"=>"RT @ConsEspRCP: Inhibidores bomba de protones asociados a mayor riesgo IAM en población general. En PLoS One. http://t.co/Ah6lzHHV7i", "created_at"=>"2015-06-12T14:23:04Z", "user"=>"bgimenez2000", "user_name"=>"Blas Giménez ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/588754055519985665/ZneIaiVI_normal.jpg"}
• {"id"=>"609367108661714944", "text"=>"RT @ConsEspRCP: Inhibidores bomba de protones asociados a mayor riesgo IAM en población general. En PLoS One. http://t.co/Ah6lzHHV7i", "created_at"=>"2015-06-12T14:30:14Z", "user"=>"SendoaBP", "user_name"=>"Sendoa Ballesteros", "user_profile_image"=>"http://pbs.twimg.com/profile_images/554588966947528704/ciTRwQvN_normal.jpeg"}
• {"id"=>"609369408117600256", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-12T14:39:23Z", "user"=>"IsabelTalegon", "user_name"=>"Isabel Talegón", "user_profile_image"=>"http://pbs.twimg.com/profile_images/588739037298614272/7jjXrW1t_normal.jpg"}
• {"id"=>"609374277192712193", "text"=>"Interesting... http://t.co/Wyz8vawrRG PPIs may increase risk of MI in general population. Must dissect this study.", "created_at"=>"2015-06-12T14:58:43Z", "user"=>"blondpharmacist", "user_name"=>"Beth Lofgren", "user_profile_image"=>"http://pbs.twimg.com/profile_images/484335728868851712/AVhTizsA_normal.jpeg"}
• {"id"=>"609384471066972160", "text"=>"Combining experimental studies and data-mining to prioritize drug safety signals http://t.co/qfLd1T2WJa", "created_at"=>"2015-06-12T15:39:14Z", "user"=>"drnigam", "user_name"=>"Nigam Shah", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1274609673/0096-1_normal.jpg"}
• {"id"=>"609386560966889472", "text"=>"Proton-Pump Inhibitors Associated with Increased MI Risk, Data-Mining Study Suggests http://t.co/rv3XBuHYub http://t.co/ASBA0x4WDk", "created_at"=>"2015-06-12T15:47:32Z", "user"=>"RikMadDrag", "user_name"=>"Dick is Major Drama", "user_profile_image"=>"http://pbs.twimg.com/profile_images/606839595179769856/jcbiP2Mp_normal.png"}
• {"id"=>"609388141636657152", "text"=>"Omeprazol e Infarto de Miocardio? Tendremos que volver a usar Ranitidina? http://t.co/WvQI9MORHb", "created_at"=>"2015-06-12T15:53:49Z", "user"=>"Sieteenpunto", "user_name"=>"Juan Tormo Molina", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3771799282/90a58f4eec8bda293ee859ed6a9cad37_normal.jpeg"}
• {"id"=>"609390728397991937", "text"=>"@AzAlRajhi\nمثبطات مضخة البروتون للوقاية من ارتجاع المعدة تزيد الإصابة بنوبات قلبية\nهنا الدراسة\nhttp://t.co/q5sy4rMaGk http://t.co/bJ1JsxtWdu", "created_at"=>"2015-06-12T16:04:06Z", "user"=>"AzAlRajhi", "user_name"=>"عبدالعزيز الراجحي", "user_profile_image"=>"http://pbs.twimg.com/profile_images/600793833635348480/hIT4gLGN_normal.jpg"}
• {"id"=>"609392374129651712", "text"=>"RT @AzAlRajhi: @AzAlRajhi\nمثبطات مضخة البروتون للوقاية من ارتجاع المعدة تزيد الإصابة بنوبات قلبية\nهنا الدراسة\nhttp://t.co/q5sy4rMaGk http:/…", "created_at"=>"2015-06-12T16:10:38Z", "user"=>"LogicalYemeni", "user_name"=>"مواطن ..", "user_profile_image"=>"http://pbs.twimg.com/profile_images/519977580615589888/wnBfvsCE_normal.jpeg"}
• {"id"=>"609394173339250688", "text"=>"This is a scary study for folks taking proton-pump inhibitors. Talk to your doc.\nhttp://t.co/MUGmNx3uYN http://t.co/3qfPTVC2x1", "created_at"=>"2015-06-12T16:17:47Z", "user"=>"JacobsonSherry", "user_name"=>"Sherry Jacobson", "user_profile_image"=>"http://pbs.twimg.com/profile_images/482557368144642048/HcOiuHl1_normal.jpeg"}
• {"id"=>"609395491999195136", "text"=>"RT @Deprescribing: Proton pump inhibitors associated with elevated risk of myocardial infarction; H2 blockers show no such association http…", "created_at"=>"2015-06-12T16:23:01Z", "user"=>"merce2511", "user_name"=>"Merce Guerra", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3767494783/422cc351091a8475659e837fbf42814c_normal.jpeg"}
• {"id"=>"609403740014120960", "text"=>"PPI drugs for GERD increase risk of heart attack by 16% - even in those with healthy hearts http://t.co/QOKve5GTT9", "created_at"=>"2015-06-12T16:55:48Z", "user"=>"AburfordMason", "user_name"=>"Aileen Burford-Mason", "user_profile_image"=>"http://pbs.twimg.com/profile_images/604117131622416384/4rMsp-6M_normal.jpg"}
• {"id"=>"609418241501343744", "text"=>"RT @AzAlRajhi: @AzAlRajhi\nمثبطات مضخة البروتون للوقاية من ارتجاع المعدة تزيد الإصابة بنوبات قلبية\nهنا الدراسة\nhttp://t.co/q5sy4rMaGk http:/…", "created_at"=>"2015-06-12T17:53:25Z", "user"=>"noo0oor200723", "user_name"=>"noo0oor_785", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000541432941/bc5c573ff31203850fd0c1727b9862cc_normal.jpeg"}
• {"id"=>"609439850840854528", "text"=>"RT @JacobsonSherry: This is a scary study for folks taking proton-pump inhibitors. Talk to your doc.\nhttp://t.co/MUGmNx3uYN http://t.co/3qf…", "created_at"=>"2015-06-12T19:19:17Z", "user"=>"HannahHernande", "user_name"=>"Hannah Hernandez", "user_profile_image"=>"http://pbs.twimg.com/profile_images/588302269730324480/NavuPkbK_normal.jpg"}
• {"id"=>"609454528266678273", "text"=>"RT @rincondesisifo: (PLoS One) La minería de datos desvela una asociación entre la exposición a IBP y un > riesgo de sufrir un IAM http://t…", "created_at"=>"2015-06-12T20:17:37Z", "user"=>"dpoza", "user_name"=>"Dolo Ruiz ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1892213299/IMG_6523__1__normal.JPG"}
• {"id"=>"609511855694958593", "text"=>"PLOS ONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/01KkykGFRx", "created_at"=>"2015-06-13T00:05:25Z", "user"=>"ACSCardiology", "user_name"=>"Anjan Gupta", "user_profile_image"=>"http://pbs.twimg.com/profile_images/427504805125562370/eU7MIWIl_normal.jpeg"}
• {"id"=>"609512432537464832", "text"=>"RT @ACSCardiology: PLOS ONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/01Kkyk…", "created_at"=>"2015-06-13T00:07:42Z", "user"=>"ShamrockShaikh", "user_name"=>"Armaan Shaikh", "user_profile_image"=>"http://pbs.twimg.com/profile_images/443083479488557056/Go4ywpDD_normal.jpeg"}
• {"id"=>"609682809960185856", "text"=>"Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population \nhttp://t.co/BGMnqqxWIE", "created_at"=>"2015-06-13T11:24:43Z", "user"=>"jordimondragon", "user_name"=>"Jordi ||★|| ✌27s2015", "user_profile_image"=>"http://pbs.twimg.com/profile_images/584308902340210688/t1EKEQGP_normal.jpg"}
• {"id"=>"609686100471357440", "text"=>"Inhibidores Bomba Protones y riesgo de I M http://t.co/pzVoEDBwvC", "created_at"=>"2015-06-13T11:37:48Z", "user"=>"jolusav", "user_name"=>"Jorge Luis Salcedo V", "user_profile_image"=>"http://pbs.twimg.com/profile_images/519279397678112768/v6Z1CTNW_normal.jpeg"}
• {"id"=>"609702759567388672", "text"=>"RT @rincondesisifo: (PLoS One) La minería de datos desvela una asociación entre la exposición a IBP y un > riesgo de sufrir un IAM http://t…", "created_at"=>"2015-06-13T12:44:00Z", "user"=>"aitana_robledo", "user_name"=>"aitana robledo", "user_profile_image"=>"http://pbs.twimg.com/profile_images/584470150063194113/6Rse5K1L_normal.jpg"}
• {"id"=>"609755450444267520", "text"=>"Data mining study suggests that proton pump inhibitors incr heart attack risk. Far from proving harm. So what to do?\nhttp://t.co/hMP041n1W0", "created_at"=>"2015-06-13T16:13:22Z", "user"=>"hmkyale", "user_name"=>"Harlan Krumholz", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1258112838/IMG_1132_normal.JPG"}
• {"id"=>"609755748223045632", "text"=>"As data mining studies proliferate, how do we validate? Guard against false positives. Know when to act? http://t.co/hMP041n1W0 #bigdata", "created_at"=>"2015-06-13T16:14:33Z", "user"=>"hmkyale", "user_name"=>"Harlan Krumholz", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1258112838/IMG_1132_normal.JPG"}
• {"id"=>"609755904842399744", "text"=>"RT @hmkyale: Data mining study suggests that proton pump inhibitors incr heart attack risk. Far from proving harm. So what to do?\nhttp://t.…", "created_at"=>"2015-06-13T16:15:11Z", "user"=>"HealthWidget", "user_name"=>"HelixHealth", "user_profile_image"=>"http://pbs.twimg.com/profile_images/573553695675166720/H2CuIPGB_normal.png"}
• {"id"=>"609757299515760640", "text"=>"RT @hmkyale: As data mining studies proliferate, how do we validate? Guard against false positives. Know when to act? http://t.co/hMP041n1W…", "created_at"=>"2015-06-13T16:20:43Z", "user"=>"RichDuszak", "user_name"=>"Rich Duszak, MD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/477541132591570944/A4jLSCnw_normal.jpeg"}
• {"id"=>"609757747341623296", "text"=>"RT @hmkyale: Data mining study suggests that proton pump inhibitors incr heart attack risk. Far from proving harm. So what to do?\nhttp://t.…", "created_at"=>"2015-06-13T16:22:30Z", "user"=>"pascalmeier74", "user_name"=>"Pascal Meier, MD,BMJ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000614995580/f7465fcc789227122b6672c78cf81b18_normal.png"}
