The Impact of Ischemia/Reperfusion Injury on Liver Allografts from Deceased after Cardiac Death versus Deceased after Brain Death Donors
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{"title"=>"The impact of ischemia/reperfusion injury on liver allografts from deceased after cardiac death versus deceased after brain death donors", "type"=>"journal", "authors"=>[{"first_name"=>"Jin", "last_name"=>"Xu", "scopus_author_id"=>"56991657300"}, {"first_name"=>"Blayne Amir", "last_name"=>"Sayed", "scopus_author_id"=>"36155725200"}, {"first_name"=>"Ana Maria", "last_name"=>"Casas-Ferreira", "scopus_author_id"=>"25929902700"}, {"first_name"=>"Parthi", "last_name"=>"Srinivasan", "scopus_author_id"=>"7103192357"}, {"first_name"=>"Nigel", "last_name"=>"Heaton", "scopus_author_id"=>"7102942546"}, {"first_name"=>"Mohammed", "last_name"=>"Rela", "scopus_author_id"=>"7005785802"}, {"first_name"=>"Yun", "last_name"=>"Ma", "scopus_author_id"=>"7404701350"}, {"first_name"=>"Susan", "last_name"=>"Fuggle", "scopus_author_id"=>"7006470337"}, {"first_name"=>"Cristina", "last_name"=>"Legido-Quigley", "scopus_author_id"=>"6506682931"}, {"first_name"=>"Wayel", "last_name"=>"Jassem", "scopus_author_id"=>"6603981064"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "sgr"=>"84959423296", "doi"=>"10.1371/journal.pone.0148815", "scopus"=>"2-s2.0-84959423296", "isbn"=>"1932-6203", "pmid"=>"26863224", "pui"=>"608575182"}, "id"=>"b3bbf2e9-fdc1-3af0-801f-aeeffce614c0", "abstract"=>"BACKGROUND AND AIMS: The shortage of organs for transplantation has led to increased use of organs procured from donors after cardiac death (DCD). The effects of cardiac death on the liver remain poorly understood, however. Using livers obtained from DCD versus donors after brain death (DBD), we aimed to understand how ischemia/reperfusion (I/R) injury alters expression of pro-inflammatory markers ceramides and influences graft leukocyte infiltration.\\n\\nMETHODS: Hepatocyte inflammation, as assessed by ceramide expression, was evaluated in DCD (n = 13) and DBD (n = 10) livers. Allograft expression of inflammatory and cell death markers, and allograft leukocyte infiltration were evaluated from a contemporaneous independent cohort of DCD (n = 22) and DBD (n = 13) livers.\\n\\nRESULTS: When examining the differences between transplant stages in each group, C18, C20, C24 ceramides showed significant difference in DBD (p<0.05) and C22 ceramide (p<0.05) were more pronounced for DCD. C18 ceramide is correlated to bilirubin, INR, and creatinine after transplant in DCD. Prior to transplantation, DCD livers have reduced leukocyte infiltration compared to DBD allografts. Following reperfusion, the neutrophil infiltration and platelet deposition was less prevalent in DCD grafts while cell death and recipients levels of serum aspartate aminotransferase (AST) of DCD allografts had significantly increased.\\n\\nCONCLUSION: These data suggest that I/R injury generate necrosis in the absence of a strong inflammatory response in DCD livers with an appreciable effect on early graft function. The long-term consequences of increased inflammation in DBD and increased cell death in DCD allografts are unknown and warrant further investigation.", "link"=>"http://www.mendeley.com/research/impact-ischemiareperfusion-injury-liver-allografts-deceased-after-cardiac-death-versus-deceased-afte", "reader_count"=>19, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>2, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>4, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>2, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>4, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Engineering"=>1, "Nursing and Health Professions"=>2, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>9, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Unspecified"=>{"Unspecified"=>4}}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2637202"], "description"=>"<p>Values are mean amounts per donor group at pre and post-transplantation stages. A clustering analysis (dendrogram) shows which lipids differ most; red depicts increased amounts and green decreased.</p>", "links"=>[], "tags"=>["cell death markers", "DCD allografts", "C 18 ceramide", "DCD livers", "influences graft leukocyte infiltration.MethodsHepatocyte inflammation", "dbd", "C 22 ceramide", "inr", "Brain Death Donors Background", "ast", "serum aspartate aminotransferase", "Cell death", "allograft leukocyte infiltration"], "article_id"=>1644384, "categories"=>["Biological Sciences"], "users"=>["Jin Xu", "Blayne Amir Sayed", "Ana Maria Casas-Ferreira", "Parthi Srinivasan", "Nigel Heaton", "Mohammed Rela", "Yun Ma", "Susan Fuggle", "Cristina Legido-Quigley", "Wayel Jassem"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148815.