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{"title"=>"Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease", "type"=>"journal", "authors"=>[{"first_name"=>"Cavin K.", "last_name"=>"Ward-Caviness", "scopus_author_id"=>"36572897000"}, {"first_name"=>"Lucas M.", "last_name"=>"Neas", "scopus_author_id"=>"7004121580"}, {"first_name"=>"Colette", "last_name"=>"Blach", "scopus_author_id"=>"55485320700"}, {"first_name"=>"Carol S.", "last_name"=>"Haynes", "scopus_author_id"=>"35393310800"}, {"first_name"=>"Karen", "last_name"=>"LaRocque-Abramson", "scopus_author_id"=>"8565587700"}, {"first_name"=>"Elizabeth", "last_name"=>"Grass", "scopus_author_id"=>"55261650500"}, {"first_name"=>"Elaine", "last_name"=>"Dowdy", "scopus_author_id"=>"7003747346"}, {"first_name"=>"Robert B.", "last_name"=>"Devlin", "scopus_author_id"=>"7102087175"}, {"first_name"=>"David", "last_name"=>"Diaz-Sanchez", "scopus_author_id"=>"7004624772"}, {"first_name"=>"Wayne E.", "last_name"=>"Cascio", "scopus_author_id"=>"7004368864"}, {"first_name"=>"Marie", "last_name"=>"Lynn Miranda", "scopus_author_id"=>"57194476887"}, {"first_name"=>"Simon G.", "last_name"=>"Gregory", "scopus_author_id"=>"7201489554"}, {"first_name"=>"Svati H.", "last_name"=>"Shah", "scopus_author_id"=>"55460965000"}, {"first_name"=>"William E.", "last_name"=>"Kraus", "scopus_author_id"=>"7103319252"}, {"first_name"=>"Elizabeth R.", "last_name"=>"Hauser", "scopus_author_id"=>"7005380287"}], "year"=>2016, "source"=>"PloS one", "identifiers"=>{"pui"=>"616147313", "sgr"=>"85016392063", "pmid"=>"27082954", "scopus"=>"2-s2.0-85016392063", "doi"=>"10.1371/journal.pone.0152670", "issn"=>"19326203"}, "id"=>"807aee65-e7cb-3d09-b7ac-b28fe43dd529", "abstract"=>"There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing suscep- tibility to these exposures. However, genome-scale investigations of these interactions have been rarely performed particularly in the case of air pollution exposures. We per- formed race-stratified genome-wide gene-environment interaction association studies on European-American (EA, N = 1623) and African-American (AA, N = 554) cohorts to investi- gate the joint influence of common single nucleotide polymorphisms (SNPs) and residential exposure to traffic (“traffic exposure”)—a recognized vascular disease risk factor—on peripheral arterial disease (PAD). Traffic exposure was estimated via the distance from the primary residence to the nearest major roadway, defined as the nearest limited access high- ways ormajor arterial. The rs755249-traffic exposure interaction was associated with PAD at a genome-wide significant level (P = 2.29x10-8) in European-Americans. Rs755249 is located in the 3’ untranslated region of BMP8A, amember of the bone morphogenic protein (BMP) gene family. Further investigation revealed several variants in BMP genes associ- ated with PAD via an interaction with traffic exposure in both the EA and AA cohorts; this included interactions with non-synonymous variants in BMP2, which is regulated by air pol- lution exposure. The BMP family of genes is linked to vascular growth and calcification and is a novel gene family for the study of PAD pathophysiology. Further investigation of BMP8A using the Genotype Tissue Expression Database revealedmultiple variants with nominally significant (P < 0.05) interaction P-values in our EA cohort were significantBMP8A eQTLs in tissue types highlight relevant for PAD such as rs755249 (tibial nerve, eQTL P = 3.6x10-6) and rs1180341 (tibial artery, eQTL P = 5.3x10-6). Together these results reveal a novel gene, and possibly gene family, associated with PAD via an interaction with traffic air pollution exposure. These results also highlight the potential for interactions stud- ies, particularly at the genome scale, to reveal novel biology linking environmental expo- sures to clinical outcomes.", "link"=>"http://www.mendeley.com/research/genetic-variants-bone-morphogenic-protein-gene-family-modify-association-between-residential-exposur", "reader_count"=>7, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>2, "Student > Master"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>2, "Student > Master"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>2, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Earth and Planetary Sciences"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

