Relevance of Post-Stroke Circulating BDNF Levels as a Prognostic Biomarker of Stroke Outcome. Impact of rt-PA Treatment
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{"title"=>"Relevance of post-stroke circulating BDNF levels as a prognostic biomarker of stroke outcome. Impact of rt-PA treatment", "type"=>"journal", "authors"=>[{"first_name"=>"Marion", "last_name"=>"Rodier", "scopus_author_id"=>"55555772900"}, {"first_name"=>"Aurore", "last_name"=>"Quirié", "scopus_author_id"=>"55355009400"}, {"first_name"=>"Anne", "last_name"=>"Prigent-Tessier", "scopus_author_id"=>"6603261998"}, {"first_name"=>"Yannick", "last_name"=>"Béjot", "scopus_author_id"=>"14038743100"}, {"first_name"=>"Agnès", "last_name"=>"Jacquin", "scopus_author_id"=>"35107441000"}, {"first_name"=>"Claude", "last_name"=>"Mossiat", "scopus_author_id"=>"6602758276"}, {"first_name"=>"Christine", "last_name"=>"Marie", "scopus_author_id"=>"7006731046"}, {"first_name"=>"Philippe", "last_name"=>"Garnier", "scopus_author_id"=>"57196849903"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84949032784", "sgr"=>"84949032784", "doi"=>"10.1371/journal.pone.0140668", "pui"=>"607111840", "pmid"=>"26469350", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203"}, "id"=>"781c1c70-1e9f-39cd-9a8b-491c18fa7e26", "abstract"=>"The recombinant form of tissue plasminogen activator (rt-PA) is the only curative treatment for ischemic stroke. Recently, t-PA has been linked to the metabolism of brain-derived neurotrophic factor (BDNF), a major neurotrophin involved in post-stroke neuroplasticity. Thus, the objective of our study was to investigate the impact of rt-PA treatment on post-stroke circulating BDNF levels in humans and in animals. Serum BDNF levels and t-PA/plasmin activity were measured at hospital admission and at up to 90 days in stroke patients receiving (n = 24) or not (n = 14) rt-PA perfusion. We investigated the relationships between serum BDNF with concurrent t-PA/plasmin activity, neurological outcomes and cardiovascular scores at admission. In parallel, serum BDNF levels and t-PA/plasmin activity were assessed before and after (1, 4 and 24h) the induction of ischemic stroke in rats. Our study revealed higher serum BDNF levels and better neurological outcome in rt-PA-treated than non-treated patients. However, serum BDNF levels did not predict stroke outcome when the whole cohort of stroke patients was analyzed. By contrast, serum BDNF levels when measured at admission and at day 90 correlated with cardiovascular scores, and those at day 1 correlated with serum t-PA/plasmin activity in the whole cohort of patients whereas no association could be found in the rt-PA-treated group. In rats devoid of cardiovascular risk, no difference in post-stroke serum BDNF levels was detected between rt-PA- and vehicle-treated animals and no correlation was found between serum BDNF levels and t-PA/plasmin activity. Overall, the data suggest that serum BDNF levels may not be useful as a prognostic biomarker of stroke outcome and that endothelial dysfunction could be a confounding factor when serum BDNF levels after stroke are used to reflect of brain BDNF levels.", "link"=>"http://www.mendeley.com/research/relevance-poststroke-circulating-bdnf-levels-prognostic-biomarker-stroke-outcome-impact-rtpa-treatme", "reader_count"=>30, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Librarian"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Other"=>6, "Student > Master"=>4, "Student > Bachelor"=>3, "Lecturer"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Librarian"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Other"=>6, "Student > Master"=>4, "Student > Bachelor"=>3, "Lecturer"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Medicine and Dentistry"=>18, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>5, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>2, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>18}, "Neuroscience"=>{"Neuroscience"=>5}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2362014"], "description"=>"<p>Population characteristics in non-treated patients (n = 14) and in rt-PA-treated patients (n = 24). Values are expressed as mean ± SEM or numbers of patients (Lesion location, stroke etiology, cardiovascular risk factors, death). BMI = Body mass index, NIHSS = National Institute of Health Stroke Scale, NS = non-significant.