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Immune-Modulatory Effects of Bu-Zhong-Yi-Qi-Tang in Ovalbumin-Induced Murine Model of Allergic Asthma

Publication Date: June 02, 2015
Journal: PLOS ONE
Authors: Sien Hung Yang, Ting I Kao, Bor Luen Chiang, Hsing Yu Chen, et al
Volume: 10
Issue: 6
Pages: e0127636
DOI: https://dx.plos.org/10.1371/journal.pone.0127636
Publisher URL: http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0127636
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/26035827
PubMed Central: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452780
Europe PMC: http://europepmc.org/abstract/MED/26035827
Web of Science: 000355699100017
Scopus: 84934987927
Mendeley: http://www.mendeley.com/research/immunemodulatory-effects-buzhongyiqitang-ovalbumininduced-murine-model-allergic-asthma

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CiteULike09 May 22:30 UTC

CiteULike

Mendeley 906 May 00:35 UTC

Mendeley | Further Information

{"title"=>"Immune-modulatory effects of bu-zhong-yi-qi-tang in ovalbumin-induced murine model of allergic asthma", "type"=>"journal", "authors"=>[{"first_name"=>"Sien Hung", "last_name"=>"Yang", "scopus_author_id"=>"7408522801"}, {"first_name"=>"Ting I.", "last_name"=>"Kao", "scopus_author_id"=>"56708145200"}, {"first_name"=>"Bor Luen", "last_name"=>"Chiang", "scopus_author_id"=>"7201942667"}, {"first_name"=>"Hsing Yu", "last_name"=>"Chen", "scopus_author_id"=>"54881375000"}, {"first_name"=>"Kuang Hua", "last_name"=>"Chen", "scopus_author_id"=>"56529845300"}, {"first_name"=>"Jiun Liang", "last_name"=>"Chen", "scopus_author_id"=>"35309581500"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84934987927", "doi"=>"10.1371/journal.pone.0127636", "issn"=>"19326203", "scopus"=>"2-s2.0-84934987927", "pui"=>"604922913"}, "id"=>"9436e449-2549-38f1-8e7f-5f7bf65913e6", "abstract"=>"BACKGROUND: Bu-zhong-yi-qi-tang (BZYQT), an herbal formula of traditional Chinese medicine, has been an effective regimen of allergic diseases for nearly 800 years. Our previous report has demonstrated its anti-inflammatory effects in patients with perennial allergic rhinitis, and the aim of this study is to investigate the anti-asthmatic effect of BZYQT. METHODS: Female BALB/cByJNarl mice were sensitized with normal saline (control group) or OVA. Mice sensitized by OVA were fed with distilled water (OVA group), oral 0.5 g/Kg (low-dose group) or 1 g/Kg (high-dose group) of BZYQT solution once daily on days 36-40 besides their routine diet. Airway hyper-responsiveness (AHR), eosinophil infiltration, levels of cytokines and total immunoglobulin E (IgE) in broncho-alveolar lavage fluid (BALF) were determined. The lungs and tracheas were removed, and histopathologic examination was subsequently performed. RESULTS: AHR was significantly reduced in both low- and high-dose BZYQT groups compared with the OVA group after inhalation of the highest dose of methacholine (50 mg/ml). The levels of eotaxin, Th2-related cytokines (IL-4, IL-5, IL-13), IgE, and eosinophil infiltration in BALF were significantly decreased in both BZYQT groups compared with the OVA group. Histopathologic examination revealed that eosinophil infiltration of the lung and trachea tissues was remarkably attenuated in both BZYQT groups. CONCLUSIONS: Oral administration of BZYQT solution may exert anti-asthmatic effect by relieving AHR in OVA-sensitized mice, which is compatible with our clinical experience. Although detailed mechanism is to be determined, we surmise that it may be correlated with the immune-modulatory effects of inhibiting Th2 responses on the basis of our limited results.", "link"=>"http://www.mendeley.com/research/immunemodulatory-effects-buzhongyiqitang-ovalbumininduced-murine-model-allergic-asthma", "reader_count"=>7, "reader_count_by_academic_status"=>{"Librarian"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Librarian"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Environmental Science"=>1, "Medicine and Dentistry"=>3, "Psychology"=>2, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Psychology"=>{"Psychology"=>2}, "Computer Science"=>{"Computer Science"=>1}, "Environmental Science"=>{"Environmental Science"=>1}}, "group_count"=>2}

ORCID09 May 11:07 UTC

Scopus | Further Information

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Web of Science®15 Jan 20:44 UTC

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Journal Comments20 Oct 04:09 UTC

