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{"title"=>"The Effectiveness of Individualized Acupuncture Protocols in the Treatment of Gulf War Illness: A Pragmatic Randomized Clinical Trial", "type"=>"journal", "authors"=>[{"first_name"=>"Lisa", "last_name"=>"Conboy", "scopus_author_id"=>"11840475200"}, {"first_name"=>"Travis", "last_name"=>"Gerke", "scopus_author_id"=>"57190518848"}, {"first_name"=>"Kai Yin", "last_name"=>"Hsu", "scopus_author_id"=>"56262412100"}, {"first_name"=>"Meredith", "last_name"=>"St John", "scopus_author_id"=>"55018550900"}, {"first_name"=>"Marc", "last_name"=>"Goldstein", "scopus_author_id"=>"57194478344"}, {"first_name"=>"Rosa", "last_name"=>"Schnyer", "scopus_author_id"=>"6506347491"}], "year"=>2016, "source"=>"PloS one", "identifiers"=>{"pmid"=>"27031099", "doi"=>"10.1371/journal.pone.0149161", "sgr"=>"85020319024", "isbn"=>"1932-6203", "scopus"=>"2-s2.0-85020319024", "issn"=>"19326203", "pui"=>"616140494"}, "id"=>"8f545839-3d2d-307e-aa4a-188900f9cae2", "abstract"=>"Background: Gulf War Illness is a Complex Medical Illness characterized by multiple symptoms, including fatigue, sleep and mood disturbances, cognitive dysfunction, and musculoskeletal pain affecting veterans of the first Gulf War. No standard of care treatment exists. Methods: This pragmatic Randomized Clinical Trial tested the effects of individualized acupuncture treatments offered in extant acupuncture practices in the community; practitioners had at least 5 years of experience plus additional training provided by the study. Veterans with diagnosed symptoms of Gulf War Illness were randomized to either six months of biweekly acupuncture treatments (group 1, n = 52) or 2 months of waitlist followed by weekly acupuncture treatments (group 2, n = 52). Measurements were taken at baseline, 2, 4 and 6 months. The primary outcome is the SF-36 physical component scale score (SF-36P) and the secondary outcome is the McGill Pain scale. Results: Of the 104 subjects who underwent randomization, 85 completed the protocol (82%). A clinically and statistically significant average improvement of 9.4 points (p = 0.03) in the SF-36P was observed for group 1 at month 6 compared to group 2, adjusting for baseline pain. The secondary outcome of McGill pain index produced similar results; at 6 months, group 1 was estimated to experience a reduction of approximately 3.6 points (p = 0.04) compared to group 2. Conclusions: Individualized acupuncture treatment of sufficient dose appears to offer significant relief of physical disability and pain for veterans with Gulf War Illness. This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs through the Gulf War Illness Research Program under Award No. W81XWH-09-2-0064. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. Trial Registration: ClinicalTrials.gov [ABSTRACT FROM AUTHOR]", "link"=>"http://www.mendeley.com/research/effectiveness-individualized-acupuncture-protocols-treatment-gulf-war-illness-pragmatic-randomized-c", "reader_count"=>33, "reader_count_by_academic_status"=>{"Researcher"=>5, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>7, "Other"=>2, "Student > Bachelor"=>5, "Lecturer"=>5, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>5, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>7, "Other"=>2, "Student > Bachelor"=>5, "Lecturer"=>5, "Professor"=>1}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>7, "Medicine and Dentistry"=>11, "Agricultural and Biological Sciences"=>1, "Arts and Humanities"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Psychology"=>3, "Social Sciences"=>7, "Computer Science"=>1, "Sports and Recreations"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Social Sciences"=>{"Social Sciences"=>7}, "Psychology"=>{"Psychology"=>3}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>7}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>1}