</p><p><sup>a</sup> Differences between the two groups of patients were analyzed using the non-parametric Mann–Whitney-U test with significance set at (*) p <0.05.</p><p><sup>b</sup> Differences between the two groups of patients were assessed using a χ2 test to which the Yates correction was applied.</p><p>Population characteristics in non-treated and in rt-PA treated patients.</p>", "links"=>[], "tags"=>["tissue plasminogen activator", "serum BDNF levels", "Ischemic stroke", "stroke outcome", "stroke patients", "brain BDNF levels"], "article_id"=>1577312, "categories"=>["Biological Sciences"], "users"=>["Marion Rodier", "Aurore Quirié", "Anne Prigent-Tessier", "Yannick Béjot", "Agnès Jacquin", "Claude Mossiat", "Christine Marie", "Philippe Garnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140668.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Population_characteristics_in_non_treated_and_in_rt_PA_treated_patients_/1577312", "title"=>"Population characteristics in non-treated and in rt-PA treated patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-15 03:58:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/2362012"], "description"=>"<p>BDNF levels were assessed before and after (1h, 4h and 24h) photothrombotic stroke induction. Values are expressed as mean ± SEM. <sup>a</sup>Differences between two groups of rats were analyzed at the different time points using the non-parametric Mann–Whitney-U test with significance set at (*) p <0.05.</p>", "links"=>[], "tags"=>["tissue plasminogen activator", "serum BDNF levels", "Ischemic stroke", "stroke outcome", "stroke patients", "brain BDNF levels"], "article_id"=>1577310, "categories"=>["Biological Sciences"], "users"=>["Marion Rodier", "Aurore Quirié", "Anne Prigent-Tessier", "Yannick Béjot", "Agnès Jacquin", "Claude Mossiat", "Christine Marie", "Philippe Garnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140668.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_serum_BDNF_levels_in_stroke_rats_treated_or_not_with_rt_PA_/1577310", "title"=>"Comparison of serum BDNF levels in stroke rats treated or not with rt-PA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-15 03:58:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/2362021"], "description"=>"<p>Correlations between serum BDNF levels and t-PA/plasmin activity in stroke rats. BDNF levels and t-PA/ plasmin activity were measured before and after (1h, 4h and 24h) photothrombotic stroke induction.</p><p><sup>a</sup>Correlation between the two parameters was evaluated using the Pearson correlation test. Significance level (*) p <0.05.</p><p><sup>b</sup>Correlation between the two parameters was evaluated using the Spearman correlation test. Significance level (*) p <0.05.</p><p>Correlations between serum BDNF levels and t-PA/plasmin activity in stroke rats.</p>", "links"=>[], "tags"=>["tissue plasminogen activator", "serum BDNF levels", "Ischemic stroke", "stroke outcome", "stroke patients", "brain BDNF levels"], "article_id"=>1577319, "categories"=>["Biological Sciences"], "users"=>["Marion Rodier", "Aurore Quirié", "Anne Prigent-Tessier", "Yannick Béjot", "Agnès Jacquin", "Claude Mossiat", "Christine Marie", "Philippe Garnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140668.t009", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlations_between_serum_BDNF_levels_and_t_PA_plasmin_activity_in_stroke_rats_/1577319", "title"=>"Correlations between serum BDNF levels and t-PA/plasmin activity in stroke rats.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-15 03:58:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/2362022", "https://ndownloader.figshare.com/files/2362023", "https://ndownloader.figshare.com/files/2362024"], "description"=>"<div><p>The recombinant form of tissue plasminogen activator (rt-PA) is the only curative treatment for ischemic stroke. Recently, t-PA has been linked to the metabolism of brain-derived neurotrophic factor (BDNF), a major neurotrophin involved in post-stroke neuroplasticity. Thus, the objective of our study was to investigate the impact of rt-PA treatment on post-stroke circulating BDNF levels in humans and in animals. Serum BDNF levels