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• http://doi.org/10.1038/s41467-018-03202-2
• http://doi.org/10.1371/journal.pone.0173880
• http://doi.org/10.1016/j.freeradbiomed.2020.01.181
• http://doi.org/10.2217/epi-2019-0145
• http://doi.org/10.1161/ATVBAHA.117.310003
• http://doi.org/10.1016/j.ebiom.2018.01.023
• http://doi.org/10.1097/CRD.0000000000000231
• http://doi.org/10.1074/mcp.RA120.002071
• http://doi.org/10.3390/ijms21186724
• http://doi.org/10.2105/AJPH.2017.303771
• http://doi.org/10.1007/s00439-019-02004-w

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• {"files"=>["https://ndownloader.figshare.com/files/4967059"], "description"=>"<p>Meta-Analysis results for suggestive (P<1x10^-5) race-stratified interactions (a) and all interactions (b).</p>", "links"=>[], "tags"=>["PAD", "SNP", "air pollution exposure", "Bone Morphogenic Protein Gene Family Modify", "eQTL P", "EA", "interaction", "BMP 8A", "traffic air pollution exposure", "bone morphogenic protein", "BMP 8A eQTLs", "gene family", "air pollution exposures", "novel gene family", "Genotype Tissue Expression Database", "AA", "variant"], "article_id"=>3183106, "categories"=>["Space Science", "Medicine", "Genetics", "Biotechnology", "Environmental Sciences not elsewhere classified", "Chemical Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Mathematical Sciences not elsewhere classified", "Infectious Diseases", "Virology"], "users"=>["Cavin K. Ward-Caviness", "Lucas M. Neas", "Colette Blach", "Carol S. Haynes", "Karen LaRocque-Abramson", "Elizabeth Grass", "Elaine Dowdy", "Robert B. Devlin", "David Diaz-Sanchez", "Wayne E. Cascio", "Marie Lynn Miranda", "Simon G. Gregory", "Svati H. Shah", "William E. Kraus", "Elizabeth R. Hauser"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152670.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Meta_Analysis_results_for_suggestive_P_1x10_sup_5_sup_race_stratified_interactions_a_and_all_interactions_b_/3183106", "title"=>"Meta-Analysis results for suggestive (P<1x10^-5) race-stratified interactions (a) and all interactions (b).", "pos_in_sequence"=>8, "defined_type"=>3, "published_date"=>"2016-04-15 08:56:30"}
• {"files"=>["https://ndownloader.figshare.com/files/4967065"], "description"=>"<p>eQTL associations for <i>BMP8A</i> variants.</p>", "links"=>[], "tags"=>["PAD", "SNP", "air pollution exposure", "Bone Morphogenic Protein Gene Family Modify", "eQTL P", "EA", "interaction", "BMP 8A", "traffic air pollution exposure", "bone morphogenic protein", "BMP 8A eQTLs", "gene family", "air pollution exposures", "novel gene family", "Genotype Tissue Expression Database", "AA", "variant"], "article_id"=>3183109, "categories"=>["Space Science", "Medicine", "Genetics", "Biotechnology", "Environmental Sciences not elsewhere classified", "Chemical Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Mathematical Sciences not elsewhere classified", "Infectious Diseases", "Virology"], "users"=>["Cavin K. Ward-Caviness", "Lucas M. Neas", "Colette Blach", "Carol S. Haynes", "Karen LaRocque-Abramson", "Elizabeth Grass", "Elaine Dowdy", "Robert B. Devlin", "David Diaz-Sanchez", "Wayne E. Cascio", "Marie Lynn Miranda", "Simon G. Gregory", "Svati H. Shah", "William E. Kraus", "Elizabeth R. Hauser"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152670.t004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/eQTL_associations_for_i_BMP8A_i_variants_/3183109", "title"=>"eQTL associations for <i>BMP8A</i> variants.", "pos_in_sequence"=>9, "defined_type"=>3, "published_date"=>"2016-04-15 08:56:30"}