• {"id"=>"609757927109365763", "text"=>"RT @hmkyale: Data mining study suggests that proton pump inhibitors incr heart attack risk. Far from proving harm. So what to do?\nhttp://t.…", "created_at"=>"2015-06-13T16:23:13Z", "user"=>"DrFerdowsi", "user_name"=>"conciergedoc", "user_profile_image"=>"http://pbs.twimg.com/profile_images/478250298277126144/pkYnu4Tz_normal.jpeg"}
• {"id"=>"609759378883919872", "text"=>"RT @hmkyale: As data mining studies proliferate, how do we validate? Guard against false positives. Know when to act? http://t.co/hMP041n1W…", "created_at"=>"2015-06-13T16:28:59Z", "user"=>"ThugMetrics", "user_name"=>"Thug Metrics", "user_profile_image"=>"http://pbs.twimg.com/profile_images/545309149953667072/f3IMwCEc_normal.jpeg"}
• {"id"=>"609762887532457984", "text"=>"RT @hmkyale: Data mining study suggests that proton pump inhibitors incr heart attack risk. Far from proving harm. So what to do?\nhttp://t.…", "created_at"=>"2015-06-13T16:42:55Z", "user"=>"Open_HeartBMJ", "user_name"=>"Open Heart", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000862828234/7RSA5SVW_normal.png"}
• {"id"=>"609763010131939328", "text"=>"RT @hmkyale: As data mining studies proliferate, how do we validate? Guard against false positives. Know when to act? http://t.co/hMP041n1W…", "created_at"=>"2015-06-13T16:43:25Z", "user"=>"MWFriedberg", "user_name"=>"Mark Friedberg", "user_profile_image"=>"http://pbs.twimg.com/profile_images/552556655301234688/BU7UxQ2a_normal.jpeg"}
• {"id"=>"609763368736403457", "text"=>"RT @hmkyale: As data mining studies proliferate, how do we validate? Guard against false positives. Know when to act? http://t.co/hMP041n1W…", "created_at"=>"2015-06-13T16:44:50Z", "user"=>"NoSQLDigest", "user_name"=>"NoSQL", "user_profile_image"=>"http://pbs.twimg.com/profile_images/499257180009529344/CSWhr7LZ_normal.jpeg"}
• {"id"=>"609769674323173377", "text"=>"Stanford Üniversitesindeki çalışma: PPI grubu mide ilaçları kalp hastalığı riskini arttırıyor\nhttp://t.co/zSvMafS2GX\nhttp://t.co/wAGmHrFTSE", "created_at"=>"2015-06-13T17:09:53Z", "user"=>"14mtd", "user_name"=>"14 MTD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/538335264167309312/-KWY70y5_normal.jpeg"}
• {"id"=>"609770237794353152", "text"=>"RT @hmkyale: Data mining study suggests that proton pump inhibitors incr heart attack risk. Far from proving harm. So what to do?\nhttp://t.…", "created_at"=>"2015-06-13T17:12:08Z", "user"=>"rafasadaba", "user_name"=>"Rafael Sádaba", "user_profile_image"=>"http://pbs.twimg.com/profile_images/586790877479227392/qr5Zyx7U_normal.jpg"}
• {"id"=>"609770301967237121", "text"=>"RT @14mtd: Stanford Üniversitesindeki çalışma: PPI grubu mide ilaçları kalp hastalığı riskini arttırıyor\nhttp://t.co/zSvMafS2GX\nhttp://t.co…", "created_at"=>"2015-06-13T17:12:23Z", "user"=>"DnmezOrhun", "user_name"=>"Milliyetçi Türkiye", "user_profile_image"=>"http://pbs.twimg.com/profile_images/568910936858427392/FA_jgjih_normal.jpeg"}
• {"id"=>"609771849770270720", "text"=>"RT @14mtd: Stanford Üniversitesindeki çalışma: PPI grubu mide ilaçları kalp hastalığı riskini arttırıyor\nhttp://t.co/zSvMafS2GX\nhttp://t.co…", "created_at"=>"2015-06-13T17:18:32Z", "user"=>"eloglubrhn", "user_name"=>"burhan eloğlu", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000845687682/440cd753872bab34e9e8a021c3eafae4_normal.jpeg"}
• {"id"=>"609785494575149056", "text"=>"RT @hmkyale: As data mining studies proliferate, how do we validate? Guard against false positives. Know when to act? http://t.co/hMP041n1W…", "created_at"=>"2015-06-13T18:12:45Z", "user"=>"DrCarrieOBGYN", "user_name"=>"Carrie Cwiak", "user_profile_image"=>"http://pbs.twimg.com/profile_images/463732668815781889/UtHcw12h_normal.jpeg"}
• {"id"=>"609795345262997506", "text"=>"RT @hmkyale: Data mining study suggests that proton pump inhibitors incr heart attack risk. Far from proving harm. So what to do?\nhttp://t.…", "created_at"=>"2015-06-13T18:51:54Z", "user"=>"miepsja", "user_name"=>"Mischa Anna Selis", "user_profile_image"=>"http://pbs.twimg.com/profile_images/423918619228401664/2dmPSX7j_normal.jpeg"}
• {"id"=>"609798755760664576", "text"=>"RT @hmkyale: Data mining study suggests that proton pump inhibitors incr heart attack risk. Far from proving harm. So what to do?\nhttp://t.…", "created_at"=>"2015-06-13T19:05:27Z", "user"=>"SonneImPark", "user_name"=>"PatriziaTamborrini", "user_profile_image"=>"http://pbs.twimg.com/profile_images/587953707444264960/HxF8Vb95_normal.jpg"}
• {"id"=>"609802387658809344", "text"=>"RT @hmkyale: As data mining studies proliferate, how do we validate? Guard against false positives. Know when to act? http://t.co/hMP041n1W…", "created_at"=>"2015-06-13T19:19:53Z", "user"=>"zante14081950", "user_name"=>"amelia beltramini", "user_profile_image"=>"http://pbs.twimg.com/profile_images/571201105309093888/Oy_AjXq__normal.png"}
• {"id"=>"609802536405610496", "text"=>"RT @hmkyale: As data mining studies proliferate, how do we validate? Guard against false positives. Know when to act? http://t.co/hMP041n1W…", "created_at"=>"2015-06-13T19:20:28Z", "user"=>"JobberTechTalk", "user_name"=>"JobberTechTalk", "user_profile_image"=>"http://pbs.twimg.com/profile_images/527549709628370944/8DxFH294_normal.png"}
• {"id"=>"609802760624672768", "text"=>"RT @ACSCardiology: PLOS ONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/01Kkyk…", "created_at"=>"2015-06-13T19:21:22Z", "user"=>"Lizfshah", "user_name"=>"Elizabeth Shah", "user_profile_image"=>"http://pbs.twimg.com/profile_images/566964605382316033/WAwd_R4N_normal.jpeg"}
• {"id"=>"609821654466740225", "text"=>"RT @hmkyale: Data mining study suggests that proton pump inhibitors incr heart attack risk. Far from proving harm. So what to do?\nhttp://t.…", "created_at"=>"2015-06-13T20:36:27Z", "user"=>"kmol62", "user_name"=>"Karen O'Leary", "user_profile_image"=>"http://pbs.twimg.com/profile_images/532781820098531328/lJeYjqsx_normal.jpeg"}
• {"id"=>"609821913968443392", "text"=>"RT @hmkyale: Data mining study suggests that proton pump inhibitors incr heart attack risk. Far from proving harm. So what to do?\nhttp://t.…", "created_at"=>"2015-06-13T20:37:28Z", "user"=>"YaleCRC", "user_name"=>"Y | CRC", "user_profile_image"=>"http://pbs.twimg.com/profile_images/588098323615191041/aq8oYR_4_normal.png"}
• {"id"=>"609821950995746816", "text"=>"RT @hmkyale: As data mining studies proliferate, how do we validate? Guard against false positives. Know when to act? http://t.co/hMP041n1W…", "created_at"=>"2015-06-13T20:37:37Z", "user"=>"YaleCRC", "user_name"=>"Y | CRC", "user_profile_image"=>"http://pbs.twimg.com/profile_images/588098323615191041/aq8oYR_4_normal.png"}
• {"id"=>"609822577092112384", "text"=>"RT @hmkyale: As data mining studies proliferate, how do we validate? Guard against false positives. Know when to act? http://t.co/hMP041n1W…", "created_at"=>"2015-06-13T20:40:06Z", "user"=>"iotHawk", "user_name"=>"IOT hawk", "user_profile_image"=>"http://pbs.twimg.com/profile_images/523500423001677825/1guVw7V4_normal.jpeg"}
• {"id"=>"609859510954426368", "text"=>"RT @hmkyale: Data mining study suggests that proton pump inhibitors incr heart attack risk. Far from proving harm. So what to do?\nhttp://t.…", "created_at"=>"2015-06-13T23:06:52Z", "user"=>"editorjoppp", "user_name"=>"J PharmPolicy & Prac", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3630240070/98a398fc9ca224bf6f163c16cc615f34_normal.png"}
• {"id"=>"609885569204781056", "text"=>"RT @DrDooleyMD: Could your #PPI med for #Heartburn increase your risk of a #HeartAttack? @JWatch \n\nhttp://t.co/RkXyY2dOJc", "created_at"=>"2015-06-14T00:50:25Z", "user"=>"souloman1", "user_name"=>"Gregory J Maddox Sr", "user_profile_image"=>"http://pbs.twimg.com/profile_images/503312898694082560/NmsvU899_normal.jpeg"}
• {"id"=>"609989110426513408", "text"=>"Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http://t.co/XggRPirHwh", "created_at"=>"2015-06-14T07:41:51Z", "user"=>"jvillacastin", "user_name"=>"Julian P Villacastin", "user_profile_image"=>"http://pbs.twimg.com/profile_images/489730043875459072/uswwC5c1_normal.jpeg"}
• {"id"=>"609989771927142400", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T07:44:29Z", "user"=>"javihdez", "user_name"=>"Javi Hernández", "user_profile_image"=>"http://pbs.twimg.com/profile_images/489920372578729984/ScT9JOb8_normal.jpeg"}
• {"id"=>"609991022299455488", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T07:49:27Z", "user"=>"RioshcvYa", "user_name"=>"María Beatriz Rios", "user_profile_image"=>"http://pbs.twimg.com/profile_images/577172954167058433/WYOkNNW__normal.jpeg"}
• {"id"=>"609995694364041217", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T08:08:01Z", "user"=>"Ed_Alania", "user_name"=>"Edgardo Alania", "user_profile_image"=>"http://pbs.twimg.com/profile_images/529367469832404992/BuzqVi6w_normal.jpeg"}
• {"id"=>"609996524873977856", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T08:11:19Z", "user"=>"clinicatorrevja", "user_name"=>"CentroClínico&Dental", "user_profile_image"=>"http://pbs.twimg.com/profile_images/440853340289638400/TjBZI5GM_normal.jpeg"}