and t-PA/plasmin activity were measured at hospital admission and at up to 90 days in stroke patients receiving (n = 24) or not (n = 14) rt-PA perfusion. We investigated the relationships between serum BDNF with concurrent t-PA/plasmin activity, neurological outcomes and cardiovascular scores at admission. In parallel, serum BDNF levels and t-PA/plasmin activity were assessed before and after (1, 4 and 24h) the induction of ischemic stroke in rats. Our study revealed higher serum BDNF levels and better neurological outcome in rt-PA-treated than non-treated patients. However, serum BDNF levels did not predict stroke outcome when the whole cohort of stroke patients was analyzed. By contrast, serum BDNF levels when measured at admission and at day 90 correlated with cardiovascular scores, and those at day 1 correlated with serum t-PA/plasmin activity in the whole cohort of patients whereas no association could be found in the rt-PA-treated group. In rats devoid of cardiovascular risk, no difference in post-stroke serum BDNF levels was detected between rt-PA- and vehicle-treated animals and no correlation was found between serum BDNF levels and t-PA/plasmin activity. Overall, the data suggest that serum BDNF levels may not be useful as a prognostic biomarker of stroke outcome and that endothelial dysfunction could be a confounding factor when serum BDNF levels after stroke are used to reflect of brain BDNF levels.</p></div>", "links"=>[], "tags"=>["tissue plasminogen activator", "serum BDNF levels", "Ischemic stroke", "stroke outcome", "stroke patients", "brain BDNF levels"], "article_id"=>1577320, "categories"=>["Biological Sciences"], "users"=>["Marion Rodier", "Aurore Quirié", "Anne Prigent-Tessier", "Yannick Béjot", "Agnès Jacquin", "Claude Mossiat", "Christine Marie", "Philippe Garnier"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0140668.s001", "https://dx.doi.org/10.1371/journal.pone.0140668.s002", "https://dx.doi.org/10.1371/journal.pone.0140668.s003"], "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relevance_of_Post_Stroke_Circulating_BDNF_Levels_as_a_Prognostic_Biomarker_of_Stroke_Outcome_Impact_of_rt_PA_Treatment_/1577320", "title"=>"Relevance of Post-Stroke Circulating BDNF Levels as a Prognostic Biomarker of Stroke Outcome. Impact of rt-PA Treatment", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-10-15 03:58:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/2362020"], "description"=>"<p>Correlations between serum BDNF levels and cardiovascular score in stroke patients. Serum BDNF levels were measured at D0 (admission), D1, D7 and D90 and correlated with cardiovascular score at admission. Significance level (*) p <0.05.</p><p><sup>b</sup>Correlation between the two parameters was evaluated using the Spearman correlation test. Significance level (*) p <0.05.</p><p>Correlation between serum BDNF and cardiovascular score in stroke patients.</p>", "links"=>[], "tags"=>["tissue plasminogen activator", "serum BDNF levels", "Ischemic stroke", "stroke outcome", "stroke patients", "brain BDNF levels"], "article_id"=>1577318, "categories"=>["Biological Sciences"], "users"=>["Marion Rodier", "Aurore Quirié", "Anne Prigent-Tessier", "Yannick Béjot", "Agnès Jacquin", "Claude Mossiat", "Christine Marie", "Philippe Garnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140668.t008", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_between_serum_BDNF_and_cardiovascular_score_in_stroke_patients_/1577318", "title"=>"Correlation between serum BDNF and cardiovascular score in stroke patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-15 03:58:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/2362017"], "description"=>"<p>BDNF levels and t-PA/plasmin activity were measured at D0 (admission), D1, D7 and D90.</p><p><sup>a</sup>Correlation between the two parameters was evaluated by using the Pearson correlation test.</p><p><sup>b</sup>Correlation between the two parameters was evaluated using the Spearman correlation test. Significance level (*) p <0.05.</p><p>Correlations between serum BDNF and t-PA/plasmin activity in stroke patients.