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{"title"=>"Pathway network analyses for autism reveal multisystem involvement, major overlaps with other diseases and convergence upon MAPK and calcium signaling", "type"=>"journal", "authors"=>[{"first_name"=>"Ya", "last_name"=>"Wen", "scopus_author_id"=>"57188839832"}, {"first_name"=>"Mohamad J.", "last_name"=>"Alshikho", "scopus_author_id"=>"57188837843"}, {"first_name"=>"Martha R.", "last_name"=>"Herbert", "scopus_author_id"=>"7103313028"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84963718872", "sgr"=>"84963718872", "pui"=>"609703281", "pmid"=>"27055244", "doi"=>"10.1371/journal.pone.0153329"}, "id"=>"3e203ac4-6551-32af-ae56-1ae764e5864c", "abstract"=>"We used established databases in standard ways to systematically characterize gene ontologies, pathways and functional linkages in the large set of genes now associated with autism spectrum disorders (ASDs). These conditions are particularly challenging-they lack clear pathognomonic biological markers, they involve great heterogeneity across multiple levels (genes, systemic biological and brain characteristics, and nuances of behavioral manifestations)-and yet everyone with this diagnosis meets the same defining behavioral criteria. Using the human gene list from Simons Foundation Autism Research Initiative (SFARI) we performed gene set enrichment analysis with the Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway Database, and then derived a pathway network from pathway-pathway functional interactions again in reference to KEGG. Through identifying the GO (Gene Ontology) groups in which SFARI genes were enriched, mapping the coherence between pathways and GO groups, and ranking the relative strengths of representation of pathway network components, we 1) identified 10 disease-associated and 30 function-associated pathways 2) revealed calcium signaling pathway and neuroactive ligand-receptor interaction as the most enriched, statistically significant pathways from the enrichment analysis, 3) showed calcium signaling pathways and MAPK signaling pathway to be interactive hubs with other pathways and also to be involved with pervasively present biological processes, 4) found convergent indications that the process \"calcium-PRC (protein kinase C)-Ras-Raf-MAPK/ERK\" is likely a major contributor to ASD pathophysiology, and 5) noted that perturbations associated with KEGG's category of environmental information processing were common. These findings support the idea that ASD-associated genes may contribute not only to core features of ASD themselves but also to vulnerability to other chronic and systemic problems potentially including cancer, metabolic conditions and heart diseases. ASDs may thus arise, or emerge, from underlying vulnerabilities related to pleiotropic genes associated with pervasively important molecular mechanisms, vulnerability to environmental input and multiple systemic co-morbidities.", "link"=>"http://www.mendeley.com/research/pathway-network-analyses-autism-reveal-multisystem-involvement-major-overlaps-other-diseases-converg", "reader_count"=>61, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>9, "Student > Master"=>5, "Other"=>5, "Student > Bachelor"=>11, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>9, "Student > Master"=>5, "Other"=>5, "Student > Bachelor"=>11, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>14, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>18, "Medicine and Dentistry"=>10, "Neuroscience"=>8, "Business, Management and Accounting"=>1, "Psychology"=>2, "Social Sciences"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Neuroscience"=>{"Neuroscience"=>8}, "Social Sciences"=>{"Social Sciences"=>3}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>18}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>14}, "Unspecified"=>{"Unspecified"=>4}}, "reader_count_by_country"=>{"Hungary"=>1, "United States"=>1, "Brazil"=>1}, "group_count"=>2}

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• http://doi.org/10.1186/s12864-017-3667-9
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Journal Comments | Further Information

• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/f046e876-be2b-402a-88f1-143f50205669", "title"=>"A note of caution about the use of SFARI Gene", "body"=>"Wen, Alshikho and Herbert have provided an interesting network analysis of candidate ASD genes as curated by the SFARI Gene database. The pathways they identify—particularly calcium and Ras/MAPK signaling—are plausible and fit reasonably well with previously published analyses. That said, as one of the people involved in the curation and production of the SFARI Gene database, I want to add a note of caution. The authors have taken an ‘unbiased’ approach by including in their analysis every gene listed in the database. While I am generally in favor of unbiased approaches, in this instance there is a chance that it could generate misleading results. Most (though not yet all) of the genes in the human gene module of SFARI Gene have been assigned a score. This score suggests the likelihood that the gene is actually a risk-conferring gene for ASD based on a careful assessment of the degree of statistical support for the gene’s association with the disorder. Contrary to the suggestion of the authors, this score does not reflect our notion of what really constitutes a reliable diagnosis of ASD, as our scheme assumes all reported diagnoses in the literature are reliable. Rather, our approach is based on what we do in fact consider to be a gold standard for relevance in human genetics—namely a careful comparison of the frequency of mutations (or polymorphisms) in a