• {"files"=>["https://ndownloader.figshare.com/files/4967005"], "description"=>"<p>The location of the North Carolina CATHGEN participants who were selected for these analyses. The locations have been randomized to a small degree to protect the identity of the individuals while maintaining the spatial structure and dependency in the data.</p>", "links"=>[], "tags"=>["PAD", "SNP", "air pollution exposure", "Bone Morphogenic Protein Gene Family Modify", "eQTL P", "EA", "interaction", "BMP 8A", "traffic air pollution exposure", "bone morphogenic protein", "BMP 8A eQTLs", "gene family", "air pollution exposures", "novel gene family", "Genotype Tissue Expression Database", "AA", "variant"], "article_id"=>3183046, "categories"=>["Space Science", "Medicine", "Genetics", "Biotechnology", "Environmental Sciences not elsewhere classified", "Chemical Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Mathematical Sciences not elsewhere classified", "Infectious Diseases", "Virology"], "users"=>["Cavin K. Ward-Caviness", "Lucas M. Neas", "Colette Blach", "Carol S. Haynes", "Karen LaRocque-Abramson", "Elizabeth Grass", "Elaine Dowdy", "Robert B. Devlin", "David Diaz-Sanchez", "Wayne E. Cascio", "Marie Lynn Miranda", "Simon G. Gregory", "Svati H. Shah", "William E. Kraus", "Elizabeth R. Hauser"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152670.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/CATHGEN_participant_Locations_/3183046", "title"=>"CATHGEN participant Locations.", "pos_in_sequence"=>2, "defined_type"=>1, "published_date"=>"2016-04-15 08:56:30"}
• {"files"=>["https://ndownloader.figshare.com/files/4967035"], "description"=>"<p>The red line in the Manhattan plots represents the Bonferroni significance level for 1,000,000 tests (P < 5x10^-8) while the blue line represents a suggestive P (P < 1x10^-5).</p>", "links"=>[], "tags"=>["PAD", "SNP", "air pollution exposure", "Bone Morphogenic Protein Gene Family Modify", "eQTL P", "EA", "interaction", "BMP 8A", "traffic air pollution exposure", "bone morphogenic protein", "BMP 8A eQTLs", "gene family", "air pollution exposures", "novel gene family", "Genotype Tissue Expression Database", "AA", "variant"], "article_id"=>3183079, "categories"=>["Space Science", "Medicine", "Genetics", "Biotechnology", "Environmental Sciences not elsewhere classified", "Chemical Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Mathematical Sciences not elsewhere classified", "Infectious Diseases", "Virology"], "users"=>["Cavin K. Ward-Caviness", "Lucas M. Neas", "Colette Blach", "Carol S. Haynes", "Karen LaRocque-Abramson", "Elizabeth Grass", "Elaine Dowdy", "Robert B. Devlin", "David Diaz-Sanchez", "Wayne E. Cascio", "Marie Lynn Miranda", "Simon G. Gregory", "Svati H. Shah", "William E. Kraus", "Elizabeth R. Hauser"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152670.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Manhattan_and_QQ_plots_for_both_the_European_American_top_and_African_American_bottom_cohorts_/3183079", "title"=>"Manhattan and QQ plots for both the European-American (top) and African-American (bottom) cohorts.", "pos_in_sequence"=>4, "defined_type"=>1, "published_date"=>"2016-04-15 08:56:30"}
• {"files"=>["https://ndownloader.figshare.com/files/4967071"], "description"=>"<p>Sequence surrounding the five most significant <i>BMP8A</i> variants in the EA GWIS.</p>", "links"=>[], "tags"=>["PAD", "SNP", "air pollution exposure", "Bone Morphogenic Protein Gene Family Modify", "eQTL P", "EA", "interaction", "BMP 8A", "traffic air pollution exposure", "bone morphogenic protein", "BMP 8A eQTLs", "gene family", "air pollution exposures", "novel gene family", "Genotype Tissue Expression Database", "AA", "variant"], "article_id"=>3183115, "categories"=>["Space Science", "Medicine", "Genetics", "Biotechnology", "Environmental Sciences not elsewhere classified", "Chemical Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Mathematical Sciences not elsewhere classified", "Infectious Diseases", "Virology"], "users"=>["Cavin K. Ward-Caviness", "Lucas M. Neas", "Colette Blach", "Carol S. Haynes", "Karen LaRocque-Abramson", "Elizabeth Grass", "Elaine Dowdy", "Robert B. Devlin", "David Diaz-Sanchez", "Wayne E. Cascio", "Marie Lynn Miranda", "Simon G. Gregory", "Svati H. Shah", "William E. Kraus", "Elizabeth R. Hauser"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152670.t005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Sequence_surrounding_the_five_most_significant_i_BMP8A_i_variants_in_the_EA_GWIS_/3183115", "title"=>"Sequence surrounding the five most significant <i>BMP8A</i> variants in the EA GWIS.", "pos_in_sequence"=>10, "defined_type"=>3, "published_date"=>"2016-04-15 08:56:30"}
