Effectiveness of Trivalent Inactivated Influenza Vaccine in Children Estimated by a Test-Negative Case-Control Design Study Based on Influenza Rapid Diagnostic Test Results
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{"title"=>"Effectiveness of trivalent inactivated influenza vaccine in children estimated by a test-negative case-control design study based on influenza rapid diagnostic test results", "type"=>"journal", "authors"=>[{"first_name"=>"Masayoshi", "last_name"=>"Shinjoh", "scopus_author_id"=>"6701516524"}, {"first_name"=>"Norio", "last_name"=>"Sugaya", "scopus_author_id"=>"7007182304"}, {"first_name"=>"Yoshio", "last_name"=>"Yamaguchi", "scopus_author_id"=>"35338272200"}, {"first_name"=>"Yuka", "last_name"=>"Tomidokoro", "scopus_author_id"=>"56891156800"}, {"first_name"=>"Shinichiro", "last_name"=>"Sekiguchi", "scopus_author_id"=>"35743965200"}, {"first_name"=>"Keiko", "last_name"=>"Mitamura", "scopus_author_id"=>"7102327656"}, {"first_name"=>"Motoko", "last_name"=>"Fujino", "scopus_author_id"=>"8659751100"}, {"first_name"=>"Hiroyuki", "last_name"=>"Shiro", "scopus_author_id"=>"6602521423"}, {"first_name"=>"Osamu", "last_name"=>"Komiyama", "scopus_author_id"=>"57192983555"}, {"first_name"=>"Nobuhiko", "last_name"=>"Taguchi", "scopus_author_id"=>"56890759600"}, {"first_name"=>"Yuji", "last_name"=>"Nakata", "scopus_author_id"=>"7202250940"}, {"first_name"=>"Naoko", "last_name"=>"Yoshida", "scopus_author_id"=>"8659751000"}, {"first_name"=>"Atsushi", "last_name"=>"Narabayashi", "scopus_author_id"=>"56652199900"}, {"first_name"=>"Michiko", "last_name"=>"Myokai", "scopus_author_id"=>"36866478100"}, {"first_name"=>"Masanori", "last_name"=>"Sato", "scopus_author_id"=>"55340286900"}, {"first_name"=>"Munehiro", "last_name"=>"Furuichi", "scopus_author_id"=>"56985664000"}, {"first_name"=>"Hiroaki", "last_name"=>"Baba", "scopus_author_id"=>"56890397200"}, {"first_name"=>"Hisayo", "last_name"=>"Fujita", "scopus_author_id"=>"55550117600"}, {"first_name"=>"Akihiro", "last_name"=>"Sato", "scopus_author_id"=>"55624474031"}, {"first_name"=>"Ichiro", "last_name"=>"Ookawara", "scopus_author_id"=>"56891625800"}, {"first_name"=>"Kenichiro", "last_name"=>"Tsunematsu", "scopus_author_id"=>"56071431200"}, {"first_name"=>"Makoto", "last_name"=>"Yoshida", "scopus_author_id"=>"10440459200"}, {"first_name"=>"Mio", "last_name"=>"Kono", "scopus_author_id"=>"56890512400"}, {"first_name"=>"Fumie", "last_name"=>"Tanaka", "scopus_author_id"=>"56890485800"}, {"first_name"=>"Chiharu", "last_name"=>"Kawakami", "scopus_author_id"=>"6701842355"}, {"first_name"=>"Takahisa", "last_name"=>"Kimiya", "scopus_author_id"=>"56891540800"}, {"first_name"=>"Takao", "last_name"=>"Takahashi", "scopus_author_id"=>"55624471657"}, {"first_name"=>"Satoshi", "last_name"=>"Iwata", "scopus_author_id"=>"55427356500"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84943279620", "pui"=>"606226561", "doi"=>"10.1371/journal.pone.0136539", "isbn"=>"1932-6203", "sgr"=>"84943279620", "pmid"=>"26317334"}, "id"=>"e0fbb26e-df58-3c3b-a378-8f464508fc89", "abstract"=>"We assessed vaccine effectiveness (VE) against medically attended, laboratory-confirmed influenza in children 6 months to 15 years of age in 22 hospitals in Japan during the 2013-14 season. Our study was conducted according to a test-negative case-control design based on influenza rapid diagnostic test (IRDT) results. Outpatients who came to our clinics with a fever of 38°C or over and had undergone an IRDT were enrolled in this study. Patients with positive IRDT results were recorded as cases, and patients with negative results were recorded as controls. Between November 2013 and March 2014, a total of 4727 pediatric patients (6 months to 15 years of age) were enrolled: 876 were positive for