</p>", "links"=>[], "tags"=>["tissue plasminogen activator", "serum BDNF levels", "Ischemic stroke", "stroke outcome", "stroke patients", "brain BDNF levels"], "article_id"=>1577315, "categories"=>["Biological Sciences"], "users"=>["Marion Rodier", "Aurore Quirié", "Anne Prigent-Tessier", "Yannick Béjot", "Agnès Jacquin", "Claude Mossiat", "Christine Marie", "Philippe Garnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140668.t005", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlations_between_serum_BDNF_and_t_PA_plasmin_activity_in_stroke_patients_/1577315", "title"=>"Correlations between serum BDNF and t-PA/plasmin activity in stroke patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-15 03:58:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/2362016"], "description"=>"<p>Serum t-PA and plasmin activity in stroke patients (non-treated, n = 12 and rt-PA-treated, n = 23) assessed at D0 (admission), D1, D7 and D90 after ischemic stroke. Values are expressed as mean ± SEM.</p><p><sup>a</sup> Differences between the two groups of patients were analyzed at the different time points using the non-parametric Mann–Whitney-U test with significance set at (*) p <0.05.</p><p>t-PA/plasmin activity in serum of stroke patients.</p>", "links"=>[], "tags"=>["tissue plasminogen activator", "serum BDNF levels", "Ischemic stroke", "stroke outcome", "stroke patients", "brain BDNF levels"], "article_id"=>1577314, "categories"=>["Biological Sciences"], "users"=>["Marion Rodier", "Aurore Quirié", "Anne Prigent-Tessier", "Yannick Béjot", "Agnès Jacquin", "Claude Mossiat", "Christine Marie", "Philippe Garnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140668.t004", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_t_PA_plasmin_activity_in_serum_of_stroke_patients_/1577314", "title"=>"t-PA/plasmin activity in serum of stroke patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-15 03:58:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/2362011"], "description"=>"<p>Values are expressed as mean ± SEM. <sup>a</sup> Differences between the two groups of patients were analyzed at the different time points using the non-parametric Mann–Whitney-U test with significance set at (*) p <0.05.</p>", "links"=>[], "tags"=>["tissue plasminogen activator", "serum BDNF levels", "Ischemic stroke", "stroke outcome", "stroke patients", "brain BDNF levels"], "article_id"=>1577309, "categories"=>["Biological Sciences"], "users"=>["Marion Rodier", "Aurore Quirié", "Anne Prigent-Tessier", "Yannick Béjot", "Agnès Jacquin", "Claude Mossiat", "Christine Marie", "Philippe Garnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140668.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_BDNF_levels_in_stroke_patients_assessed_at_D0_admission_D1_D7_non_treated_n_11_and_rt_PA_treated_n_18_and_D90_non_treated_n_8_and_rt_PA_treated_n_12_after_ischemic_stroke_/1577309", "title"=>"Serum BDNF levels in stroke patients assessed at D0 (admission), D1, D7 (non-treated, n = 11 and rt-PA-treated, n = 18) and D90 (non-treated, n = 8 and rt-PA-treated, n = 12) after ischemic stroke.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-15 03:58:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/2362019"], "description"=>"<p>Correlations between NIHSS score variations over periods ranging from D0 to D1, D0 to D7 and D0 to D90 and serum BDNF levels in stroke patients (non-treated + rt-PA-treated, n = 38) at D0, D1, and D7. Significance level p <0.05. NIHSS = National Institute of Health Stroke Scale.</p><p>Correlations between NIHSS score variations over periods ranging from D0 to D1, D0 to D7 and D0 to D90 and serum BDNF levels in stroke patients at D0, D1, and D7.</p>", "links"=>[], "tags"=>["tissue plasminogen activator", "serum BDNF levels", "Ischemic stroke", "stroke outcome", "stroke patients", "brain BDNF levels"], "article_id"=>1577317, "categories"=>["Biological Sciences"], "users"=>["Marion Rodier", "Aurore Quirié", "Anne Prigent-Tessier", "Yannick Béjot", "Agnès Jacquin", "Claude Mossiat", "Christine Marie", "Philippe Garnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140668.t007", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlations_between_NIHSS_score_variations_over_periods_ranging_from_D0_to_D1_D0_to_D7_and_D0_to_D90_and_serum_BDNF_levels_in_stroke_patients_at_D0_D1_and_D7_/1577317", "title"=>"Correlations between NIHSS score variations over periods ranging from D0 to D1, D0 to D7 and D0 to D90 and serum BDNF levels in stroke patients at D0, D1, and D7.