• {"files"=>["https://ndownloader.figshare.com/files/4967041"], "description"=>"<p>LocusZoom reveals strong LD between rs755249 in BMP8A and multiple SNPs in MACF1 among the European-Americans (top). This region has a much lower level of LD in the African-American cohort (bottom).</p>", "links"=>[], "tags"=>["PAD", "SNP", "air pollution exposure", "Bone Morphogenic Protein Gene Family Modify", "eQTL P", "EA", "interaction", "BMP 8A", "traffic air pollution exposure", "bone morphogenic protein", "BMP 8A eQTLs", "gene family", "air pollution exposures", "novel gene family", "Genotype Tissue Expression Database", "AA", "variant"], "article_id"=>3183088, "categories"=>["Space Science", "Medicine", "Genetics", "Biotechnology", "Environmental Sciences not elsewhere classified", "Chemical Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Mathematical Sciences not elsewhere classified", "Infectious Diseases", "Virology"], "users"=>["Cavin K. Ward-Caviness", "Lucas M. Neas", "Colette Blach", "Carol S. Haynes", "Karen LaRocque-Abramson", "Elizabeth Grass", "Elaine Dowdy", "Robert B. Devlin", "David Diaz-Sanchez", "Wayne E. Cascio", "Marie Lynn Miranda", "Simon G. Gregory", "Svati H. Shah", "William E. Kraus", "Elizabeth R. Hauser"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152670.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/LocusZoom_41_plots_of_the_BMP8A_region_/3183088", "title"=>"LocusZoom [41] plots of the BMP8A region.", "pos_in_sequence"=>5, "defined_type"=>1, "published_date"=>"2016-04-15 08:56:30"}
• {"files"=>["https://ndownloader.figshare.com/files/4967050"], "description"=>"<p>Clinical covariates for the CATHGEN cohort (a), air pollution study cohort (b), and GWIS cohort (c).</p>", "links"=>[], "tags"=>["PAD", "SNP", "air pollution exposure", "Bone Morphogenic Protein Gene Family Modify", "eQTL P", "EA", "interaction", "BMP 8A", "traffic air pollution exposure", "bone morphogenic protein", "BMP 8A eQTLs", "gene family", "air pollution exposures", "novel gene family", "Genotype Tissue Expression Database", "AA", "variant"], "article_id"=>3183094, "categories"=>["Space Science", "Medicine", "Genetics", "Biotechnology", "Environmental Sciences not elsewhere classified", "Chemical Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Mathematical Sciences not elsewhere classified", "Infectious Diseases", "Virology"], "users"=>["Cavin K. Ward-Caviness", "Lucas M. Neas", "Colette Blach", "Carol S. Haynes", "Karen LaRocque-Abramson", "Elizabeth Grass", "Elaine Dowdy", "Robert B. Devlin", "David Diaz-Sanchez", "Wayne E. Cascio", "Marie Lynn Miranda", "Simon G. Gregory", "Svati H. Shah", "William E. Kraus", "Elizabeth R. Hauser"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152670.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Clinical_covariates_for_the_CATHGEN_cohort_a_air_pollution_study_cohort_b_and_GWIS_cohort_c_/3183094", "title"=>"Clinical covariates for the CATHGEN cohort (a), air pollution study cohort (b), and GWIS cohort (c).", "pos_in_sequence"=>6, "defined_type"=>3, "published_date"=>"2016-04-15 08:56:30"}
• {"files"=>["https://ndownloader.figshare.com/files/4967020"], "description"=>"<p>In the first step separate SNP-traffic exposure GWIS of the EA and AA cohorts was performed. Following this suggestive (P < 1x10^-5) results were examined for replication via a meta-analysis of both cohorts using METAL[<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0152670#pone.0152670.ref031\" target=\"_blank\">31</a>]. Finally step 3 involved an examination of suggestive results from a meta-analysis of all the interactions.