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• http://doi.org/10.18325/jkmr.2016.26.3.85
• http://doi.org/10.1089/acm.2019.0307
• http://doi.org/10.1089/acm.2017.0299
• http://doi.org/10.1590/s1980-220x2017040503402
• http://doi.org/10.1016/j.jpsychires.2019.08.003
• http://doi.org/10.3390/ijerph16214143
• http://doi.org/10.1186/s40779-019-0221-x

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• {"id"=>"715699909207392256", "text"=>"The Effectiveness of Individualized Acupuncture Protocols in the Treatment of Gulf War Illness: A Pragmatic Ran... https://t.co/r9kjHbwyHg", "created_at"=>"2016-04-01T00:38:50Z", "user"=>"SPAHerbal", "user_name"=>"C.A.I. Corporation", "user_profile_image"=>"http://pbs.twimg.com/profile_images/477126522206031872/uk1aDsYB_normal.jpeg"}
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• {"id"=>"715852200338132993", "text"=>"Comprobaron los autores la normalidad de las variables utilizadas con una n=44??? Estad?stica inquietante...\nhttps://t.co/SLrq6cB6Ki", "created_at"=>"2016-04-01T10:43:59Z", "user"=>"jmmorang", "user_name"=>"J M M", "user_profile_image"=>"http://pbs.twimg.com/profile_images/484221176471126016/3aQank88_normal.jpeg"}
• {"id"=>"716159672345079808", "text"=>"#PLOSONE: The Effectiveness of Individualized Acupuncture Protocols in the Treatment of Gulf War Illness: A P ... https://t.co/frVNOy3J9K", "created_at"=>"2016-04-02T07:05:46Z", "user"=>"DrJorgeVas", "user_name"=>"Jorge Vas", "user_profile_image"=>"http://pbs.twimg.com/profile_images/640445696584359936/ov4bdozr_normal.jpg"}
• {"id"=>"716195265624018944", "text"=>"RT @DrJorgeVas: #PLOSONE: The Effectiveness of Individualized Acupuncture Protocols in the Treatment of Gulf War Illness: A P ... https://t…", "created_at"=>"2016-04-02T09:27:12Z", "user"=>"Carlesfj", "user_name"=>"Carles Fern?ndez", "user_profile_image"=>"http://pbs.twimg.com/profile_images/615249109071609857/iBq71r6i_normal.jpg"}
• {"id"=>"716218523878612992", "text"=>"RT @DrJorgeVas: #PLOSONE: The Effectiveness of Individualized Acupuncture Protocols in the Treatment of Gulf War Illness: A P ... https://t…", "created_at"=>"2016-04-02T10:59:37Z", "user"=>"PerDrewes", "user_name"=>"Per Drewes", "user_profile_image"=>"http://pbs.twimg.com/profile_images/524572734463164416/sCmkQStu_normal.jpeg"}
• {"id"=>"717228623053340672", "text"=>"RT @DrJorgeVas: #PLOSONE: The Effectiveness of Individualized Acupuncture Protocols in the Treatment of Gulf War Illness: A P ... https://t…", "created_at"=>"2016-04-05T05:53:23Z", "user"=>"draleiva", "user_name"=>"Doctora Leiva", "user_profile_image"=>"http://pbs.twimg.com/profile_images/716568021020516352/pwyDEJ9V_normal.jpg"}
• {"id"=>"717819475215704064", "text"=>"#Acupuncture \"appears to offer significant relief of physical disability & pain for veterans with Gulf War Illness\" https://t.co/I1mj9A4718", "created_at"=>"2016-04-06T21:01:13Z", "user"=>"ShaftesburyC", "user_name"=>"Shaftesbury Clinic", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2701678049/896a25e0322848de37e41c3a7409a54b_normal.jpeg"}
• {"id"=>"717823957748027392", "text"=>"RT @ShaftesburyC: #Acupuncture \"appears to offer significant relief of physical disability & pain for veterans with Gulf War Illness\" https…", "created_at"=>"2016-04-06T21:19:02Z", "user"=>"DrSuePeacock", "user_name"=>"Well-aHead", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1070149725/Sues_Logo_normal.JPG"}
• {"id"=>"720278285758894080", "text"=>"Acupuncture for PTSD https://t.co/TgT9ZCWOgZ", "created_at"=>"2016-04-13T15:51:40Z", "user"=>"SMHealingArts", "user_name"=>"SMHealingArts", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3113446009/aa3bf600fa69de52d95c11189a988a44_normal.jpeg"}