influenza A, 66 for A(H1N1)pdm09 and in the other 810 the subtype was unknown; 1405 were positive for influenza B; and 2445 were negative for influenza. Overall VE was 46% (95% confidence interval [CI], 39-52). Adjusted VE against influenza A, influenza A(H1N1) pdm09, and influenza B was 63% (95% CI, 56-69), 77% (95% CI, 59-87), and 26% (95% CI, 14-36), respectively. Influenza vaccine was not effective against either influenza A or influenza B in infants 6 to 11 months of age. Two doses of influenza vaccine provided better protection against influenza A infection than a single dose did. VE against hospitalization influenza A infection was 76%. Influenza vaccine was effective against influenza A, especially against influenza A(H1N1)pdm09, but was much less effective against influenza B. Copyright:", "link"=>"http://www.mendeley.com/research/effectiveness-trivalent-inactivated-influenza-vaccine-children-estimated-testnegative-casecontrol-de", "reader_count"=>29, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>6, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>3, "Other"=>6, "Student > Master"=>2, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>6, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>3, "Other"=>6, "Student > Master"=>2, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>11, "Agricultural and Biological Sciences"=>11, "Computer Science"=>1, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Japan"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2233860"], "description"=>"<p>a Among four hospitals which used IRDTs that can detect A(H1N1)pdm09.</p><p>b Number of patients vaccinated.</p><p>c Number of patients unvaccinated.</p><p>d VE against any influenza and VE against influenza B were higher in the north area than in the middle or south area (Breslow-Day, p < 0.05).</p><p>Effectiveness of Influenza Vaccine in Children (6 m/o-12 y/o) According to Hospital (A to V).</p>", "links"=>[], "tags"=>["children 6 months", "IRDT", "ci", "15 years", "Trivalent Inactivated Influenza Vaccine", "ve", "Influenza Rapid Diagnostic Test Results", "influenza B"], "article_id"=>1528016, "categories"=>["Uncategorised"], "users"=>["Masayoshi Shinjoh", "Norio Sugaya", "Yoshio Yamaguchi", "Yuka Tomidokoro", "Shinichiro Sekiguchi", "Keiko Mitamura", "Motoko Fujino", "Hiroyuki Shiro", "Osamu Komiyama", "Nobuhiko Taguchi", "Yuji Nakata", "Naoko Yoshida", "Atsushi Narabayashi", "Michiko Myokai", "Masanori Sato", "Munehiro Furuichi", "Hiroaki Baba", "Hisayo Fujita", "Akihiro Sato", "Ichiro Ookawara", "Kenichiro Tsunematsu", "Makoto Yoshida", "Mio Kono", "Fumie Tanaka", "Chiharu Kawakami", "Takahisa Kimiya", "Takao Takahashi", "Satoshi Iwata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0136539.t006", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effectiveness_of_Influenza_Vaccine_in_Children_6_m_o_12_y_o_According_to_Hospital_A_to_V_/1528016", "title"=>"Effectiveness of Influenza Vaccine in Children (6 m/o-12 y/o) According to Hospital (A to V).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-08-28 04:48:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2233855"], "description"=>"<p>a Only four hospitals used IRDTs that can detect H1N1pdm09.</p><p>b Chi-square test.</p><p>c Mann–Whitney <i>U</i>- test.</p><p>d Chi-square test, Cramer's V = 0.0189.</p><p>e Chi-square test, Cramer's V = 0.1830.</p><p>f Chi-square test, comparing the number of patients who visited <12 hours after the onset with the number who visited later.</p><p>g number who visited later.</p><p>h Chi-square test, Cramer's V = 0.9160.</p><p>* Neuraminidase Inhibitors.</p><p>Characteristics of Enrollees in 2013/14 Influenza Season.