• {"id"=>"610000615641583616", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T08:27:34Z", "user"=>"beariveiro", "user_name"=>"Beatriz Riveiro", "user_profile_image"=>"http://pbs.twimg.com/profile_images/590122066550120448/iWP39upe_normal.jpg"}
• {"id"=>"610008546701373440", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T08:59:05Z", "user"=>"midalaprincesa", "user_name"=>"Princesa Amidala", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3645434272/fef881363a7eb3cf6a1b40897cee5e83_normal.jpeg"}
• {"id"=>"610010556561498112", "text"=>"PPIs and risk of myocardial infarction http://t.co/K8LZyh845A", "created_at"=>"2015-06-14T09:07:04Z", "user"=>"OscarPicazo", "user_name"=>"Óscar Picazo", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000180018020/0680ab0ed45097046c3ec6a8460fed85_normal.jpeg"}
• {"id"=>"610021406131286016", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T09:50:11Z", "user"=>"secardiologia", "user_name"=>"SEC Cardiología", "user_profile_image"=>"http://pbs.twimg.com/profile_images/516851654490992640/kY3rHLFY_normal.png"}
• {"id"=>"610022251115753472", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T09:53:32Z", "user"=>"cgtorrijos", "user_name"=>"Cristian ن", "user_profile_image"=>"http://pbs.twimg.com/profile_images/495262912030998528/vbQ15X2k_normal.jpeg"}
• {"id"=>"610022456418566144", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T09:54:21Z", "user"=>"iplagar", "user_name"=>"Inmaculada Plasencia", "user_profile_image"=>"http://pbs.twimg.com/profile_images/452601004232437760/CgbzW0pl_normal.jpeg"}
• {"id"=>"610030897472086018", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T10:27:54Z", "user"=>"celeshernan", "user_name"=>"Shawn Crahan (celes)", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1764571062/710e801d_normal.jpg"}
• {"id"=>"610031101696942080", "text"=>"RT @OscarPicazo: PPIs and risk of myocardial infarction http://t.co/K8LZyh845A", "created_at"=>"2015-06-14T10:28:43Z", "user"=>"ianlane88", "user_name"=>"Ian lane", "user_profile_image"=>"http://pbs.twimg.com/profile_images/582343964038209536/dm-dezG6_normal.png"}
• {"id"=>"610046977317990400", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T11:31:48Z", "user"=>"Tenuela", "user_name"=>"Dr. Tulio Peñuela", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2049628473/image_normal.jpg"}
• {"id"=>"610067334758297600", "text"=>"Confounding in EHR data mining analyses still a big challenge... http://t.co/2I1HcFf44K https://t.co/N306sBRZNn", "created_at"=>"2015-06-14T12:52:41Z", "user"=>"pnatarajanmd", "user_name"=>"Pradeep Natarajan", "user_profile_image"=>"http://pbs.twimg.com/profile_images/434902656696721408/aywZNLO4_normal.jpeg"}
• {"id"=>"610069142620798976", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T12:59:52Z", "user"=>"rauljgarcias", "user_name"=>"Raul J. Garcia S.", "user_profile_image"=>"http://pbs.twimg.com/profile_images/557592857779777536/iD7bxGqX_normal.jpeg"}
• {"id"=>"610072986150928384", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T13:15:09Z", "user"=>"aldecrotona", "user_name"=>"Alcmeon de Crotona", "user_profile_image"=>"http://pbs.twimg.com/profile_images/479284930485444609/J3At1bdB_normal.jpeg"}
• {"id"=>"610087404872048641", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T14:12:26Z", "user"=>"catambuco", "user_name"=>"R DiazdelCastillo N.", "user_profile_image"=>"http://pbs.twimg.com/profile_images/570006659419095040/85oBod-9_normal.jpeg"}
• {"id"=>"610104812701532161", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T15:21:37Z", "user"=>"Khabelo", "user_name"=>"Edgar L. Leyva", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1182944991/73025_473479808856_680403856_5760326_285656_n_normal.jpg"}
• {"id"=>"610105151811100672", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T15:22:58Z", "user"=>"IARETUSA", "user_name"=>"IARETUSA", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1267071425/NEW_YORK_2010_061_-_copia_normal.JPG"}
• {"id"=>"610119534784155648", "text"=>"RT @pnatarajanmd: Confounding in EHR data mining analyses still a big challenge... http://t.co/2I1HcFf44K https://t.co/N306sBRZNn", "created_at"=>"2015-06-14T16:20:07Z", "user"=>"DrKevinCampbell", "user_name"=>"Dr. Kevin Campbell", "user_profile_image"=>"http://pbs.twimg.com/profile_images/482237517417029632/UogW4rmM_normal.jpeg"}
• {"id"=>"610126480056545281", "text"=>"RT @pnatarajanmd: Confounding in EHR data mining analyses still a big challenge... http://t.co/2I1HcFf44K https://t.co/N306sBRZNn", "created_at"=>"2015-06-14T16:47:43Z", "user"=>"JonPreisler", "user_name"=>"Jon Preisler", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1627995681/JP_normal.JPG"}
• {"id"=>"610157675192651776", "text"=>"RT @hmkyale: As data mining studies proliferate, how do we validate? Guard against false positives. Know when to act? http://t.co/hMP041n1W…", "created_at"=>"2015-06-14T18:51:40Z", "user"=>"KevinFaircloth1", "user_name"=>"Kevin Faircloth", "user_profile_image"=>"http://pbs.twimg.com/profile_images/581862957954539520/NAG5dr5X_normal.jpg"}
• {"id"=>"610167021142175746", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T19:28:48Z", "user"=>"Ccalledo", "user_name"=>"Cristina Calle", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000431015465/9d082373adcd85e48a2b1f94e1d47fea_normal.jpeg"}
• {"id"=>"610189199027904515", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T20:56:56Z", "user"=>"arritmias_es", "user_name"=>"arritmias_es", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1246341157/arritmias_social_box_normal.jpg"}
• {"id"=>"610190717856686083", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T21:02:58Z", "user"=>"pepebravoc", "user_name"=>"pepe bravo", "user_profile_image"=>"http://pbs.twimg.com/profile_images/587263659979755520/wI_xC4eH_normal.jpg"}
• {"id"=>"610191498324373504", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-14T21:06:04Z", "user"=>"FinaJardi", "user_name"=>"Josefina Jardí", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000479403512/629fba6db6ab7a6fedddf691e0d488dc_normal.jpeg"}
• {"id"=>"610198525658316802", "text"=>"Proton Pump Inhibitor drugs for GERD,heartburn (Nexium,Prevacid,etc)GREATLY up heart attack risk. Imp new study! http://t.co/xfsX5BpBEA", "created_at"=>"2015-06-14T21:34:00Z", "user"=>"SherryNewsViews", "user_name"=>"Sher Baker", "user_profile_image"=>"http://pbs.twimg.com/profile_images/568817324744904704/yERAOAFm_normal.jpeg"}
• {"id"=>"610229677752455168", "text"=>"Acidity drugs like Nexium increased chance of pneumonia, colon infection. New study suggests increased heart attack! http://t.co/IL0Vk3HF96", "created_at"=>"2015-06-14T23:37:47Z", "user"=>"RumiKhanMD", "user_name"=>"Rumi Khan", "user_profile_image"=>"http://pbs.twimg.com/profile_images/538486725421441024/3Piz6_BI_normal.jpeg"}
• {"id"=>"610242259762741248", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-15T00:27:47Z", "user"=>"DianitaDavila1", "user_name"=>" Artemisa", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000320556687/342654ffb40867c8045f2a6dfe65cc7d_normal.jpeg"}
• {"id"=>"610494703222542337", "text"=>"Uso de Inhibidores de la bomba de protones y riesgo de infarto de miocardio en la población general\nhttp://t.co/YpuSZ42gPh", "created_at"=>"2015-06-15T17:10:54Z", "user"=>"luisotobajas", "user_name"=>"Luis Tobajas Belvís", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1266733527/untitled_normal.jpg"}
• {"id"=>"610531822179627008", "text"=>"(PLOS) Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/puXcNBOzLf #PtSafety", "created_at"=>"2015-06-15T19:38:24Z", "user"=>"sanoysalvoblog", "user_name"=>"Sano y salvo", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2203866990/Sano_y_Salvo_logo_cuadrado_normal.JPG"}
• {"id"=>"610532136169402368", "text"=>"RT @sanoysalvoblog: (PLOS) Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/puXcNBOz…", "created_at"=>"2015-06-15T19:39:39Z", "user"=>"cecilicp", "user_name"=>"Cecilia Calvo Pita", "user_profile_image"=>"http://pbs.twimg.com/profile_images/417770071650365440/DRqhv9YH_normal.jpeg"}
• {"id"=>"610535342593196032", "text"=>"RT @sanoysalvoblog: (PLOS) Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/puXcNBOz…", "created_at"=>"2015-06-15T19:52:23Z", "user"=>"jcolladopuerta", "user_name"=>"Jesus Collado", "user_profile_image"=>"http://abs.twimg.com/sticky/default_profile_images/default_profile_5_normal.png"}
• {"id"=>"610536012343844864", "text"=>"RT @sanoysalvoblog: (PLOS) Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/puXcNBOz…", "created_at"=>"2015-06-15T19:55:03Z", "user"=>"Firefly_fan", "user_name"=>"Marc Casañas Escarré", "user_profile_image"=>"http://pbs.twimg.com/profile_images/580025858800398336/4x3U29zH_normal.jpg"}
• {"id"=>"610546808369094656", "text"=>"RT @sanoysalvoblog: (PLOS) Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/puXcNBOz…", "created_at"=>"2015-06-15T20:37:57Z", "user"=>"IcaSemes", "user_name"=>"Grupo ICA-SEMES", "user_profile_image"=>"http://pbs.twimg.com/profile_images/496394189828288513/mE_SEVSF_normal.jpeg"}