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Heat_map_showing_distinct_ceramides_profiles_of_DBD_and_DCD_tissue_in_46_transplant_samples_/1644384", "title"=>"Heat-map showing distinct ceramides profiles of DBD and DCD tissue in 46 transplant samples.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-10 11:50:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/2637203"], "description"=>"<p>(A) Leukocyte infiltration and FasL expression in liver allografts prior to transplantation. Biopsies from DBD and DCD liver biopsies were stained with monoclonal antibodies against neutrophil elastase, CD3 and FasL. (B) Expression of ICAM-1 in liver allografts prior to transplantation.</p>", "links"=>[], "tags"=>["cell death markers", "DCD allografts", "C 18 ceramide", "DCD livers", "influences graft leukocyte infiltration.MethodsHepatocyte inflammation", "dbd", "C 22 ceramide", "inr", "Brain Death Donors Background", "ast", "serum aspartate aminotransferase", "Cell death", "allograft leukocyte infiltration"], "article_id"=>1644385, "categories"=>["Biological Sciences"], "users"=>["Jin Xu", "Blayne Amir Sayed", "Ana Maria Casas-Ferreira", "Parthi Srinivasan", "Nigel Heaton", "Mohammed Rela", "Yun Ma", "Susan Fuggle", "Cristina Legido-Quigley", "Wayel Jassem"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148815.g004", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunohistochemistry_results_prior_to_transplantation_/1644385", "title"=>"Immunohistochemistry results prior to transplantation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-10 11:50:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/2637207"], "description"=>"<p>(A) pre-reperfusion biopsies in DBD, (B) post-reperfusion biopsies in DBD, (C) pre-reperfusion biopsies in DCD, (D) post-reperfusion biopsies in DCD.</p>", "links"=>[], "tags"=>["cell death markers", "DCD allografts", "C 18 ceramide", "DCD livers", "influences graft leukocyte infiltration.MethodsHepatocyte inflammation", "dbd", "C 22 ceramide", "inr", "Brain Death Donors Background", "ast", "serum aspartate aminotransferase", "Cell death", "allograft leukocyte infiltration"], "article_id"=>1644388, "categories"=>["Biological Sciences"], "users"=>["Jin Xu", "Blayne Amir Sayed", "Ana Maria Casas-Ferreira", "Parthi Srinivasan", "Nigel Heaton", "Mohammed Rela", "Yun Ma", "Susan Fuggle", "Cristina Legido-Quigley", "Wayel Jassem"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148815.g005", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_TUNEL_staining_in_pre_and_post_reperfusion_biopsies_in_DBD_and_DCD_livers_/1644388", "title"=>"Representative TUNEL staining in pre- and post-reperfusion biopsies in DBD and DCD livers.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-10 11:50:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/2637209"], "description"=>"<p>(A) Recipient serum levels of aspartate aminotransferase (AST) following transplantation. (B) Neutrophil infiltration, platelet activation and expression of vWF post-reperfusion. (C) Correlation between post-reperfusion cell death and WIT.</p>", "links"=>[], "tags"=>["cell death markers", "DCD allografts", "C 18 ceramide", "DCD livers", "influences graft leukocyte infiltration.MethodsHepatocyte inflammation", "dbd", "C 22 ceramide", "inr", "Brain Death Donors Background", "ast", "serum aspartate aminotransferase", "Cell death", "allograft leukocyte infiltration"], "article_id"=>1644389, "categories"=>["Biological Sciences"], "users"=>["Jin Xu", "Blayne Amir Sayed", "Ana Maria Casas-Ferreira", "Parthi Srinivasan", "Nigel Heaton", "Mohammed Rela", "Yun Ma", "Susan Fuggle", "Cristina Legido-Quigley", "Wayel Jassem"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148815.g006", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunohistochemistry_results_following_reperfusion_/1644389", "title"=>"Immunohistochemistry results following reperfusion.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-10 11:50:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/2637210"], "description"=>"<div><p>Background and aims</p><p>The shortage of organs for transplantation has led to increased use of organs procured from donors after cardiac death (DCD). The effects of cardiac death on the liver remain poorly understood, however. Using livers obtained from DCD versus donors after brain death (DBD), we aimed to understand how ischemia/reperfusion (I/R) injury alters expression of pro-inflammatory markers ceramides and influences graft leukocyte infiltration.</p><p>Methods</p><p>Hepatocyte inflammation, as assessed by ceramide expression, was evaluated in DCD (n = 13) and DBD (n = 10) livers. Allograft expression of inflammatory and cell death markers, and allograft leukocyte infiltration were evaluated from a contemporaneous independent cohort of DCD (n = 22) and DBD (n = 13) livers.