particular gene in cases versus controls. While some of the details of this approach might differ depending on who is doing the assessment, we think this general framework is widely accepted. The authors correctly point out that not all of the genes on the SFARI Gene list are accompanied by a score, and this is something we are working to rectify. I would like to point out, however, that our scoring efforts prioritize genes that clearly have more support than others, and as such the genes in the top three categories are essentially complete. We suggest that researchers doing similar analyses focus on these genes (most of which are reported in cases of idiopathic autism), since they are much more likely to contain bona fide risk genes than those in the bottom three categories. Finally, I would note that we are currently re-designing the SFARI Gene site, to make it easier to understand and use the scoring system that has been implemented. This new version of the site should be launched by June of this year.\n\nAlan Packer\nSimons Foundation Autism Research Initiative", "highlightedText"=>"", "isRemoved"=>false, "created"=>"2016-04-15T14:52:48Z", "lastModified"=>"2016-04-15T14:52:48Z", "creator"=>{"userId"=>"1024173"}, "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0153329", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2016-04-15T14:52:48Z", "replies"=>[]}

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• {"id"=>"718186724052983808", "text"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement, Overlaps with Other Diseases ... https://t.co/NnwwRdzZJY @PLOSONE", "created_at"=>"2016-04-07T21:20:32Z", "user"=>"PLOSNeuro", "user_name"=>"PLOS Neuro Community", "user_profile_image"=>"http://pbs.twimg.com/profile_images/503986620375121921/8OqTRBs1_normal.jpeg"}
• {"id"=>"718186927342690305", "text"=>"RT @PLOSNeuro: Pathway Network Analyses for Autism Reveal Multisystem Involvement, Overlaps with Other Diseases ... https://t.co/NnwwRdzZJY…", "created_at"=>"2016-04-07T21:21:21Z", "user"=>"RebelSpeducator", "user_name"=>"Pam Zich", "user_profile_image"=>"http://pbs.twimg.com/profile_images/707318341594128385/5xgA56bN_normal.jpg"}
• {"id"=>"718193789475635200", "text"=>"'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-04-07T21:48:37Z", "user"=>"PaulWhiteleyPhD", "user_name"=>"Paul Whiteley", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000344449848/35f9d576889f4cf18b0bcf1f367afa4f_normal.jpeg"}
• {"id"=>"718194823526813696", "text"=>"RT @PaulWhiteleyPhD: 'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-04-07T21:52:44Z", "user"=>"Firefly_fan", "user_name"=>"Marc Casa?as Escarr?", "user_profile_image"=>"http://pbs.twimg.com/profile_images/712304824340107264/eUv75PQo_normal.jpg"}
• {"id"=>"718195926993649664", "text"=>"RT @PaulWhiteleyPhD: 'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-04-07T21:57:07Z", "user"=>"LucindaNatDoc", "user_name"=>"Lucinda Miller", "user_profile_image"=>"http://pbs.twimg.com/profile_images/619230677175783425/fbRCfnOG_normal.jpg"}
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• {"id"=>"718198617585147904", "text"=>"RT @PLOSNeuro: Pathway Network Analyses for Autism Reveal Multisystem Involvement, Overlaps with Other Diseases ... https://t.co/NnwwRdzZJY…", "created_at"=>"2016-04-07T22:07:48Z", "user"=>"TwistedCattle", "user_name"=>"Twisted Cattle", "user_profile_image"=>"http://pbs.twimg.com/profile_images/716162487608020992/P1B2j-WB_normal.jpg"}
• {"id"=>"718205664967823360", "text"=>"RT @PaulWhiteleyPhD: 'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-04-07T22:35:48Z", "user"=>"Gut_Goddess", "user_name"=>"Dr Grace/Gut Goddess", "user_profile_image"=>"http://pbs.twimg.com/profile_images/657001876831907844/UJRCrMn-_normal.png"}
• {"id"=>"718206980758880256", "text"=>"RT @PaulWhiteleyPhD: 'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-04-07T22:41:02Z", "user"=>"kellyfj1", "user_name"=>"Frank Kelly", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2223252725/frank2_normal.jpg"}
• {"id"=>"718207356371353600", "text"=>"RT @PLOSNeuro: Pathway Network Analyses for Autism Reveal Multisystem Involvement, Overlaps with Other Diseases ... https://t.co/NnwwRdzZJY…", "created_at"=>"2016-04-07T22:42:32Z", "user"=>"HannahPradeep", "user_name"=>"Hannah Pradeep-Kumar", "user_profile_image"=>"http://pbs.twimg.com/profile_images/712991669138890752/iQUTmRSQ_normal.jpg"}
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• {"id"=>"718262749558607878", "text"=>"RT @PaulWhiteleyPhD: 'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-04-08T02:22:38Z", "user"=>"SharonGibbsPhD", "user_name"=>"Sharon Gibbs", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000054160575/86aafdf561274cf25e894e35d1668d41_normal.jpeg"}
• {"id"=>"718326141648572416", "text"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement\nhttps://t.co/ZiAd8rj414 https://t.co/uU3aJclbma", "created_at"=>"2016-04-08T06:34:32Z", "user"=>"harschellekens", "user_name"=>"Harriet Schellekens", "user_profile_image"=>"http://pbs.twimg.com/profile_images/700253705417969664/yODeyjpA_normal.jpg"}
• {"id"=>"718350861144088576", "text"=>"#PLOSONE: Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Disea ... https://t.co/Y6deVwnNYL", "created_at"=>"2016-04-08T08:12:46Z", "user"=>"leoniedelt", "user_name"=>"Jen Leavesley", "user_profile_image"=>"http://pbs.twimg.com/profile_images/701844718049746944/lx7QFySn_normal.jpg"}
• {"id"=>"718357456997494784", "text"=>"RT @leoniedelt: #PLOSONE: Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Disea ... https://t…", "created_at"=>"2016-04-08T08:38:58Z", "user"=>"suzyg001", "user_name"=>"Sue Gerrard", "user_profile_image"=>"http://pbs.twimg.com/profile_images/486464312890761217/KalzIzva_normal.png"}
