Enterococcus durans TN-3 Induces Regulatory T Cells and Suppresses the Development of Dextran Sulfate Sodium (DSS)-Induced Experimental Colitis
Publication Date
July 20, 2016
Journal
PLOS ONE
Authors
Toshihiro Kanda, Atsushi Nishida, Masashi Ohno, Hirotsugu Imaeda, et al
Volume
11
Issue
7
Pages
e0159705
DOI
https://dx.plos.org/10.1371/journal.pone.0159705
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0159705
Web of Science
000380170100070
Scopus
84979620552
Mendeley
http://www.mendeley.com/research/enterococcus-durans-tn3-induces-regulatory-t-cells-suppresses-development-dextran-sulfate-sodium-dss
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Mendeley | Further Information

{"title"=>"Enterococcus durans TN-3 induces regulatory T cells and suppresses the development of dextran sulfate sodium (DSS)-induced experimental colitis", "type"=>"journal", "authors"=>[{"first_name"=>"Toshihiro", "last_name"=>"Kanda", "scopus_author_id"=>"57077785300"}, {"first_name"=>"Atsushi", "last_name"=>"Nishida", "scopus_author_id"=>"7102999671"}, {"first_name"=>"Masashi", "last_name"=>"Ohno", "scopus_author_id"=>"57037899400"}, {"first_name"=>"Hirotsugu", "last_name"=>"Imaeda", "scopus_author_id"=>"7003439554"}, {"first_name"=>"Takashi", "last_name"=>"Shimada", "scopus_author_id"=>"7402200122"}, {"first_name"=>"Osamu", "last_name"=>"Inatomi", "scopus_author_id"=>"8076700000"}, {"first_name"=>"Shigeki", "last_name"=>"Bamba", "scopus_author_id"=>"6601940818"}, {"first_name"=>"Mitsushige", "last_name"=>"Sugimoto", "scopus_author_id"=>"8265532300"}, {"first_name"=>"Akira", "last_name"=>"Andoh", "scopus_author_id"=>"57078176700"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84979620552", "sgr"=>"84979620552", "pui"=>"611323742", "pmid"=>"27438072", "doi"=>"10.1371/journal.pone.0159705"}, "id"=>"46f4b7e9-5680-33f3-a67c-d4df346eee95", "abstract"=>"BACKGROUND AND AIMS: Probiotic properties of Enterococcus strains have been reported previously. In this study, we investigated the effects of Enterococcus (E.) durans TN-3 on the development of dextran sulfate sodium (DSS) colitis. METHODS: BALB/c mice were fed with 4.0% DSS in normal chow. Administration of TN-3 (10mg/day) was initiated 7days before the start of DSS feeding. Mucosal cytokine expression was analyzed by real time-PCR and immunohistochemistry. The lymphocyte subpopulation were analyzed by flow cytometry. The gut microbiota profile was analyzed by a terminal-restriction fragment length polymorphism method (T-RFLP). RESULTS: The disease activity index and histological colitis score were significantly lower in the DSS plus TN-3 group than in the DSS group. The mucosal mRNA expression of proinflammatory cytokines (IL-1beta, IL-6, IL-17A and IFN-gamma) decreased significantly in the DSS plus TN-3 group as compared to the DSS group. The proportion of regulatory T cells (Treg cells) in the mucosa increased significantly in the DSS plus TN-3 group as compared to the DSS group. Both fecal butyrate levels and the diversity of fecal microbial community were significantly higher in the TN-3 plus DSS group than in the DSS group. CONCLUSIONS: E. durans TN-3 exerted an inhibitory effect on the development of DSS colitis. This action might be mediated by the induction of Treg cells and the restoration of the diversity of the gut microbiota.", "link"=>"http://www.mendeley.com/research/enterococcus-durans-tn3-induces-regulatory-t-cells-suppresses-development-dextran-sulfate-sodium-dss", "reader_count"=>11, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>1, "Student > Bachelor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>1, "Student > Bachelor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

Scopus | Further Information

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