</p>", "links"=>[], "tags"=>["PAD", "SNP", "air pollution exposure", "Bone Morphogenic Protein Gene Family Modify", "eQTL P", "EA", "interaction", "BMP 8A", "traffic air pollution exposure", "bone morphogenic protein", "BMP 8A eQTLs", "gene family", "air pollution exposures", "novel gene family", "Genotype Tissue Expression Database", "AA", "variant"], "article_id"=>3183064, "categories"=>["Space Science", "Medicine", "Genetics", "Biotechnology", "Environmental Sciences not elsewhere classified", "Chemical Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Mathematical Sciences not elsewhere classified", "Infectious Diseases", "Virology"], "users"=>["Cavin K. Ward-Caviness", "Lucas M. Neas", "Colette Blach", "Carol S. Haynes", "Karen LaRocque-Abramson", "Elizabeth Grass", "Elaine Dowdy", "Robert B. Devlin", "David Diaz-Sanchez", "Wayne E. Cascio", "Marie Lynn Miranda", "Simon G. Gregory", "Svati H. Shah", "William E. Kraus", "Elizabeth R. Hauser"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152670.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Flowchart_displaying_the_analysis_plan_undertaken_/3183064", "title"=>"Flowchart displaying the analysis plan undertaken.", "pos_in_sequence"=>3, "defined_type"=>1, "published_date"=>"2016-04-15 08:56:30"}
• {"files"=>["https://ndownloader.figshare.com/files/4966918", "https://ndownloader.figshare.com/files/4966975", "https://ndownloader.figshare.com/files/4966969", "https://ndownloader.figshare.com/files/4966960", "https://ndownloader.figshare.com/files/4966954", "https://ndownloader.figshare.com/files/4966951", "https://ndownloader.figshare.com/files/4966945", "https://ndownloader.figshare.com/files/4966939", "https://ndownloader.figshare.com/files/4966933", "https://ndownloader.figshare.com/files/4966930", "https://ndownloader.figshare.com/files/4966978"], "description"=>"<div><p>There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing susceptibility to these exposures. However, genome-scale investigations of these interactions have been rarely performed particularly in the case of air pollution exposures. We performed race-stratified genome-wide gene-environment interaction association studies on European-American (EA, N = 1623) and African-American (AA, N = 554) cohorts to investigate the joint influence of common single nucleotide polymorphisms (SNPs) and residential exposure to traffic (“traffic exposure”)—a recognized vascular disease risk factor—on peripheral arterial disease (PAD). Traffic exposure was estimated via the distance from the primary residence to the nearest major roadway, defined as the nearest limited access highways or major arterial. The rs755249-traffic exposure interaction was associated with PAD at a genome-wide significant level (P = 2.29x10^-8) in European-Americans. Rs755249 is located in the 3’ untranslated region of <i>BMP8A</i>, a member of the bone morphogenic protein (BMP) gene family. Further investigation revealed several variants in BMP genes associated with PAD via an interaction with traffic exposure in both the EA and AA cohorts; this included interactions with non-synonymous variants in <i>BMP2</i>, which is regulated by air pollution exposure. The BMP family of genes is linked to vascular growth and calcification and is a novel gene family for the study of PAD pathophysiology. Further investigation of <i>BMP8A</i> using the Genotype Tissue Expression Database revealed multiple variants with nominally significant (P < 0.05) interaction P-values in our EA cohort were significant BMP8A eQTLs in tissue types highlight relevant for PAD such as rs755249 (tibial nerve, eQTL P = 3.6x10^-6) and rs1180341 (tibial artery, eQTL P = 5.3x10^-6). Together these results reveal a novel gene, and possibly gene family, associated with PAD via an interaction with traffic air pollution exposure. These results also highlight the potential for interactions studies, particularly at the genome scale, to reveal novel biology linking environmental exposures to clinical outcomes.