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Spontaneous Cannabinoid Receptor 2 (CB₂) Expression in the Cochlea of Adult Albino Rat and Its Up-Regulation after Cisplatin Treatment

Publication Date: August 26, 2016
Journal: PLOS ONE
Authors: Sergio Martín Saldaña, Almudena Trinidad, Elvira Ramil, Antonio J. Sánchez López, et al
Volume: 11
Issue: 8
Pages: e0161954
DOI: https://dx.plos.org/10.1371/journal.pone.0161954
Publisher URL: http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0161954
Scopus: 84990068165
Mendeley: http://www.mendeley.com/research/spontaneous-cannabinoid-receptor-2-cb2-expression-cochlea-adult-albino-rat-upregulation-after-cispla

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Mendeley 614 May 09:11 UTC

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{"title"=>"Spontaneous Cannabinoid Receptor 2 (CB2) expression in the cochlea of adult albino rat and its up-regulation after cisplatin treatment", "type"=>"journal", "authors"=>[{"first_name"=>"Sergio", "last_name"=>"Martín-Saldaña", "scopus_author_id"=>"57090865500"}, {"first_name"=>"Almudena", "last_name"=>"Trinidad", "scopus_author_id"=>"56109606600"}, {"first_name"=>"Elvira", "last_name"=>"Ramil", "scopus_author_id"=>"57193902939"}, {"first_name"=>"Antonio J.", "last_name"=>"Sánchez-López", "scopus_author_id"=>"37665880200"}, {"first_name"=>"Maria José", "last_name"=>"Coronado", "scopus_author_id"=>"6701544332"}, {"first_name"=>"Esther", "last_name"=>"Martínez-Martínez", "scopus_author_id"=>"57064203100"}, {"first_name"=>"José Miguel", "last_name"=>"García", "scopus_author_id"=>"7406129118"}, {"first_name"=>"José Ramón", "last_name"=>"García-Berrocal", "scopus_author_id"=>"7003616169"}, {"first_name"=>"Rafael", "last_name"=>"Ramírez-Camacho", "scopus_author_id"=>"7004248940"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"612518074", "pmid"=>"27564061", "doi"=>"10.1371/journal.pone.0161954", "issn"=>"19326203", "scopus"=>"2-s2.0-84990068165", "sgr"=>"84990068165"}, "id"=>"de4725ae-b53d-3047-a113-b6002e51f402", "abstract"=>"We provide evidence for the presence of cannabinoid CB2 receptors in some cellular types of the cochlea of the adult albino rat. Cannabinoids and their receptors are increasingly being studied because of their high potential for clinical use. As a hyperspecialized portion of the peripheral nervous system, study of the expression and function of cannabinoid receptors in the hearing organ is of high interest. Stria vascularis and inner hair cells express CB2 receptor, as well as neurites and cell bodies of the spiral ganglion. Cellular types such as supporting cells and outer hair cells, in which the expression of other types of functional receptors has been reported, do not significantly express CB2 receptors in this study. An up-regulation of CB2 gene expression was detected after an ototoxic event such as cisplatin treatment, probably due to pro-inflammatory events triggered by the drug. That fact suggests promising potential of CB2 receptor as a therapeutic target for new treatments to palliate cisplatin-induced hearing loss and other ototoxic events which triggers inflammatory pathways.", "link"=>"http://www.mendeley.com/research/spontaneous-cannabinoid-receptor-2-cb2-expression-cochlea-adult-albino-rat-upregulation-after-cispla", "reader_count"=>6, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Student > Ph. D. Student"=>3, "Other"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Student > Ph. D. Student"=>3, "Other"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>1, "Neuroscience"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

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