• {"id"=>"718358110612664321", "text"=>"@SoniaBoue read that link - it looks like it. Might explain some of the early deaths! https://t.co/iYZKAqdrE2", "created_at"=>"2016-04-08T08:41:34Z", "user"=>"leoniedelt", "user_name"=>"Jen Leavesley", "user_profile_image"=>"http://pbs.twimg.com/profile_images/701844718049746944/lx7QFySn_normal.jpg"}
• {"id"=>"718362333152731136", "text"=>"RT @PaulWhiteleyPhD: 'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-04-08T08:58:21Z", "user"=>"autismepi", "user_name"=>"Annabelle Lee", "user_profile_image"=>"http://pbs.twimg.com/profile_images/589864865587593218/9Waz6zHw_normal.jpg"}
• {"id"=>"718432540575535104", "text"=>"??????????????????ASD????????????????????????Pathway Network Analyses for Autism Reveal Multisystem Involvement, …https://t.co/kC0d9iyQoI", "created_at"=>"2016-04-08T13:37:20Z", "user"=>"uranus_2", "user_name"=>"????????", "user_profile_image"=>"http://pbs.twimg.com/profile_images/650483455248064512/EOJq3sZX_normal.png"}
• {"id"=>"718432638977966086", "text"=>"RT @uranus_2: ??????????????????ASD????????????????????????Pathway Network Analyses for Autism Reveal Multisystem Involvement, …https://t.c…", "created_at"=>"2016-04-08T13:37:43Z", "user"=>"noz_censored", "user_name"=>"noz", "user_profile_image"=>"http://pbs.twimg.com/profile_images/716851270179422208/yw3G0r1k_normal.jpg"}
• {"id"=>"718433834430177280", "text"=>"RT @uranus_2: ??????????????????ASD????????????????????????Pathway Network Analyses for Autism Reveal Multisystem Involvement, …https://t.c…", "created_at"=>"2016-04-08T13:42:28Z", "user"=>"g066209", "user_name"=>"Hide S", "user_profile_image"=>"http://pbs.twimg.com/profile_images/715176535234375680/XvIEys3x_normal.jpg"}
• {"id"=>"718442217778634753", "text"=>"This morning I got an email from Documenting Hope about new research that AGAIN connects autism to... https://t.co/uA8e0ZRVPC", "created_at"=>"2016-04-08T14:15:47Z", "user"=>"ginabad", "user_name"=>"Gina Badalaty", "user_profile_image"=>"http://pbs.twimg.com/profile_images/562727885773864960/Ltx9H_T5_normal.jpeg"}
• {"id"=>"718452707527376897", "text"=>"Just starting to digest. Pathway Network Analyses for #Autism Reveal Multisystem Involvement... https://t.co/zyXnltEPFL @TheCoffeeKlatch", "created_at"=>"2016-04-08T14:57:28Z", "user"=>"holisticneurodr", "user_name"=>"Dr. Scott Theirl", "user_profile_image"=>"http://pbs.twimg.com/profile_images/530024431997820930/DhQhmTfu_normal.jpeg"}
• {"id"=>"718459824959201280", "text"=>"RT @PaulWhiteleyPhD: 'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-04-08T15:25:45Z", "user"=>"bobbiesola", "user_name"=>"Bobbie Edwards", "user_profile_image"=>"http://pbs.twimg.com/profile_images/718283584046559232/EqtrUZ0q_normal.jpg"}
• {"id"=>"718475024198406144", "text"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases https://t.co/Sbp0THNTxn", "created_at"=>"2016-04-08T16:26:09Z", "user"=>"AutismFreeBrain", "user_name"=>"AutismFreeBrain", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3657853133/53f537b4cc0cb396b8e26b072c64d282_normal.jpeg"}
• {"id"=>"718475719651762176", "text"=>"Autism Free Brain is pleased to announce the publication of Dr. Martha Herbert's most recent scientific paper,... https://t.co/lorIi6Wdgi", "created_at"=>"2016-04-08T16:28:54Z", "user"=>"AutismFreeBrain", "user_name"=>"AutismFreeBrain", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3657853133/53f537b4cc0cb396b8e26b072c64d282_normal.jpeg"}
• {"id"=>"718480397571649537", "text"=>"RT @PaulWhiteleyPhD: 'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-04-08T16:47:30Z", "user"=>"TweetingAutism", "user_name"=>"Treating Autism", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1423517740/talogoshrunk3_normal.jpg"}
• {"id"=>"718482441380491265", "text"=>"#PLOSONE: Pathway Network Analyses for #Autism Reveal Multisystem Involvement, Major Overlaps with Other Disea ... https://t.co/bF5F9jDUbk", "created_at"=>"2016-04-08T16:55:37Z", "user"=>"richardmills18", "user_name"=>"richard mills", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2109227112/RM_normal.jpg"}
• {"id"=>"718489785254293504", "text"=>"#PLOSONE: Pathway Network Analyses for #Autism Reveal Multisystem Involvement, Major Overlaps with Other Disea ... https://t.co/TrUAFnZ9KT", "created_at"=>"2016-04-08T17:24:48Z", "user"=>"mission2heal", "user_name"=>"Christina Schmidt", "user_profile_image"=>"http://pbs.twimg.com/profile_images/587741509413314561/IR1Al_Y3_normal.jpg"}
• {"id"=>"718507312684625920", "text"=>"Pathway Network Analyses for Autism reveal Multisystem Involvement, Major Overlaps with Other Diseases https://t.co/q2lskCYKqT …", "created_at"=>"2016-04-08T18:34:27Z", "user"=>"autismepi", "user_name"=>"Annabelle Lee", "user_profile_image"=>"http://pbs.twimg.com/profile_images/589864865587593218/9Waz6zHw_normal.jpg"}
• {"id"=>"718515062315556864", "text"=>"Pathway Network Analyses for #Autism...Convergence upon MAPK and #Calcium Signaling https://t.co/WPCUfV1zML #EMF #Cancer", "created_at"=>"2016-04-08T19:05:14Z", "user"=>"petermsullivan9", "user_name"=>"Peter Sullivan", "user_profile_image"=>"http://pbs.twimg.com/profile_images/648274307714445312/q7_RwmXq_normal.jpg"}
• {"id"=>"718522776970227714", "text"=>"Serious scientists...sounds science...a new publication from previous AutismOne keynote speaker, Martha Herbert,... https://t.co/QOcx7MrlvI", "created_at"=>"2016-04-08T19:35:54Z", "user"=>"AutismOne", "user_name"=>"AutismOne", "user_profile_image"=>"http://pbs.twimg.com/profile_images/216619433/AutismOne_Logo_Small_normal.jpg"}