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Figshare 6308 May 14:08 UTC

Figshare

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{"files"=>["https://ndownloader.figshare.com/files/2092991"], "description"=>"The peaks indicate the existence of glycyrrhizin, AHB, Ferulic acid, and MPB in both panels, which proves the authenticity of BZYQT.", "links"=>[], "tags"=>["OVA group", "ahr", "eosinophil infiltration", "BZYQT solution", "balf", "balb", "BZYQT groups.ConclusionsOral administration", "Th 2 responses", "il"], "article_id"=>1434539, "categories"=>["Biological Sciences"], "users"=>["Sien-Hung Yang", "Ting-I Kao", "Bor-Luen Chiang", "Hsing-Yu Chen", "Kuang-Hua Chen", "Jiun-Liang Chen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127636.g001", "stats"=>{"downloads"=>1, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HPLC_data_of_Bu_Zhong_Yi_Qi_Tang_BZYQT_Upper_BZYQT_Lower_standard_sample_/1434539", "title"=>"HPLC data of Bu-Zhong-Yi-Qi-Tang (BZYQT) (Upper: BZYQT; Lower: standard sample).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-02 03:22:41"}
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{"files"=>["https://ndownloader.figshare.com/files/2092998"], "description"=>"After last OVA challenge, mice were exposed to a series of incremental dosages of methacholine (6.25, 12.5, 25, 50 mg/ml). The Penh values were then recorded, indicating AHR of mice under each dosage of methacholine stimulation. Control group (●, n = 10), OVA group (○, n = 4), Low dose (0.5 g/Kg) BZYQT group (△, n = 8), High dose (1 g/Kg) BZYQT group (▼, n = 8). Data were presented in mean ± standard deviation. ** p< 0.01 compared with the OVA group.", "links"=>[], "tags"=>["OVA group", "ahr", "eosinophil infiltration", "BZYQT solution", "balf", "balb", "BZYQT groups.ConclusionsOral administration", "Th 2 responses", "il"], "article_id"=>1434541, "categories"=>["Biological Sciences"], "users"=>["Sien-Hung Yang", "Ting-I Kao", "Bor-Luen Chiang", "Hsing-Yu Chen", "Kuang-Hua Chen", "Jiun-Liang Chen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127636.g002", "stats"=>{"downloads"=>2, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_oral_administration_of_BZYQT_on_airway_hyperresponsiveness_AHR_/1434541", "title"=>"Effect of oral administration of BZYQT on airway hyperresponsiveness (AHR).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-02 03:22:41"}
{"files"=>["https://ndownloader.figshare.com/files/2092999"], "description"=>"The concentrations of IL-4 (A), IL-5 (B), and IL-13 (C) were determined by ELISA. Data were presented in mean ± standard deviation. * p < 0.05 compared with the OVA group.", "links"=>[], "tags"=>["OVA group", "ahr", "eosinophil infiltration", "BZYQT solution", "balf", "balb", "BZYQT groups.ConclusionsOral administration", "Th 2 responses", "il"], "article_id"=>1434542, "categories"=>["Biological Sciences"], "users"=>["Sien-Hung Yang", "Ting-I Kao", "Bor-Luen Chiang", "Hsing-Yu Chen", "Kuang-Hua Chen", "Jiun-Liang Chen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127636.g003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_BZYQT_regulated_Th2_cytokines_in_BALF_of_asthmatic_murine_model_sensitized_by_OVA_/1434542", "title"=>"BZYQT regulated Th2 cytokines in BALF of asthmatic murine model sensitized by OVA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-02 03:22:41"}

PMC Usage Stats 149717 Jan 22:23 UTC

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{"unique-ip"=>"21", "full-text"=>"25", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"26", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
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{"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
{"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
{"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
{"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
{"unique-ip"=>"11", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
{"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
{"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
{"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
{"unique-ip"=>"24", "full-text"=>"27", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
{"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
{"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
{"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
{"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
{"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
{"unique-ip"=>"7", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
{"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
{"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
{"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
{"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
{"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
{"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
{"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
{"unique-ip"=>"22", "full-text"=>"19", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
{"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
{"unique-ip"=>"23", "full-text"=>"24", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
{"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
{"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
{"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
{"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
{"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
{"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
{"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"10"}
{"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
{"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
{"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
{"unique-ip"=>"20", "full-text"=>"16", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
{"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
{"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
{"unique-ip"=>"28", "full-text"=>"38", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
{"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
{"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
{"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
{"unique-ip"=>"30", "full-text"=>"35", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
{"unique-ip"=>"16", "full-text"=>"12", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
{"unique-ip"=>"15", "full-text"=>"24", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
{"unique-ip"=>"17", "full-text"=>"21", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
{"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
{"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
{"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
{"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
{"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}

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