The Carboxy Terminus of the Ligand Peptide Determines the Stability of the MHC Class I Molecule H-2Kb: A Combined Molecular Dynamics and Experimental Study
- Publication Date
- August 13, 2015
- Journal
- PLOS ONE
- Authors
- Esam Tolba Abualrous, Sunil Kumar Saini, Venkat Raman Ramnarayan, Florin Tudor Ilca, et al
- Volume
- 10
- Issue
- 8
- Pages
- e0135421
- DOI
- https://dx.plos.org/10.1371/journal.pone.0135421
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0135421
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/26270965
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535769
- Europe PMC
- http://europepmc.org/abstract/MED/26270965
- Web of Science
- 000359492800067
- Scopus
- 84942903569
- Mendeley
- http://www.mendeley.com/research/carboxy-terminus-ligand-peptide-determines-stability-mhc-class-i-molecule-h2kb-combined-molecular-dy
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Mendeley | Further Information
{"title"=>"The carboxy terminus of the ligand peptide determines the stability of the MHC class i molecule H-2Kb: A combined molecular dynamics and experimental study", "type"=>"journal", "authors"=>[{"first_name"=>"Esam Tolba", "last_name"=>"Abualrous", "scopus_author_id"=>"55578775700"}, {"first_name"=>"Sunil Kumar", "last_name"=>"Saini", "scopus_author_id"=>"57201596571"}, {"first_name"=>"Venkat Raman", "last_name"=>"Ramnarayan", "scopus_author_id"=>"56004378000"}, {"first_name"=>"Florin Tudor", "last_name"=>"Ilca", "scopus_author_id"=>"56398508700"}, {"first_name"=>"Martin", "last_name"=>"Zacharias", "scopus_author_id"=>"7005598310"}, {"first_name"=>"Sebastian", "last_name"=>"Springer", "scopus_author_id"=>"8773026400"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84942903569", "sgr"=>"84942903569", "pui"=>"606195813", "pmid"=>"26270965", "doi"=>"10.1371/journal.pone.0135421"}, "id"=>"be5eafa3-3aeb-393c-b437-d22364f61a9b", "abstract"=>"Major histocompatibility complex (MHC) class I molecules (proteins) bind peptides of eight to ten amino acids to present them at the cell surface to cytotoxic T cells. The class I binding groove binds the peptide via hydrogen bonds with the peptide termini and via diverse interactions with the anchor residue side chains of the peptide. To elucidate which of these interactions is most important for the thermodynamic and kinetic stability of the peptide-bound state, we have combined molecular dynamics simulations and experimental approaches in an investigation of the conformational dynamics and binding parameters of a murine class I molecule (H-2Kb) with optimal and truncated natural peptide epitopes. We show that the F pocket region dominates the conformational and thermodynamic properties of the binding groove, and that therefore the binding of the C terminus of the peptide to the F pocket region plays a crucial role in bringing about the peptide-bound state of MHC class I.", "link"=>"http://www.mendeley.com/research/carboxy-terminus-ligand-peptide-determines-stability-mhc-class-i-molecule-h2kb-combined-molecular-dy", "reader_count"=>19, "reader_count_by_academic_status"=>{"Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Master"=>4, "Other"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Master"=>4, "Other"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>8, "Physics and Astronomy"=>1, "Chemistry"=>3, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Chemistry"=>{"Chemistry"=>3}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Canada"=>1}, "group_count"=>0}CrossRef
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Scopus | Further Information
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Relative Metric
{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}Loading … 

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