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{"title"=>"Schizophrenia-Associated MIR204 Regulates Noncoding RNAs and Affects Neurotransmitter and Ion Channel Gene Sets", "type"=>"journal", "authors"=>[{"first_name"=>"Sophia", "last_name"=>"Cammaerts", "scopus_author_id"=>"40761070900"}, {"first_name"=>"Mojca", "last_name"=>"Strazisar", "scopus_author_id"=>"24473777000"}, {"first_name"=>"Bart", "last_name"=>"Smets", "scopus_author_id"=>"57114665100"}, {"first_name"=>"Sarah", "last_name"=>"Weckhuysen", "scopus_author_id"=>"57189237862"}, {"first_name"=>"Annelie", "last_name"=>"Nordin", "scopus_author_id"=>"49662065700"}, {"first_name"=>"Peter", "last_name"=>"De Jonghe", "scopus_author_id"=>"20435787800"}, {"first_name"=>"Rolf", "last_name"=>"Adolfsson", "scopus_author_id"=>"7005437216"}, {"first_name"=>"Peter", "last_name"=>"De Rijk", "scopus_author_id"=>"6603945133"}, {"first_name"=>"Jurgen", "last_name"=>"Del Favero", "scopus_author_id"=>"7004449531"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "sgr"=>"84958063751", "scopus"=>"2-s2.0-84958063751", "pui"=>"608080424", "doi"=>"10.1371/journal.pone.0144428", "pmid"=>"26714269"}, "id"=>"20970109-f34d-364f-a121-1a9fbd0349fd", "abstract"=>"As regulators of gene expression, microRNAs (miRNAs) are likely to play an important role in the development of disease. In this study we present a large-scale strategy to identify miRNAs with a role in the regulation of neuronal processes. Thereby we found variant rs7861254 located near the MIR204 gene to be significantly associated with schizophrenia. This variant resulted in reduced expression of miR-204 in neuronal-like SH-SY5Y cells. Analysis of the consequences of the altered miR-204 expression on the transcriptome of these cells uncovered a new mode of action for miR-204, being the regulation of noncoding RNAs (ncRNAs), including several miRNAs, such as MIR296. Furthermore, pathway analysis showed downstream effects of miR-204 on neurotransmitter and ion channel related gene sets, potentially mediated by miRNAs regulated through miR-204.", "link"=>"http://www.mendeley.com/research/schizophreniaassociated-mir204-regulates-noncoding-rnas-affects-neurotransmitter-ion-channel-gene-se", "reader_count"=>17, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>5, "Student > Ph. D. Student"=>5, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>5, "Student > Ph. D. Student"=>5, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>2, "Neuroscience"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Sweden"=>1}, "group_count"=>0}

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• http://doi.org/10.3389/fnbeh.2021.649129
• http://doi.org/10.1038/s41380-020-00953-7
• http://doi.org/10.3389/fncel.2019.00587
• http://doi.org/10.3389/fnins.2020.580524
• http://doi.org/10.1016/j.jad.2017.05.017
• http://doi.org/10.1007/s40495-018-0129-2
• http://doi.org/10.3892/mmr.2016.5853