• {"id"=>"721650167250874368", "text"=>"New pragmatic RCT: effects of #acupuncture on physical disability & pain in veterans with Gulf War Illness;\n@PLOSONE https://t.co/IrK5gTOPhN", "created_at"=>"2016-04-17T10:43:02Z", "user"=>"IntegrativeMFM", "user_name"=>"David Carr", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2875322678/f7a163e2a617a048148976b4b0ff2376_normal.jpeg"}

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• {"files"=>["https://ndownloader.figshare.com/files/4907320"], "description"=>"<p>Scores moving in the negative direction indicate improvement. Scores moving in the negative direction indicate improvement.</p>", "links"=>[], "tags"=>["Randomized Clinical Trial", "McGill pain index", "group 1", "Gulf War Illness", "acupuncture treatments", "group 2. ConclusionsIndividualized acupuncture treatment", "McGill Pain scale.ResultsOf", "6 months", "Gulf War Illness Research Program", "Individualized Acupuncture Protocols", "care treatment exists.MethodsThis", "outcome", "SF", "Complex Medical Illness", "W 81XWH Opinions", "veteran", "Pragmatic Randomized Clinical Trial BackgroundGulf War Illness", "NCT", "component scale score"], "article_id"=>3149929, "categories"=>["Medicine", "Neuroscience", "Biotechnology", "Immunology", "Cancer", "Science Policy", "Mental Health", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Lisa Conboy", "Travis Gerke", "Kai-Yin Hsu", "Meredith St John", "Marc Goldstein", "Rosa Schnyer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149161.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Summary_of_model_based_simulations_sup_xxxiii_sup_of_changes_in_mean_McGill_Pain_Scale_at_4_measurement_timepoints_/3149929", "title"=>"Summary of model-based simulations^xxxiii of changes in mean McGill Pain Scale at 4 measurement timepoints.", "pos_in_sequence"=>4, "defined_type"=>1, "published_date"=>"2016-03-31 07:25:01"}
• {"files"=>["https://ndownloader.figshare.com/files/4907338"], "description"=>"<p>Baseline Characteristics of the Study Population. Standard Deviations (SD) are offered for age, baseline pain, and baseline Sf-36(P).</p>", "links"=>[], "tags"=>["Randomized Clinical Trial", "McGill pain index", "group 1", "Gulf War Illness", "acupuncture treatments", "group 2. ConclusionsIndividualized acupuncture treatment", "McGill Pain scale.ResultsOf", "6 months", "Gulf War Illness Research Program", "Individualized Acupuncture Protocols", "care treatment exists.MethodsThis", "outcome", "SF", "Complex Medical Illness", "W 81XWH Opinions", "veteran", "Pragmatic Randomized Clinical Trial BackgroundGulf War Illness", "NCT", "component scale score"], "article_id"=>3149932, "categories"=>["Medicine", "Neuroscience", "Biotechnology", "Immunology", "Cancer", "Science Policy", "Mental Health", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Lisa Conboy", "Travis Gerke", "Kai-Yin Hsu", "Meredith St John", "Marc Goldstein", "Rosa Schnyer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149161.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Baseline_Characteristics_of_the_Study_Population_/3149932", "title"=>"Baseline Characteristics of the Study Population.", "pos_in_sequence"=>5, "defined_type"=>3, "published_date"=>"2016-03-31 07:25:01"}