• {"id"=>"718528325426221056", "text"=>"\"Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and... https://t.co/uSIsMSsaq6", "created_at"=>"2016-04-08T19:57:57Z", "user"=>"Planet_Autism", "user_name"=>"Planet Autism", "user_profile_image"=>"http://pbs.twimg.com/profile_images/541611229425332224/ptG1Oql7_normal.jpeg"}
• {"id"=>"718534179835633664", "text"=>"RT @uranus_2: ??????????????????ASD????????????????????????Pathway Network Analyses for Autism Reveal Multisystem Involvement, …https://t.c…", "created_at"=>"2016-04-08T20:21:12Z", "user"=>"ynabe39", "user_name"=>"????", "user_profile_image"=>"http://pbs.twimg.com/profile_images/711431454450782208/k2qVFemA_normal.jpg"}
• {"id"=>"718535124304834561", "text"=>"RT @uranus_2: ??????????????????ASD????????????????????????Pathway Network Analyses for Autism Reveal Multisystem Involvement, …https://t.c…", "created_at"=>"2016-04-08T20:24:58Z", "user"=>"haruki571", "user_name"=>"????", "user_profile_image"=>"http://pbs.twimg.com/profile_images/640939455910576128/fObZR30J_normal.png"}
• {"id"=>"718537833078624256", "text"=>"RT @mission2heal: #PLOSONE: Pathway Network Analyses for #Autism Reveal Multisystem Involvement, Major Overlaps with Other Disea ... https:…", "created_at"=>"2016-04-08T20:35:43Z", "user"=>"DawnTollefson", "user_name"=>"Dtautismmom", "user_profile_image"=>"http://pbs.twimg.com/profile_images/657525588119322624/2jByZTo2_normal.jpg"}
• {"id"=>"718563519763980288", "text"=>"RT @petermsullivan9: Pathway Network Analyses for #Autism...Convergence upon MAPK and #Calcium Signaling https://t.co/WPCUfV1zML #EMF #Canc…", "created_at"=>"2016-04-08T22:17:48Z", "user"=>"miles_wilma", "user_name"=>"wilma miles", "user_profile_image"=>"http://pbs.twimg.com/profile_images/655487672090148864/4MWjY7e__normal.jpg"}
• {"id"=>"718575416542277632", "text"=>"RT @uranus_2: ??????????????????ASD????????????????????????Pathway Network Analyses for Autism Reveal Multisystem Involvement, …https://t.c…", "created_at"=>"2016-04-08T23:05:04Z", "user"=>"feraounien", "user_name"=>"isihama hiroko", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2282575460/e4zc8it7km0sq701pp9n_normal.jpeg"}
• {"id"=>"718583832241266688", "text"=>"RT @uranus_2: ??????????????????ASD????????????????????????Pathway Network Analyses for Autism Reveal Multisystem Involvement, …https://t.c…", "created_at"=>"2016-04-08T23:38:30Z", "user"=>"aonamida_pencil", "user_name"=>"???????????????", "user_profile_image"=>"http://pbs.twimg.com/profile_images/712602590345728000/0WtWM8_C_normal.jpg"}
• {"id"=>"718586360123244544", "text"=>"New research on autism genes; there is hope! @marthaherbertmd et al https://t.co/Yx2Qw1jNcZ #autism #hope #genes#adhd #add", "created_at"=>"2016-04-08T23:48:33Z", "user"=>"FosteringNutri", "user_name"=>"Mandy Lee", "user_profile_image"=>"http://pbs.twimg.com/profile_images/689956611893399555/fIHEP2kq_normal.jpg"}
• {"id"=>"718600906476916736", "text"=>"RT @uranus_2: ??????????????????ASD????????????????????????Pathway Network Analyses for Autism Reveal Multisystem Involvement, …https://t.c…", "created_at"=>"2016-04-09T00:46:21Z", "user"=>"Angelline17", "user_name"=>"Angele", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3706918269/f2e641d86e8934aacd860e710afdf84c_normal.jpeg"}
• {"id"=>"718603783786405890", "text"=>"RT @AutismFreeBrain: Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases https://t.co/S…", "created_at"=>"2016-04-09T00:57:47Z", "user"=>"Just4TheCause", "user_name"=>"Just for the Cause", "user_profile_image"=>"http://pbs.twimg.com/profile_images/508497439360172032/iJINQp0T_normal.jpeg"}
• {"id"=>"718617043700998146", "text"=>"PLOS ONE: Pathway Network Analyses for Autism Reveal Multisystem Involvement https://t.co/XIHPkKZaPN", "created_at"=>"2016-04-09T01:50:29Z", "user"=>"DrMariosAdamou", "user_name"=>"Prof Marios Adamou", "user_profile_image"=>"http://pbs.twimg.com/profile_images/519169089148059650/73xqk4gX_normal.jpeg"}
• {"id"=>"718668753723133954", "text"=>"RT @PLOSNeuro: Pathway Network Analyses for Autism Reveal Multisystem Involvement, Overlaps with Other Diseases ... https://t.co/NnwwRdzZJY…", "created_at"=>"2016-04-09T05:15:57Z", "user"=>"Bryana_Oliver", "user_name"=>"Bryana Nicole", "user_profile_image"=>"http://pbs.twimg.com/profile_images/718425978259812353/2ZOaO_Xm_normal.jpg"}
• {"id"=>"718787177878937600", "text"=>"@WrongYouAre1 Wrong You Are, Again! See 'Hannah Poling Case' and this study. Autism involves a multi-system overlap. https://t.co/0KPlEmaKMb", "created_at"=>"2016-04-09T13:06:32Z", "user"=>"RosanneMLindsay", "user_name"=>"Rosanne Lindsay", "user_profile_image"=>"http://pbs.twimg.com/profile_images/600382262648045568/DFEKTo8L_normal.jpg"}
• {"id"=>"718825751189979136", "text"=>"RT @uranus_2: ??????????????????ASD????????????????????????Pathway Network Analyses for Autism Reveal Multisystem Involvement, …https://t.c…", "created_at"=>"2016-04-09T15:39:48Z", "user"=>"tokoroten510", "user_name"=>"????? ??????? ??????", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000066235932/6f38a0ff0670da6ed1c1f57cf59b59be_normal.jpeg"}
• {"id"=>"718915857758429184", "text"=>"RT @PaulWhiteleyPhD: 'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-04-09T21:37:51Z", "user"=>"anappleeveryday", "user_name"=>"Sarah Hanratty", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000629297015/200c04e4a06bdd273db49622a485d4d1_normal.jpeg"}
• {"id"=>"718931442605142016", "text"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other... https://t.co/lacXAnA6i4", "created_at"=>"2016-04-09T22:39:47Z", "user"=>"HBriele", "user_name"=>"Briele Hap.", "user_profile_image"=>"http://pbs.twimg.com/profile_images/490930644256444417/eHFMlkiH_normal.jpeg"}