</p></div>", "links"=>[], "tags"=>["PAD", "SNP", "air pollution exposure", "Bone Morphogenic Protein Gene Family Modify", "eQTL P", "EA", "interaction", "BMP 8A", "traffic air pollution exposure", "bone morphogenic protein", "BMP 8A eQTLs", "gene family", "air pollution exposures", "novel gene family", "Genotype Tissue Expression Database", "AA", "variant"], "article_id"=>3183001, "categories"=>["Space Science", "Medicine", "Genetics", "Biotechnology", "Environmental Sciences not elsewhere classified", "Chemical Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Mathematical Sciences not elsewhere classified", "Infectious Diseases", "Virology"], "users"=>["Cavin K. Ward-Caviness", "Lucas M. Neas", "Colette Blach", "Carol S. Haynes", "Karen LaRocque-Abramson", "Elizabeth Grass", "Elaine Dowdy", "Robert B. Devlin", "David Diaz-Sanchez", "Wayne E. Cascio", "Marie Lynn Miranda", "Simon G. Gregory", "Svati H. Shah", "William E. Kraus", "Elizabeth R. Hauser"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0152670.s001", "https://dx.doi.org/10.1371/journal.pone.0152670.s010", "https://dx.doi.org/10.1371/journal.pone.0152670.s009", "https://dx.doi.org/10.1371/journal.pone.0152670.s008", "https://dx.doi.org/10.1371/journal.pone.0152670.s007", "https://dx.doi.org/10.1371/journal.pone.0152670.s006", "https://dx.doi.org/10.1371/journal.pone.0152670.s005", "https://dx.doi.org/10.1371/journal.pone.0152670.s004", "https://dx.doi.org/10.1371/journal.pone.0152670.s003", "https://dx.doi.org/10.1371/journal.pone.0152670.s002", "https://dx.doi.org/10.1371/journal.pone.0152670.s011"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Genetic_Variants_in_the_Bone_Morphogenic_Protein_Gene_Family_Modify_the_Association_between_Residential_Exposure_to_Traffic_and_Peripheral_Arterial_Disease/3183001", "title"=>"Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease", "pos_in_sequence"=>1, "defined_type"=>4, "published_date"=>"2016-04-15 08:56:30"}
• {"files"=>["https://ndownloader.figshare.com/files/4967056"], "description"=>"<p>Suggestive (P < 1x10^-5) interactions for the EA (a) and AA (b) GWIS.</p>", "links"=>[], "tags"=>["PAD", "SNP", "air pollution exposure", "Bone Morphogenic Protein Gene Family Modify", "eQTL P", "EA", "interaction", "BMP 8A", "traffic air pollution exposure", "bone morphogenic protein", "BMP 8A eQTLs", "gene family", "air pollution exposures", "novel gene family", "Genotype Tissue Expression Database", "AA", "variant"], "article_id"=>3183100, "categories"=>["Space Science", "Medicine", "Genetics", "Biotechnology", "Environmental Sciences not elsewhere classified", "Chemical Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Mathematical Sciences not elsewhere classified", "Infectious Diseases", "Virology"], "users"=>["Cavin K. Ward-Caviness", "Lucas M. Neas", "Colette Blach", "Carol S. Haynes", "Karen LaRocque-Abramson", "Elizabeth Grass", "Elaine Dowdy", "Robert B. Devlin", "David Diaz-Sanchez", "Wayne E. Cascio", "Marie Lynn Miranda", "Simon G. Gregory", "Svati H. Shah", "William E. Kraus", "Elizabeth R. Hauser"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152670.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Suggestive_P_1x10_sup_5_sup_interactions_for_the_EA_a_and_AA_b_GWIS_/3183100", "title"=>"Suggestive (P < 1x10^-5) interactions for the EA (a) and AA (b) GWIS.", "pos_in_sequence"=>7, "defined_type"=>3, "published_date"=>"2016-04-15 08:56:30"}

PMC Usage Stats | Further Information

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• {"unique-ip"=>"17", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"5"}
• {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
• {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
• {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
• {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
• {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
• {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
• {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
• {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
• {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
• {"unique-ip"=>"2", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
• {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
• {"unique-ip"=>"6", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
• {"unique-ip"=>"16", "full-text"=>"6", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
• {"unique-ip"=>"14", "full-text"=>"71", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2020", "month"=>"12"}

Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}

F1000Prime