</p>", "links"=>[], "tags"=>["children 6 months", "IRDT", "ci", "15 years", "Trivalent Inactivated Influenza Vaccine", "ve", "Influenza Rapid Diagnostic Test Results", "influenza B"], "article_id"=>1528011, "categories"=>["Uncategorised"], "users"=>["Masayoshi Shinjoh", "Norio Sugaya", "Yoshio Yamaguchi", "Yuka Tomidokoro", "Shinichiro Sekiguchi", "Keiko Mitamura", "Motoko Fujino", "Hiroyuki Shiro", "Osamu Komiyama", "Nobuhiko Taguchi", "Yuji Nakata", "Naoko Yoshida", "Atsushi Narabayashi", "Michiko Myokai", "Masanori Sato", "Munehiro Furuichi", "Hiroaki Baba", "Hisayo Fujita", "Akihiro Sato", "Ichiro Ookawara", "Kenichiro Tsunematsu", "Makoto Yoshida", "Mio Kono", "Fumie Tanaka", "Chiharu Kawakami", "Takahisa Kimiya", "Takao Takahashi", "Satoshi Iwata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0136539.t001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_Enrollees_in_2013_14_Influenza_Season_/1528011", "title"=>"Characteristics of Enrollees in 2013/14 Influenza Season.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-08-28 04:48:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2233856"], "description"=>"<p>a Adjusted for comorbidity (yes or no, except H1N1 analysis), area (north area, middle area, south of the Kanto region), months of onset.</p><p>b Adjusted for age (0–15 y/o).</p><p>c Adjusted for time tested after the onset (<12, 12–48 and >48 hours).</p><p>d Patients tested only >12 hours after onset.</p><p>Data for 3046 patients were available; 1499 for any influenza (A; 537, H1N1; 43, B; 962) and 1547 for influenza negative.</p><p>e Two hospitals have no information on comorbidity.</p><p>f Only four institutes used IRDTs that can detect A(H1N1)pdm09. One hospital had no information on comorbidity.</p><p>g Not analyzed because few patients developed influenza.</p><p>* (vaccinated/cases) [vaccinated/controls].</p><p>Effectiveness of Influenza Vaccine for Children in 2013/14 Influenza Season (N = 4727).</p>", "links"=>[], "tags"=>["children 6 months", "IRDT", "ci", "15 years", "Trivalent Inactivated Influenza Vaccine", "ve", "Influenza Rapid Diagnostic Test Results", "influenza B"], "article_id"=>1528012, "categories"=>["Uncategorised"], "users"=>["Masayoshi Shinjoh", "Norio Sugaya", "Yoshio Yamaguchi", "Yuka Tomidokoro", "Shinichiro Sekiguchi", "Keiko Mitamura", "Motoko Fujino", "Hiroyuki Shiro", "Osamu Komiyama", "Nobuhiko Taguchi", "Yuji Nakata", "Naoko Yoshida", "Atsushi Narabayashi", "Michiko Myokai", "Masanori Sato", "Munehiro Furuichi", "Hiroaki Baba", "Hisayo Fujita", "Akihiro Sato", "Ichiro Ookawara", "Kenichiro Tsunematsu", "Makoto Yoshida", "Mio Kono", "Fumie Tanaka", "Chiharu Kawakami", "Takahisa Kimiya", "Takao Takahashi", "Satoshi Iwata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0136539.t002", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effectiveness_of_Influenza_Vaccine_for_Children_in_2013_14_Influenza_Season_N_4727_/1528012", "title"=>"Effectiveness of Influenza Vaccine for Children in 2013/14 Influenza Season (N = 4727).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-08-28 04:48:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2233857"], "description"=>"<p>a Among the 4 hospitals which used IRDTs that can detect H1N1pdm09.</p><p>Effectiveness of Influenza Vaccine for Children, by Vaccine Doses (6m/o-12y/o).