• {"files"=>["https://ndownloader.figshare.com/files/4907356"], "description"=>"<p>Mean and empirical 95% confidence limits estimated for both SF-36P and McGill from 5000 simulations of the fitted GEE models.</p>", "links"=>[], "tags"=>["Randomized Clinical Trial", "McGill pain index", "group 1", "Gulf War Illness", "acupuncture treatments", "group 2. ConclusionsIndividualized acupuncture treatment", "McGill Pain scale.ResultsOf", "6 months", "Gulf War Illness Research Program", "Individualized Acupuncture Protocols", "care treatment exists.MethodsThis", "outcome", "SF", "Complex Medical Illness", "W 81XWH Opinions", "veteran", "Pragmatic Randomized Clinical Trial BackgroundGulf War Illness", "NCT", "component scale score"], "article_id"=>3149935, "categories"=>["Medicine", "Neuroscience", "Biotechnology", "Immunology", "Cancer", "Science Policy", "Mental Health", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Lisa Conboy", "Travis Gerke", "Kai-Yin Hsu", "Meredith St John", "Marc Goldstein", "Rosa Schnyer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149161.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Mean_and_empirical_95_confidence_limits_estimated_for_both_SF_36P_and_McGill_from_5000_simulations_of_the_fitted_GEE_models_/3149935", "title"=>"Mean and empirical 95% confidence limits estimated for both SF-36P and McGill from 5000 simulations of the fitted GEE models.", "pos_in_sequence"=>6, "defined_type"=>3, "published_date"=>"2016-03-31 07:25:01"}
• {"files"=>["https://ndownloader.figshare.com/files/4907371"], "description"=>"<p>Estimates and accompanying statistical values from the GEE modeling of the 6-month outcome SF-36P.</p>", "links"=>[], "tags"=>["Randomized Clinical Trial", "McGill pain index", "group 1", "Gulf War Illness", "acupuncture treatments", "group 2. ConclusionsIndividualized acupuncture treatment", "McGill Pain scale.ResultsOf", "6 months", "Gulf War Illness Research Program", "Individualized Acupuncture Protocols", "care treatment exists.MethodsThis", "outcome", "SF", "Complex Medical Illness", "W 81XWH Opinions", "veteran", "Pragmatic Randomized Clinical Trial BackgroundGulf War Illness", "NCT", "component scale score"], "article_id"=>3149944, "categories"=>["Medicine", "Neuroscience", "Biotechnology", "Immunology", "Cancer", "Science Policy", "Mental Health", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Lisa Conboy", "Travis Gerke", "Kai-Yin Hsu", "Meredith St John", "Marc Goldstein", "Rosa Schnyer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149161.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Estimates_and_accompanying_statistical_values_from_the_GEE_modeling_of_the_6_month_outcome_SF_36P_/3149944", "title"=>"Estimates and accompanying statistical values from the GEE modeling of the 6-month outcome SF-36P.", "pos_in_sequence"=>7, "defined_type"=>3, "published_date"=>"2016-03-31 07:25:01"}
• {"files"=>["https://ndownloader.figshare.com/files/4907299", "https://ndownloader.figshare.com/files/4907302", "https://ndownloader.figshare.com/files/4907305", "https://ndownloader.figshare.com/files/4907308"], "description"=>"<div><p>Background</p><p>Gulf War Illness is a Complex Medical Illness characterized by multiple symptoms, including fatigue, sleep and mood disturbances, cognitive dysfunction, and musculoskeletal pain affecting veterans of the first Gulf War. No standard of care treatment exists.</p><p>Methods</p><p>This pragmatic Randomized Clinical Trial tested the effects of individualized acupuncture treatments offered in extant acupuncture practices in the community; practitioners had at least 5 years of experience plus additional training provided by the study. Veterans with diagnosed symptoms of Gulf War Illness were randomized to either six months of biweekly acupuncture treatments (group 1, n = 52) or 2 months of waitlist followed by weekly acupuncture treatments (group 2, n = 52). Measurements were taken at baseline, 2, 4 and 6 months. The primary outcome is the SF-36 physical component scale score (SF-36P) and the secondary outcome is the McGill Pain scale.