• {"id"=>"718931953316139008", "text"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other... https://t.co/TKn2HlxCSl", "created_at"=>"2016-04-09T22:41:49Z", "user"=>"HBriele", "user_name"=>"Briele Hap.", "user_profile_image"=>"http://pbs.twimg.com/profile_images/490930644256444417/eHFMlkiH_normal.jpeg"}
• {"id"=>"719071130720468992", "text"=>"RT @uranus_2: ??????????????????ASD????????????????????????Pathway Network Analyses for Autism Reveal Multisystem Involvement, …https://t.c…", "created_at"=>"2016-04-10T07:54:51Z", "user"=>"toraigan11", "user_name"=>"???", "user_profile_image"=>"http://pbs.twimg.com/profile_images/706797246214328320/_9lUk7TX_normal.jpg"}
• {"id"=>"719267748078034944", "text"=>"#Autism MAPK/ERK,Calcium signaling pathways-Acetaminophen activated?https://t.co/3fXV0FNurT https://t.co/graggR7s6N \nhttps://t.co/q2lskCYKqT", "created_at"=>"2016-04-10T20:56:09Z", "user"=>"autismepi", "user_name"=>"Annabelle Lee", "user_profile_image"=>"http://pbs.twimg.com/profile_images/589864865587593218/9Waz6zHw_normal.jpg"}
• {"id"=>"719279468800512000", "text"=>"RT @PaulWhiteleyPhD: 'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-04-10T21:42:43Z", "user"=>"TheLateTalker", "user_name"=>"Cherab Lisa Geng", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2309296340/zekl083q3sjbdsx6xchi_normal.jpeg"}
• {"id"=>"719279573393870852", "text"=>"RT @PaulWhiteleyPhD: 'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-04-10T21:43:08Z", "user"=>"TheLateTalker", "user_name"=>"Cherab Lisa Geng", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2309296340/zekl083q3sjbdsx6xchi_normal.jpeg"}
• {"id"=>"719280246747504640", "text"=>"'Autism genes' might not be just genes for autism. To the researchers knowledge this is the first pathway-pathway … https://t.co/Oz9e9Fll7W", "created_at"=>"2016-04-10T21:45:49Z", "user"=>"dr_alex27", "user_name"=>"DR Alex", "user_profile_image"=>"http://pbs.twimg.com/profile_images/539497815974477824/zyHY6okO_normal.png"}
• {"id"=>"719304651519041536", "text"=>"RT @uranus_2: ??????????????????ASD????????????????????????Pathway Network Analyses for Autism Reveal Multisystem Involvement, …https://t.c…", "created_at"=>"2016-04-10T23:22:47Z", "user"=>"mayday185", "user_name"=>"_(?3 ??)_", "user_profile_image"=>"http://pbs.twimg.com/profile_images/716384357930237952/mKYyRAJS_normal.jpg"}
• {"id"=>"719305004906061824", "text"=>"#Science https://t.co/d2Pyo1lBDK 'Autism genes' might not be just genes for autism. To the researchers knowledge this is the first pathway…", "created_at"=>"2016-04-10T23:24:11Z", "user"=>"lofalexandria", "user_name"=>"LibraryOfAlexandria", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3085409108/417d6208a7c01653d710955311551083_normal.png"}
• {"id"=>"719553518961606656", "text"=>"https://t.co/scviH6Y9j5 https://t.co/kmuzCnuzFU", "created_at"=>"2016-04-11T15:51:42Z", "user"=>"GraziTheMan", "user_name"=>"Grazi", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2265337737/7pyimooidhuqjm93v93b_normal.jpeg"}
• {"id"=>"719556322149167104", "text"=>"Pathway Network Analyses for #Autism Reveal Multisystem Involvement. https://t.co/wYArMfK1eT #comorbidities #biomed", "created_at"=>"2016-04-11T16:02:50Z", "user"=>"New_Beginnings_", "user_name"=>"New Beginnings", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2165490856/nbnlogo_normal.jpg"}
• {"id"=>"719805792887517184", "text"=>"RT @uranus_2: ??????????????????ASD????????????????????????Pathway Network Analyses for Autism Reveal Multisystem Involvement, …https://t.c…", "created_at"=>"2016-04-12T08:34:09Z", "user"=>"nalakifumi", "user_name"=>"nalakifumi", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1211921768/CA340043_normal.JPG"}
• {"id"=>"721316078148825088", "text"=>"@simba_83 @DrJ_WasTaken @VeritasDolor @DavidJuurlink hmm. Link got cut off. Try this one https://t.co/ObHmlQ7K4q", "created_at"=>"2016-04-16T12:35:29Z", "user"=>"Raven_PA_", "user_name"=>"Master Muppet ? 2.0", "user_profile_image"=>"http://pbs.twimg.com/profile_images/687061769475473408/HbTDCecD_normal.jpg"}
• {"id"=>"721316240531329025", "text"=>"@DrJ_WasTaken @simba_83 @VeritasDolor @DavidJuurlink Sry link got cut off https://t.co/ObHmlQ7K4q", "created_at"=>"2016-04-16T12:36:07Z", "user"=>"Raven_PA_", "user_name"=>"Master Muppet ? 2.0", "user_profile_image"=>"http://pbs.twimg.com/profile_images/687061769475473408/HbTDCecD_normal.jpg"}
• {"id"=>"721504937256083456", "text"=>"@julestw9 @LouiseBloxham Synergizing Toxicities, epigenetics, etc... Very mixed bag on that https://t.co/ObHmlQ7K4q", "created_at"=>"2016-04-17T01:05:56Z", "user"=>"Raven_PA_", "user_name"=>"Master Muppet ? 2.0", "user_profile_image"=>"http://pbs.twimg.com/profile_images/687061769475473408/HbTDCecD_normal.jpg"}
• {"id"=>"721670576125952000", "text"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Conver... https://t.co/t4MFN4yQFB", "created_at"=>"2016-04-17T12:04:07Z", "user"=>"mychildthrive", "user_name"=>"My Child Will Thrive", "user_profile_image"=>"http://pbs.twimg.com/profile_images/688772658050121730/KG09JAWk_normal.png"}
• {"id"=>"723510380891373570", "text"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement\n\nhttps://t.co/RGrXSr9mMZ", "created_at"=>"2016-04-22T13:54:51Z", "user"=>"R_Tehubijuluw", "user_name"=>"Raymond Tehubijuluw", "user_profile_image"=>"http://pbs.twimg.com/profile_images/718185905203343361/7ubas7jZ_normal.jpg"}
• {"id"=>"725390722556416004", "text"=>"@Atheist_Eh @DaveTheDrone @Stew__McCall @aspiritcan in your case perhaps. However its far more complicated than that https://t.co/ObHmlQ7K4q", "created_at"=>"2016-04-27T18:26:40Z", "user"=>"Raven_PA_", "user_name"=>"Master Muppet ? 2.0", "user_profile_image"=>"http://pbs.twimg.com/profile_images/687061769475473408/HbTDCecD_normal.jpg"}