</p>", "links"=>[], "tags"=>["children 6 months", "IRDT", "ci", "15 years", "Trivalent Inactivated Influenza Vaccine", "ve", "Influenza Rapid Diagnostic Test Results", "influenza B"], "article_id"=>1528013, "categories"=>["Uncategorised"], "users"=>["Masayoshi Shinjoh", "Norio Sugaya", "Yoshio Yamaguchi", "Yuka Tomidokoro", "Shinichiro Sekiguchi", "Keiko Mitamura", "Motoko Fujino", "Hiroyuki Shiro", "Osamu Komiyama", "Nobuhiko Taguchi", "Yuji Nakata", "Naoko Yoshida", "Atsushi Narabayashi", "Michiko Myokai", "Masanori Sato", "Munehiro Furuichi", "Hiroaki Baba", "Hisayo Fujita", "Akihiro Sato", "Ichiro Ookawara", "Kenichiro Tsunematsu", "Makoto Yoshida", "Mio Kono", "Fumie Tanaka", "Chiharu Kawakami", "Takahisa Kimiya", "Takao Takahashi", "Satoshi Iwata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0136539.t003", "stats"=>{"downloads"=>0, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effectiveness_of_Influenza_Vaccine_for_Children_by_Vaccine_Doses_6m_o_12y_o_/1528013", "title"=>"Effectiveness of Influenza Vaccine for Children, by Vaccine Doses (6m/o-12y/o).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-08-28 04:48:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2233858"], "description"=>"<p>a Among the 4 hospitals which used IRDTs that can detect A(H1N1)pdm09.</p><p>Effectiveness of Influenza Vaccine for Preventing Influenza Hospitalization.</p>", "links"=>[], "tags"=>["children 6 months", "IRDT", "ci", "15 years", "Trivalent Inactivated Influenza Vaccine", "ve", "Influenza Rapid Diagnostic Test Results", "influenza B"], "article_id"=>1528014, "categories"=>["Uncategorised"], "users"=>["Masayoshi Shinjoh", "Norio Sugaya", "Yoshio Yamaguchi", "Yuka Tomidokoro", "Shinichiro Sekiguchi", "Keiko Mitamura", "Motoko Fujino", "Hiroyuki Shiro", "Osamu Komiyama", "Nobuhiko Taguchi", "Yuji Nakata", "Naoko Yoshida", "Atsushi Narabayashi", "Michiko Myokai", "Masanori Sato", "Munehiro Furuichi", "Hiroaki Baba", "Hisayo Fujita", "Akihiro Sato", "Ichiro Ookawara", "Kenichiro Tsunematsu", "Makoto Yoshida", "Mio Kono", "Fumie Tanaka", "Chiharu Kawakami", "Takahisa Kimiya", "Takao Takahashi", "Satoshi Iwata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0136539.t004", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effectiveness_of_Influenza_Vaccine_for_Preventing_Influenza_Hospitalization_/1528014", "title"=>"Effectiveness of Influenza Vaccine for Preventing Influenza Hospitalization.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-08-28 04:48:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2233859"], "description"=>"<p>a Among four hospitals which used IRDTs that can detect A(H1N1)pdm09.</p><p>* (vaccinated/cases) [vaccinated/controls].</p><p>Effectiveness of Influenza Vaccine, by Phase.</p>", "links"=>[], "tags"=>["children 6 months", "IRDT", "ci", "15 years", "Trivalent Inactivated Influenza Vaccine", "ve", "Influenza Rapid Diagnostic Test Results", "influenza B"], "article_id"=>1528015, "categories"=>["Uncategorised"], "users"=>["Masayoshi Shinjoh", "Norio Sugaya", "Yoshio Yamaguchi", "Yuka Tomidokoro", "Shinichiro Sekiguchi", "Keiko Mitamura", "Motoko Fujino", "Hiroyuki Shiro", "Osamu Komiyama", "Nobuhiko Taguchi", "Yuji Nakata", "Naoko Yoshida", "Atsushi Narabayashi", "Michiko Myokai", "Masanori Sato", "Munehiro Furuichi", "Hiroaki Baba", "Hisayo Fujita", "Akihiro Sato", "Ichiro Ookawara", "Kenichiro Tsunematsu", "Makoto Yoshida", "Mio Kono", "Fumie Tanaka", "Chiharu Kawakami", "Takahisa Kimiya", "Takao Takahashi", "Satoshi Iwata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0136539.t005", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effectiveness_of_Influenza_Vaccine_by_Phase_/1528015", "title"=>"Effectiveness of Influenza Vaccine, by Phase.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-08-28 04:48:11"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"24", "full-text"=>"30", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
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  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
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  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"27", "full-text"=>"31", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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