• {"id"=>"610559416346218496", "text"=>"RT @sanoysalvoblog: (PLOS) Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/puXcNBOz…", "created_at"=>"2015-06-15T21:28:03Z", "user"=>"GrupoGEPEM", "user_name"=>"Grupo GEPEM", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000613419637/b517481bc01185c0c7865f506be1e7b0_normal.jpeg"}
• {"id"=>"610561526479613952", "text"=>"Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/LuLaS1KX6y #Plosone", "created_at"=>"2015-06-15T21:36:26Z", "user"=>"HospChiefPharm", "user_name"=>"Andrew Davies", "user_profile_image"=>"http://pbs.twimg.com/profile_images/550709336146997248/WFjxHpuR_normal.jpeg"}
• {"id"=>"610696306802171904", "text"=>"RT @HospChiefPharm: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/LuLaS1KX6y #Plo…", "created_at"=>"2015-06-16T06:32:00Z", "user"=>"SJaglin", "user_name"=>"Stephane Jaglin", "user_profile_image"=>"http://pbs.twimg.com/profile_images/592040014416105473/LDT00lqE_normal.png"}
• {"id"=>"610754660174069761", "text"=>"RT @HospChiefPharm: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/LuLaS1KX6y #Plo…", "created_at"=>"2015-06-16T10:23:52Z", "user"=>"Ricardommd", "user_name"=>"Ricardo Martinez", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1596446812/DSCI0004_normal.JPG"}
• {"id"=>"610800868363862016", "text"=>"From the AGA - More News on PPIs\nInterpretation of Study on PPI-Heart Attack Risk\n\nhttp://t.co/GSzhZlofBa", "created_at"=>"2015-06-16T13:27:29Z", "user"=>"UtahGastro", "user_name"=>"UtahGastroenterology", "user_profile_image"=>"http://pbs.twimg.com/profile_images/534671308877885440/Ar6_8fmo_normal.jpeg"}
• {"id"=>"610897823005933568", "text"=>"Demasiado omeprazole? http://t.co/c2CVG0rXPY", "created_at"=>"2015-06-16T19:52:45Z", "user"=>"desotomayorma", "user_name"=>"M Alvarez Sotomayor", "user_profile_image"=>"http://pbs.twimg.com/profile_images/553303064741179392/HiRAGNYv_normal.jpeg"}
• {"id"=>"610931016501436416", "text"=>"RT @rincondesisifo: (PLoS One) La minería de datos desvela una asociación entre la exposición a IBP y un > riesgo de sufrir un IAM http://t…", "created_at"=>"2015-06-16T22:04:39Z", "user"=>"cgtorrijos", "user_name"=>"Cristian ن", "user_profile_image"=>"http://pbs.twimg.com/profile_images/495262912030998528/vbQ15X2k_normal.jpeg"}
• {"id"=>"610945455992766464", "text"=>"@luistlopez @AEMPSGOB después de este artículo debermos pensar si recetar IBPs http://t.co/s4hOr0l3Jc", "created_at"=>"2015-06-16T23:02:02Z", "user"=>"cgtorrijos", "user_name"=>"Cristian ن", "user_profile_image"=>"http://pbs.twimg.com/profile_images/495262912030998528/vbQ15X2k_normal.jpeg"}
• {"id"=>"610977294316908544", "text"=>"PLOS ONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population #bigdata http://t.co/VfdcuYfOCS", "created_at"=>"2015-06-17T01:08:33Z", "user"=>"smack2461", "user_name"=>"Steve Mack", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2913202604/2f79e2e774192985432e409a21b07edc_normal.jpeg"}
• {"id"=>"610986449177964544", "text"=>"RT @smack2461: PLOS ONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population #bigdata http://t.co/V…", "created_at"=>"2015-06-17T01:44:55Z", "user"=>"NoSQLDigest", "user_name"=>"NoSQL", "user_profile_image"=>"http://pbs.twimg.com/profile_images/499257180009529344/CSWhr7LZ_normal.jpeg"}
• {"id"=>"610994703152984064", "text"=>"This is concerning http://t.co/ek8PWEIdw1", "created_at"=>"2015-06-17T02:17:43Z", "user"=>"GundaSiska", "user_name"=>"Gunda Siska PharmD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/608032844628258816/b93Egaml_normal.jpg"}
• {"id"=>"610998402969677824", "text"=>"RT @GundaSiska: This is concerning http://t.co/ek8PWEIdw1", "created_at"=>"2015-06-17T02:32:25Z", "user"=>"Jimbo3420", "user_name"=>"James Hui", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2969612779/015dfc2fb8bb9bcad72d58e7fad83985_normal.jpeg"}
• {"id"=>"611107965035249664", "text"=>"Enlace al estudio original sobre relacion de omeprazol con elevacion del riesgo cardiaco http://t.co/SLBTFRj5ew", "created_at"=>"2015-06-17T09:47:47Z", "user"=>"bibliosalud", "user_name"=>"Elena Primo", "user_profile_image"=>"http://pbs.twimg.com/profile_images/589869888660996096/xCsH911s_normal.jpg"}
• {"id"=>"611173382168649728", "text"=>"Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population. http://t.co/KCudWz3k4N", "created_at"=>"2015-06-17T14:07:44Z", "user"=>"TheSvikari", "user_name"=>"The Svikari", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2512279727/1ayumk9xojk2096itnv6_normal.jpeg"}
• {"id"=>"611173629590503424", "text"=>"#PLOSONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/6eQaSabptT", "created_at"=>"2015-06-17T14:08:43Z", "user"=>"drglab", "user_name"=>"DRG Laboratory", "user_profile_image"=>"http://pbs.twimg.com/profile_images/581094010741125120/0m4oi7dT_normal.png"}
• {"id"=>"611233054300983296", "text"=>"#IBP´s y riesgo #cardiovascular; se necesitan más estudios clínicos http://t.co/qAa2MVwbu8", "created_at"=>"2015-06-17T18:04:50Z", "user"=>"tufarmaceuTIC", "user_name"=>"tufarmaceuTIC", "user_profile_image"=>"http://pbs.twimg.com/profile_images/443341423367053314/87NOC0y0_normal.jpeg"}
• {"id"=>"611278041403289600", "text"=>"RT @tufarmaceuTIC: #IBP´s y riesgo #cardiovascular; se necesitan más estudios clínicos http://t.co/qAa2MVwbu8", "created_at"=>"2015-06-17T21:03:36Z", "user"=>"Angel021281", "user_name"=>"Angel Escudero", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2962672621/2810d667881e7e3a0d7652b34ac3037d_normal.jpeg"}
• {"id"=>"611280350199812096", "text"=>"RT @tufarmaceuTIC: #IBP´s y riesgo #cardiovascular; se necesitan más estudios clínicos http://t.co/qAa2MVwbu8", "created_at"=>"2015-06-17T21:12:47Z", "user"=>"BeorleguiPili", "user_name"=>"Pili ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/554308679399649280/xqVXVWgr_normal.jpeg"}
• {"id"=>"611282203406901248", "text"=>"RT @tufarmaceuTIC: #IBP´s y riesgo #cardiovascular; se necesitan más estudios clínicos http://t.co/qAa2MVwbu8", "created_at"=>"2015-06-17T21:20:09Z", "user"=>"jpnavarro82", "user_name"=>"Juan Pablo Navarro", "user_profile_image"=>"http://pbs.twimg.com/profile_images/536299081627615233/YT6sZKou_normal.jpeg"}
• {"id"=>"611444893945307136", "text"=>"RT @bibliosalud: Enlace al estudio original sobre relacion de omeprazol con elevacion del riesgo cardiaco http://t.co/SLBTFRj5ew", "created_at"=>"2015-06-18T08:06:37Z", "user"=>"Bibliosaude", "user_name"=>"Bibliosaude", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2647732462/4c72b5c9393583f62b6321b7f1c7887f_normal.jpeg"}
• {"id"=>"611944814221746176", "text"=>"Yet another reason why long term use of #PPIs (proton pump inhibitors) is a terrible idea. Better to eat right. http://t.co/gVTalnxiwD", "created_at"=>"2015-06-19T17:13:07Z", "user"=>"drdaphnemiller", "user_name"=>"Daphne Miller MD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/477521703174537216/s8VV8h3B_normal.jpeg"}
• {"id"=>"611962511856832512", "text"=>"RT @drdaphnemiller: Yet another reason why long term use of #PPIs (proton pump inhibitors) is a terrible idea. Better to eat right. http://…", "created_at"=>"2015-06-19T18:23:27Z", "user"=>"SjogrensForum", "user_name"=>"Sjögrens Forum", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1083947731/birds_normal.jpg"}
• {"id"=>"612003800187039744", "text"=>"RT @AndyStringer: Proton Pump Inhibitors (Omperazole,et al) increase heart attack risk by 16-21%. No increase for H2 blockers. http://t.co/…", "created_at"=>"2015-06-19T21:07:31Z", "user"=>"imhassan00", "user_name"=>"الحرية", "user_profile_image"=>"http://pbs.twimg.com/profile_images/452543517085032448/tEuigaHE_normal.png"}
• {"id"=>"612473111041044480", "text"=>"RT @GundaSiska: This is concerning http://t.co/ek8PWEIdw1", "created_at"=>"2015-06-21T04:12:23Z", "user"=>"tedtadashilvc", "user_name"=>"Ted Tadashihiroshige", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1135067895/image002_normal.jpg"}
• {"id"=>"612815105261109248", "text"=>"RT @drdaphnemiller: Yet another reason why long term use of #PPIs (proton pump inhibitors) is a terrible idea. Better to eat right. http://…", "created_at"=>"2015-06-22T02:51:21Z", "user"=>"soltoseedfarm", "user_name"=>"Sol to Seed Farm", "user_profile_image"=>"http://pbs.twimg.com/profile_images/580916551441756160/Ifdl1VEo_normal.jpg"}
• {"id"=>"612954762548527104", "text"=>"RT @jvillacastin: Reflujo o acidez estómago: inhibidores bomba de protones parecen elevar riesgo de infarto. Los bloqueadores H2, no. http:…", "created_at"=>"2015-06-22T12:06:18Z", "user"=>"CeciliAlania", "user_name"=>"Cecilia Alania", "user_profile_image"=>"http://pbs.twimg.com/profile_images/582360535817195520/wenlD4ss_normal.jpg"}
• {"id"=>"613004810284081152", "text"=>"RT @hmkyale: Data mining study suggests that proton pump inhibitors incr heart attack risk. Far from proving harm. So what to do?\nhttp://t.…", "created_at"=>"2015-06-22T15:25:10Z", "user"=>"must_hyde", "user_name"=>"Mustafa", "user_profile_image"=>"http://pbs.twimg.com/profile_images/575865956985008128/AE8KJ1KR_normal.jpeg"}