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• {"id"=>"682542443103948800", "text"=>"#PLOSONE: Schizophrenia-Associated MIR204 Regulates Noncoding RNAs and Affects Neurotransmitter and Ion Chann ... https://t.co/EgetbqV22A", "created_at"=>"2015-12-31T12:42:54Z", "user"=>"anandgururajan", "user_name"=>"Anand Gururajan", "user_profile_image"=>"http://pbs.twimg.com/profile_images/578648710768381952/Zel5A4Ds_normal.jpeg"}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/2618147"], "description"=>"<p>(a) Average normalized relative quantity (NRQ) for miR-204-5p and miR-204-3p in MIR204WT (CC genotype, black bars, clones 1–3) and MIR204SNP cells (TT genotype, white bars, clones 1–3) normalized for transduction efficiency. (b) Average normalized expression values (NEV) for significantly differently expressed genes between MIR204WT (CC genotype, black bars, clones 4–5) and MIR204SNP (TT genotype, white bars, clones 4–6) cells. (c) Log2 fold changes of miRNAs significantly differently expressed in MIR204SNP cells (clones 4–6) compared to MIR204WT cells (clones 4–5). Error bars in panels (a-b) represent standard deviation of biological replicates, error bars in (c) represent standard error as calculated by DESeq2.</p>", "links"=>[], "tags"=>["5y", "Affects Neurotransmitter", "Ion Channel Gene Sets", "MIR 296.", "mir", "pathway analysis", "regulation", "role", "MIR 204 gene", "gene expression", "variant rs 7861254", "mirna", "ion channel", "noncoding RNAs", "gene sets"], "article_id"=>1631200, "categories"=>["Biological Sciences"], "users"=>["Sophia Cammaerts", "Mojca Strazisar", "Bart Smets", "Sarah Weckhuysen", "Annelie Nordin", "Peter De Jonghe", "Rolf Adolfsson", "Peter De Rijk", "Jurgen Del Favero"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0144428.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_QPCR_a_microarray_b_and_small_RNA_sequencing_results_c_for_MIR204_cells_/1631200", "title"=>"QPCR (a), microarray (b) and small RNA sequencing results (c) for <i>MIR204</i> cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-05 14:55:03"}
• {"files"=>["https://ndownloader.figshare.com/files/2618148", "https://ndownloader.figshare.com/files/2618149"], "description"=>"<div><p>As regulators of gene expression, microRNAs (miRNAs) are likely to play an important role in the development of disease. In this study we present a large-scale strategy to identify miRNAs with a role in the regulation of neuronal processes. Thereby we found variant rs7861254 located near the <i>MIR204</i> gene to be significantly associated with schizophrenia. This variant resulted in reduced expression of miR-204 in neuronal-like SH-SY5Y cells. Analysis of the consequences of the altered miR-204 expression on the transcriptome of these cells uncovered a new mode of action for miR-204, being the regulation of noncoding RNAs (ncRNAs), including several miRNAs, such as <i>MIR296</i>. Furthermore, pathway analysis showed downstream effects of miR-204 on neurotransmitter and ion channel related gene sets, potentially mediated by miRNAs regulated through miR-204.</p></div>", "links"=>[], "tags"=>["5y", "Affects Neurotransmitter", "Ion Channel Gene Sets", "MIR 296.", "mir", "pathway analysis", "regulation", "role", "MIR 204 gene", "gene expression", "variant rs 7861254", "mirna", "ion channel", "noncoding RNAs", "gene sets"], "article_id"=>1631201, "categories"=>["Biological Sciences"], "users"=>["Sophia Cammaerts", "Mojca Strazisar", "Bart Smets", "Sarah Weckhuysen", "Annelie Nordin", "Peter De Jonghe", "Rolf Adolfsson", "Peter De Rijk", "Jurgen Del Favero"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0144428.s001", "https://dx.doi.org/10.1371/journal.pone.0144428.s002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Schizophrenia_Associated_MIR204_Regulates_Noncoding_RNAs_and_Affects_Neurotransmitter_and_Ion_Channel_Gene_Sets/1631201", "title"=>"Schizophrenia-Associated <i>MIR204</i> Regulates Noncoding RNAs and Affects Neurotransmitter and Ion Channel Gene Sets", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2016-01-05 14:55:02"}
• {"files"=>["https://ndownloader.figshare.com/files/2618145"], "description"=>"<p>(a-b) MFE structure for hsa-mir-204 with variant rs7861254, (a) wild type miRNA, (b) variant miRNA. As the variant is located 107 nt outside the hairpin, flanking regions of 150 nt were included for the predictions. Centroid and MEA predictions with this flank size also showed large structural changes (but different changes), while predictions with flanks of 200 nt resulted in minor changes far away from the hairpin. (c-d) MFE structure of hsa-mir-618 for variant rs2682818, (c) wild type miRNA, (d) variant miRNA. The variant is predicted to induce a shift of the first base of the miR-618 sequence into an internal loop. Flanks of 100 nt were used for this prediction. Predictions were also run for the hairpin with flank sizes of 50 nt, 150 nt and 200 nt and centroid and MEA structures: all predicted the same change within the hairpin. Color scheme: magenta: mature miRNA, orange: seed region, dark blue: terminal loop, cyan: hairpin. The variant is colored in red and indicated by an arrow. Structural changes induced by the variant are colored in black.</p>", "links"=>[], "tags"=>["5y", "Affects Neurotransmitter", "Ion Channel Gene Sets", "MIR 296.", "mir", "pathway analysis", "regulation", "role", "MIR 204 gene", "gene expression", "variant rs 7861254", "mirna", "ion channel", "noncoding RNAs", "gene sets"], "article_id"=>1631198, "categories"=>["Biological Sciences"], "users"=>["Sophia Cammaerts", "Mojca Strazisar", "Bart Smets", "Sarah Weckhuysen", "Annelie Nordin", "Peter De Jonghe", "Rolf Adolfsson", "Peter De Rijk", "Jurgen Del Favero"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0144428.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MFE_secondary_structure_predictions_of_hsa_mir_204_and_hsa_mir_618_as_generated_by_miRVaS_/1631198", "title"=>"MFE secondary structure predictions of hsa-mir-204 and hsa-mir-618 as generated by miRVaS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-05 14:55:04"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}

F1000Prime