Impact of Bacterial Vaginosis, as Assessed by Nugent Criteria and Hormonal Status on Glycosidases and Lectin Binding in Cervicovaginal Lavage Samples
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{"title"=>"Impact of bacterial vaginosis, as assessed by nugent criteria and hormonal status on glycosidases and lectin binding in cervicovaginal lavage samples", "type"=>"journal", "authors"=>[{"first_name"=>"Bernard J.", "last_name"=>"Moncla", "scopus_author_id"=>"6701620974"}, {"first_name"=>"Catherine A.", "last_name"=>"Chappell", "scopus_author_id"=>"55440388600"}, {"first_name"=>"Lara K.", "last_name"=>"Mahal", "scopus_author_id"=>"6603165885"}, {"first_name"=>"Brian M.", "last_name"=>"Debo", "scopus_author_id"=>"57151311900"}, {"first_name"=>"Leslie A.", "last_name"=>"Meyn", "scopus_author_id"=>"6701807835"}, {"first_name"=>"Sharon L.", "last_name"=>"Hillier", "scopus_author_id"=>"56442082300"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84959472838", "sgr"=>"84959472838", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0127091", "pmid"=>"26011704", "pui"=>"608635441"}, "id"=>"5a6d6435-e47e-389b-a5b3-3a1961c94889", "abstract"=>"The objective of this study was to evaluate the impact of hormonal status and bacterial vaginosis (BV) on the glycosidases present and glycosylation changes as assessed by lectin binding to cervicovaginal lavage constituents. Frozen cervicovaginal lavage samples from a completed study examining the impact of reproductive hormones on the physicochemical properties of vaginal fluid were utilized for the present study. In the parent study, 165 women were characterized as having BV, intermediate or normal microflora using the Nugent criteria. The presence of glycosidases in the samples was determined using quantitative 4-methyl-umbelliferone based assays, and glycosylation was assessed using enzyme linked lectin assays (ELLA). Women with BV had elevated sialidase, α-galactosidase, β-galactosidase and α-glucosidase activities compared to intermediate or normal women (P<0.001, 0.003, 0.006 and 0.042 respectively). The amount of sialic acid (Sambucus nigra, P = 0.003) and high mannose (griffithsin, P<0.001) were reduced, as evaluated by lectin binding, in women with BV. When the data were stratified according to hormonal status, α-glucosidase and griffithsin binding were decreased among postmenopausal women (P<0.02) when compared to premenopausal groups. These data suggest that both hormonal status and BV impact the glycosidases and lectin binding sites present in vaginal fluid. The sialidases present at increased levels in women with BV likely reduce the number of sialic acid binding sites. Other enzymes likely reduce griffithsin binding. The alterations in the glycosidase content, high mannose and sialic acid binding sites in the cervicovaginal fluid associated with bacterial vaginosis may impact susceptibility to viruses, such as HIV, that utilize glycans as a portal of entry.", "link"=>"http://www.mendeley.com/research/impact-bacterial-vaginosis-assessed-nugent-criteria-hormonal-status-glycosidases-lectin-binding-cerv", "reader_count"=>15, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>4, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>4, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>2, "Social Sciences"=>1, "Immunology and Microbiology"=>1, "Engineering"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Chemistry"=>{"Chemistry"=>2}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Slovenia"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2083266"], "description"=>"<p><sup>1</sup>Data are presented as medians (range) in μMoles substrate hydrolyzed per min per mg protein. Griffithsin is measured as pg/ng protein.</p><p><sup>2</sup><i>P</i>-value from Kruskal-Wallis test across all groups.</p><p><sup>3</sup><i>P</i>-value <0.02 from Mann-Whitney U test comparing post-menopausal women to women of reproductive age.</p><p><sup>4</sup><i>P</i>-value = 0.02 and 0.047 from Mann-Whitney U test comparing women in days 1–14 of cycle to women in days 15–28 of the cycle for, respectively Griffithsin and α-glucosidase.</p><p>Median levels of glycosidases and lectin binding stratified by hormonal group, excluding women with bacterial vaginosis.