• {"id"=>"613441289351241728", "text"=>"Uso de inhibidor de la bomba de protones y el riesgo de infarto de miocardio en la población general. http://t.co/A8ddN3S3Wf", "created_at"=>"2015-06-23T20:19:35Z", "user"=>"PFVAtlantico", "user_name"=>"PFV Atlantico", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3507861225/30c51c806e08a56c2e056cb5ce2179c1_normal.png"}
• {"id"=>"613509498091630592", "text"=>"@Mary_jpan هل فيه دراسات ذكرت ذلك...لم اطلع على مقارنات واضحة في \nهذا المجال..والظاهر انه لافرق في ذلك\n\n http://t.co/2B3E5LVr98", "created_at"=>"2015-06-24T00:50:37Z", "user"=>"Dr_ahmadalmeman", "user_name"=>"د. أحمد الميمان", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000494095222/f173fb89c22947b3373895f0fc72df13_normal.jpeg"}
• {"id"=>"613509587661029376", "text"=>"PLOS ONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population - http://t.co/2B3E5LVr98", "created_at"=>"2015-06-24T00:50:58Z", "user"=>"Dr_ahmadalmeman", "user_name"=>"د. أحمد الميمان", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000494095222/f173fb89c22947b3373895f0fc72df13_normal.jpeg"}
• {"id"=>"613516533088698368", "text"=>"RT @Dr_ahmadalmeman: PLOS ONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population - http://t.co/2B…", "created_at"=>"2015-06-24T01:18:34Z", "user"=>"ph_amjad", "user_name"=>"Amjad أمجد", "user_profile_image"=>"http://pbs.twimg.com/profile_images/607055708152954880/-hU71gLp_normal.jpg"}
• {"id"=>"613667901413937152", "text"=>"Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction \n\nSome heartburn drugs(PPIs)can cause heart attacks http://t.co/CvyPqoXF8f", "created_at"=>"2015-06-24T11:20:03Z", "user"=>"drzoltanrona", "user_name"=>"Zoltan P. Rona", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3409482772/e4f8c816a6c46765fee39655e8b2889e_normal.jpeg"}
• {"id"=>"613932728623493120", "text"=>"RT @hmkyale: Data mining study suggests that proton pump inhibitors incr heart attack risk. Far from proving harm. So what to do?\nhttp://t.…", "created_at"=>"2015-06-25T04:52:23Z", "user"=>"theheartdoc", "user_name"=>"Dr. Mark Goldberger", "user_profile_image"=>"http://pbs.twimg.com/profile_images/550554174539464705/cXrjKjPH_normal.jpeg"}
• {"id"=>"614072234785775617", "text"=>"#PLOSONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/VaZFiy77jB #PPIsHeartRisk", "created_at"=>"2015-06-25T14:06:44Z", "user"=>"bettycjung", "user_name"=>"Betty C. Jung", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3721554518/6356719fe6ebfc38dff05fa72c34abad_normal.jpeg"}
• {"id"=>"614360585212403712", "text"=>"Los IBP aumentan el riesgo de infarto de miocardio en población general\nhttp://t.co/hKgfB1ocPw\nProtector ¿de qué?", "created_at"=>"2015-06-26T09:12:32Z", "user"=>"J_Hortal", "user_name"=>"Joaquín Hortal", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1657533269/J_Hortal_normal.jpg"}
• {"id"=>"614569616074010624", "text"=>"PLOS ONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/lguJ8ZExB7", "created_at"=>"2015-06-26T23:03:09Z", "user"=>"IlindelatorreMD", "user_name"=>"Dr Ilin Gilberto dl", "user_profile_image"=>"http://pbs.twimg.com/profile_images/586989000923164673/3bnVFLXy_normal.jpg"}
• {"id"=>"614569894957457408", "text"=>"PLOS ONE: Uso de IBP y el riesgo de Infarto de miocardio en población general. http://t.co/lguJ8ZExB7", "created_at"=>"2015-06-26T23:04:15Z", "user"=>"IlindelatorreMD", "user_name"=>"Dr Ilin Gilberto dl", "user_profile_image"=>"http://pbs.twimg.com/profile_images/586989000923164673/3bnVFLXy_normal.jpg"}
• {"id"=>"614571107639795712", "text"=>"PLOS ONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/AHa1ywsuJo", "created_at"=>"2015-06-26T23:09:04Z", "user"=>"IlindelatorreMD", "user_name"=>"Dr Ilin Gilberto dl", "user_profile_image"=>"http://pbs.twimg.com/profile_images/586989000923164673/3bnVFLXy_normal.jpg"}
• {"id"=>"614571505117229057", "text"=>"PLOS ONE: Uso de IBP y riesgo de Infarto de Miocardio en población general. http://t.co/AHa1ywsuJo", "created_at"=>"2015-06-26T23:10:39Z", "user"=>"IlindelatorreMD", "user_name"=>"Dr Ilin Gilberto dl", "user_profile_image"=>"http://pbs.twimg.com/profile_images/586989000923164673/3bnVFLXy_normal.jpg"}
• {"id"=>"614615658475724800", "text"=>"RT @IlindelatorreMD: PLOS ONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/AHa1…", "created_at"=>"2015-06-27T02:06:06Z", "user"=>"r_delacerna", "user_name"=>"Roger De la Cerna", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1504036793/249252_10150337291802578_607022577_9905407_577473_n_normal.png"}
• {"id"=>"614834810217893888", "text"=>"http://t.co/UvMd69m6Q1\n#التعارضات_الدوائية_كيف_تحدث http://t.co/jW2BE3yWYs", "created_at"=>"2015-06-27T16:36:56Z", "user"=>"Saudi_Pharma_07", "user_name"=>"مستشارك الدوائي", "user_profile_image"=>"http://pbs.twimg.com/profile_images/605346815374848001/E8jpRa7w_normal.png"}
• {"id"=>"614835592287817728", "text"=>"RECENT data (June 10, 2015) supports the association of PPI exposure with risk for MI in the general population.\nhttp://t.co/UvMd69m6Q1", "created_at"=>"2015-06-27T16:40:02Z", "user"=>"Saudi_Pharma_07", "user_name"=>"مستشارك الدوائي", "user_profile_image"=>"http://pbs.twimg.com/profile_images/605346815374848001/E8jpRa7w_normal.png"}
• {"id"=>"615520130676592640", "text"=>"Proton-Pump Inhibitors and Increased Cardiovascular Risk: Hype or Harm? http://t.co/AnqWkz6nQe", "created_at"=>"2015-06-29T14:00:09Z", "user"=>"luisfcifuentes", "user_name"=>"Luis F Cifuentes M.D", "user_profile_image"=>"http://pbs.twimg.com/profile_images/420604230844440576/1dfeaFzZ_normal.jpeg"}
• {"id"=>"615543609174044672", "text"=>"http://t.co/QogluGpbRl😁", "created_at"=>"2015-06-29T15:33:27Z", "user"=>"fierro_yol", "user_name"=>"YolFierro", "user_profile_image"=>"http://pbs.twimg.com/profile_images/606456810912935938/KJxC_F09_normal.jpg"}
• {"id"=>"616023867014803456", "text"=>"Finally read the article on PPI association with long-term vascular effects. No association with H2 antagonists. \nhttp://t.co/WWC4OFN1Au", "created_at"=>"2015-06-30T23:21:49Z", "user"=>"Jfpohl", "user_name"=>"John F. Pohl", "user_profile_image"=>"http://pbs.twimg.com/profile_images/448287398107967488/TXdWjoUC_normal.jpeg"}
• {"id"=>"616114642960691201", "text"=>"#adversedrugreaction #omeprazole could raise the risk of myocardial infarction http://t.co/4VOBbg6QdU", "created_at"=>"2015-07-01T05:22:32Z", "user"=>"sebasvignoli", "user_name"=>"Sebastián Vignoli", "user_profile_image"=>"http://pbs.twimg.com/profile_images/581892438140293120/UHK2k0i5_normal.jpg"}
• {"id"=>"616698795514970112", "text"=>"#PPI use in #GERD is associated with elevated risk of #MI in the general population,no association with #H2Blockers. http://t.co/JtdZxZFkeW", "created_at"=>"2015-07-02T20:03:45Z", "user"=>"Rafi90Nasir", "user_name"=>"Dr.Nasir ", "user_profile_image"=>"http://abs.twimg.com/sticky/default_profile_images/default_profile_6_normal.png"}
• {"id"=>"616896647424032768", "text"=>"Protonenpumpen-Inhibitoren (PPI) erhöhen das #Herzinfarkt-Risiko um 21%, H2-Blocker jedoch nicht http://t.co/0gufz6RXpj #Naturheilkunde", "created_at"=>"2015-07-03T09:09:56Z", "user"=>"k_erdfelder", "user_name"=>"Karsten Erdfelder", "user_profile_image"=>"http://pbs.twimg.com/profile_images/601027428627173378/MU1F7DQA_normal.jpg"}
• {"id"=>"617474679004110848", "text"=>"http://t.co/MUXQDSMfm9\n\nFascinating use of data mining and experimental study design with some very interesting results. Highly recommend.", "created_at"=>"2015-07-04T23:26:50Z", "user"=>"colinbanas_VCU", "user_name"=>"Colin Banas ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/525343587173556224/dzWXic5a_normal.jpeg"}
• {"id"=>"617736837789024257", "text"=>"#PLOSONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population http://t.co/sE6YGOIVyE", "created_at"=>"2015-07-05T16:48:33Z", "user"=>"drzaw", "user_name"=>"USMLE (Road to M.D)", "user_profile_image"=>"http://pbs.twimg.com/profile_images/565667219523108864/8_TyqQ9A_normal.jpeg"}
• {"id"=>"618757660838596608", "text"=>"Estudio que asocia Omeprazol y similares con mayor riesgo:\nhttp://t.co/uuJ1KeonXK", "created_at"=>"2015-07-08T12:24:56Z", "user"=>"centinel5051", "user_name"=>"Centinel", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2421414821/d4e6bikwaeao9r06w6i2_normal.jpeg"}
• {"id"=>"618761855998271488", "text"=>"RT @centinel5051: Estudio que asocia Omeprazol y similares con mayor riesgo:\nhttp://t.co/uuJ1KeonXK", "created_at"=>"2015-07-08T12:41:37Z", "user"=>"futurlandia", "user_name"=>"m.a.g.", "user_profile_image"=>"http://pbs.twimg.com/profile_images/607567739671203840/5l2fIrLZ_normal.jpg"}
• {"id"=>"618762039838830593", "text"=>"RT @centinel5051: Estudio que asocia Omeprazol y similares con mayor riesgo:\nhttp://t.co/uuJ1KeonXK", "created_at"=>"2015-07-08T12:42:20Z", "user"=>"Esteban761", "user_name"=>"Esteban Martín", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2740556709/0fcf3b06074b2440c570653b76bd84a3_normal.jpeg"}
