Autoantibody-Targeted Treatments for Acute Exacerbations of Idiopathic Pulmonary Fibrosis
- Publication Date
- June 17, 2015
- Journal
- PLOS ONE
- Authors
- Michael Donahoe, Vincent G. Valentine, Nydia Chien, Kevin F. Gibson, et al
- Volume
- 10
- Issue
- 6
- Pages
- e0127771
- DOI
- https://dx.plos.org/10.1371/journal.pone.0127771
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0127771
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/26083430
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470587
- Europe PMC
- http://europepmc.org/abstract/MED/26083430
- Web of Science
- 000356567400017
- Scopus
- 84939140106
- Mendeley
- http://www.mendeley.com/research/autoantibodytargeted-treatments-acute-exacerbations-idiopathic-pulmonary-fibrosis
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Mendeley | Further Information
{"title"=>"Autoantibody-targeted treatments for acute exacerbations of idiopathic pulmonary fibrosis", "type"=>"journal", "authors"=>[{"first_name"=>"Michael", "last_name"=>"Donahoe", "scopus_author_id"=>"6701599925"}, {"first_name"=>"Vincent G.", "last_name"=>"Valentine", "scopus_author_id"=>"7003857529"}, {"first_name"=>"Nydia", "last_name"=>"Chien", "scopus_author_id"=>"56779775200"}, {"first_name"=>"Kevin F.", "last_name"=>"Gibson", "scopus_author_id"=>"7202666589"}, {"first_name"=>"Jay S.", "last_name"=>"Raval", "scopus_author_id"=>"36449699100"}, {"first_name"=>"Melissa", "last_name"=>"Saul", "scopus_author_id"=>"6604051800"}, {"first_name"=>"Jianmin", "last_name"=>"Xue", "scopus_author_id"=>"8519864400"}, {"first_name"=>"Yingze", "last_name"=>"Zhang", "scopus_author_id"=>"55739972400"}, {"first_name"=>"Steven R.", "last_name"=>"Duncan", "scopus_author_id"=>"56744127600"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84939140106", "isbn"=>"1932-6203", "scopus"=>"2-s2.0-84939140106", "pui"=>"605585509", "pmid"=>"26083430", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0127771"}, "id"=>"e5dd64c9-fad7-3f21-aeb8-b0e059a880c6", "abstract"=>"BACKGROUND: Severe acute exacerbations (AE) of idiopathic pulmonary fibrosis (IPF) are medically untreatable and often fatal within days. Recent evidence suggests autoantibodies may be involved in IPF progression. Autoantibody-mediated lung diseases are typically refractory to glucocorticoids and nonspecific medications, but frequently respond to focused autoantibody reduction treatments. We conducted a pilot trial to test the hypothesis that autoantibody-targeted therapies may also benefit AE-IPF patients.\\n\\nMETHODS: Eleven (11) critically-ill AE-IPF patients with no evidence of conventional autoimmune diseases were treated with therapeutic plasma exchanges (TPE) and rituximab, supplemented in later cases with intravenous immunoglobulin (IVIG). Plasma anti-epithelial (HEp-2) autoantibodies and matrix metalloproteinase-7 (MMP7) were evaluated by indirect immunofluorescence and ELISA, respectively. Outcomes among the trial subjects were compared to those of 20 historical control AE-IPF patients treated with conventional glucocorticoid therapy prior to this experimental trial.\\n\\nRESULTS: Nine (9) trial subjects (82%) had improvements of pulmonary gas exchange after treatment, compared to one (5%) historical control. Two of the three trial subjects who relapsed after only five TPE responded again with additional TPE. The three latest subjects who responded to an augmented regimen of nine TPE plus rituximab plus IVIG have had sustained responses without relapses after 96-to-237 days. Anti-HEp-2 autoantibodies were present in trial subjects prior to therapy, and were reduced by TPE among those who responded to treatment. Conversely, plasma MMP7 levels were not systematically affected by therapy nor correlated with clinical responses. One-year survival of trial subjects was 46+15% vs. 0% among historical controls. No serious adverse events were attributable to the experimental medications.\\n\\nCONCLUSION: This pilot trial indicates specific treatments that reduce autoantibodies might benefit some severely-ill AE-IPF patients. These findings have potential implications regarding mechanisms of IPF progression, and justify considerations for incremental trials of autoantibody-targeted therapies in AE-IPF patients.\\n\\nTRIAL REGISTRATION: ClinicalTrials.gov NCT01266317.", "link"=>"http://www.mendeley.com/research/autoantibodytargeted-treatments-acute-exacerbations-idiopathic-pulmonary-fibrosis", "reader_count"=>33, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>9, "Other"=>6, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>9, "Other"=>6, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>25, "Agricultural and Biological Sciences"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>25}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "group_count"=>3}CrossRef
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Scopus | Further Information
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- {"id"=>"1008359137691013120", "text"=>"Support for what we observe in patients: https://t.co/bFFPaE8ROX https://t.co/IVhsAjm16Y", "created_at"=>"2018-06-17T14:42:07Z", "user"=>"DKNYPitt", "user_name"=>"Daniel Kass", "user_profile_image"=>"http://pbs.twimg.com/profile_images/656822037353222145/X23ddhEk_normal.jpg"}
- {"id"=>"617493251319308289", "text"=>"Striking results from pilot study of plasma exchange + rituximab +/- IVIg for #AEIPF @PLOSONE. Need a full trial. http://t.co/ivHImLmty7", "created_at"=>"2015-07-05T00:40:38Z", "user"=>"drstanbrook", "user_name"=>"Matthew Stanbrook", "user_profile_image"=>"http://pbs.twimg.com/profile_images/572539896621101056/2lD09Y6e_normal.jpeg"}
- {"id"=>"617722830667427840", "text"=>"RT @drstanbrook: Striking results from pilot study of plasma exchange + rituximab +/- IVIg for #AEIPF @PLOSONE. Need a full trial. http://t…", "created_at"=>"2015-07-05T15:52:54Z", "user"=>"twhcmr", "user_name"=>"Lee Fidler", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000092840468/c1b07ed4a041bbc5eef75befc3a8a8c0_normal.jpeg"}
- {"id"=>"619918289532268544", "text"=>"rituximab in advanced IPF? Small open-label, encouraging since Acute Exacerbation poor outcome\nhttp://t.co/Jp22BH4FAB\nhttp://t.co/M5nHKyu8N1", "created_at"=>"2015-07-11T17:16:52Z", "user"=>"MauriceOnTW", "user_name"=>"Maurice", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1399243728/ball_normal.gif"}
- {"id"=>"691597757442854912", "text"=>"Autoantibody - Targeted Treatments as an alternative in some cases for treatment of #AEx #IPF https://t.co/vRs4XjOo9f", "created_at"=>"2016-01-25T12:25:29Z", "user"=>"carlosneumoruiz", "user_name"=>"Dr. Carlos Ruiz G.", "user_profile_image"=>"http://pbs.twimg.com/profile_images/676580690171858944/9FNh-44y_normal.jpg"}
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Relative Metric
{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}Loading … 

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