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-15 03:58:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/2362018"], "description"=>"<p>NIHSS score reduction between non-treated (n = 14) and rt-PA-treated patients (n = 24) over periods ranging from D0 to D1, D0 to D7 and D0 to D90. Values are expressed as mean ± SEM. Differences between the two groups of patients were analyzed at the different time points using the non-parametric Mann–Whitney-U test with significance set at (*) p <0.05. NIHSS = National Institute of Health Stroke Scale.</p><p>NIHSS score reduction between non-treated and rt-PA-treated patients over periods ranging from D0 to D1, D0 to D7 and D0 to D90.</p>", "links"=>[], "tags"=>["tissue plasminogen activator", "serum BDNF levels", "Ischemic stroke", "stroke outcome", "stroke patients", "brain BDNF levels"], "article_id"=>1577316, "categories"=>["Biological Sciences"], "users"=>["Marion Rodier", "Aurore Quirié", "Anne Prigent-Tessier", "Yannick Béjot", "Agnès Jacquin", "Claude Mossiat", "Christine Marie", "Philippe Garnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140668.t006", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_NIHSS_score_reduction_between_non_treated_and_rt_PA_treated_patients_over_periods_ranging_from_D0_to_D1_D0_to_D7_and_D0_to_D90_/1577316", "title"=>"NIHSS score reduction between non-treated and rt-PA-treated patients over periods ranging from D0 to D1, D0 to D7 and D0 to D90.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-15 03:58:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/2362015"], "description"=>"<p>Platelet counts in the blood of stroke patients (non-treated, n = 11 and rt-PA-treated, n = 21) was assessed at D0 (admission), D1 and D7 after ischemic stroke. Values are expressed as mean ± SEM.</p><p><sup>a</sup> Differences between the two groups of patients were analyzed at the different time points using the non-parametric Mann–Whitney-U test with significance set at (*) p <0.05.</p><p>Comparison of platelet counts in stroke patients treated or not with rt-PA.</p>", "links"=>[], "tags"=>["tissue plasminogen activator", "serum BDNF levels", "Ischemic stroke", "stroke outcome", "stroke patients", "brain BDNF levels"], "article_id"=>1577313, "categories"=>["Biological Sciences"], "users"=>["Marion Rodier", "Aurore Quirié", "Anne Prigent-Tessier", "Yannick Béjot", "Agnès Jacquin", "Claude Mossiat", "Christine Marie", "Philippe Garnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140668.t003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_platelet_counts_in_stroke_patients_treated_or_not_with_rt_PA_/1577313", "title"=>"Comparison of platelet counts in stroke patients treated or not with rt-PA.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-15 03:58:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/2362013"], "description"=>"<p>Levels were measured at D0 (admission), D1, D7 and D90 after ischemic stroke. Values are expressed as means ± SEM.</p><p><sup>a</sup> Comparisons between the two groups of patients were analyzed at the different time points using the non-parametric Mann–Whitney-U test with significance set at (*) p <0.05.</p><p>Serum BDNF levels in stroke patients with a systolic blood pressure lower or higher than 160 mmHg at the admission.</p>", "links"=>[], "tags"=>["tissue plasminogen activator", "serum BDNF levels", "Ischemic stroke", "stroke outcome", "stroke patients", "brain BDNF levels"], "article_id"=>1577311, "categories"=>["Biological Sciences"], "users"=>["Marion Rodier", "Aurore Quirié", "Anne Prigent-Tessier", "Yannick Béjot", "Agnès Jacquin", "Claude Mossiat", "Christine Marie", "Philippe Garnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140668.t001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_BDNF_levels_in_stroke_patients_with_a_systolic_blood_pressure_lower_or_higher_than_160_mmHg_at_the_admission_/1577311", "title"=>"Serum BDNF levels in stroke patients with a systolic blood pressure lower or higher than 160 mmHg at the admission.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-15 03:58:41"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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