• {"id"=>"620677060525170688", "text"=>"Chronic Use of Proton Pump Inhibitors Increases Heart Risk http://t.co/MNWvrvkVcv", "created_at"=>"2015-07-13T19:31:57Z", "user"=>"PPegkas", "user_name"=>"Panagiotis Pegkas", "user_profile_image"=>"http://pbs.twimg.com/profile_images/472465699491676161/Wr6U8zhh_normal.jpeg"}
• {"id"=>"630917838124019712", "text"=>"RT @DrMazMD: #PPI use linked to heart attacks http://t.co/n3P1ElEqAL http://t.co/AxLgpohMgF", "created_at"=>"2015-08-11T01:45:09Z", "user"=>"815wrldtrvlr", "user_name"=>"815wrldtrvlr", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3360841374/ce439388313971a73a5985b665b793f2_normal.jpeg"}
• {"id"=>"634344452769906688", "text"=>"IFM: Get Your Patients Off Acid-Blockers\nhttp://t.co/SFqM9ZnowY\nhttp://t.co/7RBsOxvwBs\nhttp://t.co/a218TbviPv http://t.co/6uJaQkLQQJ", "created_at"=>"2015-08-20T12:41:17Z", "user"=>"CastlDalmunzie", "user_name"=>"Dalmunzie Castle ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/608074729040134144/cK8GvtSv_normal.jpg"}
• {"id"=>"638801717614788608", "text"=>"Proton Pump Inhibitor Usage & Risk of Myocardial Infarction in the General Population http://t.co/q7MVL5zcGh https://t.co/W201X29a0J", "created_at"=>"2015-09-01T19:52:52Z", "user"=>"dbarthjones", "user_name"=>"Daniel Barth-Jones", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2364130865/55svxk70p5n6a5s1xuur_normal.jpeg"}
• {"id"=>"638801868207038464", "text"=>"RT @dbarthjones: Proton Pump Inhibitor Usage & Risk of Myocardial Infarction in the General Population http://t.co/q7MVL5zcGh https://t.co/…", "created_at"=>"2015-09-01T19:53:28Z", "user"=>"EnvyMeGreatly", "user_name"=>"#EnvyMeOnly1", "user_profile_image"=>"http://pbs.twimg.com/profile_images/636791931398438912/Lb2pqxx2_normal.jpg"}
• {"id"=>"639176294626889728", "text"=>"Säureblocker (PPI) erhöhen Infarktrisiko http://t.co/rxJI2MPmIf", "created_at"=>"2015-09-02T20:41:18Z", "user"=>"Medaktuell", "user_name"=>"Dr.med.Elmar Gieseke", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1630517720/17032009032_normal.jpg"}
• {"id"=>"652321920126447616", "text"=>"Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population. \n\nhttp://t.co/aQ93dKNBwC", "created_at"=>"2015-10-09T03:17:19Z", "user"=>"IlindelatorreMD", "user_name"=>"Dr Ilin Gilberto dlT", "user_profile_image"=>"http://pbs.twimg.com/profile_images/642902295387217920/wci6DflN_normal.jpg"}
• {"id"=>"652322520029376512", "text"=>"RT @IlindelatorreMD: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population. \n\nhttp://t.co/aQ93dKNBwC", "created_at"=>"2015-10-09T03:19:42Z", "user"=>"atenea475", "user_name"=>"Ariana García ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/614793491785379840/kaKBEnzn_normal.jpg"}
• {"id"=>"652324544988868608", "text"=>"RT @IlindelatorreMD: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population. \n\nhttp://t.co/aQ93dKNBwC", "created_at"=>"2015-10-09T03:27:45Z", "user"=>"Pako_CM_", "user_name"=>"☤Metzembaum☤\t", "user_profile_image"=>"http://pbs.twimg.com/profile_images/629069970811424768/Cn2Ljs9m_normal.jpg"}
• {"id"=>"652325335887818752", "text"=>"RT @IlindelatorreMD: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population. \n\nhttp://t.co/aQ93dKNBwC", "created_at"=>"2015-10-09T03:30:54Z", "user"=>"iiCanela", "user_name"=>"Irene Canela", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1422585010/Imagen005__2__normal.jpg"}
• {"id"=>"659763045082734592", "text"=>"RT @DrMazMD: #PPI use linked to heart attacks http://t.co/n3P1ElEqAL http://t.co/AxLgpohMgF", "created_at"=>"2015-10-29T16:05:42Z", "user"=>"815wrldtrvlr", "user_name"=>"815wrldtrvlr", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3360841374/ce439388313971a73a5985b665b793f2_normal.jpeg"}
• {"id"=>"659766678146936832", "text"=>"RT @DrMazMD: #PPI use linked to heart attacks http://t.co/n3P1ElEqAL http://t.co/AxLgpohMgF", "created_at"=>"2015-10-29T16:20:08Z", "user"=>"MiriamRoseMc", "user_name"=>"Miriam McGrath", "user_profile_image"=>"http://pbs.twimg.com/profile_images/494133966748676096/NvRiN5AA_normal.jpeg"}
• {"id"=>"667699097231613953", "text"=>"#PLOSONE: IBPs y aumento del riesgo de infarto https://t.co/11dWsCFugn", "created_at"=>"2015-11-20T13:40:44Z", "user"=>"cgtorrijos", "user_name"=>"Cristian ن", "user_profile_image"=>"http://pbs.twimg.com/profile_images/622698583444320256/IPHldVGA_normal.jpg"}
• {"id"=>"693560706281529344", "text"=>"PLOS ONE: Proton Pump Inhibitor Usage, Risk of Myocardial Infarction in Gen Pop @andrewswright @NYTHealth comment? https://t.co/TrrnzTtRpn", "created_at"=>"2016-01-30T22:25:32Z", "user"=>"bonuslife", "user_name"=>"Walter Medlin MD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/893400754/wm_crop_normal.jpg"}
• {"id"=>"697242119145127936", "text"=>"@tom_pharma ?tude pointe risq IM augment? avec IPP seul (ind?pendamment clopido) , pantoprazol devant (fig1page 9) https://t.co/dXaqlsGDEE", "created_at"=>"2016-02-10T02:14:09Z", "user"=>"marjo_lab", "user_name"=>"Lab Marjolaine", "user_profile_image"=>"http://pbs.twimg.com/profile_images/654052638372274178/pyM7v-QB_normal.png"}
• {"id"=>"701324295927177216", "text"=>"#PLOSONE: Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population https://t.co/NmvhKCz7yu", "created_at"=>"2016-02-21T08:35:16Z", "user"=>"1900b", "user_name"=>"Mathijs Bunck", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3728223870/228521ac823f7ab474a9ed96ec84c112_normal.jpeg"}
• {"id"=>"701543226126299142", "text"=>"RT @blondpharmacist: Interesting... http://t.co/Wyz8vawrRG PPIs may increase risk of MI in general population. Must dissect this study.", "created_at"=>"2016-02-21T23:05:13Z", "user"=>"srowe2003", "user_name"=>"Shaun Rowe", "user_profile_image"=>"http://pbs.twimg.com/profile_images/701491526770118656/J6LJVtZ5_normal.jpg"}
• {"id"=>"719099878404657152", "text"=>"@Dr_Turfu et pas que :IDM, insuff r?nale, infections, d?mence... https://t.co/Wcu6xwXkqe https://t.co/xnOB25D0Z8 https://t.co/Y8PvKiFg7k", "created_at"=>"2016-04-10T09:49:05Z", "user"=>"Dr_Agibus", "user_name"=>"Dr Agibus", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000353421115/d962dc2152e0e972b8ef2742c9f9ba0c_normal.jpeg"}
• {"id"=>"719102881719283712", "text"=>"RT @Dr_Agibus: @Dr_Turfu et pas que :IDM, insuff r?nale, infections, d?mence... https://t.co/Wcu6xwXkqe https://t.co/xnOB25D0Z8 https://t.c…", "created_at"=>"2016-04-10T10:01:01Z", "user"=>"Dr_Turfu", "user_name"=>"Habib Potter", "user_profile_image"=>"http://pbs.twimg.com/profile_images/696987858612129792/x0BLPUMx_normal.jpg"}
• {"id"=>"719263584216358912", "text"=>"RT @Dr_Agibus: @Dr_Turfu et pas que :IDM, insuff r?nale, infections, d?mence... https://t.co/Wcu6xwXkqe https://t.co/xnOB25D0Z8 https://t.c…", "created_at"=>"2016-04-10T20:39:36Z", "user"=>"Vdb_Loris", "user_name"=>"Loris Vandenborre", "user_profile_image"=>"http://pbs.twimg.com/profile_images/656190281146994688/K7dv26AI_normal.jpg"}
• {"id"=>"728810845942075393", "text"=>"RT @drnigam: Combining experimental studies and data-mining to prioritize drug safety signals http://t.co/qfLd1T2WJa", "created_at"=>"2016-05-07T04:57:00Z", "user"=>"AbhiHKale", "user_name"=>"Abhi Sawarkar", "user_profile_image"=>"http://pbs.twimg.com/profile_images/728684230109106176/DxJIci1u_normal.jpg"}
• {"id"=>"769573779068551170", "text"=>"For heartburn, go as easy as you can with PPI drugs. They can prompt vitamin depletion with longterm dangers\nhttps://t.co/VRLy1XYSuc", "created_at"=>"2016-08-27T16:34:21Z", "user"=>"HealthyOBastard", "user_name"=>"Healthy Old Bast@rd", "user_profile_image"=>"http://pbs.twimg.com/profile_images/768343299249741825/QgPDXpRd_normal.jpg"}
• {"id"=>"792088601727234048", "text"=>"Uso de inhibidores de la bomba de protones (omeprazol) y riesgo de infarto de miocardio en la poblaci?n general.... https://t.co/pINwG7SSih", "created_at"=>"2016-10-28T19:40:13Z", "user"=>"alfonso_casi", "user_name"=>"Salud juntos", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2493277753/8zaqxo1s48ytxqf5q20n_normal.jpeg"}
• {"id"=>"871568146708045825", "text"=>"Proton Pump Inhibitors (like Prilosec) increase the risk of a Heart Attack https://t.co/AORQNMxjZp", "created_at"=>"2017-06-05T03:23:33Z", "user"=>"WeitzSportChiro", "user_name"=>"WeitzSportsChiro", "user_profile_image"=>"http://pbs.twimg.com/profile_images/858425678038933504/2mYqaCY7_normal.jpg"}
• {"id"=>"871703092013785088", "text"=>"RT @WeitzSportChiro: Proton Pump Inhibitors (like Prilosec) increase the risk of a Heart Attack https://t.co/AORQNMxjZp", "created_at"=>"2017-06-05T12:19:47Z", "user"=>"jovanclordim", "user_name"=>"Jovan Lordim", "user_profile_image"=>"http://pbs.twimg.com/profile_images/776932526384353281/FnmVmo07_normal.jpg"}