• {"id"=>"742162885913268224", "text"=>"RT @PaulWhiteleyPhD: 'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-06-13T01:13:15Z", "user"=>"AutismCanada", "user_name"=>"Autism Canada", "user_profile_image"=>"http://pbs.twimg.com/profile_images/715948434776150018/N7Ty5i3l_normal.jpg"}
• {"id"=>"742242853548609536", "text"=>"RT @PaulWhiteleyPhD: 'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-06-13T06:31:01Z", "user"=>"AutismRealityNB", "user_name"=>"Harold L Doherty", "user_profile_image"=>"http://pbs.twimg.com/profile_images/675952054305714176/c_QwmilQ_normal.jpg"}
• {"id"=>"742248423135412224", "text"=>"RT @PaulWhiteleyPhD: 'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-06-13T06:53:09Z", "user"=>"edsonalexpep", "user_name"=>"Jose Luis Hernandez ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1351226835/ultreya_2_normal.jpg"}
• {"id"=>"752242664565866496", "text"=>"RT @PaulWhiteleyPhD: 'Autism genes' might not be just genes for autism https://t.co/AjG3Lc0nXo New from @marthaherbertmd et al.", "created_at"=>"2016-07-10T20:46:41Z", "user"=>"EyeOfGnosis", "user_name"=>"WisdomWillReign", "user_profile_image"=>"http://pbs.twimg.com/profile_images/746985114261917696/5jvyOmS7_normal.jpg"}
• {"id"=>"809092243655159808", "text"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Conver... https://t.co/t4MFN4yQFB", "created_at"=>"2016-12-14T17:46:37Z", "user"=>"mychildthrive", "user_name"=>"My Child Will Thrive", "user_profile_image"=>"http://pbs.twimg.com/profile_images/688772658050121730/KG09JAWk_normal.png"}
• {"id"=>"817102693546213376", "text"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Conver... https://t.co/t4MFN4yQFB", "created_at"=>"2017-01-05T20:17:17Z", "user"=>"mychildthrive", "user_name"=>"My Child Will Thrive", "user_profile_image"=>"http://pbs.twimg.com/profile_images/688772658050121730/KG09JAWk_normal.png"}
• {"id"=>"825103889779277824", "text"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Conver... https://t.co/t4MFN4yQFB", "created_at"=>"2017-01-27T22:11:11Z", "user"=>"mychildthrive", "user_name"=>"My Child Will Thrive", "user_profile_image"=>"http://pbs.twimg.com/profile_images/688772658050121730/KG09JAWk_normal.png"}
• {"id"=>"846928070347014144", "text"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Conver... https://t.co/t4MFN4yQFB", "created_at"=>"2017-03-29T03:32:41Z", "user"=>"mychildthrive", "user_name"=>"My Child Will Thrive", "user_profile_image"=>"http://pbs.twimg.com/profile_images/688772658050121730/KG09JAWk_normal.png"}
• {"id"=>"874436584648691713", "text"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Conver... https://t.co/t4MFN4yQFB", "created_at"=>"2017-06-13T01:21:42Z", "user"=>"mychildthrive", "user_name"=>"My Child Will Thrive", "user_profile_image"=>"http://pbs.twimg.com/profile_images/688772658050121730/KG09JAWk_normal.png"}
• {"id"=>"900213274460946432", "text"=>"https://t.co/gc6acxyk0u", "created_at"=>"2017-08-23T04:29:04Z", "user"=>"Oxyconmdamu", "user_name"=>"Bearzapine,PharmC", "user_profile_image"=>"http://pbs.twimg.com/profile_images/868633428039696384/r6y1mReb_normal.jpg"}
• {"id"=>"900213356744847360", "text"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Disea ... https://t.co/gc6acxyk0u", "created_at"=>"2017-08-23T04:29:24Z", "user"=>"Oxyconmdamu", "user_name"=>"Bearzapine,PharmC", "user_profile_image"=>"http://pbs.twimg.com/profile_images/868633428039696384/r6y1mReb_normal.jpg"}
• {"id"=>"908407435446153216", "text"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Conver... https://t.co/t4MFN4yQFB", "created_at"=>"2017-09-14T19:09:44Z", "user"=>"mychildthrive", "user_name"=>"My Child Will Thrive", "user_profile_image"=>"http://pbs.twimg.com/profile_images/688772658050121730/KG09JAWk_normal.png"}
• {"id"=>"931282814783426560", "text"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Conver... https://t.co/t4MFN4yQFB", "created_at"=>"2017-11-16T22:08:20Z", "user"=>"mychildthrive", "user_name"=>"My Child Will Thrive", "user_profile_image"=>"http://pbs.twimg.com/profile_images/688772658050121730/KG09JAWk_normal.png"}
• {"id"=>"982231949149331456", "text"=>"@edencsmith @vrolijk5 Oh, you thought THAT was interesting? Check this out: https://t.co/qF4oATMVjr", "created_at"=>"2018-04-06T12:22:00Z", "user"=>"ekverstania", "user_name"=>"Tania Melnyczuk | AutisticStrategies.net", "user_profile_image"=>"http://pbs.twimg.com/profile_images/964114140498464769/kduZ27_p_normal.jpg"}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/4927393", "https://ndownloader.figshare.com/files/4927396", "https://ndownloader.figshare.com/files/4927399"], "description"=>"<div><p>We used established databases in standard ways to systematically characterize gene ontologies, pathways and functional linkages in the large set of genes now associated with autism spectrum disorders (ASDs). These conditions are particularly challenging—they lack clear pathognomonic biological markers, they involve great heterogeneity across multiple levels (genes, systemic biological and brain characteristics, and nuances of behavioral manifestations)—and yet everyone with this diagnosis meets the same defining behavioral criteria. Using the human gene list from Simons Foundation Autism Research Initiative (SFARI) we performed gene set enrichment analysis with the Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway Database, and then derived a pathway network from pathway-pathway functional interactions again in reference to KEGG. Through identifying the GO (Gene Ontology) groups in which SFARI genes were enriched, mapping the coherence between pathways and GO groups, and ranking the relative strengths of representation of pathway network components, we 1) identified 10 disease-associated and 30 function-associated pathways 2) revealed