The Effect of High Dose Folic Acid throughout Pregnancy on Homocysteine (Hcy) Concentration and Pre-Eclampsia: A Randomized Clinical Trial
Publication Date
May 11, 2016
Journal
PLOS ONE
Authors
Manizheh Sayyah Melli, Amir Ghorbanihaghjo, Mahasti Alizadeh, Maryamalsadat Kazemi Shishvan, et al
Volume
11
Issue
5
Pages
e0154400
DOI
https://dx.plos.org/10.1371/journal.pone.0154400
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0154400
Scopus
84969793660
Mendeley
http://www.mendeley.com/research/effect-high-dose-folic-acid-throughout-pregnancy-homocysteine-hcy-concentration-preeclampsia-randomi
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Mendeley | Further Information

{"title"=>"The effect of high dose folic acid throughout pregnancy on homocysteine (Hcy) concentration and pre-eclampsia: A randomized clinical trial", "type"=>"journal", "authors"=>[{"first_name"=>"Manizheh", "last_name"=>"Sayyah-Melli", "scopus_author_id"=>"8847181100"}, {"first_name"=>"Amir", "last_name"=>"Ghorbanihaghjo", "scopus_author_id"=>"10044951700"}, {"first_name"=>"Mahasti", "last_name"=>"Alizadeh", "scopus_author_id"=>"23007554800"}, {"first_name"=>"Maryamalsadat", "last_name"=>"Kazemi-Shishvan", "scopus_author_id"=>"40261626500"}, {"first_name"=>"Morteza", "last_name"=>"Ghojazadeh", "scopus_author_id"=>"23093330400"}, {"first_name"=>"Sanam", "last_name"=>"Bidadi", "scopus_author_id"=>"25623308100"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84969793660", "doi"=>"10.1371/journal.pone.0154400", "pui"=>"610397775", "pmid"=>"27166794", "scopus"=>"2-s2.0-84969793660", "issn"=>"19326203", "isbn"=>"1932-6203"}, "id"=>"442d2923-18c8-32f4-a14a-5cec93bec028", "abstract"=>"Pre-eclampsia is a pregnancy-related multi-systemic hypertensive disorder and affects at least 5% of pregnancies. This randomized clinical trial aimed at assessing the effect of low doses and high doses of folic acid on homocysteine (Hcy) levels, blood pressure, urea, creatinine and neonatal outcome. A randomized clinical trial was done at Alzahra Teaching Hospital, Tabriz University of Medical Sciences from April 2008 to March 2013. Four-hundred and sixty nulliparous pregnant women were randomly assigned into two groups. Group 1 (n = 230) received 0.5 mg of folic acid and group 2 (n = 230) received 5 mg of folic acid per daily. They were followed until delivery. Blood pressure and laboratory changes, including plasma Hcy levels, were measured and compared between the groups. Homocysteine concentrations were significantly higher at the time of delivery in group 1 (13.17±3.89 μmol/l) than in group 2 (10.31±3.54, μmol/l) (p<0.001). No statistically significant differences were observed in systolic and diastolic blood pressure (p = 0.84 and 0.15, respectively). Birth weight was significantly higher in group 2 (p = 0.031) and early abortion was significantly higher in group 1 than group 2 (p = 0.001). This study has provided evidence that a high dosage of folic acid supplements throughout pregnancy reduces Hcy concentrations at the time of delivery.", "link"=>"http://www.mendeley.com/research/effect-high-dose-folic-acid-throughout-pregnancy-homocysteine-hcy-concentration-preeclampsia-randomi", "reader_count"=>26, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Librarian"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>3, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Librarian"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>3, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>3, "Medicine and Dentistry"=>12, "Agricultural and Biological Sciences"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Decision Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Decision Sciences"=>{"Decision Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>6}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>2}

Scopus | Further Information

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  • {"unique-ip"=>"128", "full-text"=>"163", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"97", "full-text"=>"103", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"125", "full-text"=>"139", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"158", "full-text"=>"169", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"116", "full-text"=>"128", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"136", "full-text"=>"151", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"122", "full-text"=>"152", "pdf"=>"17", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"2", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"159", "full-text"=>"190", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"120", "full-text"=>"143", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"119", "full-text"=>"128", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"83", "full-text"=>"94", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"71", "full-text"=>"81", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"112", "full-text"=>"119", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"109", "full-text"=>"121", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}

Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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