• {"id"=>"871704873397624833", "text"=>"RT @WeitzSportChiro: Proton Pump Inhibitors (like Prilosec) increase the risk of a Heart Attack https://t.co/AORQNMxjZp", "created_at"=>"2017-06-05T12:26:51Z", "user"=>"DelimaAntonio", "user_name"=>"DEEP THIS STATE", "user_profile_image"=>"http://pbs.twimg.com/profile_images/852371332352417792/KvqenmUP_normal.jpg"}
• {"id"=>"872283884557389825", "text"=>"RT @WeitzSportChiro: Proton Pump Inhibitors (like Prilosec) increase the risk of a Heart Attack https://t.co/AORQNMxjZp", "created_at"=>"2017-06-07T02:47:38Z", "user"=>"juliebutera", "user_name"=>"julie butera", "user_profile_image"=>"http://pbs.twimg.com/profile_images/813892823909011456/CECKrw8l_normal.jpg"}

Wikipedia

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/2105205"], "description"=>"<p>There are 227,438 patients with gastroesophageal reflux disease (GERD) who are at least 18 years old in this confirmation cohort. In all study groups other than the one in which clopidogrel patients are excluded, the populations are matched based on clopidogrel use and other covariates such as age, gender, race, length of observation, and number of unique drugs mentioned in the record as well as the number of unique disease concepts (as proxies for health status). The matching process attempts to achieve a ratio of 1:5 (exposure to control), but will settle for 1:3, 1:2, or 1:1 if there are not enough controls from which to draw. The length of observation in the PF dataset makes balancing variables difficult, so confounding cannot be entirely ruled out even after matching.</p><p>† patients on clopidogrel are excluded</p><p>‡ patients are restricted by age</p><p>Study group populations for the PF dataset.</p>", "links"=>[], "tags"=>["gerd", "Myocardial infarction", "clopidogrel users", "association", "data sources", "hr", "Proton Pump Inhibitor Usage", "prioritize drug safety signals", "pharmacovigilance algorithms", "General Population Background", "PPI usage", "mi", "H 2 blockers", "ci", "gastroesophageal reflux disease", "clopidogrel use", "year 2000. ConclusionsConsistent", "novel approach", "survival analysis", "PPI exposure"], "article_id"=>1444827, "categories"=>["Biological Sciences"], "users"=>["Nigam H. Shah", "Paea LePendu", "Anna Bauer-Mehren", "Yohannes T. Ghebremariam", "Srinivasan V. Iyer", "Jake Marcus", "Kevin T. Nead", "John P. Cooke", "Nicholas J. Leeper"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124653.t004", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_group_populations_for_the_PF_dataset_/1444827", "title"=>"Study group populations for the PF dataset.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-10 03:13:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2105204"], "description"=>"<p>PPI exposure and control groups for patients with gastroesophageal reflux disease (GERD) are balanced across a number of basic covariates. Importantly, the use of clopidogrel is equally balanced across exposed and control groups. Continuous variables (no. of unique disease mentions, no. unique drug mentions, length of observation) are binned according to their distributions. Before matching, H₂ blocker patients tend to be sicker, have more diseases and more drugs mentioned in their record. After matching, these variables are mostly balanced.</p><p>Balance of variables in patients on H₂ blockers in the STRIDE dataset.</p>", "links"=>[], "tags"=>["gerd", "Myocardial infarction", "clopidogrel users", "association", "data sources", "hr", "Proton Pump Inhibitor Usage", "prioritize drug safety signals", "pharmacovigilance algorithms", "General Population Background", "PPI usage", "mi", "H 2 blockers", "ci", "gastroesophageal reflux disease", "clopidogrel use", "year 2000. ConclusionsConsistent", "novel approach", "survival analysis", "PPI exposure"], "article_id"=>1444826, "categories"=>["Biological Sciences"], "users"=>["Nigam H. Shah", "Paea LePendu", "Anna Bauer-Mehren", "Yohannes T. Ghebremariam", "Srinivasan V. Iyer", "Jake Marcus", "Kevin T. Nead", "John P. Cooke", "Nicholas J. Leeper"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124653.t003", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Balance_of_variables_in_patients_on_H_2_blockers_in_the_STRIDE_dataset_/1444826", "title"=>"Balance of variables in patients on H₂ blockers in the STRIDE dataset.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-10 03:13:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2105199"], "description"=>"<p>The Kaplan–Meier curves in the fig show the survival probability from cardiovascular mortality according to PPI usage over an 8 years follow-up period in the ongoing Genetic Determinants of Peripheral Artery Disease (GenePAD) study. PPI usage is associated with a 2.22 fold (CI 1.19–4.16) increased risk of cardiovascular mortality, relative to controls in unadjusted Cox proportional hazards models.</p>", "links"=>[], "tags"=>["gerd", "Myocardial infarction", "clopidogrel users", "association", "data sources", "hr", "Proton Pump Inhibitor Usage", "prioritize drug safety signals", "pharmacovigilance algorithms", "General Population Background", "PPI usage", "mi", "H 2 blockers", "ci", "gastroesophageal reflux disease", "clopidogrel use", "year 2000. ConclusionsConsistent", "novel approach", "survival analysis", "PPI exposure"], "article_id"=>1444821, "categories"=>["Biological Sciences"], "users"=>["Nigam H. Shah", "Paea LePendu", "Anna Bauer-Mehren", "Yohannes T. Ghebremariam", "Srinivasan V. Iyer", "Jake Marcus", "Kevin T. Nead", "John P. Cooke", "Nicholas J. Leeper"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124653.g002", "stats"=>{"downloads"=>1, "page_views"=>30, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Survival_plot_from_the_prospectively_followed_GenePAD_study_confirms_that_PPI_use_is_associated_adverse_outcome_/1444821", "title"=>"Survival plot from the prospectively followed GenePAD study confirms that PPI use is associated adverse outcome.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-10 03:13:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2105198"], "description"=>"<p>No association is identified for H₂ Blocker use: In the fig, the dotted red line represents the reference point indicating no elevated risk for myocardial infarction (MI). The odds ratio and 95% confidence interval for each exposure are indicated by a blue dot and blue line, respectively, which are also represented numerically to the right of each fig. The size of the dot is proportional to the exposure size of each group (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0124653#pone.0124653.t001\" target=\"_blank\">Table 1</a>). Fig A, derived from STRIDE (N = 70,477), shows that PPIs have a class-level effect for MI in the general population of patients with GERD. By comparison, H₂ blockers, an alternate treatment, have no association. Fig B breaks down the associations for each PPI individually. Figs C and D use stratification to show that the signals are corroborated in two independent datasets (STRIDE and Practice Fusion) and are robust in important subgroups. Fig C shows that, for the STRIDE dataset, when patients on clopidogrel are excluded, the associations are unchanged. Also, in lower-risk age groups for MI, the associations are still present. Similar trends are seen in these subgroups in the Practice Fusion (PF) dataset (N = 227,438) shown in Fig D.</p>", "links"=>[], "tags"=>["gerd", "Myocardial infarction", "clopidogrel users", "association", "data sources", "hr", "Proton Pump Inhibitor Usage", "prioritize drug safety signals", "pharmacovigilance algorithms", "General Population Background", "PPI usage", "mi", "H 2 blockers", "ci", "gastroesophageal reflux disease", "clopidogrel use", "year 2000. ConclusionsConsistent", "novel approach", "survival analysis", "PPI exposure"], "article_id"=>1444820, "categories"=>["Biological Sciences"], "users"=>["Nigam H. Shah", "Paea LePendu", "Anna Bauer-Mehren", "Yohannes T. Ghebremariam", "Srinivasan V. Iyer", "Jake Marcus", "Kevin T. Nead", "John P. Cooke", "Nicholas J. Leeper"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124653.g001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PPI_use_is_associated_with_an_increased_risk_for_MI_regardless_of_age_or_clopidogrel_use_/1444820", "title"=>"PPI use is associated with an increased risk for MI, regardless of age or clopidogrel use.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-10 03:13:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2105206", "https://ndownloader.figshare.com/files/2105207", "https://ndownloader.figshare.com/files/2105208"], "description"=>"<div><p>Background and Aims</p><p>Proton pump inhibitors (PPIs) have been associated with adverse clinical outcomes amongst clopidogrel users after an acute coronary syndrome. Recent pre-clinical results suggest that this risk might extend to subjects without any prior history of cardiovascular disease. We explore this potential risk in the general population via data-mining approaches.