calcium signaling pathway and neuroactive ligand-receptor interaction as the most enriched, statistically significant pathways from the enrichment analysis, 3) showed calcium signaling pathways and MAPK signaling pathway to be interactive hubs with other pathways and also to be involved with pervasively present biological processes, 4) found convergent indications that the process “calcium-PRC (protein kinase C)-Ras-Raf-MAPK/ERK” is likely a major contributor to ASD pathophysiology, and 5) noted that perturbations associated with KEGG’s category of environmental information processing were common. These findings support the idea that ASD-associated genes may contribute not only to core features of ASD themselves but also to vulnerability to other chronic and systemic problems potentially including cancer, metabolic conditions and heart diseases. ASDs may thus arise, or emerge, from underlying vulnerabilities related to pleiotropic genes associated with pervasively important molecular mechanisms, vulnerability to environmental input and multiple systemic co-morbidities.</p></div>", "links"=>[], "tags"=>["autism spectrum disorders", "ASD", "Autism Reveal Multisystem Involvement", "Simons Foundation Autism Research Initiative", "gene", "Pathway Network Analyses", "KEGG", "enrichment analysis", "pathway network components", "SFARI", "MAPK"], "article_id"=>3164134, "categories"=>["Biochemistry", "Medicine", "Microbiology", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health", "Infectious Diseases", "Computational Biology"], "users"=>["Ya Wen", "Mohamad J. Alshikho", "Martha R. Herbert"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0153329.s001", "https://dx.doi.org/10.1371/journal.pone.0153329.s002", "https://dx.doi.org/10.1371/journal.pone.0153329.s003"], "stats"=>{"downloads"=>6, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Pathway_Network_Analyses_for_Autism_Reveal_Multisystem_Involvement_Major_Overlaps_with_Other_Diseases_and_Convergence_upon_MAPK_and_Calcium_Signaling/3164134", "title"=>"Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling", "pos_in_sequence"=>1, "defined_type"=>4, "published_date"=>"2016-04-07 05:14:01"}
• {"files"=>["https://ndownloader.figshare.com/files/4927483"], "description"=>"<p>Pathway groupings and pathway-pathway interactions.</p>", "links"=>[], "tags"=>["autism spectrum disorders", "ASD", "Autism Reveal Multisystem Involvement", "Simons Foundation Autism Research Initiative", "gene", "Pathway Network Analyses", "KEGG", "enrichment analysis", "pathway network components", "SFARI", "MAPK"], "article_id"=>3164200, "categories"=>["Biochemistry", "Medicine", "Microbiology", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health", "Infectious Diseases", "Computational Biology"], "users"=>["Ya Wen", "Mohamad J. Alshikho", "Martha R. Herbert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153329.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Pathway_groupings_and_pathway_pathway_interactions_/3164200", "title"=>"Pathway groupings and pathway-pathway interactions.", "pos_in_sequence"=>6, "defined_type"=>3, "published_date"=>"2016-04-07 05:14:01"}
• {"files"=>["https://ndownloader.figshare.com/files/4927561"], "description"=>"<p>ASD genes in the pathway neuroactive ligand-receptor interaction.</p>", "links"=>[], "tags"=>["autism spectrum disorders", "ASD", "Autism Reveal Multisystem Involvement", "Simons Foundation Autism Research Initiative", "gene", "Pathway Network Analyses", "KEGG", "enrichment analysis", "pathway network components", "SFARI", "MAPK"], "article_id"=>3164266, "categories"=>["Biochemistry", "Medicine", "Microbiology", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health", "Infectious Diseases", "Computational Biology"], "users"=>["Ya Wen", "Mohamad J. Alshikho", "Martha R. Herbert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153329.t004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/ASD_genes_in_the_pathway_neuroactive_ligand_receptor_interaction_/3164266", "title"=>"ASD genes in the pathway neuroactive ligand-receptor interaction.", "pos_in_sequence"=>9, "defined_type"=>3, "published_date"=>"2016-04-07 05:14:01"}
• {"files"=>["https://ndownloader.figshare.com/files/4927405"], "description"=>"<p>Pathways were grouped into subsets of two classes. Pathways in the Disease class are surrounded by a black border; the remainder of the pie chart sections are in the Functional class. Labels indicate pathway groupings (number of pathways in grouping/percentage of total number of pathways).</p>", "links"=>[], "tags"=>["autism spectrum disorders", "ASD", "Autism Reveal Multisystem Involvement", "Simons Foundation Autism Research Initiative", "gene", "Pathway Network Analyses", "KEGG", "enrichment analysis", "pathway network components", "SFARI", "MAPK"], "article_id"=>3164140, "categories"=>["Biochemistry", "Medicine", "Microbiology", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health", "Infectious Diseases", "Computational Biology"], "users"=>["Ya Wen", "Mohamad J. Alshikho", "Martha R. Herbert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153329.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Pathway_groupings_/3164140", "title"=>"Pathway groupings.", "pos_in_sequence"=>2, "defined_type"=>1, "published_date"=>"2016-04-07 05:14:01"}