</p>", "links"=>[], "tags"=>["bv", "impact", "fluid", "lectin binding sites", "sialic acid binding sites", "lectin binding", "glycosidase", "cervicovaginal lavage samples", "cervicovaginal lavage constituents", "ELLA", "griffithsin binding", "hiv", "status"], "article_id"=>1426840, "categories"=>["Biological Sciences"], "users"=>["Bernard J. Moncla", "Catherine A. Chappell", "Lara K. Mahal", "Brian M Debo", "Leslie A Meyn", "Sharon L. Hillier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127091.t002", "stats"=>{"downloads"=>4, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Median_levels_of_glycosidases_and_lectin_binding_stratified_by_hormonal_group_excluding_women_with_bacterial_vaginosis_/1426840", "title"=>"Median levels of glycosidases and lectin binding stratified by hormonal group, excluding women with bacterial vaginosis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-26 16:27:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/2083271", "https://ndownloader.figshare.com/files/2083272"], "description"=>"<div><p>The objective of this study was to evaluate the impact of hormonal status and bacterial vaginosis (BV) on the glycosidases present and glycosylation changes as assessed by lectin binding to cervicovaginal lavage constituents. Frozen cervicovaginal lavage samples from a completed study examining the impact of reproductive hormones on the physicochemical properties of vaginal fluid were utilized for the present study. In the parent study, 165 women were characterized as having BV, intermediate or normal microflora using the Nugent criteria. The presence of glycosidases in the samples was determined using quantitative 4-methyl-umbelliferone based assays, and glycosylation was assessed using enzyme linked lectin assays (ELLA). Women with BV had elevated sialidase, α-galactosidase, β-galactosidase and α-glucosidase activities compared to intermediate or normal women (<i>P</i><0.001, 0.003, 0.006 and 0.042 respectively). The amount of sialic acid (<i>Sambucus nigra</i>, <i>P</i> = 0.003) and high mannose (griffithsin, <i>P</i><0.001) were reduced, as evaluated by lectin binding, in women with BV. When the data were stratified according to hormonal status, α-glucosidase and griffithsin binding were decreased among postmenopausal women (<i>P</i><0.02) when compared to premenopausal groups. These data suggest that both hormonal status and BV impact the glycosidases and lectin binding sites present in vaginal fluid. The sialidases present at increased levels in women with BV likely reduce the number of sialic acid binding sites. Other enzymes likely reduce griffithsin binding. The alterations in the glycosidase content, high mannose and sialic acid binding sites in the cervicovaginal fluid associated with bacterial vaginosis may impact susceptibility to viruses, such as HIV, that utilize glycans as a portal of entry.</p></div>", "links"=>[], "tags"=>["bv", "impact", "fluid", "lectin binding sites", "sialic acid binding sites", "lectin binding", "glycosidase", "cervicovaginal lavage samples", "cervicovaginal lavage constituents", "ELLA", "griffithsin binding", "hiv", "status"], "article_id"=>1426842, "categories"=>["Biological Sciences"], "users"=>["Bernard J. Moncla", "Catherine A. Chappell", "Lara K. Mahal", "Brian M Debo", "Leslie A Meyn", "Sharon L. Hillier"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0127091.s001", "https://dx.doi.org/10.1371/journal.pone.0127091.s002"], "stats"=>{"downloads"=>13, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Impact_of_Bacterial_Vaginosis_as_Assessed_by_Nugent_Criteria_and_Hormonal_Status_on_Glycosidases_and_Lectin_Binding_in_Cervicovaginal_Lavage_Samples_/1426842", "title"=>"Impact of Bacterial Vaginosis, as Assessed by Nugent Criteria and Hormonal Status on Glycosidases and Lectin Binding in Cervicovaginal Lavage Samples", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-05-26 16:27:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/2083265"], "description"=>"<p><sup>1</sup>Data are presented as medians (range) in μMoles substrate hydrolyzed per min per mg protein. Griffithsin is measured as pg/ng protein.</p><p><sup>2</sup><i>P</i>-value from Kruskal-Wallis test.</p><p><sup>4</sup><i>P</i>-value = 0.04 from Mann-Whitney U test comparing normal women to women with bacterial vaginosis for alpha galactosidase.</p><p>Enzymatic activities and lectin binding in the cervicovaginal fluid of premenopausal women, stratified by Nugent scores.</p>", "links"=>[], "tags"=>["bv", "impact", "fluid", "lectin binding sites", "sialic acid binding sites", "lectin binding", "glycosidase", "cervicovaginal lavage samples", "cervicovaginal lavage constituents", "ELLA", "griffithsin binding", "hiv", "status"], "article_id"=>1426839, "categories"=>["Biological Sciences"], "users"=>["Bernard J. Moncla", "Catherine A. Chappell", "Lara K. Mahal", "Brian M Debo", "Leslie A Meyn", "Sharon L. Hillier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127091.t001", "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Enzymatic_activities_and_lectin_binding_in_the_cervicovaginal_fluid_of_premenopausal_women_stratified_by_Nugent_scores_/1426839", "title"=>"Enzymatic activities and lectin binding in the cervicovaginal fluid of premenopausal women, stratified by Nugent scores.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-26 16:27:06"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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