</p><p>Results</p><p>Of the 104 subjects who underwent randomization, 85 completed the protocol (82%). A clinically and statistically significant average improvement of 9.4 points (p = 0.03) in the SF-36P was observed for group 1 at month 6 compared to group 2, adjusting for baseline pain. The secondary outcome of McGill pain index produced similar results; at 6 months, group 1 was estimated to experience a reduction of approximately 3.6 points (p = 0.04) compared to group 2.</p><p>Conclusions</p><p>Individualized acupuncture treatment of sufficient dose appears to offer significant relief of physical disability and pain for veterans with Gulf War Illness. This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs through the Gulf War Illness Research Program under Award No. W81XWH-09-2-0064. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense.</p><p>Trial Registration</p><p>ClinicalTrials.gov <a href=\"https://clinicaltrials.gov/ct2/show/NCT01305811\" target=\"_blank\">NCT01305811</a></p></div>", "links"=>[], "tags"=>["Randomized Clinical Trial", "McGill pain index", "group 1", "Gulf War Illness", "acupuncture treatments", "group 2. ConclusionsIndividualized acupuncture treatment", "McGill Pain scale.ResultsOf", "6 months", "Gulf War Illness Research Program", "Individualized Acupuncture Protocols", "care treatment exists.MethodsThis", "outcome", "SF", "Complex Medical Illness", "W 81XWH Opinions", "veteran", "Pragmatic Randomized Clinical Trial BackgroundGulf War Illness", "NCT", "component scale score"], "article_id"=>3149914, "categories"=>["Medicine", "Neuroscience", "Biotechnology", "Immunology", "Cancer", "Science Policy", "Mental Health", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Lisa Conboy", "Travis Gerke", "Kai-Yin Hsu", "Meredith St John", "Marc Goldstein", "Rosa Schnyer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0149161.s001", "https://dx.doi.org/10.1371/journal.pone.0149161.s002", "https://dx.doi.org/10.1371/journal.pone.0149161.s003", "https://dx.doi.org/10.1371/journal.pone.0149161.s004"], "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/The_Effectiveness_of_Individualized_Acupuncture_Protocols_in_the_Treatment_of_Gulf_War_Illness_A_Pragmatic_Randomized_Clinical_Trial/3149914", "title"=>"The Effectiveness of Individualized Acupuncture Protocols in the Treatment of Gulf War Illness: A Pragmatic Randomized Clinical Trial", "pos_in_sequence"=>1, "defined_type"=>4, "published_date"=>"2016-03-31 07:25:01"}
• {"files"=>["https://ndownloader.figshare.com/files/4907311"], "description"=>"<p>PLOS CONSORT Flow Diagram: Diagram of Screening, Randomization, and Follow-up.</p>", "links"=>[], "tags"=>["Randomized Clinical Trial", "McGill pain index", "group 1", "Gulf War Illness", "acupuncture treatments", "group 2. ConclusionsIndividualized acupuncture treatment", "McGill Pain scale.ResultsOf", "6 months", "Gulf War Illness Research Program", "Individualized Acupuncture Protocols", "care treatment exists.MethodsThis", "outcome", "SF", "Complex Medical Illness", "W 81XWH Opinions", "veteran", "Pragmatic Randomized Clinical Trial BackgroundGulf War Illness", "NCT", "component scale score"], "article_id"=>3149917, "categories"=>["Medicine", "Neuroscience", "Biotechnology", "Immunology", "Cancer", "Science Policy", "Mental Health", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Lisa Conboy", "Travis Gerke", "Kai-Yin Hsu", "Meredith St John", "Marc Goldstein", "Rosa Schnyer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149161.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/PLOS_CONSORT_Flow_Diagram_Diagram_of_Screening_Randomization_and_Follow_up_/3149917", "title"=>"PLOS CONSORT Flow Diagram: Diagram of Screening, Randomization, and Follow-up.", "pos_in_sequence"=>2, "defined_type"=>1, "published_date"=>"2016-03-31 07:25:01"}

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}

F1000Prime