• {"files"=>["https://ndownloader.figshare.com/files/4927453"], "description"=>"<p>a. Overlapping genes in calcium and MAPK signaling pathways. b. The voltage-gated calcium channel mediates the influx of Ca²⁺, which modulates PKC and Ras. Growth factors bind to the extracellular domain of receptor tyrosine kinases (RTKs), and signal molecules Grb2 (growth factor receptor-bound protein 2) and Sos (son of sevenless) are consequently recruited to the internal docking site, resulting in Ras activation. Ras triggers a phosphorylation cascade including Raf and MEK. This leads to ERK activation and translocation to the nucleus, where ERK then activates transcription factors that mediate gene expression. The ASD genes are listed in light blue frames close to the corresponding gene products that are shown in orange.</p>", "links"=>[], "tags"=>["autism spectrum disorders", "ASD", "Autism Reveal Multisystem Involvement", "Simons Foundation Autism Research Initiative", "gene", "Pathway Network Analyses", "KEGG", "enrichment analysis", "pathway network components", "SFARI", "MAPK"], "article_id"=>3164173, "categories"=>["Biochemistry", "Medicine", "Microbiology", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health", "Infectious Diseases", "Computational Biology"], "users"=>["Ya Wen", "Mohamad J. Alshikho", "Martha R. Herbert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153329.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Integrated_MAPK_and_calcium_signaling_in_ASDs_/3164173", "title"=>"Integrated MAPK and calcium signaling in ASDs.", "pos_in_sequence"=>4, "defined_type"=>1, "published_date"=>"2016-04-07 05:14:01"}
• {"files"=>["https://ndownloader.figshare.com/files/4927534"], "description"=>"<p>Involvement of ASD genes in the ASD pathway network.</p>", "links"=>[], "tags"=>["autism spectrum disorders", "ASD", "Autism Reveal Multisystem Involvement", "Simons Foundation Autism Research Initiative", "gene", "Pathway Network Analyses", "KEGG", "enrichment analysis", "pathway network components", "SFARI", "MAPK"], "article_id"=>3164242, "categories"=>["Biochemistry", "Medicine", "Microbiology", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health", "Infectious Diseases", "Computational Biology"], "users"=>["Ya Wen", "Mohamad J. Alshikho", "Martha R. Herbert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153329.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Involvement_of_ASD_genes_in_the_ASD_pathway_network_/3164242", "title"=>"Involvement of ASD genes in the ASD pathway network.", "pos_in_sequence"=>8, "defined_type"=>3, "published_date"=>"2016-04-07 05:14:01"}
• {"files"=>["https://ndownloader.figshare.com/files/4927465"], "description"=>"<p>The flow chart in <b>a,</b> summarizes the analyses and related results. The conclusions are visualized into a cellular model in <b>b.</b> The relationship between genes, gene products, environmental information processing and phenotypes is schematized in <b>c</b>.</p>", "links"=>[], "tags"=>["autism spectrum disorders", "ASD", "Autism Reveal Multisystem Involvement", "Simons Foundation Autism Research Initiative", "gene", "Pathway Network Analyses", "KEGG", "enrichment analysis", "pathway network components", "SFARI", "MAPK"], "article_id"=>3164182, "categories"=>["Biochemistry", "Medicine", "Microbiology", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health", "Infectious Diseases", "Computational Biology"], "users"=>["Ya Wen", "Mohamad J. Alshikho", "Martha R. Herbert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153329.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_systematic_biological_framework_/3164182", "title"=>"A systematic biological framework.", "pos_in_sequence"=>5, "defined_type"=>1, "published_date"=>"2016-04-07 05:14:01"}
• {"files"=>["https://ndownloader.figshare.com/files/4927423"], "description"=>"<p>Pathways are grouped vertically under two classes, Disease and Function. The color of each node within the groupings represents the p-value of that pathway. The size of each node represents the number of ASD genes in that pathway. Interactions between pairs of pathways are indicated by edges. The pathway-pathway interaction matrix is in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153329#pone.0153329.s003\" target=\"_blank\">S3 Table</a>.</p>", "links"=>[], "tags"=>["autism spectrum disorders", "ASD", "Autism Reveal Multisystem Involvement", "Simons Foundation Autism Research Initiative", "gene", "Pathway Network Analyses", "KEGG", "enrichment analysis", "pathway network components", "SFARI", "MAPK"], "article_id"=>3164155, "categories"=>["Biochemistry", "Medicine", "Microbiology", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health", "Infectious Diseases", "Computational Biology"], "users"=>["Ya Wen", "Mohamad J. Alshikho", "Martha R. Herbert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153329.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/ASD_pathway_network_/3164155", "title"=>"ASD pathway network.", "pos_in_sequence"=>3, "defined_type"=>1, "published_date"=>"2016-04-07 05:14:01"}
• {"files"=>["https://ndownloader.figshare.com/files/4927504"], "description"=>"<p>Enrichment analyses for gene ontologies.</p>", "links"=>[], "tags"=>["autism spectrum disorders", "ASD", "Autism Reveal Multisystem Involvement", "Simons Foundation Autism Research Initiative", "gene", "Pathway Network Analyses", "KEGG", "enrichment analysis", "pathway network components", "SFARI", "MAPK"], "article_id"=>3164221, "categories"=>["Biochemistry", "Medicine", "Microbiology", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health", "Infectious Diseases", "Computational Biology"], "users"=>["Ya Wen", "Mohamad J. Alshikho", "Martha R. Herbert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153329.t002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Enrichment_analyses_for_gene_ontologies_/3164221", "title"=>"Enrichment analyses for gene ontologies.", "pos_in_sequence"=>7, "defined_type"=>3, "published_date"=>"2016-04-07 05:14:01"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}

F1000Prime