</p><p>Methods</p><p>Using a novel approach for mining clinical data for pharmacovigilance, we queried over 16 million clinical documents on 2.9 million individuals to examine whether PPI usage was associated with cardiovascular risk in the general population.</p><p>Results</p><p>In multiple data sources, we found gastroesophageal reflux disease (GERD) patients exposed to PPIs to have a 1.16 fold increased association (95% CI 1.09–1.24) with myocardial infarction (MI). Survival analysis in a prospective cohort found a two-fold (HR = 2.00; 95% CI 1.07–3.78; P = 0.031) increase in association with cardiovascular mortality. We found that this association exists regardless of clopidogrel use. We also found that H₂ blockers, an alternate treatment for GERD, were not associated with increased cardiovascular risk; had they been in place, such pharmacovigilance algorithms could have flagged this risk as early as the year 2000.</p><p>Conclusions</p><p>Consistent with our pre-clinical findings that PPIs may adversely impact vascular function, our data-mining study supports the association of PPI exposure with risk for MI in the general population. These data provide an example of how a combination of experimental studies and data-mining approaches can be applied to prioritize drug safety signals for further investigation.</p></div>", "links"=>[], "tags"=>["gerd", "Myocardial infarction", "clopidogrel users", "association", "data sources", "hr", "Proton Pump Inhibitor Usage", "prioritize drug safety signals", "pharmacovigilance algorithms", "General Population Background", "PPI usage", "mi", "H 2 blockers", "ci", "gastroesophageal reflux disease", "clopidogrel use", "year 2000. ConclusionsConsistent", "novel approach", "survival analysis", "PPI exposure"], "article_id"=>1444828, "categories"=>["Biological Sciences"], "users"=>["Nigam H. Shah", "Paea LePendu", "Anna Bauer-Mehren", "Yohannes T. Ghebremariam", "Srinivasan V. Iyer", "Jake Marcus", "Kevin T. Nead", "John P. Cooke", "Nicholas J. Leeper"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0124653.s001", "https://dx.doi.org/10.1371/journal.pone.0124653.s002", "https://dx.doi.org/10.1371/journal.pone.0124653.s003"], "stats"=>{"downloads"=>14, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Proton_Pump_Inhibitor_Usage_and_the_Risk_of_Myocardial_Infarction_in_the_General_Population_/1444828", "title"=>"Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-06-10 03:13:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2105203"], "description"=>"<p>PPI exposure and control groups for patients with gastroesophageal reflux disease (GERD) are balanced across a number of basic covariates. Importantly, the use of clopidogrel is equally balanced across exposed and control groups. Other variables (no. of unique disease mentions, no. unique drug mentions, length of observation) are binned according to their distributions. Before matching, PI patients tend to be sicker, have more diseases and more drugs mentioned in their record. After matching, these variables are balanced.</p><p>Balance of variables for patients on PPIs in the STRIDE dataset.</p>", "links"=>[], "tags"=>["gerd", "Myocardial infarction", "clopidogrel users", "association", "data sources", "hr", "Proton Pump Inhibitor Usage", "prioritize drug safety signals", "pharmacovigilance algorithms", "General Population Background", "PPI usage", "mi", "H 2 blockers", "ci", "gastroesophageal reflux disease", "clopidogrel use", "year 2000. ConclusionsConsistent", "novel approach", "survival analysis", "PPI exposure"], "article_id"=>1444825, "categories"=>["Biological Sciences"], "users"=>["Nigam H. Shah", "Paea LePendu", "Anna Bauer-Mehren", "Yohannes T. Ghebremariam", "Srinivasan V. Iyer", "Jake Marcus", "Kevin T. Nead", "John P. Cooke", "Nicholas J. Leeper"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124653.t002", "stats"=>{"downloads"=>2, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Balance_of_variables_for_patients_on_PPIs_in_the_STRIDE_dataset_/1444825", "title"=>"Balance of variables for patients on PPIs in the STRIDE dataset.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-10 03:13:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2105201"], "description"=>"<p>The x-axis is calendar year; the y-axis on the left is the unadjusted odds ratio; the y-axis on the right is the number of patients exposed. The solid red line is the point estimate of the odds ratio. The dotted red lines are the confidence intervals. The blue line is the number of patients exposed. Vertical lines mark the earliest detected signal—the year when the lower bound on the 95% confidence interval rises above 1.0. Signal detection algorithms on clinical notes would have flagged lansoprazole for monitoring as early as the year 2000.</p>", "links"=>[], "tags"=>["gerd", "Myocardial infarction", "clopidogrel users", "association", "data sources", "hr", "Proton Pump Inhibitor Usage", "prioritize drug safety signals", "pharmacovigilance algorithms", "General Population Background", "PPI usage", "mi", "H 2 blockers", "ci", "gastroesophageal reflux disease", "clopidogrel use", "year 2000. ConclusionsConsistent", "novel approach", "survival analysis", "PPI exposure"], "article_id"=>1444823, "categories"=>["Biological Sciences"], "users"=>["Nigam H. Shah", "Paea LePendu", "Anna Bauer-Mehren", "Yohannes T. Ghebremariam", "Srinivasan V. Iyer", "Jake Marcus", "Kevin T. Nead", "John P. Cooke", "Nicholas J. Leeper"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124653.g003", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cumulative_risk_and_exposure_plots_reveal_that_pharmacovigilance_algorithms_could_have_flagged_lansoprazole_for_monitoring_as_early_as_the_year_2000_/1444823", "title"=>"Cumulative risk and exposure plots reveal that pharmacovigilance algorithms could have flagged lansoprazole for monitoring as early as the year 2000.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-10 03:13:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2105202"], "description"=>"<p>There are 93,149 patients with gastroesophageal reflux disease (GERD), of which 70,477 are at least 18 years old. In all study groups other than the one in which clopidogrel patients are excluded, the populations are matched (and balanced) based on clopidogrel use and other covariates such as age, gender, race, length of observation, number of unique drugs mentioned in the record, and validated proxies of health status (based on the number of unique disease concepts attributed to each patient). The matching process attempts to achieve a ratio of 1:5 (exposure to control), but will settle for 1:3 or 1:1 if there are not enough controls from which to draw.</p><p>* balanced for clopidogrel use</p><p>† patients on clopidogrel are excluded</p><p>‡ patients are restricted by age</p><p>Study group populations for the STRIDE dataset, including 5:1 propensity matching.</p>", "links"=>[], "tags"=>["gerd", "Myocardial infarction", "clopidogrel users", "association", "data sources", "hr", "Proton Pump Inhibitor Usage", "prioritize drug safety signals", "pharmacovigilance algorithms", "General Population Background", "PPI usage", "mi", "H 2 blockers", "ci", "gastroesophageal reflux disease", "clopidogrel use", "year 2000. ConclusionsConsistent", "novel approach", "survival analysis", "PPI exposure"], "article_id"=>1444824, "categories"=>["Biological Sciences"], "users"=>["Nigam H. Shah", "Paea LePendu", "Anna Bauer-Mehren", "Yohannes T. Ghebremariam", "Srinivasan V. Iyer", "Jake Marcus", "Kevin T. Nead", "John P. Cooke", "Nicholas J. Leeper"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124653.t001", "stats"=>{"downloads"=>6, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_group_populations_for_the_STRIDE_dataset_including_5_1_propensity_matching_/1444824", "title"=>"Study group populations for the STRIDE dataset, including 5:1 propensity matching.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-10 03:13:51"}

PMC Usage Stats | Further Information

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• {"unique-ip"=>"306", "full-text"=>"361", "pdf"=>"30", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"19", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
• {"unique-ip"=>"160", "full-text"=>"182", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
• {"unique-ip"=>"215", "full-text"=>"234", "pdf"=>"23", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
• {"unique-ip"=>"283", "full-text"=>"333", "pdf"=>"21", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2019", "month"=>"4"}
• {"unique-ip"=>"187", "full-text"=>"213", "pdf"=>"18", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
• {"unique-ip"=>"131", "full-text"=>"122", "pdf"=>"20", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
• {"unique-ip"=>"149", "full-text"=>"160", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
• {"unique-ip"=>"194", "full-text"=>"210", "pdf"=>"23", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}

F1000Prime