Plasma Metabolomics Biosignature According to HIV Stage of Infection, Pace of Disease Progression, Viremia Level and Immunological Response to Treatment
Publication Date
December 12, 2016
Authors
Bruno Scarpelini, Michelle Zanoni, Maria Cecilia Araripe Sucupira, Hong Ha M. Truong, et al
Volume
11
Issue
12
Pages
e0161920
DOI
https://dx.plos.org/10.1371/journal.pone.0161920
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0161920
Web of Science
000392745600002
Scopus
85006059478
Mendeley
http://www.mendeley.com/research/plasma-metabolomics-biosignature-according-hiv-stage-infection-pace-disease-progression-viremia-leve
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Mendeley | Further Information

{"title"=>"Plasma metabolomics biosignature according to HIV stage of infection, pace of disease progression, viremia level and immunological response to treatment", "type"=>"journal", "authors"=>[{"first_name"=>"Bruno", "last_name"=>"Scarpelini", "scopus_author_id"=>"57192369750"}, {"first_name"=>"Michelle", "last_name"=>"Zanoni", "scopus_author_id"=>"37038925700"}, {"first_name"=>"Maria Cecilia Araripe", "last_name"=>"Sucupira", "scopus_author_id"=>"6701644926"}, {"first_name"=>"Hong Ha M.", "last_name"=>"Truong", "scopus_author_id"=>"16168331700"}, {"first_name"=>"Luiz Mario Ramos", "last_name"=>"Janini", "scopus_author_id"=>"6507253503"}, {"first_name"=>"Ismael Dale Cotrin", "last_name"=>"Segurado", "scopus_author_id"=>"57192373209"}, {"first_name"=>"Ricardo Sobhie", "last_name"=>"Diaz", "scopus_author_id"=>"56591560600"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"613644309", "sgr"=>"85006059478", "pmid"=>"27941971", "scopus"=>"2-s2.0-85006059478", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0161920", "issn"=>"19326203"}, "id"=>"0afc769f-fc5c-3828-af23-18e46e47b608", "abstract"=>"BACKGROUND We evaluated plasma samples HIV-infected individuals with different phenotypic profile among five HIV-infected elite controllers and five rapid progressors after recent HIV infection and one year later and from 10 individuals subjected to antiretroviral therapy, five of whom were immunological non-responders (INR), before and after one year of antiretroviral treatment compared to 175 samples from HIV-negative patients. A targeted quantitative tandem mass spectrometry metabolomics approach was used in order to determine plasma metabolomics biosignature that may relate to HIV infection, pace of HIV disease progression, and immunological response to treatment. RESULTS Twenty-five unique metabolites were identified, including five metabolites that could distinguish rapid progressors and INRs at baseline. Severe deregulation in acylcarnitine and sphingomyelin metabolism compatible with mitochondrial deficiencies was observed. β-oxidation and sphingosine-1-phosphate-phosphatase-1 activity were down-regulated, whereas acyl-alkyl-containing phosphatidylcholines and alkylglyceronephosphate synthase levels were elevated in INRs. Evidence that elite controllers harbor an inborn error of metabolism (late-onset multiple acyl-coenzyme A dehydrogenase deficiency [MADD]) was detected. CONCLUSIONS Blood-based markers from metabolomics show a very high accuracy of discriminating HIV infection between varieties of controls and have the ability to predict rapid disease progression or poor antiretroviral immunological response. These metabolites can be used as biomarkers of HIV natural evolution or treatment response and provide insight into the mechanisms of the disease.", "link"=>"http://www.mendeley.com/research/plasma-metabolomics-biosignature-according-hiv-stage-infection-pace-disease-progression-viremia-leve", "reader_count"=>19, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>2, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>5}}, "group_count"=>0}

Scopus | Further Information

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