</p><p>Results</p><p>When examining the differences between transplant stages in each group, C18, C20, C24 ceramides showed significant difference in DBD (p<0.05) and C22 ceramide (p<0.05) were more pronounced for DCD. C18 ceramide is correlated to bilirubin, INR, and creatinine after transplant in DCD. Prior to transplantation, DCD livers have reduced leukocyte infiltration compared to DBD allografts. Following reperfusion, the neutrophil infiltration and platelet deposition was less prevalent in DCD grafts while cell death and recipients levels of serum aspartate aminotransferase (AST) of DCD allografts had significantly increased.</p><p>Conclusion</p><p>These data suggest that I/R injury generate necrosis in the absence of a strong inflammatory response in DCD livers with an appreciable effect on early graft function. The long-term consequences of increased inflammation in DBD and increased cell death in DCD allografts are unknown and warrant further investigation.</p></div>", "links"=>[], "tags"=>["cell death markers", "DCD allografts", "C 18 ceramide", "DCD livers", "influences graft leukocyte infiltration.MethodsHepatocyte inflammation", "dbd", "C 22 ceramide", "inr", "Brain Death Donors Background", "ast", "serum aspartate aminotransferase", "Cell death", "allograft leukocyte infiltration"], "article_id"=>1644390, "categories"=>["Biological Sciences"], "users"=>["Jin Xu", "Blayne Amir Sayed", "Ana Maria Casas-Ferreira", "Parthi Srinivasan", "Nigel Heaton", "Mohammed Rela", "Yun Ma", "Susan Fuggle", "Cristina Legido-Quigley", "Wayel Jassem"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148815", "stats"=>{"downloads"=>2, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Impact_of_Ischemia_Reperfusion_Injury_on_Liver_Allografts_from_Deceased_after_Cardiac_Death_versus_Deceased_after_Brain_Death_Donors_/1644390", "title"=>"The Impact of Ischemia/Reperfusion Injury on Liver Allografts from Deceased after Cardiac Death versus Deceased after Brain Death Donors", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-02-10 11:50:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/2637199"], "description"=>"<p>Two independent cohorts of immunohistochemistry and targeted lipids analysis found that DBD and DCD liver allografts have different pathways for I/R injury.</p>", "links"=>[], "tags"=>["cell death markers", "DCD allografts", "C 18 ceramide", "DCD livers", "influences graft leukocyte infiltration.MethodsHepatocyte inflammation", "dbd", "C 22 ceramide", "inr", "Brain Death Donors Background", "ast", "serum aspartate aminotransferase", "Cell death", "allograft leukocyte infiltration"], "article_id"=>1644381, "categories"=>["Biological Sciences"], "users"=>["Jin Xu", "Blayne Amir Sayed", "Ana Maria Casas-Ferreira", "Parthi Srinivasan", "Nigel Heaton", "Mohammed Rela", "Yun Ma", "Susan Fuggle", "Cristina Legido-Quigley", "Wayel Jassem"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148815.g001", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_design_/1644381", "title"=>"Study design.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-10 11:50:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/2637201"], "description"=>"<p>(A) OPLS-DA score plot visualizing the grouping of pre vs. post for all biopsies. (B) S-plot illustrating ceramides correlation to groups for model in A. (C) OPLS-DA score plot showing group separation between pre- and post-transplant for none steatotic grafts. (D) S-plot indicating ceramides correlation to groups for model in C.</p>", "links"=>[], "tags"=>["cell death markers", "DCD allografts", "C 18 ceramide", "DCD livers", "influences graft leukocyte infiltration.MethodsHepatocyte inflammation", "dbd", "C 22 ceramide", "inr", "Brain Death Donors Background", "ast", "serum aspartate aminotransferase", "Cell death", "allograft leukocyte infiltration"], "article_id"=>1644383, "categories"=>["Biological Sciences"], "users"=>["Jin Xu", "Blayne Amir Sayed", "Ana Maria Casas-Ferreira", "Parthi Srinivasan", "Nigel Heaton", "Mohammed Rela", "Yun Ma", "Susan Fuggle", "Cristina Legido-Quigley", "Wayel Jassem"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148815.g002", "stats"=>{"downloads"=>2, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multivariate_analysis_of_pre_vs_post_biopsies_and_ceramides_distribution_/1644383", "title"=>"Multivariate analysis of pre vs. post biopsies and ceramides distribution.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-10 11:50:59"}

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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